열처리를 달리한 시유의 저장중 품질 변화

권순하(Soon Ha Kwon),안정좌(Joung Jwa Ahn),곽해수(Hae Soo Kwak) 한국낙농식품응용생물학회 1998 Journal of Dairy Science and Biotechnology (JMSB) Vol.16 No.2

N/A This study was carried out to investigate changes of microbiological and sensory properties in various heat-treated market milks (LTLT, HTST, and UHT milks) stored at 10℃ during 15d. Ti-tratable acidity (TA) increased with storage, while pH tended to decrease. During the initial 9d, no difference was found in TA, however, after 9d, it was slightly higher in HTST and UHT milks than that in LTLT milk. In LTLT and HTST milks, total viable cells and psychrotrophs were dramatically increased during storage. In addition, coliform and pathogenic bacteria were found at 12 and 15d. In UHT milk, total viable cells were found only at 15d. In sensory evaluation, LTLT and HTST milks developed a negligible off-flavor until 9d. At 12d, it became stronger in HTST milk than that in LTLT milk. In UHT milk, off-flavor was detected at 9d and increased rapidly thereafter. The degree of off-flavor was little higher in HTST and UHT milks, compared with that of LTLT milk after 9d storage. These observations indicated that LTLT and TTST milks may not be microbiologically acceptable after 5d, while off-flavor was not detectable until 9d. In comparison, UHT milk keeps a good quality in microorganism until 15d, however, it may not be accepted in sensory aspect after 9d storage.

증례 : 감염 ; 국내에서 발생한 중추신경계 합병증을 동반한 삼일열 말라리아 1예

권순하 ( Soon Ha Kwon ),궁현정 ( Hyeon Jeong Goong ),이은정 ( Eun Jung Lee ),전민혁 ( Min Hyok Jeon ),김태형 ( Tae Hyong Kim ),박선아 ( Sun A Park ),추은주 ( Eun Ju Choo ) 대한내과학회 2012 대한내과학회지 Vol.82 No.3

A 51-year-old man diagnosed with Plasmodium vivax malaria was transferred to our clinic with newly developed drowsy mentality and myoclonus after the initiation of hydroxychloroquine therapy. Following therapy to treat the vivax malaria and supportive care, the patient recovered completely with no sequelae. Cerebral complications caused by vivax malaria are very rare worldwide, and only two cases have been reported in Korea. Here, we report the third published case of P. vivax infection with cerebral complications in Korea. (Korean J Med 2012;82:382-385)

원저 : 위장관 ; 조기 대장암의 내시경 절제 후 추적 결과 분석 -진행신생물의 발견율과 이에 영향을 미치는 인자를 중심으로

권순하 ( Soon Ha Kwon ),추진우 ( Jin Woo Choo ),김현건 ( Hyun Gun Kim ),전성란 ( Seong Ran Jeon ),이병후 ( Byung Hoo Lee ),이태희 ( Tae Hee Lee ),김완중 ( Wan Jung Kim ),고봉민 ( Bong Min Ko ),김진오 ( Jin-oh Kim ),조주영 ( Joo Yo 대한소화기학회 2013 대한소화기학회지 Vol.62 No.4

목적: 대장암의 예방에 있어서 대장내시경 검사는 가장 효과적인 검사법이지만 적절한 질 관리와 추적 관찰이 전제가 되어야 한다. 즉 조기 대장암을 진단하고 내시경으로 완전 절제 하였던 경우에도 추적검사에서 조기 대장암이 발견되는 경우가 있어 적절한 추적검사가 반드시 필요하다. 이번 연구에서는 조기 대장암 내시경 절제 후 대장내시경 추적검사 결과를 분석하여 진행 샘종과 점막암의 발견율 및 발견율과 관련된 인자를 알아보고자 하였다. 대상 및 방법: 2003년 5월부터 2011년 12월까지 순천향대학교 서울병원에서 대장내시경을 시행하고 대장 폴립을 내시경으로 절제한 후 조직검사에서 조기 대장암으로 진단된 환자 중에 1회 이상 대장내시경 추적검사를 받은 환자를 대상으로 추적검사 결과를 분석하였다. 수술을 받은 경우와 추적 관찰이 되지 않은 경우는 제외하였다. 조기 대장암은 림프절 전이에 관계없이 암세포가 점막 또는 점막하층까지만 침범한 경우로 정의하였고, 진행 샘종과 점막암을 통칭하여 진행 신생물로 정의하였다. 조기 대장암 내시경 절제 후 첫 번째 대장내시경 검사에서 진행 신생물의 발견율을 알아보고, 지표 대장내시경 검사에서 진행 신생물 발견율에 영향을 주는 인자를 분석하였다. 결과: 총 305명의 조기 대장암 환자 중에 추적 관찰이 불가한 환자 50명, 내시경 절제 후 수술을 받은 환자 44명을 제외하고 211명의 환자를 대상으로 분석하였다. 총 211명의 환자 중에 첫 번째 대장내시경 추적검사에서 진행 신생물은 15명(7.1%)에서 발견되었다. 1년 이내 첫 번째 대장내시경 추적검사를 하였던 경우는 198명(93.8%)이었고, 진행 신생물은 14명(7.0%)에서 발견되었다. 1년 이내 첫 번째 대장내시경 추적 검사에서 진행 신생물이 발견된 군과 발견되지 않는 군 사이에서 지표 대장내시경 검사 당시 부적절한 대장 청결도(OR, 18.237; 95% CI, 3.741- 88.895; p<0.001)와 대장 폴립이 3개 이상인 경우(OR, 9.479; 95% CI, 1.103-81.452; p=0.040)가 대장내시경 추적검사에서 진행 신생물 발견율의 증가와 관련이 있었다. 결론: 1년 이내 대장내시경 추적검사에서 대부분의 진행 신생물이 발견된 점을 생각할 때, 조기 대장암을 내시경 절제 후 대장내시경 추적검사를 1년 이내에 시행하는 것을 고려해야 한다. 최적의 추적검사의 시기는 장 정결도와 폴립의 수를 고려하여 결정하여야 하며 특히 조기 대장암 진단 당시 대장 청결도가 부적절한 경우 및 대장 폴립이 3개 이상인 경우에는 1년 이내 대장내시경 추적검사를 시행할 것을 고려해야 한다. Background/Aims: Early colon cancer can be effectively diagnosed and treated by colonoscopy, and surveillance colonoscopy is necessary to detect precursor lesions or new early colon cancer. We analyzed the surveillance results of patients with endoscopically resected early colon cancer to evaluate the detection rate of advanced neoplasia and its associated factors. Methods: We conducted a retrospective study at Soonchunhyang University Seoul Hospital, from May 2003 to December 2011. Patients who underwent endoscopic resection for early colon cancer, showed mucosal and submucosal invasion on histopathologic examination, and received surveillance colonoscopy at least once were enrolled in the current study. Patients who underwent operation and those who were lost during surveillance period were excluded. Results: Among a total of 305 patients diagnosed with early colon cancer, 211 patients met our inclusion criteria. Of these patients, 15 (7.1%) advanced neoplasias were detected at first colonoscopy. One hundred ninety-eight patients (93.8%) underwent surveillance colonoscopy within one year and 14 (7.0%) advanced neoplasias were detected in this group of patients. When patients with and without advanced neoplasia at first surveillance colonoscopy performed within one year were compared, inadequate bowel preparation (OR, 18.237; 95% CI, 3.741-88.895; p<0.001) and three or more colon polyps (OR, 9.479; 95% CI, 1.103-81.452; p=0.040) were significant risk factors for detecting advanced neoplasia. Conclusions: Considering the high detection rate of advanced neoplasia at first surveillance colonoscopy in patients with endoscopically resected early colon cancer, surveillance interval should be within one year, especially when the bowel preparation has been inadequate and three or more colon polyps have been detected. (Korean J Gastroenterol 2013;62:219-226)

초점 분절성 사구체 경화증을 동반한 사구체옆세포 종양

김진국 ( Jin Kuk Kim ),권순하 ( Soon Ha Kwon ),김은정 ( Eun Jung Kim ),정철호 ( Chul Ho Chung ),박무용 ( Moo Yong Park ),최수정 ( Soo Jeong Choi ),황승덕 ( Seung Duk Hwang ),고은석 ( Eun Seok Ko ),김민의 ( Min Eui Kim ) 대한신장학회 2010 Kidney Research and Clinical Practice Vol.29 No.6

Purpose: Juxtaglomerular cell tumor is a rare cause of secondary hypertension. Focal segmental glomerulosclerosis (FSGS) is a clinicopathological entity associated with renal insufficiency and proteinuria. The exact diagnosis and proper management are important in both juxtaglomerular cell tumor and FSGS. We experienced a 26-year-old male who complained of a palpable abdomen mass associated with proteinuria and hypertension. Ultimately, he was diagnosed with a juxtaglomerular cell tumor combined with FSGS after nephrectomy. After operation, his hypertension normalized, while his renal function deteriorated.

국내 전방부대와 해외 파병부대의 질병발생에 대한 고찰

서민우 ( Min Woo Seo ),김문수 ( Moon Soo Kim ),박대현 ( Dae Hyeon Park ),권순하 ( Soon Ha Kwon ),우찬명 ( Chan Myong Woo ),최진욱 ( Jin Wook Choi ),이본 ( Bonn Lee ) 국군의무사령부 2016 대한군진의학학술지 Vol.47 No.1

Objectives; The aim of the research is designed to provied a comparison of the disease occurrence rate between the frontline troops in South korea and the overseas dispatched United Nation (UN) troops for according medical managemeent. Methods; Total six months period of medical records documented from 01/05/2015 to 31/10/2015 were utilized to give a contrast of the disease outbreaks by the front line troop with the overseas dispatch troops. Results; Based on the comparison data following results are shown as below; First of all, Frequency of practicing medical unit is reported higher in the overseas dispatch troops group. Second, No difference has been confirmed on the patient distribution rate of according medical specialties between the two groups. Third, Most frequent conditional diagnosis lists are sprain & strain, upper repiratory infection (URI), allergy, contusion, dental care in order for the front line troops. However, in the overseas dispatched troops group, minor injury, dental care, sprain & strain, URI, and entero-colitis were noted consecutively. Forth, Minor heat related disease is more fequent in the overseas grous whereas more serious presentation is orientated in the frontline group in South korea. Fifth, Infectious disease outbreak more frequently in the overseas dispatch troops especially focusing on gastro-intestinal symptoms. Conclusions : This finding offers a guiding reference for understanding the speciality and specificity on the disposition of the disease outbreak rate between the overseas dispatch UN troops and the frontline Korean troops.

누에 고치색 유전자 발현의 다양성 검정 및 색채과학적 해석

한명세 ( Myung Sae Han ),박현로 ( Hyun Ro Park ),한상미 ( Sang Mi Han ),남기수 ( Ki Soo Nam ),권순하 ( Soon Ha Kwon ),임종성 ( Jong Sung Lim ),( Mau Tuan Nguyen ) 한국잠사학회 1999 한국잠사곤충학회지 Vol.41 No.1

Child class C의 조기 간세포암 환자와 Child class A의 진행성 간세포암 환자에서의 생존 비교

박의주 ( Eui Ju Park ),장재영 ( Jae Young Jang ),정승원 ( Soung Won Jeong ),추진우 ( Jin Woo Choo ),김진녕 ( Jin Nyoung Kim ),권순하 ( Soon Ha Kwon ),이병무 ( Byoung Moo Lee ),이세환 ( Sae Hwan Lee ),김상균 ( Sang Gyune Kim ),차 대한간암학회 2013 대한간암학회지 Vol.13 No.2

Background/Aims: The prognosis of hepatocellular carcinoma (HCC) is affected by stage as well as liver function. We analyzed the survival outcome of early stage HCC in Child class C patients and advanced HCC in Child class A patients. Methods: Among 453 HCC patients with good performance status Group A included 33 consecutive Child class C patients with early stage (I II) HCC and Group B included 45 consecutive Child class A patients with advanced stage (III IV) HCC. We investigated the clinical characteristics cirrhotic complications and prognostic factors related with survival in each group and compared overall survival between two groups. Results: Age prothrombin time total bilirubin and Model for End-Stage Liver Disease (MELD) scores were significantly higher in Group A. Male sex platelet count albumin sodium (Na) hepatitis B virus alpha fetoprotein (AFP) and portal vein thrombosis were significantly higher in Group B. Complications of cirrhosis such as variceal bleeding ascites and hepatic encephalopathy were increased in Group A (P<0.05). Patients with an elevated AFP (>400 ng/mL) tended to exhibit poor survival as it increased in Group A (P=0.084). MELD scores>15 (Hazard ratio[HR] 17.84 95% confidence interval [CI] 3.70-85.93 P<0.001) stage IV (HR:3.27, 95% CI 1.10-9.75 P=0.033) and absence of HCC treatment (HR: 3.70 95% CI 1.06-12.50, P=0.040) were independent poor prognostic factors in Group B. Median overall survival was 24.6 months (95% CI 10.6-38.4) for Group A and 13.5 months (95% CI 4.6-22.3) for Group B (P=0.278). In the HCC treatment group there were no significant differences of median overall survival between Group A and Group B respectively (27.1 vs. 15.7 months P=0.338). In patients with conservative treatment Group A and Group B had a significantly different median overall survival of 13.6 and 2.5 months respectively (P=0.012). In patients of Group B median overall survival was significantly higher in patients who received treatment of HCC compared to those who did not respectively (15.7 vs. 2.5 months P<0.001). Conclusions: Overall median survival was not different between both groups. However in Child class A patients with advanced stage HCCs the cumulative median survival was higher in patients who received treatment of HCC compared to those who did not. Therefore advanced stage HCC patients with good liver function should be considered for HCC treatments.

흉강경을 이용한 폐생검으로 확진된 철폐증

권순하,김양기,이영목,장안수,김기업,고은석,어수택 순천향의학연구소 2010 Journal of Soonchunhyang Medical Science Vol.16 No.1

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애기수영의 알레로파시 효과와 생장

권순하,길봉섭 圓光大學校 基礎自然科學硏究所 1997 基礎科學硏究誌 Vol.16 No.1

애기수영의 생태특성을 구명하기 위하여 실험실과 야외조사를 병행 실시하였다. 애기수영 식물은 발아 후 직립위주의 신장생장을 하고 뒤이어서 지하경을 뻗어 옆으로 불어나며 그 위에 새로운 개체가 돋아나고 더 많은 분자와 새 개체가 증가하는 왕성한 생장을 하였다. 애기수영의 수용성추출액에 대한 발아율과 신장율은 실험식물별로 다르지만 대체로 추출액의 농도에 반비례적인 경향을 나타냈다. 한편 애기수영식물을 GC와 HPLC로 분석하여 6종류의 화학물질을 분리했고 이들 화학물질이 애기수영의 allelopathy효과에 관계가 있는 일부물질일 것으로 추정되었다. 애기수영 식물은 4월경부터 왕성한 생장으로 주위의 다른 식물보다 우세한 지위를 차지하고 군락을 형성하며, 아울러 화학물질을 주위환경에 방출하여 다른식물보다 우위를 차지하는 생태특성이 있다는 사실을 밝혀냈다. Allelopathic effects and growth ecology of Rumex aceteosella were investigated both in the laboratory and in the field. Seed germination and seeding growth of the experimental species(receptor one) were inhibited by the extra time. Especially toxic activities were shown at even the low concentration of the extracts, which were prepared for 24hrs. Extracts from the root showed more toxic than that from the above-ground part of the plant. Rhizome development of the plant was vigorously formed. Thin layer chromatography was used to analyse phytochemical substances, and six phenolic compounds such as caffeic acid, protocatechuic acid, ferulic acid, vanillic acid, pyrogallol and gentisic acid were identified from the extracts of Rumex acetosella plant. It is assumed, therefore, that the above phenolic compounds and rhizome extension of the plant would be responsible for the allelopathic potential and the dominant occupation of this plant in the fields.