오공(蜈蚣)이 노령(老齡)에 따른 mouse의 면역(免疫) 기능(機能)에 미치는 영향(影響)

김길섭,서운교,정지천,Kim, Gil-Seop,Seo, Un-Kyo,Jeong, Ji-Cheon 대한한방내과학회 1998 大韓韓方內科學會誌 Vol.19 No.1

To clarify the activating effects of Scolopendrae corpus on immunological function, its effect on primary and secondary antibodies production in mice of various ages was investigated. Scolopendrae corpus increased the number of both antibody producing cells(anti-IgM and anti-IgG producing plaque forming cells, PFC) and phagocytic activity of peritoneal macrophage. Futhermore, these phenomena were significantly increased with aging in mice. Scolopendrae corpus also increased natural killer cell activity concerning to cancer immunology. These results suggest that Scolopendrae corpus markedly increases the reduced activity in the elderly and activates the immune response in senescence mice.

오공(蜈蚣)이 마우스에서 2단계(段階) 발암화(發癌化) 과정(過程)에 미치는 영향(影響)

김길섭,황영근,윤철호,서운교,김종대,정지천,남경수,강정준,Kim, Kil-Sub,Hwang, Young-Guen,Yoon, Cheol-Ho,Seo, Un-Kyo,Kim, Jong-Dae,Jeong, Ji-Cheon,Nam, Kyung-Soo,Kang, Jeong-Jun 대한한방내과학회 1999 大韓韓方內科學會誌 Vol.20 No.1

To clarifiy the effects of Scolopendrae corpus(S-C) on turmor promotion in two-stage carcinogenesis in mice was investigated. In vivo system, S-C were seen to gave an inhibitory activity on TPA-induced mouse ear edema. In addition, the S-C were proved to have antitumor-promoting activity in two-stage mouse skin carcinogenesis induced by DMBA and two-stage mouse lung carcinogenesis induced by 4-NQO as a initiator plus TPA and glycerol as a promoter. Moreover, S-C significantly exhibited an cytolytic effect in $HepG_2$ cells and showed significant antitumor activity against Sarcoma-180 bearing mice by oral administration. These results suggest that S-C could be effective in adjuvant chemotherapy for human cancer.

三和散이 大腦皮質 microsome分劃에서 Na-K-ATPase活性에 미치는 影響

金吉燮(Kim Gil Seop),鄭智天(Jeong Ji Cheon) 대한한의학회 1995 대한한의학회지 Vol.16 No.1

신장(腎臟) 조직(組織)에서 제조의 항산화(抗酸化) 효과(效果)의 기전(機轉) 연구(硏究)

정지천,문상원,김길섭,Jeong, Ji-Cheon,Moon, Sang-Won,Kim, Kil-Seop 대한한방내과학회 1998 大韓韓方內科學會誌 Vol.19 No.1

This study was carried out to examine mechanisms by which Holotrichia (HTC) produces protective effect against renal cell injury. HTC extraction (5%) prevented $H_2O_2(50mM)$-induced LDH release and lipid peroxidation in renal cortical slices. When slices were treated with 5% HTC extraction, cellular glutathione content and the superoxide dismutase activity were not altered in control and $H_2O_2$-treated tissues. When slices were treated with 50 mM $H_2O_2$, the catalase activity was significantly inhibited, which was completely restored by addition of 5% HTC. Treatment of slices with 5% HTC extraction increased the glutation peroxidase activity in $H_2O_2$-treated tissues. These results suggest that HTC prevents oxidant-induced cell injury and lipid peroxidation by increasing the activities of catalase and glutathione peroxidase in renal cortical slices.

Green SCM 도입이 기업성과에 미치는 영향

안현숙(Ahn, Hyun-Sook),김길섭(Kim, Kil-Sub) 한국물류학회 2015 물류학회지 Vol.25 No.3

본 논문은 Green SCM(그린공급사슬관리)도입기업의 내⋅외적 요인이 기업성과에 미치는 영향력을 사회적 책임이라는 매개변수를 중심으로 실증 분석하였다. Green SCM도입, 사회적 책임, 성과에 관한 이론적 배경을 바탕으로 연구모형 및 가설을 설정하였다. 본 연구에서는 Green SCM을 도입한 개 92개 기업을 대상으로 Smart PLS 2.0과 SPSS 20.0을 이용하여 실증연구를 수행하였다. 분석결과, 첫째, Green SCM도입기업의 내적 요인인 최고경영층의 지원, 지각된 이점, 재무적 여유가 있는 기업들은 사회적 책임에 긍정적인 영향을 미치는 것으로 나타났다. 둘째, 외적요인 중 공급업체의 압력은 사회적 책임에 긍정적인 영향을 미치는 것으로 나타났지만 경쟁업체의 압력은 사회적 책임에 유의한 영향을 미치지 않는 것으로 나타났다. 셋째, 지속가능한 경영을 위한기업의 사회적 책임은 기업의 재무성과 및 생산운영성과에 긍정적인 영향을 미치는 것으로 나타났다. 본 연구의 결과는 향후 Green SCM을 도입하려는 기업들에게 사회적 책임에 대한 중요성과 이러한 사회적 책임을 인식하는 기업들은 곧 성과에도 영향을 미친다는 시사점을 제공해줄 수 있을 것이다. The purpose of this study is examine the factors influencing business performance of on internal and external factors and social responsibility of adoption of Green SCM. This Model tests various theoretical research hypotheses relating to GSCM adoption, Social Responsibility and business performance. The proposed model is analyzed to target 92 manufacturing firms. Smart Partial Least Squares(PLS) 2.0 have been utilized for deriving the study results. The result of hypothesis testing are as follows. First, Top management support, perceived benefit and financial slackpositively influence social responsibility. Second, supplier pressure positively influence Social Responsibility, but competitive pressure does not significantly influence social esponsibility.Finally, social responsibility positively influence financial and operation performance. The results of this study will provide useful information to managers who are responsible for execute Green SCM in Strategic

男性不姙症의 治療에 對한 文獻的 考察

김길섭,서운교,鄭智天 東國大學校韓醫學硏究所 1994 東國韓醫學硏究所論文集 Vol.3 No.-

Studying documents & papers on the cure of mate sterility to conclusion as follows. 1. The methodes of cure were applied Onbosinyang, Jaeumbosin, Soganheul, Joseubhwadam, Boickgihyul, Hwalhyeolhwaua, Boickbisn, etc. And the causes of disease were applied Sinyanghue, Sineumhue, Ganulgihe, Damseubneon, Gihwelyanghue, Gichehyeolul, Bisinyanghue, etc. 2. Prescription were applied Chanyukdan Ojayuenjonghwan on Sinyanghue, Yukmijihwan Jibekjihwanghwan on Sinuemhue, Sihosogansan Soyosan on Ganulgiche, Changchuldodamtang Bihebunchungeum on Damseubneon, Sibjyundaebotang Paljintang on Gihyeolyanghue, Sobokchu-kuatang Gueasengjungtang on Gichehyeolul, Sibjayukguntang Bisinssangbohwan on Bisinyanghue, etc. and Ojayunjonghwan being added in the base to cure another causes of disease as well as Sinhue. 3. The cause of disease were presonted to be Sinhue mostly ; Sinvanghue particulatly. And there were usually 25∼42years old, married lives of 3~8years, cure periods of 2∼5mon-ths, general effectiveness(approximately 76%), pregnancies(approximately 47%). 4, The methodes of cure in oriental medical prepared with the causes of disease in western one are showed in blow ; The cause of semen formation disorder is considered the methodes of cure in Onbosinyang, Jaeumbosin, Boickbin and the cause of functional ejaculation disorder in mind is considered the method of cure in Sogangegwu on the base in Bosin.

Effects of Scolopendrae corpus on Immune Response in Mice of Different Ages

김길섭,서운규,정지천,김철호,이동목,송해범,이항우,남경수 한국생명과학회 1998 한국생명과학회 학술발표회 Vol.20 No.-

To clarify the activating effects of Scolopendrae corpus on immunological function, its effect on primary and secondary antibodies production in mice of various ages was investigated. Scolopendrae corpus increased the number of both antibody producing cells(anti-IgM and anti-IgG producing plaque forming cells, PFC) and phagocytic activity of peritoneal macrophage. Futhermore, these phenomena were significantly increased with aging in mice. Scolopendrae corpus also increased natural killer cell activity concerning to cancer immunology. These results suggest that Scolopendrae corpus markedly increases the reduced activity in the elderly and activates the immune response in senescence mice.

폐결핵 환자에서 분리된 결핵균의 검경 및 배양에 관하여

김대용,김길섭 충남대학교 교지편집위원회 1980 寶雲 - 충남대학교 Vol.- No.10

충남 공주 소재 국립 공주병원에 입원한 결핵 환자 중 1980년 3월부터 동년 6월까지 객담 채취 가능한 환자 220명의 객담을 채취하여 현미경 검경으로 Gaffky지수와 Granularity지수를 조사하고 Sodium hydroxide법으로 객담을 처리한 뒤 배양 하였다. 70명의 환자에서 분리된 균주는 절대 농도법에 의한 감수성 검사를 실시하였다. 이상과 같은 실험으로 다음의 결과를 얻었다. 1. 입원 환자 220명중 남자가 152명, 여자가 68명으로 남자가 많았다. 2. 발생 연령은 20세에서 29세가 34.5%로 가장 많았다. 3. 집균도말 양성자중 66.3%만 직접도말 양성 이었고 배양 양성자중 78.6%만이 직접도말 양성이므로 직접도말보다 배양 검사가 균 검출율이 높았다. 4. 직접도말 양성자중 배양 음성이 29.0%이었고 Gaffky지수와 배양과는 연관성이 있었으나 Granularity지수와는 큰 연관성이 없었다. 5. 내성률은 isoniazid 1ml당 1㎕에서 16.6%, Streptomycin 1ml당 10㎕ 에서는 37.0%의 내성률을 보였다. Accuracy of monitoring of the pulmonary tuberculosis was ssessed by microscopic and cultural results on 220 patients from whom were adminitted to the Gongju National Hospital from March to June in 1980. The drug sensitivity test was carried out. The results were summarized as follows: 1. The sex distribution of 220 patients was 152 males and 68 females. 2. The peak incidence occurred in 20 to 29 age group on both sex. 3. Culture was considerable more sensitive than smear in detecting the presence of mycobacteria. 78.6% of all culture positive were positive stains. 4. Twenty-nine per cent of all smear positive specimens were negative on culture. 5. In drug sensitivity test. Drug resistant strains were found 16.8% of isoniazid (1ug/ml) and 37.0% streptomycin (10ug/ml). Although the prevalence of pulmonary tuberculosis has declined with effective drug regimens. The control of tuberculosis still come to the hard problem in Korea. Because of prolongation of duration of illness and increasing occurrence of resistant bacilli to be attributable to ill-reasonable drug medication. Accuracy of diagnosis might be performed by culture and effective drug regimen might be made by drug sensitivity.