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NEW DEVELOPMENT OF HYPERGAM AND ITS TEST OF PERFORMANCE FOR γ-RAY SPECTRUM ANALYSIS
박병건,최희동 한국원자력학회 2012 Nuclear Engineering and Technology Vol.44 No.7
The HyperGam program was developed for the analysis of complex HPGe γ-ray spectra. The previous version of HyperGam was mainly limited to the analysis of γ-ray peaks and the manual logging of the result. In this study, it is specifically developed into a tool for the isotopic analysis of spectra. The newly developed features include nuclide identification and activity determination. An algorithm for nuclide identification was developed to identify the peaks in the spectrum by considering the yield, efficiency, energy and peak area for the γ-ray lines emitted from the radionuclide. The detailed performance of nuclide identification and activity determination was accessed using the IAEA 2002 set of test spectra. By analyzing the test spectra, the numbers of radionuclides identified truly (true hit), falsely (false hit) or missed (misses) were counted and compared with the results from the IAEA 2002 tests. The determined activities of the radionuclides were also compared for four test spectra of several samples. The result of the performance test is promising in comparison with those of the well-known software packages for γ-ray spectrum analysis.
Xanthium strumarium Linne 에탄올 추출물의 약리학적 활성
박병건,임창진 강원대학교 기초과학연구소 2010 기초과학연구 Vol.21 No.-
Xanthium strumarium Linne 에탄올 추출물 (XSE)의 anticancer, anti-inflammatory, antioxidant, anti-angiogenic 활성 등 약리학적 활성을 구명하였다. XSE는 LPS에 의해 활성화된 RAW264.7 대식세포에서 NO의 생성과 활성 산소종 (ROS)의 수준을 감소시켰다. 또한 안정된 free radical을 감소시켰다. 이 실험에서 사용한 XSE의 농도는 대식세포의 생존에는 영향을 주지 않았다. 이러한 결과, Xanthium strumarium Linne의 항염증 활성이 NO의 생성이 억제됨으로서 일어나는 것이라는 것을 시사한다.
박병건,이상준,정필상,Park, Byung-Kuhn,Lee, Sang-Joon,Chung, Phil-Sang 대한후두음성언어의학회 2011 대한후두음성언어의학회지 Vol.22 No.1
Laser is a relatively recent addition to laryngeal surgery. Since their invention, laser use and applications have expanded rapidly. The use of lasers in surgery has offered a time- and cost-efficient alternative to cold surgical techniques and has been used in the treatment of numerous laryngeal pathologies, including stenoses, recurrent respiratory papillomatosis, leukoplakia, nodules, malignant laryngeal disease, and polypoid degeneration (Reinke's edema). Despite the notable benefits, laser surgery is not without disadvantages. Laser heat can increase scarring and cause damage to adjacent tissue. With laser laryngeal microsurgery, there is potential for airway fire, endolaryngeal bleeding, perichondritis, chondritis, granuloma, surgical emphysema, laryngeal stenosis and web formation, postoperative edema and swallowing problem. Surgeons should be known about these complications and could manage properly.
기니픽 유양동 폐쇄술에 사용한 물질의 효과 및 조직병리학적 비교 연구
박병건,강명구,황찬호,김재룡,박동은 대한이비인후과학회 2004 대한이비인후과학회지 두경부외과학 Vol.47 No.11
Background and Objectives:The present study was undertaken to determine and to compare the characteristics of bone wax, fibrofatty tisues or bone graft materials (Lubboc)Materials and Method:The guinea pigs were used to perform obliteration of the dorsal bullae of the temporal bone using bone wax, fibrofatty tisues or Lubboc. Twelve weeks after transplantation, the animals were sacrificed, and histological sections were prepared. Histological evaluations were performed to determine changes of the dorsal bulae mucosa of the temporal bone and the implanted materials. Results:reactions within the dorsal bullae mucosa of the temporal bone. A large amount of absorption was observed in the fibrofatty tissue. On the other hand, in the case using Luboc, real bonds between the new bone and native bone were observed, as wel as a ma-ture trabecular bone traversing throughout the entire implant materials. Bone formation as induced by the Lubocimplantation appeared to be a physiological reaction, which was further supported by observation of extensive neovascularization within the Conclusion:Based on our curent observations, we consider Lubbocas a superior implant material for bone wax and fibrofatty tisues.
아프리카산 발톱개구리 치아의 백악질에 관한 형태학적 연구
박병건,이영훈 대한구강해부학회 2021 대한구강해부학회지 Vol.42 No.1
치아는 백악질과 치아주위인대, 이틀뼈로 구성된 치아주위조직에 의해서 지지된다. 백악질은 조직학적특성에 따라 무세포성시멘트질과 세포성시멘트질로 구분된다. 아프리카산 발톱개구리의 치아는 일생동안탈락과 대체되는 과정을 반복하는 다생치아이고, 치아판와 모자시기, 종시기, 기능단계치아와 같은 여러 시기의 치아와 치배로 이루어져 있다. 또한, 치아주위조직중 백악질도 주기적으로 흡수와 재형성 과정을 반복한다. 그러나 아프리카산 발톱개구리 치아의 백악질에 관한 형태학적 특성은 잘 알려져 있지 않다. 실험동물은 변태 후 3개월 된 어린 개구리와 3년 이상 된 성숙한 개구리를 사용하였다. 각 실험동물의 위턱을 채취하여 4% 파라포름알데하이드 용액으로 4℃에서 14~16시간 동안 고정하였다. 고정된 조직을 10% EDTA/1x PBS 용액으로 탈회하였고, 파라핀에 포매한 후 5 μm 연속절편을 제작하여H-E, picrosirius red (PR), Masson’s trichrome (MT) 염색, Integrin binding sialoprotein (IBSP) in situ hybridization을 실시하였다. 뿌리집(HERS)은 분절화되지 않고 이어져 치아뿌리 전체면을 덮고 있다. 기능단계 치아는 위턱뼈에 유착되어 있고, PR 염색과 MT 염색을 실시한 결과 아교섬유는 뿌리집과 치아가 맞닿는 부위와 뿌리집으로 덮여 있지 않는 치아뿌리의 유착부위에서 관찰되었으나, IBSP 는 뿌리집으로 덮여 있지 않는 치아뿌리의 유착부위에서만 발현되었다. 아프리카산 발톱개구리의 치아에서 아교섬유의 분포와 IBSP 의 발현을 결과로 치아는 기저부에서 위턱뼈와 유착되는 치아주위조직중 일부에서 세포성시멘트질을 포함하는 것으로 추측된다. 이러한 결과는 향후아프리카산 발톱개구리의 치아에서 백악질의 미세구조와 분자유전학적 연구에 활용될 수 있을 것이다.
생쥐 악하선 Granular Convoluted Tubules에 미치는 Estrogen의 영향
朴炳建,張起完,李武三 全北大學校 齒醫學硏究所 1988 전북치대논문집 Vol.6 No.1
The granular convoluted tubules(GCT), which are specialized duct system of the mouse submandibular gland, produce epidermal growth factor(EGF), nerve growth factor(NGF), renin, and kallikrein. GCT cells in the submandibular glands of female mice were studied by morphometric and immunohistochemical means at 2, 4, 8 weeks after ovariectomy. The relative proportion of GCT's was established by determining a tubules to acini (T/A) ratio. In normal female mice, the T/A ratio was 0.295(2Ws), 0.306(4Ws), 0.317(8Ws). The T/A ratio of mature mice with ovariectomized was increased significantly and was 0.333(2Ws), 0.447(4Ws), 1.071(8Ws) (p<0.01). This increase was suppressed by B-estradiol administered to ovariectomized mice at a dose of 1㎍/0.1㎖ of olive oil/day but not by olive oil(0.1㎖/day). The functional capacity of GCT cells was estimated by immunohistochemical staining for EGF. The number and size of immunoreactive GCT cells for EGF were significantly increased in ovariectomized mice (p<0.01), but were not increased by treatment of B-estradiol to ovariectomized mice.