자궁경부암의 방사선치료 후 방사선대장염 발생의 위험인자

강남용(Nam Young Kang),김주성(Joo Sung Kim),우홍균(Hong Gyun Wu),김병관(Byeong Gwan Kim),남상민(Sang Min Nam),장은정(Eun Jeong Jang),정현채(Hyun Chae Jung),송인성(In Sung Song) 대한소화기학회 2002 대한소화기학회지 Vol.40 No.4

Background/Aims: Radiation therapy is an effective treatment modality for uterine cervix carcinoma. The adverse effects, however, can be seen as acute and chronic colitis, which may lead to serious complications including fistula, bleeding, and stricture. The aim of this study was to evaluate the clinical characteristics of radiation- induced colitis and analyze the predictive factors of chronic bowel complications. Methods: All 192 consecutive patients were enrolled from January 1995 to April 1998. The characteristics of acute and chronic complications were analyzed retrospectively. The acute and chronic complications were graded according to EORTC/RTOG grading criteria. Risk factors of chronic colitis were obtained by univariate and multivariate analyses. Results: Of 192 patients, 142 (74%) developed acute bowel complications (38/grade I, 93/II, and 11/III). The common symptoms were diarrhea, abdominal pain, and nausea. Fifty-six (29%) of the 192 patients developed chronic bowel complications (23/grade I, 10/II, 11/III, and 12/IV). In univariate analysis, age, body mass index, hypertension, abdominal surgery, and intracavitary radiation (ICR) were statistically significant in the development of chronic colitis. Multivariate analysis revealed that ICR had the greatest prognostic significance. Conclusions: The patients treated with ICR have a high probability of developing chronic radiation-induced colitis. A meticulous follow-up is needed to manage these patients promptly. ( Korean J Gastroenterol 2002; 40: 247-254)

심한 폐기종 환자에서의 양측성 폐용적 감축술

강남용 ( Nam Young Kang ),박재석 ( Jae Seuk Park ),이명인 ( Myeung In Lee ),하동열 ( Dong Yeol Ha ),지영구 ( Young Koo Jee ),이계영 ( Kye Young Lee ),김건열 ( Keun Yeol Kim ),서필원 ( Pil Weon Seo ) 대한결핵 및 호흡기학회 1998 Tuberculosis and Respiratory Diseases Vol.45 No.3

유성견에서 교정적 치아이동에 따른 치주조직 변화에 관한 연구

강남용(Nam Yong Kang),윤영주(Young Jooh Yoon),김광원(Kwang Won Kim) 조선대학교 구강생물학연구소 1997 Oral Biology Research (Oral Biol Res) Vol.21 No.2

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원발성 장림프종의 세포형에 따른 임상양상 및 예후인자

장은정(Eun Jeong Jang),김주성(Joo Sung Kim),김철우(Chul Woo Kim),김찬규(Chan Gyoo Kim),김지원(Ji Won Kim),강남용(Nam Young Kang),정현채(Hyun Chae Jung),송인성(In Sung Song) 대한소화기학회 2002 대한소화기학회지 Vol.40 No.1

N/A

유성견에서 교정적 치아이동에 따른 치주조직 변화에 관한 연구

강남용,윤영주,김광원 朝鮮大學校 口腔生物學硏究所 1997 Oral Biology Research (Oral Biol Res) Vol.21 No.2

For orthodontic movement, optimal orthodontic force should be maintained without periodontal breakdown and alveolar bone should be remodeled physiologically. Therefore, to obtain proper occlustion through tooth movement within alveolar bone, we should know the biomechanics of teeth and supporting tissures. The present shudy was performed to observe histologic changes of periodontal tissue immediately after application of orthodontic force and during the retention period ingrowing young adult dogs. In this study, experimental group contained between mandibular left canine and 1st molar and control group contained contralateral teeth of same animal. The .018"X.022" stainless steel closed coil spring (Den-taurum Co.) was ligated on the experimental teeth at initial 200gm-force from mandivular canine to 1st molar. The animals(4 to 6 months aged young adult dogs) were sacrificed on 0, 14, 28 days after the finish of application, and then tissue samples were divided into hematoxylin-eosin(HE) staining section, ground section, alkaline phosphatase(ALP) staining section, and tartrate-resistant acid phosphatase(TRAP) staining section. Therefore, the preparations were examined under light microscopy. The following results were obtained: 1. Immediately after the finish of appliance activation, the periodontal space was increased in tension side, but decreased in pressure side compared to that of control. The hyalinized zone was also observed in the periodontium. 2. After the 14-day retention, periodontal space was decreased in tension side and slightly increased in pressure side compared to that of immediately after the finishof appliance activation. The hyalinized zone was repaired and a few osteoblasts showing slightly new bone formation were seen. Osteoblasts were scarcely observed along the alveolar bone. 3. After the 28-day retention, the periodontal fibers are normally repaired. A lot of TRAP(+) osteoclasts and increased alveolar bone resorption were observed in pressure side, and ALP(+) osteoblast and increased new bone formation were observed in tension side.

유성견에서 교정적 치아이동에 따른 치주조직 변화에 관한 연구

강남용,윤영주,김광원 대한치과교정학회 1997 대한치과교정학회지 Vol.27 No.4

교정력에 의한 치주조직의 변화를 알아보기 위해 성장중인 유성견에서 단기간의 교정력이 가해진 직후와 보정기간 동안 일어나는 치아와 골조직의 변화양상을 조직학적으로 관찰하였다. 본 연구에서는 생후 4-6개월된 유성견 3마리를 이용하여, 각 실험동물의 하악 좌측 견치와 제1대구치는 실험군으로, 우측 견치와 제1대구치는 대조군으로 하였다. 하악견치와 제1대구치에 치관사이에서 최초 교정력이 200mg이 되도록 0.018"X0.022" S.S closed coil spring(Dentarum Co)의 길이를 조절하여 치아에 결찰시키고 장치는 1주간 활성화기간을 갖는 후 14일, 28일의 보정기간을 거쳐 희생시켜 하악골을 절제하여 통법에 따라 H-E염색군, 연마표본군, ALP염색군, TRAP염색군등으로 나누어 염색을 시행하여 다음과 같은 결과를 얻었다. 1. 교정력을 종료한 직후 견인측 치주인대 폭경이 대조군보다 더 증가된 상을 보이고, 반대로 압박측은 폭경이 감소된 소견을 보이며 치주인대의 섬유들이 치축에 수직으로 압축되며 초자양 변성이 관찰되었다. 대조군에서 관찰되는 다수의 규칙적인 배열을 보였던 조골세포가 견인측에서는 간혹 관찰되었다. 2. 교정력 종료후 14일 보정기간 경과군 치주인대내 섬유아세포들이 증식되어 초자지질대가 회복되는 소견이 관찰되었고 견인측 치주인대의 폭경이 교정력을 종료한 직후군보다 감소하였으며, 소수의 ALP(+) 조골세포와 함께 신생골형성도 관찰되었다. 압박측 치주인대의 폭경은 교정력을 종료한 직후군보다 다소 증가하였으며 골흡수도 증가되었다. 3. 교정력 종료후 28일 보정기간 경과군 치주인대섬유는 정상적으로 회복되어 대조군과 유사한 양상을 보였고 견인측 치조골내 다수의 ALP(+)조골세포와 활발한 신생골형성이 관찰됨과 더불어 압박측 치조골은 다수의 TRAP(+)파골세포와 왕성한 골흡수양상을 보였다. 이상의 결과를 종합해 볼때 교정력을 7일간 가한 직후 유리질화가 관찰되었고 교정력을 종료후 28일 보정기간 경과군에서 압박측에서는 파골세포 견인측에서는 조골세포의 활성과 함께 각각에서 왕성한 골 흡수와 신생골형성이 관찰됨을 알 수 있다. For orthodontic tooth movement, optimal orthodontic force should be maintained without periodontal breakdown and alveolar bone should be remodeled physiologically. Therefore, To obtain proper occlusion through tooth movement within alveolar bone, we should know the biomechanics of teeth and supporting tissues. The present study was performed to observe histologic changes of periodontal tissue immediately after application of orthodontic force and during the retention period in growing young adult dogs. In this study, of same animal. The 0.18"X0.22" stainless steel closed coil spring(Dentaurum Co.) was ligated on the experimental teeth at initial 200gm-force from mandibular canine to 1st molar. The animals(4 to 6 months aged young adult dogs)were sacrificed on 0, 14, 28 days after the finish of appliance activation, and the tissue samples were divided into himatoxylin-eosin(HE) staining section, groud section, alkaline phosphatase(ALP) staining section, and tartrate-resistant acid phosphatase(TRAP) staining section. Thereafter, the proparations were examined under light microscopy. The following results were obtained: 1. Immediately after the finish of appliance activation, the periodontal space was increased in tension side, but decreased in pressure side compared to that of control. The hyalinized zone was also observed in the periodontium. 2. After the 14-day retention, peridontal space was decreased in tension side ans slightly increased in pressure side compared to that of immediately after the finish of appliance activation. The hyalinized zone was repaired and a few osteoblasts showing slightly new bone formation were seen. Osteoblasts were scarcely observed along the alveolar bone. 3. After the 28-day retention, peridontal fibers are normally repaired. A lot of TRAP(+) osteoclasts and increased alveolar bone resorption were observed in pressure side, and AP(+) osteoblast and increased new bone formation were observed in tension side.

폐선암의 심장침습 부위에서 발생한 종양색전에 의한 뇌경색증 1예

황의창,류센,김인호,박현종,강남용,이명용 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.7

대장종양의 조직병리학적 소견과 선구 형태(Pit Pattern)의 비교

김정원,이우진,임창영,송일한,류센,강남용,허재형,진영주,노임환,고재향 대한소화기내시경학회 1999 Clinical Endoscopy Vol.19 No.6

Background/Aims: To investigate the morphological and histopathological associations between an individual pit seen on stereomicroscopy or magnifying colonoscopy and an individual crypt seen in histological sections of colorectal tumors. Methods: Fifty two colorectal lesions were examined by colonoscopy. The mucosal pits of the lesions were observed using a magnifying colonoscopy with a zoom 1 to 100 magnification after administering indigo carmine spray. The pits of the excised specimens were observed by using a stereomicroscopy after 0.2% cresyl violet stain. The pit patterns were classified into six types: normal round pit (I); asteroid pit (II); small round pit (IIIs); large tubular pit (IIIL); gyrus-like pit (IV); and non-structural pattern or amorphysm (V). Histologic diagnoses were determined by H&E staining under light microscopy. Results: The histologic findings according to the pit patterns were 1 chronic nonspecific inflammation and 1 submucosal tumor in 2 cases with type I pit pattern; 4 hyperplastic polyps in 4 cases with type II; 1 hyperplastic polyp, 16 adenomas with low-grade dysplasia, 3 adenomas with high-grade dysplasia, and 1 carcinoma in situ in 21 cases with type IIIL; 4 adenomas with low-grade dysplasia, 3 adenomas with high-grade dysplasia, and 4 carcinoma in situ in 11 cases with type IV; 1 adenoma with low-grade dysplasia in 1 case with type II IIIL; 3 adenomas with low-grade dysplasia, 4 adenomas with high-grade dysplasia, and 2 carcinoma in situ in 9 cases with type IIIL IV; 1 adenoma with high-grade dysplasia, 2 carcinoma in situ, and 1 adenocarcinoma in 4 cases with type IV V. In assessing the histologic findings according to pit pattern by stereomicroscopy, the overall diagnostic predictive value was 82.6% (43/52), and the diagnostic accuracy in differential diagnosis between nonneoplastic and neoplastic lesions was 98% (51/52). The ratio of agreement of the pit pattern between the magnifying colonoscopy and the stereomicroscopy was 68% (17/25). Conclusions: The results suggest that there was a close correlation between the pit patterns and the histologic findings of colorectal tumors, and that the observation of pit patterns of colorectal lesions provides a differential diagnosis between neoplastic and nonneoplastic lesions.

급성 간부전으로 발현된 Wilson병 1예

김정원,김화영,임창영,김인호,송일한,신정우,노임환,윤세영,유권,강남용,명나혜,최정 대한소화기학회 2000 대한소화기학회지 Vol.35 No.1

Wilson's disease is an autosomal recessive inherited disorder characterized by increased body store of copper due to deranged copper metabolism. In wilson's disease, hepatic manifestations can be detected in earlier stage than neuropsychiatric manifestations. Though there were several reports of Wilson's disease presenting hepatic symptoms in Korea, the case of Wilson's disease presenting acute hepatic failure at the age over 30 years was not reported. Here, we report a case of Wilson's disease presenting acute hepatic failure in a 31-year-old man. He was admitted to our hospital due to jaundice and ascites. Main findings were the presence of Kayser-Fleischer ring, decreased serum ceruloplasmin, worsening liver function and Coomb's negative hemolytic anemia, but no neuropsychiatric symptoms were observed. The pathologic finding of the liver revealed cirrhotic change and severe cholestasis with a periportal hepatocytes containing copper-positive granules. He was successfully treated with penicillamine.

점막하층 침윤 조기 위암에서 심달도 분류에 의한 조직병리학적 고찰

김정원,임창영,정민,노임환,고재향,강남용,최정,홍석균,송일한 대한소화기학회 2000 대한소화기학회지 Vol.35 No.3

Background/Aims: We determined the possibility of endosocpic mucosal resection in early gastric cancer with submucosal (sm) invasion, especially carcinoma in which the depth of invasion is limited within superficial. Methods: We retrospectively reviewed 35 cases of early gastric carcinoma with submucosal invasion resected by subtotal or total gastrectomy from 1994 through 1998. We analyzed several histopathological factors in relation to degree of submucosal invasion through final pathologic reports. Degree of sm invasion was designated as follows: sm1- the depth of invasion was limited within superficial, one third of the sm layer; sm2- the invasion was limited within two third of sm layer; sm3- the invasion was limited within distal one third of sm layer. Results: On analysis of the degree of carcinoma invasion into the sm layer, the rate of lymph node metastasis in sm1, sm2, sm3, and sm2+3 were 16.7%, 33.3%, 17.6%, and 21.7%, respectively. The rates of lymphatic ducts or vessels permeation in sm1, sm2, sm3, and sm2+3 were 25%, 33.3%, 11.2%, and 17.4%, respectively. The frequencies of poorly differentiated carcinoma in sm1, sm2, sm3, and sm2+3 were 16.7%, 33.3%, 52.9%, and 47.8%, respectively. Conclusions: Poorly differentiated carcinoma and lymph node metastasis were observed less often in sm1 than in sm2 and sm3.