농어촌 의료보험이 병원에 미치는 영향

김인필,Kim, In-Pil 대한병원협회 1988 대한병원협회지 Vol.17 No.1

各種 疾患에 있어서 血淸 γ-glutamyl transpeptidase의 診斷的 有用性

金仁弼,金箕洪 최신의학사 1975 最新醫學 Vol.18 No.11

γ-Glutamyl transpeptidase (GGT) is an enzyme that acts a catalyst for transferring γ-glutamyl group from certain γ-glutamylpeptides to suitable acceptors. In the presence of L-amino acid or peptides, transpeptidation occurs. In 1950 Hanes et al. found this enzyme in the kidney, pancreas and mammary glands of the sheep. Since 1950, nearly all works in clinical application has been done in Poland. In the past 10 years considerable numbers of clinical observations have been reported from Scandinavia, Netherlands, Germany, Italy, England, Unites States of America, Canada, etc. Interest and studies in GGT have been focused on its value in the diagnosis of various hepatobiliary diseases. Recently, GGT has been studied for the diagnosis of myocardial infarction, epilepsy, alcoholics, etc. GGT test has not been yet put in practice in Korea. In this laboratory, values of serum GGT activity among Koreans were measured by Szasz's kinetic photometric method reported in 1969. In a series of author's test on 24 disease groups with total patient number of 362, the serum values of ALP, GOT, GPT and GGT were measured from the period Sept. 1973 to Aug. 1974. Comparative analysis of these enzyme values in relation with each disease group was made in order to evaluate the efficacy of GGT value, i. e. the elevated percentage and times the upper limit of normal value of each enzyme were compared with each other to evaluate the clinical applicability of serum GGT activity. Elevated GGT value was obtained in hepatitis,, liver cirrhosis, primary hepatoma, biliary system disease (including cholelithiasis, cholecystitis and cholangitis), myocardial infarction and pancreatitis groups. The elevation frequency of each of these diseases is more than 80%. In each disease group, percentage of frequency of abnormal elevation and times the upper limit of these 4 enzymes in the order of ALP, GOT, GPT and GGT are listed as follows: In hepatitis group: 77 : 95 : 98 : 97, 1.4 : 7.4 : 12.0:5. 1; in cirrhosis group:57 : 74 : 60 : 88, 1.4 2.0 : 1.6 : 5.4; in hepatoma group:80 : 80 : 80 : 90, 2.6 : 3.1:1.9 : 9. 3; in biliary system disease group: 96 : 79 : 75 : 96, 2.4:3.3:3.9 : 7.8; in myocardial infarction group: 0 :75 :75 : 100, 0.6 :2.6 : 2.1 3.9; in pancreatitis group: 40:40 :60:80, 1.5:1.4 :2.7:2.6. From these-results, the following conclusions are obtained: In hepatitis group, GOT is most sensitive with 98 elevated percentage and 12 times the upper limit of normal, and GGT is also a sensitive test to the same extent as GOT with 97 elevated percentage and 5. 1 times -the -upper limit -of normal. In cirrhosis group, GGT appears to be -most reliable with 88 elevated frequency. In hepatoma group, GGT is markedly increased in both elevated percentage and times the upper limit of normal. Only hepatoma and cholelithiasis groups show more than 9 times the upper limit of normal among 24 disease groups. In biliary system disease grtoup, GGT is most reliable and ALP is next to GGT in its sensitiveness. In a series of author's tests on myocardial infarction group elevated GGT values are observed, while GOT falls to low value. In pancreatitis group, GGT test is very sensitive with 80 elevated percentage and 2.6 times the upper limit of normal, while GPT is less sensitive with 60 elevated percentage and 2.7 times the upper limit of norrgal, Typhoid fever in Korea is one of -prevalent infectious diseases, and it is found that GGT seems to be a significant test. On the other hand, GGT in nephrotic syndrome, malignant tumor, hypertension, diabetes mellitus, enteric 1etver sAd stomach carcinoma show more than 1.0 times the upper limit of norwal,and relatively high elevated percentage (36 to 56%). In each group, elevated percentage and times the upper limit of normal of ALP, GOT. GPT and GGT -areas follows: In nephrotic syndrome group: 33 : 0 : 0 : 56, 0.-9 : 0.6 0.6 : 2. 1; in malignant tumor group: 27 : 27 9 54, i.' : 1.1 :0.8:1.8; in hypertension group: 0 : 9 : 14 : 45, 0.7 : 0.7:0.8: 1.3; in diabetes group: 1-5:0!0-C50. in enteric fever group: 22:13:13-:38, 0.9:0.9:1.0:1.6; in stomach earoinoma group: 38-:13:13:38. 1.2:0.8:0.8:1.1. tlevert4idess, -the slight elevation of GGT in these disease groups draw the author's attention in iasterpretaUieoa of rte clinical significance. The elevation of GGT in both malignant neoplasm and stomach careisooa is highly suggestive of their metastasis to the liver if ALP is elevated simaltaneously. Gol4barg et-al. reported that 92% of malignant tumors without metastasis to the liver showed normal GGT aedvit r. Rutenberg et al. also reported that 86% of malignant tumors without liver metastasis,exciudiag primary carcinoma of hepato-biliary system and pancreas showed normal GGT activity. n eptgTig foot grolup inchl4ing so-called fever of unknown origin without definite evidence of typhai4 f#VAW, troth C.GT and GPT show increase in both elevated percentage and times the upped limit of gored? In nephrotic syndrome, hypertension and diabetes groups the elevation of GGT is difficult to j explain, but t is proably due -to the slight liver involvement. In cerebral thrpmbosis, pulmonary tuberculosis, pneumonia, bronchitis, peptic ulcer, gastritis, CO iptoxicatigzi, a an. ne?rosis groups, there is little clinical significance of GGT test.

고준위 방사성 폐기물 처분장 설계를 위한 Diagonal 환기 회로 내 공기량 분배에 관한 연구

황인필(In-phil Hwang),최희주(Heui-joo Choi),노장훈(Jang-hoon Roh),김진(Jin Kim) 한국암반공학회 2012 터널과지하공간 Vol.22 No.3

In this study, diagonal ventilation circuits that are advantageous in air flow direction control were studied. Based on the results of the study, it could be seen that air volumes in diagonal ventilation circuits could also be calculated using numerical formulas or programs if the air volumes and air flow directions to be infused into diagonal branches are determined in advance as with other serial/parallel circuits. To apply the results, design plans for high level radioactive waste repositories applied with diagonal ventilation circuits and parallel ventilation circuits. To compared the each design plans and obtain expected operation results, ventilation network simulations were conducted through the Ventsim program which is a ventilation networking program. Based on the results, in the case of diagonal repositories that was expected to cause great increases in resistance, fan pressure was 1570 pa, total flux was 84 ㎥/s, fan efficiency was 76.4%, fan power consumption was 181.2 ㎾ and annual fan operating costs were 178,710,838 and thus maximum around 8% differences were shown in pressure and flux values and a difference of around 1.5% was shown in terms of operating costs. 본 연구에서는 방사성 폐기물 처분장 설계 시 필요할 수 있는 공기 유동 방향의 제어에 이점을 가진 Diagonal 환기 회로에 대해서 연구하였다. 연구 결과, Diagonal 환기 회로에서도 Diagonal 갱도(Branch)로 유입시킬 공기량과 공기 유동 방향을 미리 정한다면 다른 직·병렬 회로와 마찬가지로 수식이나 프로그램에 의한 공기량을 산정할 수 있음을 알 수 있었다. 이를 적용하기 위해 앞으로 처분될 고준위 방사성 폐기물의 추정 데이터를 통해 Diagonal 환기 회로와 병렬식 환기 회로가 적용된 고준위 방사성 폐기물 처분장의 설계안을 마련하였다. 마련된 설계안 별 비교 및 예상 운영 결과를 얻기 위해서 환기 네트워킹 프로그램인 Ventsim 프로그램을 통해 환기 네트워크 시뮬레이션을 수행하였다. 그 결과 저항 증가가 큰 수치로 발생할 것으로 예상되었던 Diagonal 처분장은 병렬식 환기 회로가 적용된 처분장과 비교하였을 때, 팬 압력은 1570 pa, 총 유량 84 ㎥/s, 팬 효율 76.4%, 팬 소요 전력 181.2 ㎾ 및 연간 팬 운영 비용 178,710,838원으로 압력과 유량값에서 최대 8% 정도의 차이를 보였고, 운영 비용 측면에서는 1.5%의 차이를 보였다.

The difference of detection rate of avian influenza virus in the wild bird surveillance using various methods

김강산,김태식,손주성,Van Dam Lai,박정은,왕승준,정원화,모인필 대한수의학회 2019 Journal of Veterinary Science Vol.20 No.5

Korea is located within the East Asian-Australian flyway of wild migratory birds duringthe fall and winter seasons. Consequently, the likelihood of introduction of numeroussubtypes and pathotypes of the Avian influenza (AI) virus to Korea has been thought to bevery high. In the current study, we surveyed wild bird feces for the presence of AI virus thathad been introduced to Korea between September 2017 and February 2018. To identify andcharacterize the AI virus, we employed commonly used methods, namely, virus isolation (VI)via egg inoculation, real-time reverse transcription-polymerase chain reaction (rRT-PCR),conventional RT-PCR (cRT-PCR) and a newly developed next generation sequencing (NGS)approach. In this study, 124 out of 11,145 fresh samples of wild migratory birds tested wererRT-PCR positive; only 52.0% of VI positive samples were determined as positive by rRT-PCRfrom fecal supernatant. Fifty AI virus specimens were isolated from fresh fecal samples andtyped. The cRT-PCR subtyping results mostly coincided with the NGS results, although NGSdetected the presence of 11 HA genes and four NA genes that were not detected by cRTPCR. NGS analysis confirmed that 12% of the identified viruses were mixed-subtypes whichwere not detected by cRT-PCR. Prevention of the occurrence of AI virus requires a workflowfor rapid and accurate virus detection and verification. However, conventional methodsof detection have some limitations. Therefore, different methods should be combinedfor optimal surveillance, and further studies are needed in aspect of the introduction andapplication of new methods such as NGS.

Segmental Aplasia of the Right Uterine Horn in a Primiparous Holstein Cow

김일화,강현구,허태영,이혜림,모인필 한국임상수의학회 2012 한국임상수의학회지 Vol.29 No.5

An infertile, three-year-old primiparous cow was diagnosed preliminarily with pyometra by rectal palpation at 180 days postpartum. Ultrasonography showed that the cranial portion of the right uterine horn was distended with fluid, while the base portion of the horn was missing. A dense band of tissue connected the cranial portion of the uterine horn to the uterine body. However, the left uterine horn was normal. Gross postmortem analysis of the reproductive organs confirmed the ultrasonographic observations. Histopathological observations also showed that dark red-brown mucus filled the thin-walled right uterine horn, where neither caruncles nor uterine glands were observed. Finally, this primiparous Holstein cow was diagnosed with segmental aplasia of the right uterine horn.

실리콘 하이드로겔 렌즈의 반복적 건조로 인한 렌즈형태 및 자·타각적 증상의 변화

김소라,강병호,정인필,박미정 한국안광학회 2012 한국안광학회지 Vol.17 No.4

Purpose: In this study, the changes in the shape of silicone hydrogel lenses, dryness of lens and objective/subjective symptoms that could be induced by repeating dryness of lens and objective/subjective symptoms were investigated. Methods: After drying and rehydrating of silicone hydrogel lenses with different lens material and thickness for 4 times, their overall diameters and base curves were compared. Subjective symptoms, non-invasive tear break-up time (NIBUTs) and blinking rate were evaluated after wearing dehydrated silicone hydrogel lens. Results: Overall diameter and base curve increased in all tested silicone hydrogel lenses by repeating dryness and rehydration. The degree of change in over all diameter and base curve were variable on the material. There were irregular change of lens parameters in thicker lens. When the subjects wore silicone hydrogel lenses after drying and rehydrating, their NIBUTs were decreased and blink rates were increased regardless of lens material or thickness. In addition, repetitive drying of silicone hydrogel lenses affected the lens fitting. Therefore, subjective symptoms such as itching, pain, irritation, foreign body sensation, dryness tended to be increased. Conclusions:The results obtained from the study may suggest to develop durable silicone hydrogel contact lenses against dry environment since the changes in parameters of silicone hydrogel lens and the subjective discomfort were observed after repetitive drying and rehydration. 목적: 본 연구에서는 반복적인 건조에 의해 유발되는 실리콘 하이드로겔 렌즈의 형태 변화 및 착용시의 자·타각적 증상의 변화에 대해 알아보고자 하였다. 방법: 재질 혹은 두께가 다른 실리콘 하이드로겔 렌즈를 4회씩 건조하고 수화시킨 후 전체 직경과 베이스커브의 변화를 비교하였으며, 건조되었던 실리콘 하이드로겔 렌즈를 착용한 후착용자의 자각적 증상 및 비침입성 눈물막 파괴시간과 순목횟수를 측정하였다. 결과: 반복되는 건조와 수화로 인하여 모든 실리콘 하이드로겔 렌즈의 전체 직경과 베이스커브가 증가하였다. 전체 직경과 베이스커브가 변하는 정도는 재질에 따라 각기 상이하였으며 두꺼운 렌즈에서는 건조수화 횟수에 따라 불규칙적인 변화가 나타났다. 실리콘하이드로겔 렌즈의 재질이나 두께에 관계없이 건조수화 과정을 거친 렌즈를 착용하였을 때에는 착용자의 비침입성눈물막 파괴시간은 감소하였으며, 순목횟수는 증가하였다. 또한, 반복적인 건조수화는 렌즈의 착용감에도 영향을 미쳐 가려움, 통증, 자극감, 이물감, 건조감이 증가하는 경향이 있었다. 결론: 본 연구 결과를 통하여 반복적인 건조수화로 실리콘 하이드로겔 렌즈의 형태 변화 및 이에 따른 착용감 저하 유발을 확인하였으므로 건조한 환경에 대하여 강한 내구성을 가지는 실리콘 하이드로겔 콘택트렌즈의 개발 필요성을 제안할 수 있다.

Pyometra and Serosal Inclusion Cysts of the Uterus in a Bitch

이준암,김일화,모인필,강현구,장동우 한국임상수의학회 2013 한국임상수의학회지 Vol.30 No.4

Pyometra is a diestrual, chronic disease process with acute manifestations in the adult, ovary-intact bitch. Serosal inclusion cysts develop during postpartum involution as mesothelium becomes trapped during rapid uterine contraction. A 10-year-old golden retriever bitch presented with lethargy, anorexia, tachypnea, abdominal distention,and abnormal vaginal discharge. Radiographic, ultrasound, and laboratory examinations were performed. On ultrasound examination, the uterus was distended by fluid containing echogenic "snow storm" particles; cystic structures containing anechoic fluid were found adjacent to the body of the uterus. Leukocytosis, neutrophilia, and anemia were diagnosed by a complete blood cell count. The initial diagnosis was pyometra, and an ovariohysterectomy was performed. Macroscopically,the uterine body and horns were expanded and partially adhered to the abdominal wall; numerous cysts containing clear fluid protruded over the entire surface of the uterus. Escherichia coli that was sensitive to enrofloxacin,was cultured from the lumen of the uterus. Histopathological assessment confirmed a final diagnosis of pyometra and serosal inclusion cysts of the uterus.

A Study on the Determination of the Seasonal Heat Transfer Coefficient in KURT Under Forced Convection

윤찬훈,권상기,황인필,김진 한국방사성폐기물학회 2010 방사성폐기물학회지 Vol.8 No.3

고준위 방사성 폐기물 처분장의 경우 폐기물의 방사성 붕괴에 의해 열이 발생되며, 암반을 통한 열전달 에 의해 처분장 주변 환경이 변화됨으로써 처분장의 안전성에 영향을 미칠 수 있다. 그러므로 지하 처분장 대기의 열전달계수를 결정하는 것은 매우 중요하다. 이에 본 연구에서는 Korea Atomic Energy Research Institute Underground Research Tunnel (KURT)에서 내부 환경 인자들의 측정을 통해 강제대류시 열전달계수를 산정하였다. 실험을 위해 KURT 내 히터구간의 막장 벽면에는 길이 2 m, 용량 5 kw의 히터를 삽 입하여 암반 내부를 90℃로 가열하였고, 외부와 연결된 급기용 팬에 의해 신선한 공기를 공급하였다. 연구 결과, 외부공기 공급 후 히터구간 대기의 기류속도는 평균 0.81 m/s로 측정되었고 레이놀즈수는 약 310,000 340,000의 값을 나타냈다. 그리고 강제대류조건에서 히터구간 내 계절별 열전달계수는 각각 여 름철 7.68 W/m2·K와 겨울철 7.24 W/m2·K의 수치를 나타냈다.

도축 한우에서 난소낭종의 기능성 평가

강현구,이청산,김일화,모인필,이기창,서국현 韓國受精卵移植學會 2006 한국동물생명공학회지 Vol.21 No.1

도축장에서 도축된 한우 중 난소낭종에 이환된 소 86두를 대상으로 수침법으로 초음파 검사를 실시하여 낭종의 직경, 낭종내강의 직경, 낭종벽의 두께를 측정하였으며 낭종액 중 농도와 농도를 측정하여 다음과 같은 결과를 얻었다. 난소낭종에 이환된 소 86두는 해부학적 및 초음파 검사에 의하여 단포성 난포낭종 51두(59.3%), 다포성 난포낭종 19두(22.1%), 단포성 황체낭종 13두(15.1%), 다포성 황체낭종 3두(3.5%)의 발생률을 나타내어 황체 To evaluate the functional status of ovarian cyst in Korean native cows, progesterone () and estrogen () level of cystic follicular fluid, ultrasonography for measuring the cystic diameter and thickness of cystic wall, and histological findings were investigated in cystic ovaries from slaughtered Korean native cows. Ovarian cysts were classified as single follicular cyst 51 cows (59.3%), multiple follicular cysts 19 cows (22.1%), single luteal cyst 13 cows (15.1%) and multiple luteal cysts 3 cows (3.5 %) by anatomical and ultrasonography. Ovarian cysts were classified as follicular cysts (54 cows), luteal cyst (16 cows) and non-functional ovarian cyst (16 cows) by hormone analysis, anatomical finding and ultasonography The luteal cyst was accurately diagnosed by cystic wall thickness, but follicular cysts was misdiagnosed 16 cows of 70 cystic cows The cystic fluid concentration was 3.3 ng/ml in follicular cysts and 30.1 ng/ml luteal cysts. There was significantly positive correlations between cystic wall thickness and serum concentration in follicular (, p<0.001) and luteal cysts (, p<0.001). These results indicated that ovarian cysts had various stages of degeneration and luteal cyst was accurately diagnosed measurement of cystic wall thickness by ultrasonography, but follicular cysts were not diagnosed only cystic diameter and cystic wall thickness.

산지초지 활성화 방안

김지현,김원호,김인필,이정훈,배상희 한국초지조사료학회 2015 한국초지조사료학회 학술대회논문집 Vol.2015 No.11