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김태정,임성빈,정진형,Kim, Tae-Jung,Lim, Sung-Bin,Chung, Chin-Hyung 대한치주과학회 2002 Journal of Periodontal & Implant Science Vol.32 No.3
Various long-term studies have shown that titanium implants as abutments for different types of prostheses have become a predictable adjunct in the treatment of partially or fully edentulous patients. The continuous exposure of dental implants to the oral cavity with all its possible contaminants creates a problem. A lack of attachment, together with or caused by bacterial insult, may lead to peri-implantitis and eventual implant failure. Removal of plaque and calculus deposits from dental titanium implants with procedures and instruments originally made for cleaning natural teeth or roots may cause major alterations of the delicate titanium oxide layer. Therefore, the ultimate goal of a cleaning procedure should be to remove the contaminants and restore the elemental composition of the surface oxide without changing the surface topography and harming the surrounding tissues. Among many chemical and mechanical procedure, air-powder abrasive have been known to be most effective for cleaning and detoxification of implant surface. Most of published studies show that the dental laser may be useful in the treatment of pen-implantitis. $CO_2$ laser and Soft Diode laser were reported to kill bacteria of implant surface. The purpose of this study was to obtain clinical guide by application these laser to implant surface by means of Non-contact Surface profilometer and X-ray photoelectron spectroscopy(XPS) with respect to surface roughness and atomic composition. Experimental rough pure titanium cylinder models were fabricated. All of them was air-powder abraded for 1 minute and they were named control group. And then, the $CO_2$ laser treatment under dry, hydrogen peroxide and wet condition or the Soft Diode laser treatment under Toluidine blue O solution condition was performed on the each of the control models. The results were as follows: 1. Mean Surface roughness(Ra) of all experimental group was decreased than that of control group. But it wasn't statistically significant. 2. XPS analysis showed that in the all experimental group, titanium level were decreased, when compared with control group. 3. XPS analysis showed that the level of oxygen in the experimental group 1, 3($CO_2$ laser treatment under dry and wet condition) and 4(Soft Diode laser was used under toluidine blue O solution) were decreased, when compared with control group. 4. XPS analysis showed that the atomic composition of experimental group 2($CO_2$ laser treatment under hydrogen peroxide) was to be closest to that of control group than the other experimental group. From the result of this study, this may be concluded. Following air-powder abrasive treatment, the $CO_2$ laser in safe d-pulse mode and the Soft Diode laser used with photosensitizer would not change rough titanium surface roughness. Especially, $CO_2$ laser treatment under hydrogen peroxide gave the best results from elemental points of view, and can be used safely to treat peri-implantitis.
주현철(Hyeon Cheol Joo),김태정(Tae-Chung Kim),이수호(Su Ho Lee),정병환(Byung Hwan Jung) 한국자동차공학회 2009 한국자동차공학회 학술대회 및 전시회 Vol.2009 No.11
Prediction of NVH performance of an engine block at the initial design stage is important, because NVH characteristics of a structure are related to global stiffness balance, not to local band-aids. The NVH performance of an engine structure is related to skeleton stiffness, skirt radius, flange and tubing locations altogether. In this paper, an example of NVH characteristics prediction using CAE is presented first. These results are compared to measured experimental results to prove its reliability, and the CAE prediction technique is adapted into a challenging light-weight thin-wall engine block development. Necessary modifications are tried and verified with CAE, and finally a weight reduction of 11.2㎏ is achieved with better NVH performance than current mass-production units.
BMP-2를 함유한 2상 알지네이트 담체를 이용한 골수줄기세포의 골분화
임현주,김학태,오은정,김태정,김한도,최진현,정호윤,Lim, Hyun-Ju,Kim, Hak-Tae,Oh, Eun-Jung,Kim, Tae-Jung,Ghim, Han-Do,Choi, Jin-Hyun,Chung, Ho-Yun 대한성형외과학회 2010 Archives of Plastic Surgery Vol.37 No.3
Purpose: The object of this study is to develop a novel BMP-2 delivery system for continuous osteogenic differentiation and to induce osteogenesis of stem cells using a bi-phase alginate carrier in vitro. Methods: Alginate nanoparticle loaded BMP-2 was prepared by the reverse emulsification-diffusion technique. Physical properties and release profiles of alginate carriers were measured by Instron and ELISA kit, respectively. Cell viability and alkaline phosphate activity of hBMSCs differentiation was also evaluated by MTS and Metra BAP assays, respectively. Results: Optimal concentration for bi-phase alginate carrier was determined as 2 wt% by evaluating mechanical and biological properties, and differentiation of BMSCs for bone regeneration. The 2% bi-phase alginate carrier had the lowest initial and final release ratio. In addition, the 2% bi-phase alginate carrier had a little higher ALP activity than the homogeneous carrier. An improved controlled release profile was obtained by combining alginate hydrogel with lyophilized particles. Conclusion: Bi-phase alginate carrier has many advantages such as biocompatibility and controlled release capability. It is expected to be effective as a scaffold and carrier in bone tissue engineering.
인공피부를 위한 키토산-PLGA-PEO 나노섬유/PLGA 마이크로섬유 융복합 지지체
임현주 ( Hyun Ju Lim ),김철주 ( Cheol Joo Kim ),오은정 ( Eun Jung Oh ),김태정 ( Tae Jung Kim ),정소연 ( So Yeon Jung ),최진현 ( Jin Hyun Choi ),이원주 ( Weon Ju Lee ),권오형 ( Oh Hyeong Kwon ),정호윤 ( Ho Yun Chung ) 한국조직공학과 재생의학회 2011 조직공학과 재생의학 Vol.8 No.2s
When the skin is seriously damaged through disease or trauma, artificial skin using synthetic or natural polymer is essential due to limitation of self-repair and donor-site morbidity. Generally, microfiber has demerit of cell maintenance limits after cell seeding and nanofiber has demerit of structural weakness. In this study, we prepared hybrid scaffolds composed of the nanofibers of chitosan-poly(lactic-co-glycolic acid) (PLGA)-poly ethylene oxide and microfibers of PLGA for artificial skin. The morphology and hydrophilicity of the scaffolds were characterized by scanning electron microscope (SEM) and contact angle machine. Dermal sheath cells, one of hair follicle stem cells were applied on the scaffolds and analyzed. Hybrid scaffolds possessed high hydrophilicity and exhibited good cell adhesion and viability at appropriate nano/microfiber ratio. Thus, this hybrid scaffold shows a potential as a material for artificial skin.
Moisture Wound Healing Characteristics of Alginate Sponge and Hydrogel
Ga Young Park(박가영),Jeong Hyun Yeum(염정현),Dong Joon Yang(양동준),Guen Oh Park(박근오),Yun Hee Kim(김윤희),Saewha Jeon(전세화),Tae Jung Kim(김태정),Eun Jung Oh(오은정),Ho Yun Chung(정호윤),Jin Hyun Choi(최진현) 한국고분자학회 2018 폴리머 Vol.42 No.1
건조/가교법으로 제조한 알지네이트 스폰지 및 하이드로젤의 물리적, 생물학적 특성 및 창상치유 특성을 고찰하였다. 하이드로젤은 스폰지 대비 높은 평형 함수율을 보유하였고, 자체적으로 수분을 함유하고 있기 때문에 상대적으로 우수한 습윤 창상치유 환경을 제공할 수 있었다. 알지네이트 스폰지 및 하이드로젤의 사이토카인 결속효과에 기인하여 대식세포로부터 분비되는 전염증성 사이토카인의 함량이 감소됨을 확인하였으며, 특히 하이드로젤의 사이토카인 억제효과가 더욱 두드러지게 나타났는데, 이는 보다 팽윤된 상태에서 알지네이트 분자의 사이토카인에 대한 결속력이 증가함을 의미한다. 창상형성 초기 하이드로젤에 의한 창상치유 및 수축 효과가 스폰지에 비해 우수한 것으로 나타났으나, 상피화는 스폰지를 적용했을 때 보다 우세하게 진행되었다. 조직학적 평가와 RNA 발현 분석으로부터 알지네이트 스폰지 및 하이드로젤은 혈관 및 콜라겐 섬유의 형성, 상피조직의 재생 및 단백질의 생성 등을 촉진함을 확인하였다. Alginate sponge and hydrogel were prepared by a drying/crosslinking method and their wound healing characteristics were investigated comparatively. The alginate hydrogel had a higher equilibrium water content than the sponge, providing a moist wound healing condition without absorbing exudate from a wound. The amounts of proinflammatory cytokines released by macrophages were lowered due to the cytokine-binding effects of the alginate sponge and hydrogel. The hydrogel lowered the cytokine level more dominantly than the sponge, suggesting that the affinity of alginate molecules to cytokines increases at a more swollen state. The hydrogel allowed superior wound healing and contraction at the early stage of application. However, epithelialization was conspicuous when the sponge was applied. It was confirmed through histological examination and RNA expression analysis that angiogenesis, formation of collagen fibers, regeneration of epithelium, and production of protein were promoted using the alginate sponge and hydrogel as wound dressing materials.