난관내막증의 임상 및 병리학적 특성에 관한 연구

김정구,김종혁,박태식,이경희,김석현,최영민,신창재,문신용,이진용,장윤석,Kim, Jung-Gu,Kim, Jong-Hyeok,Park, Tae-Sic,Lee, Kyung-Hee,Kim, Seok-Hyun,Choi, Young-Min,Shin, Chang-Jae,Moon, Shin-Yong,Lee, Jin-Yong,Chang, Yoon-Seok 대한생식의학회 1991 Clinical and Experimental Reproductive Medicine Vol.18 No.2

Endosalpingiosis is defined as the ectopic location of tubal epithelium. The term is purely descriptive and does not necessarily imply either the direct origin from tubal mucosa or the similarity of function. This study was performed to evaluate the clinical and pathologic characteristics of endosalpingiosis in the patients with endosalpingiosis proven by pathologic investigation. The medical histories and pathologic reports of 22 endosalpingiosis patients who received the laparotomy at Seoul National University Hospital from August, 1982 to December, 1990 were reviewed. The results were as follows: 1. Age distribution was from 26 to 46 years with the mean age of 34.0 years. 2. Twelve(54.6%) patients were nulligravida and the chief complaint of these patients was infertility(45.5%). 3. Six (27.3%) patients had the previous laparoscopic tubal sterilization by electrocautery or ring application. 4. Four (18.2%) patients had previous history of tubal pregnancy. 5. The most prevalent location of endosalpingiosis was the proximal segment of the salpinx, and the length of the proximal stump from the lesion was less than 1cm in 16(72.7%) patients.

자궁내막증환자에서 성선자극호르몬 유리호르몬 협동제 치료후 체액성 면역인자의 변화양상

김정구,김동호,최두석,김대원,문신용,강순범,이용희,이진용,Kim, Jung-Gu,Kim, Dong-Ho,Choi, Doo-Suck,Kim, Dae-Won,Moon, Shin-Yong,Kang, Soong-Beom,Lee, Yong-Hee,Lee, Jin-Yong 대한생식의학회 2000 Clinical and Experimental Reproductive Medicine Vol.27 No.1

자궁내막증 환자의 복강액내 항자궁내막항체에 관한 연구

김정구,김동호,최두석,김대원,문신용,강순범,이진용,Kim, Jung-Gu,Kim, Dong-Ho,Choi, Doo-Suck,Kim, Dae-Won,Moon, Shin-Yong,Kang, Soong-Beom,Lee, Jin-Yong 대한생식의학회 1998 Clinical and Experimental Reproductive Medicine Vol.25 No.1

We have previously demonstrated that specific antigens involved in autoimmunity in endometriosis may be endometrial proteins with molecular weight (mw) of 71, 92, and 103 kilodalton (kDa). The purposes of this study were to determine the incidence of IgG antibodies against these endometrial antigens in peritoneal fluid of patients with endometriosis and to evaluate the antigenic differences between the endometria of patients with and without endometriosis. Forty peritoneal fluid (PF) from 24 patients with endometriosis and 16 patients without endometriosis (control patients) were tested against endometrial protein from patients (n=8) with endometriosis and from control patients (n=10) by western blot. Fifteen (62.5%) of 24 PF samples from patients with endometriosis had specific Immunoglobuiin (Ig) G antibodies against one of three endometrial proteins with mw of 71, 92 and 103 kDa but none of PF samples from control patients had these antibodies. The electrophoretic pattern of endometrial proteins from patients with endometriosis was similiar to that from control patients. Furthemore there was no significant difference in specific PF Immunoglobulin G binding to endometrial proteins regardless of origin of these proteins. Our data indicate that specific humoral immune response can be found in PF of patients with endometriosis and that specific antigens inducing this immune response are present in human endometrium and that there is no antigenic difference between the endometria of patients with and without endometriosis.

자궁내막증 환자의 복강액내 IGF가 자궁내막 기질세포 증식에 미치는 영향

김정구,서창석,김석현,최영민,문신용,이진용,Kim, Jung-Gu,Suh, Chang-Seok,Kim, Seok-Hyun,Choi, Young-Min,Moon, Shin-Yong,Lee, Jin-Yong 대한생식의학회 1999 Clinical and Experimental Reproductive Medicine Vol.26 No.3

The purposes of this study were to evaluate the effects of insulin-like growth factor (IGF)s in peritoneal fluid (PF) from patients with and without endometriosis on the proliferation of endometrial stromal cells and to investigate the effects of type I IGF receptor antibody on the response of endometrial stromal cells to PF from patients with endometriosis. IGFs in PF from patients with endometriosis (n=14) and without endometriosis (n=10) were measured by immunoradiometric assay and PF samples were divided into low IGF-I PF group (less than 85 ng/ml) and high IGF-I PF group (more than 85 ng/ml). Endometrial stromal cells from patients without endometriosis were cultured in serum free media in the presence or absence of 1 % PF and thymidine incorporation test were used to evaluate the proliferation of endometrial stromal cells. Also cultures were incubated with type I IGF receptor monoclonal antibody (${\alpha}IR_3$) before adding PF. PF from patients with endometriosis and without endometriosis increased thymidine incorporation in endometrial stromal cells. In patients with endometriosis, high IGF-I PF group had high IGF-II levels and resulted in higher thymidine incorporation than low IGF-I PF group but no significant difference in increase in thymidine incorporation between high IGF-I and low IGF-I PF group was noted in patients without endometriosis. There was not a significant correlation between increase in thymidine incorporation and IGF-I levels in PF from patients without endometriosis but in PF from patients with endometriosis. Preincubation with ${\alpha}IR_3$ significantly inhibited the mitogenic response of endometrial stromal cells to PF. Our data indicate that IGF-I in PF may be involved in the growth of ectopic endometrium in patients with endometriosis.

자궁내막증에서 순환 항자궁내막 항체의 유용성

김정구,박창수,최영민,신창재,문신용,장윤석,이진용,Kim, Jung-Gu,Park, Chang-Soo,Choi, Young-Min,Shin, Chang-Jae,Moon, Shin-Yong,Chang, Yoon-Seok,Lee, Jin-Yong 대한생식의학회 1993 Clinical and Experimental Reproductive Medicine Vol.20 No.1

Antiendometrial antibodies were tested by passive hemagglutination assay(PHA) and enzyme linked immunosorbent assay(ELISA) in sera of 45 patients with endometriosis and 21 controls for the evaluation of its clinical usefulness. Both titers(reciprocal) of serum antiendometrial antibody by PHA and ELISA reactivity against endometrial antigens at 405nm were significantly higher in patients with endometriosis than in the control group. Of 45 patients with endometriosis, twenty-six(57.8%) by PHA and twenty-three(51.1%) by ELISA were determined antiendometrial antibody positive but none of the controls were positive. Antiendometrial antibody titers were followed up by PHA and ELISA in 14 patients with high antiendometrial antibody titers before and after treatment with Decapeptyl. There was a decreasing tendency of antiendometrial antibody titers after treatment but there was no statistical significance. These data suggest that the measurement of circulating antiendometrial antibody may be useful for the diagnosis but not for the follow up of endometriosis.

기초과학 활성화와 대학의 역할

김정구,Kim, Jeong-Gu 한국대학교육협의회 1992 大學敎育 Vol.57 No.-

How AMOREPACIFIC Became a Globally Successful Cosmetic Company through Unconventional but Sensational Marketing?

김정구,한정수,전미나,김미예,Joshua Y. Kim 한국마케팅학회 2013 ASIA MARKETING JOURNAL Vol.14 No.4

AMOREPACIFIC has rapidly grown to become a successful global brand by persistently seeking and achieving success in foreign markets. In 2011, AMOREPACIFIC was ranked as one of the global top 20 cosmetics companies. What makes AMOREPACIFIC's global success noteworthy is that AMOREPACIFIC challenged the France and the US market, where competition level is the toughest. Lolita Lempicka, AMOREPACIFIC's perfume brand, was chosen as one of the top seven most popular brands in the women's perfume market in France. In addition, Amorepacific, AMOREPACIFIC's namesake skincare brand, is currently recognized as a top prestige brand in the USA. Their success played a significant role as a bridgehead for AMOREPACIFIC in becoming a global cosmetics company. The main object of this case study is to analyze how AMOREPACIFIC became a global cosmetic company through building key brands such as Lolita Lempicka and Amorepafic, among others. Therefore, this study reviewed AMOREPACIFIC's unconventional approach in launching Lolita Lempicka in France, and Amorepacific in the US by focusing on how they foresaw the future opportunities and employed innovative marketing strategies. Specifically, we focused on Amorepacific’s marketing strategy under the critical period when AMOREPACIFIC achieved great success in France with Lolita Lempicka (between 1997 and 2004) and in US with the brand, Amorepacific (2003-2008). The case of AMOREPACIFIC's success in the global markets can give valuable lessons to companies that want to extend their businesses to foreign countries and ultimately become global. One such lesson is the importance of building a successful pioneer brand in a powerful bridgehead market. While domestic competitors first entered into less competitive markets such as those in South-East Asia, AMOREPACIFIC challenged the toughest markets such as the French and US markets where the incumbent companies waged the most intensive and severe battles against Lolita Lempick and Amorepacific. Through the success in France and US market, however, AMOREPACIFIC built a powerful base for its successful global expansion. Another valuable lesson is the importance of foresight in uncovering great opportunities hidden behind the trends without losing focus on the brand’s core character and values. Lolita Lempicka and Amorepacific showed excellence in foresight competition, which led them to succeed against the intense competition from Goliath companies. If Lolita Lempicka and Amorepacific had just followed the popular market trend at the time, they would have never succeeded.

A Case Study of Shinsegae E-mart: How E-mart Became the Number One Distribution Company even against Economic Crisis and the Entry of Walmart?

김정구,전미나,한정수,김미예,Jungung Park,Joshua Y. Kim 한국마케팅학회 2012 ASIA MARKETING JOURNAL Vol.14 No.3

The success story of E-mart fascinated many academics and practitioners alike. Though E-mart began as a nameless discount store in Chang-dong, Seoul in 1993, it has transformed itself into a leading distribution company and one of the most powerful brands in Korea. Surprisingly, it achieved the great success against the two crises it met: the national economic crisis and the invasion of the global giant Walmart. The main objective of this case study is to formally examine how E-mart overcame the two crises. More specifically, this case study highlights the ways with which E-mart turned those difficulties into opportunities for growth. In our examination of the E-mart case, we could clearly see E-mart's competence and spirit that allowed it to turn crises into advantageous opportunities. E-mart attracted the customers who wanted value-oriented consumption by its positioning as the “Lowest price discount store", when consumer sentiment was frozen under the economic crisis. Furthermore, when a large-scale foreign discount store like Walmart entered the Korea market, E-mart built its core competencies as the ‘Korean style discount store’. These ingenious positioning and efforts resulted in E-mart taking over their archrival, Walmart, and forced the global Goliath to exit the Korean market. The case of E-mart's effective crisis management teaches many important lessons and a few core lessons that apply to many companies. One such lesson is the importance of positioning which enabled E-mart to turn crises into opportunities. Granted, the strategy of positioning as the ‘Korean style discount store', or ’Lowest price discount store' was possible due to overall support with cost reduction, development and management of their own system, an apprentice educate system, etc. based on an excellent selection of location of the store and efficient distribution systems. Still, the positioning strategy of E-mart was truly ground breaking in distancing itself from its competitors. The lessons from E-mart will help those companies currently in a stagnant situation or a crisis to turn their obstacles into great success.

지금이 바로 교육혁신과 기초연구 강화할 때이다!

김정구,Kim, Jeong-Gu 한국과학기술단체총연합회 2008 과학과 기술 Vol.42 No.1

마그네슘 합금제 휠 제조에 관한 연구

김정구,신일성,금동화,Kim, Jung-Gu,Shin, Il-Seong,Kum, Dong-Hwa 한국재료학회 1999 한국재료학회지 Vol.9 No.7

마그네슘은 20여년간 자동차 산업에서 휠소재로 사용되어 왔다. 마그네슘 휠은 무게가 알루미늄 휠보다 25% 가벼워서 주행성이 우수하다. 이 연구의 목적은 사형주조 및 영구금형주조 공정에 의한 AZ91D 합금제 췰을 개발하는 것이다 보호개스$(SF_6+CO_2)$를 사용하는 비플럭스 용해기술을 적용하여 용탕의 산화와 불순물의 유입을 배제하였다 마그네슘 용탕은 가압식 펌프시스템을 사용하여 가열된 파이프를 통하여 모울드에 자동으로 공급된다. 열처리 및 인고트의 조성에 따른 AZ91B 합금제 휠의 기계적 특성을 조사하였다. Magnesium has been used as wheel materials in the automotive industry for more than 20 years. The magnesium wheels, which are lighter by 25% than aluminum wheels, provide easy controllability providing excellent road holding by the reduction of weight. The purpose of this work is to develop cast AZ91D alloy wheel by sand cast and permanent mold cast. The fluxless melting with the protective gas $(SF_6+CO_2)$ was Performed to eliminate oxidation of melt and impurity. The transfer of molten magnesium to the mold was done by using gas-pressurized Pump system through the heated pipe. The mechanical properites of AZ91D alloy wheel were investigated as a function of heat treatment, ingot composition.