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양은수(Eun Soo Yang),박태준(Tae Joon Park),박태군(Tae Gun Park),류종철(Jong Cheol Ryu),신원창(Won Chang Shin),최원충(Won Choong Choi),이진호(Jin Ho Lee),김관엽(Kwan Yup Kim) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.2
The double pylorus is a fistulous communication between the gastric antrum and duodenal bulb. Although its incidence is rare, reports concerning double pylorus are increasing with the recent development of upper gastrontestinal endoscopy. In most instances, it is believed to be a complication of peptic ulcer disease. We recently experienced a case of double pylous in 63- year old male presenting as epigastric pain and melena. Endoscopy revealed an ulcer on the lesser curvature side of gastric antrum and the opening of gastroduodenal fistula within the antral ulcer. We showed the fistula connecting antral ulcer with the duodenal bulb by passing the cathter through it. W e reported this case as a double pylorus accompanied by gastric an- tral ulcer with review of the literature. (Korean J Gastroentero11994; 26: 343 347)
복수중에서의 혈청 및 복수내 Adenosine Deaminase 활성도 측정의 진단적 가치
박태군(Tae Koon Park),양은수(Eun Soo Yang),박태준(Tae Joon Park),이희승(Hee Seung Lee),류종철(Jong Cheol Ryu),신원창(Won Chang Shin),최원충(Won Chong Choi),이진호(Jin Ho Lee),김관엽(Kwan Yop Kim) 대한내과학회 1994 대한내과학회지 Vol.47 No.1
N/A Objectives: In this study, we would like to evaluate the diagnostic value of adenosine deaminase activity in serum and ascitic fluid from patients with ascites of various causes, including tuberculous peritonitis, liver cirrhosis with or without hepatoma, and cancer peritonitis. Methods: The ADA was assessed in serum and ascitic fluid, and simultaneous calculation of ascitic fluid/ serum ADA ratios were obtained in 89 patients with ascites due to various causes; 42 for liver cirrhosis, 18 for hepatoma, 14 for tuberculous peritonitis, 15 for malignant ascites. Results: 1) Serum ADA activity was significantly higher in patients with liver cirrhosis than those with other causes of ascites, with the level of 61.3±49.0 U/L, and the corresponding ADA levels of other diseases were 42.8±20.4 U/L in hepatoma, 46.1±21.9 U/L in tuberculous peritonitis, 24.0±19.8 U/L in malignant ascites (p<0.05). 2) Ascitic fluid ADA activity was highest in patients with tuberculous peritonitis than those with non-tuber-culous causes of ascites, with the level of 82.0±72.3 U/L, and the corresponding ADA levels of other diseases were 21.1±31.7U/L in liver cirrhosis, 8.8±7.7U/L in hepatoma, 29.0±19.7 U/L in malignant ascites (p<0.05). Ascitic fluid ADA level greater than 80 U/L had a specificity of 97%, sensitivity of 50%, and diagnostic efficiency of 76% for the diagnosis of tuberculous peritonitis. 3) The ascitic fluid/serum ADA ratios were significantly higher in patients with malignant ascites than those with other causes of ascites, with the level of 3.5±7.0, and the corresponding levels of other diseases were 0.8±1.8 in liver cirrhosis, 0.3±0.4 in hepatoma, 1.7±1.3 in tuberculous peritonitis (p<0.05). Conclusion: These results suggest that the assessment of serum and ascitic fluid ADA activity, and simultaneous calculation of ascitic fluid/serum ADA ratios would be useful in the differential diagnosis between patients with tuberculous peritnnitis and non-tuberculous causes of ascites.
김홍용(Hong Yong Kim),고일향(Il Hyang Ko),이진호(Jin Ho Lee),김관엽(Kwan Yop Kim),류종철(Jong Cheol Ryu),차순주(Soon Joo Cha),신원창(Won Chang Shin),박태준(Tae Joon Park),최원충(Won chung Choi) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.4
Carcinoid tumors which arise from enterochromaffin cells are usually found in the appendix, ileun, bronchus and rectum. Carcinoid tumors of the biliary tract are exceedingly rare and pre-operative diagnosis is very difficult. We report a case of carcinoid tumor of the gallbladder in a 43-year-old man presenting jaundice and right upper quadrant abdominal pain as a chief complaint. A tumor of the neck of gallbladder was demonstrated with ultrasonography, computed tomography, endoscopic retrograde cholangiopan-creatography, and percutaneous cholangiography and was confirmed as carcinoid tumor at operation.
박태준,양은수,류종철,박태군,이희승,신원창,이진호,김관엽 인제대학교 1994 仁濟醫學 Vol.15 No.1
1989년 9월부터 1993년 7월까지 인제대학교 의과대학 상계백병원에서 실시한 위내시경 소견이 조기위암이며 내시경 직시하 생검결과 선암으로 판명되어, 근치적 위절제술을 시행받은 23명의 환자에서 임상적 특징을 알아보고, 문헌고찰과 함께 보고하는 바이다. The incidence and mortality rate of stomach cancer ranks well ahead of all malignancies in Korea. The prognosis is excellent in early gastric cancer of which the overall 5 years survival rate of 85∼95% is comparative with that of advanced gastric cancer of 15∼49%. So early detection with very sensitive mordality of gastroscope and surgery is the only premise to decrease the mortality rate of gastric cancer. This report deals with the clinical aspects of 23 cases of early gastric cancer, which were confirmed with histopathologic examination of resected stomach during the 4 years from September 1989 to July 1993 at Sanggye Paik hospital, Seoul, Korea. Out of 23 cases of early gastric cancer, 14 cases were male, 9 cases were female, and the male to female ratio was 1.6 : 1. The most common type of early gastric cancer was talc type(43.5%), IIc and its combined type comprised most of them(87.0%). The most prevalent sloe of lesion was gastric angle(43.5%) and the most common direction was lesser curvature(73.9%) 19 cases of 23(78.3%) were between 1∼3cm in size, and there was no statistical significance between the size of the lesion and lymph node metastasis. Of the 9 cases with mucosal lesion, there were 2 cases with lymph node metastasis(22.2%), but 7cases(50.0% ) of 14 cases with submucosal lesion presented lymph node metastasis. Diagnostic accuracy of endoscopy on detection of early gastric cancer was 17 cases(73.9%) of total 23 cases in our study. As with other report, histopathulogic examination of resected stomach revealed adenocarcinoma, tubular type as the most common type. Frequent complaint of patients with early gastric cancer was epigastric pain(65.2%), and duration of the symptom was less than 12 months in 17 cases(73.1%) of 23 patients with early gastric cancer.
전수영,정운태,황성보,류종철,최수전,고일향 인제대학교 1993 仁濟醫學 Vol.14 No.4
저자들은 폐결핵 추정하에 치료를 받았던 Sarcoidosis 환자 1례를 경험했기에 문헌적 고찰과 함께 보고하는 바이다. Sarcoidosis is a granulomatous disease of unknown etiology In which pulmonary manifestations typically predominate with protean extrapulmonary and systemic manifestations. In sarcoidosis, pulmonary symptoms include dyspnea on exertion, non-productive cough and wheezing. Typical radiologic finding is a diffuse infiltration with or without bilateral symmetric hilar lymphadenopathy. Sarcoidosis should be differentiated with pulmonary tuberculosis because of its clincal and radiological slmilarity in Korea, an endemic area of pulmonary tuberculosis. We report a case of sarcoidosis patient whose symptoms were not improved by treatment with anti-tuberculous medication, but by steroid therapy following the diagnosis of sarcoidosis made by biopsy.
이홍기,류종철,김선운,엄수정,이형준,송진호,김두일,김동수 인제대학교 2000 仁濟醫學 Vol.21 No.2
Coronary arteriovenous fistula is relatively rare congenital heart disease which consists of a communication between a coronary artery and a cardiac chamber, a great artery or the Vena Cava. Although it is the most common anomaly that can affect coronary perfusion, bilateral involvement of coronary fistula constitutes an uncommon subgroup of coronary arteriovenous fistulas. We report a case of bilateral coronary arteriovenous fistula coexistent with bicuspid aortic valve presenting symptom of angina.
ADP에 의해서 활성화된 혈관평활근 세포의 증식에 관여하는 Integrin의 종류와 신호 전달 경로
박찬복,이지현,류종철,차태준,주승재,이재우 고신대학교 의학부 2004 高神大學校 醫學部 論文集 Vol.19 No.1
Background: Adenosine diphosphate(ADP), which is usually secreted from activated platelets activates integrin αvβ3. αvβ5, and α5β1 on human vascular smooth muscle cells. Integrins have an important role in the proliferation of vascular smooth muscle cells. ADP may stimulate the proliferation of vascular smooth muscle dells by the activation of integrins. Integrins mediating ADP-stimulate the proliferation of vascular smooth muscle cells and signal transduction pathway of ADP stimulation were investigated in this study. Methods: MTT(3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay was used to evaluate ADP or ATP-stimulated proliferation of human aortic smooth muscle cells (HASMC). In some experiments, HASMC were incubated with U73122, an inhibitor of phospholipase C, or monoclonal antibodies (mAb) to integrins after ADP of ATP stimulation. Results: ADP and ATP increased the proliferation of HASMC in a dose-dependent manner. U73122 inhibited ADP or ATP stimulated proliferation of HASMC ADP-stimulated proliferation of HASMC was inhibited either by c7E3, a blocking mAb to integrin β3 or by LM609, a blocking mAb to integrin αvβ3(37% and 26% inhibition, respectively: p<0.05), but neither by P1F5, a blocking mAb to integrin αvβ5 nor by JBSS, a blocking mAb to integrin α5β1. Conclusion: These results indicate that ADP increases the proliferation of human vascular smooth muscle cells through phospholipase C pathway, and only integrin αvβ3 mediates ADP-stimulated proliferation of human vascular smooth muscle cells.