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조류 인플루엔자와 구제역 바이러스 차단방역을 위한 미산성 차아염소산수의 소독 조건
김진윤,윤동식,이화용,정우석,박승춘,Kim, Jin-Yoon,Yun, Dong-Sik,Lee, Haw-Yong,Jeong, Woo-Seog,Park, Seung-Chun 대한수의학회 2019 大韓獸醫學會誌 Vol.59 No.2
This study examined the disinfection conditions (exposure time, 0-30 min; exposure temperature, $4^{\circ}C-65^{\circ}C$) of hypochlorous acid water (HOCl) in automobile disinfection equipment. The study tested poliovirus type 1 (PV1), low pathogenic avian influenza virus (AIV, H9N2), and foot and mouth disease virus (FMDV, O type). As a result, the PV1 and FMD viruses were inactivated easily (virus titer 4 log value) by HOCl (> 100 ppm) but the AIV required higher exposure temperatures (> $55^{\circ}C$). In conclusion, the exposure temperature and time are important factors in deactivating AIV and FMDV.
Citronella 및 lemongrass oil의 생리활성 및 단회 경구 투여 독성시험
박지용,김진윤,장승희,김해중,이승진,박승춘,Park, Ji-Yong,Kim, Jin-Yoon,Jang, Seung-Hee,Kim, Hae-Jung,Lee, Seung-Jin,Park, Seung-Chun 대한수의학회 2015 大韓獸醫學會誌 Vol.55 No.1
This study was performed to investigate the antibacterial, antioxidant, and termite repellent effects of citronella oil (CiO) and lemongrass oil (LO). When the antibacterial activity against Staphylococcus (S.) aureus with various levels of antibacterial resistance were tested, a 0.05% concentration of CiO and LO completely inhibited the growth of all tested S. aureus strains. Evaluation of the antioxidant effect demonstrated that the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity of CiO was 2~3 times greater than that of LO. Among trial products made with various combinations of CiO and LO, a CiO : LO ratio of 6 : 4 had the most potent termite repellent effects. Assessment of acute toxicity of the trial product showed that the $LD_{50}$ was more than 2,000 mg/kg. Based on the above results, CiO and LO have antibacterial, antioxidant, and termite repellent activities. Therefore, both compounds could be potential termites repellent reagents.
김진윤,박선규,윤정수,김항중 대한마취과학회 1995 Korean Journal of Anesthesiology Vol.28 No.5
The proliferation of high-technology infusion devices has greatly influenced the practice of anesthesia by allowing precise delivery intraoperatively and postoperatively of intravenous anesthetics, analgesics, and vasopressors. During continuous drug administration to pediatric patients, unfavorable pharmacologic effects have occured. These effects were attributed to variations in flow from infusion devices. The intent of this investigation was to evaluate the influence of infusion devices on the accuracy and continuity effused fluid. Hartmann's solution was run through eight infusion pump at 5, 10, 15, 20, 25, 30, 40, 60, 80 and 100ml/hr. The volume of the fluid was measured for one hour at each flow rate using a infusion device analyzer(IDA-2) in vitro. Flow accuracy(ml/hr) was calculated by dividing the effused volume by the effusion time ; this value was subsequently expressed as a percentage of the desired flow rate. Flow continuity was expressed by the coefficient of variance(CV); analysis of variance with SAS was used for comparisons. Results were as follows ; 1) The flow accuracy values ranged from 98.8% to 114.2% of the desired rate. 2) Seven infusion pumps had flow rates within 5% of the desired rates at each flow rate but one pump had more than 10% of desired rate. 3) Each of the respective infusion pumps produced various levels of flow continuity and ranged from 0.7% to 2.5%(CV value). Conclusion , further evaluations are needed to differentiate continuity from other infusion devices(e.g., syringe infusion pump) in vitro and evaluations are needed to define the clinical significance in vivo. Future use of flow-rate data will likely be of significant value in establishing policies and procedures for the utilization of infusion devices and guidelines for product selection.
신경병증성 통증 쥐 모델에서 전신적으로 투여한 Ketamine의 선행진통 효과
이보령,김진윤,박선규,구길회,우영철,정용훈,백종화,박정원,이인구 중앙대학교 의과대학 의과학연구소 2003 中央醫大誌 Vol.28 No.2-3
Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, has been used for the treatment of neuropathic pain. But the preemptive analgesic effect of ketamine in neuropathic pain is not widely known. The purpose of this study was to evaluate the preemptive effect of systemic ketamine in neuropathic pain rat model. Eighteen male rats were divided into ketamine (n=9) and control (n=9) group. The rats were injected with ketamine (5% ketamine 20 mg/kg, intraperitoneal) at 30 min before operation in ketamine group but normal saline in control group. Neuropathic pain model was made by L5 spinal nerve ligation. The spontaneous pain behaviors (weight bearing, licking, limping, motor weakness, foot deformity) and foot withdrawal response frequency (RF) by von Frey filament (VFF, 0.4-2.0-10.0-15.0 g) were measured at pre and post operative 3, 5, 7, 14, 21 and 28th day (POD3-28). There was no difference in spontaneous pain behaviors between two groups. RF with VFF 0.4 and 2.0 g increased from POD3 to POD28 in both groups (p<0.05). RF with VFF 10.0 g increased from POD21 in ketamine group and from POD3 in control group (p<0.05). RF with VFF 15.0 g increased from POD21 in ketamine group and from POD5 in control group (p<0.05). Ketamine group showed lower RF than control group at POD3 and POD7 with VFF 15.0 g (p<0.05). In conclusion systemic injection of high dose ketamine for preemptive analgesia in neuropathic pain rat model delayed the onset of mechanical hyperalgesia with VFF 10.0 and 15.0 g for 3 weeks, but did not prevent the development of neuropathic pain.
무호흡상태의 개에서 기관지내 지속적인 공기주입이 심폐기계에 미치는 영향
박선규,김석주,라은길,김진윤 대한마취과학회 1998 Korean Journal of Anesthesiology Vol.35 No.4
Background : Mass casualties from organophosphrous inhalation die from respiratory depression. Gas supplies and equipment are limited for mechanical ventilation of multiple subjects. Endobronchial insufflation of air (EIA) requires only a compresssor and airway catheters. We examined clinical usefulness of EIA in a model of apnea produced by tetrodotoxin (TTX) infusion. Methods : Five anesthetized dogs were applied the conventional mechanical ventilation (CMV) while 12 mcg/kg TTX was infused IV over 90 min to produce apnea. EIA at 1 L/kg/min was delivered through a 35 cm long 0.8 cm I.D. catheter with a forked end placed astride the carina. Measurements of cardiovascular and respiratory function were made after TTX (time=0) on CMV, and then serially for 4 hours of EIA. Results: All dogs survived through 4 hours study. PaO2 decreased significantly within 30 min and then slowly increased significantly after 60 min. PaCO2 increased significantly within 30 min and decreased significantly after 60 min. HR increased significantly after 20 min and MAP increased significantly after 60 min. Mean SD of PaO2, PaCO2, pHa, SaO2, cardiac output, mean pulmonary pressure, mean arterial pressure, systemic vascular resistance, central venous pressure and Qs/Qt are shown in table. Spontaneous respiratory efforts slowly returned after 45 min of EIA and resulted in the improvement of gas exchange. Conclusion : EIA is a field ventilatory technique useful when other equipment may not be available. The airway catheter can be placed by cricothyroidotomy. EIA supports life and produces normal survivors in apneic dogs. (Korean J Anesthesiol 1998; 35: 599∼606)