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Enrlich 腹水癌移植에 따른 마우스의 淋巴臟器의 病理組織學的 變化
安亘煥 최신의학사 1975 最新醫學 Vol.18 No.7
A gravimetric and histopathologic study of lymph node, spleen and thymus changes associated with growth of transplanted Ehrlich carcinoma in mice was carried out to understand the immunological mechanisms during the growth of tumor. The tumor induced vigorous histological response in the regional and nonregional lymph nodes and spleen, whereas no significant histological response was identified in thymus. The early response evident at 7 days after tumor grafting was confined to the paracortical area of lymph node and periarterial lymphatic sheath of spleen, which was characterized by pronounced increase in numbers of large pyroninophilic cells and moderate increase in content of lymphocytes. By day 14, plasmacytosis in medulla of lymph node and marginal zone of spleen and active germinal centers were apparent besides continued presence of large pyroninophilic cells in paracortical area of lymph node and periarterial lymphatic sheath of spleen. During the later stages of the tumor growth, the early response, which was similar to that usually associated with cell-mediated immune mechanism, disappeared but plasmacytosis and prominent germinal centers, which were possibly related to the humoral immune mechanism, remained active. It is suggested that failure of rejection of the tumor may be possibly due to specific defect existing in the lymphoid organs. The plasmacytosis suggests that plasma cells develop in response to the tumor and are producing antibody, possibly "blocking" antibody.
촉매층의 제조 방법이 고분자 전해질 연료전지의 성능에 미치는 영향
오인환,전해수,임태원,홍성안,이정규,하흥용 한국화학공학회 2001 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.39 No.1
고분자 전해질 연료전지의 전극성능을 향상시키기 위하여 전극의 조성 및 구조가 전극 성능에 미치는 영향을 살펴보았다. 전극의 성능은 촉매층내 전해질 이오노머의 조성과 분포에 의해 가장 큰 영향을 받았으며, 전극내 전체 이오노머의 양을 촉매층 무게에 대하여 1/3 첨가하고, 전체 이오노머 중에서 촉매층내에 1/4, 전해질 막과 촉매층 계면에 3/4으로 이오노머를 분포시키는 것이 최적 조건임을 알 수 있었다. 전극용 촉매잉크 제조시 전해질 용해법 대신 콜로이드법을 사용하면 전극의 수소이온 전도도와 반응물 확산속도가 증가되어 전극성능이 향상되었다. 전극 제조법에 따른 성능변화는 순환 전위법과 임피던스 측정법 등의 전기화학 분석법이나 저항층을 이용한 전극성능 분석법 등을 통해 확인하였다. The performance of polymer electrolyte membrane fuel cells(PEMFC) has investigated by varying composition of the electrodes which consist of catalyst and proton-conductive ionomer. Their performance appeared to be significantly affected by the total amount and the distribution of the ionomer in the electrodes. The best performance was obtained when the ionomer content was 1/3 of the total amount of the catalyst(by weight); but, 1/4 of the ionomer was inside the catalytic layer and 3/4 at the interface between the catalytic layer and polymer electrolyte membrane. The performance of the electrodes was also influenced by the preparation method of catalyst inks which were composed of solvent, catalyst powders and ionomer solution, in such a manner that the so called "colloidal method" showed better results than did the conventional "solution method". The former method appeared to secure continuity of the ionomer network and also a higher porosity in the catalytic layer, resulting in a higher proton conductivity and a less mass transfer resistance. The effect of preparation methods was investigated by employing the various electrochemical analysis techniques.