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PLGA/DBP지지체에 파종된 신경계세포가 골수간엽줄기세포의 분화와 증식에 미치는 영향
김수미 ( Su Mi Kim ),김순희 ( Soon Hee Kim ),김초민 ( Cho Min Kim ),오아영 ( A Young Oh ),김근아 ( Geun Ah Kim ),이일우 ( Il Woo Lee ),이종문 ( John M. Rhee ),강길선 ( Gilson Khang ),김문석 ( Moon Suk Kim ),이해방 ( Hai Bang Lee ) 한국조직공학·재생의학회 2007 조직공학과 재생의학 Vol.4 No.4
Poly(lactic-co-glycolic acid)(PLGA) is a biodegradable synthetic polymer with acceptable mechanical strength and has well-controlled degradation rate. Demineralized bone particle(DBP) contains powerful bioactive molecules. Bone marrow mesenchymal stem cells(BMSCs) are important progenitor and supporting cells that have the intrinsic ability to self-renewal and differentiate into multiple functional cells. In this study, we fabricated natural/ synthetic hybrid PLGA scaffolds included 20% of DBP(PLGA/DBP). Schwann cells(SCs) and olfactory ensheathing cells(OECs) were seeded on PLGA/DBP scaffolds. We confirmed that effects of PLGA/DBP scaffolds seeded OEC and SC on proliferation and differentiation of BMSCs. PLGA/DBP scaffolds seeded OECs and SCs were superior to differentiation into neuronal cell proliferation of BMSCs. This phenomenon was expected due to cytokine secreted by OECs and SCs promote proliferation and differentiation of BMSCs.
김근,장봉현,이종태,김규태,Kim, Keun,Chang, Bong-Hyun,Lee, Jong-Tae,Kim, Kyu-Tae 대한흉부심장혈관외과학회 1993 Journal of Chest Surgery (J Chest Surg) Vol.26 No.5
We analyzed the patients who were admitted to Surgical Intensive Care Unit[SICU] of Kyungpook National University Hospital from January 1987 through December 1991. The results were as followings: The total number of patients for 5 years was 2446 and 1553[63.5%] were male,893[36.5%] were female. The average age was 34.1 years old and the greatest age group was the 1-9 age group.The number of the patients in the Department of Thoracic and Cardiovascular Surgery, which was the highest among all departments,was 1608 [65.7%].Congenital Heart disease was the most common among all diseases.The patients who had undergone any kinds of operations were 89.9% of all patients.The averge stay in SICU was 5.2 days.The overall mortality rate was 12.1% ,which included hopelessly discharged patients and the highest mortality rate occurred in the patients over 80 years old.The highest cause of death was cardiac problem[30.4%]. The next was sepsis.The proportion of patients who had received a mechanical ventilatory support was 35.7% and 52% of those patients belonged to the department of thoracic and cardiovascular surgery.