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Enrlich 腹水癌移植에 따른 마우스의 淋巴臟器의 病理組織學的 變化
安亘煥 최신의학사 1975 最新醫學 Vol.18 No.7
A gravimetric and histopathologic study of lymph node, spleen and thymus changes associated with growth of transplanted Ehrlich carcinoma in mice was carried out to understand the immunological mechanisms during the growth of tumor. The tumor induced vigorous histological response in the regional and nonregional lymph nodes and spleen, whereas no significant histological response was identified in thymus. The early response evident at 7 days after tumor grafting was confined to the paracortical area of lymph node and periarterial lymphatic sheath of spleen, which was characterized by pronounced increase in numbers of large pyroninophilic cells and moderate increase in content of lymphocytes. By day 14, plasmacytosis in medulla of lymph node and marginal zone of spleen and active germinal centers were apparent besides continued presence of large pyroninophilic cells in paracortical area of lymph node and periarterial lymphatic sheath of spleen. During the later stages of the tumor growth, the early response, which was similar to that usually associated with cell-mediated immune mechanism, disappeared but plasmacytosis and prominent germinal centers, which were possibly related to the humoral immune mechanism, remained active. It is suggested that failure of rejection of the tumor may be possibly due to specific defect existing in the lymphoid organs. The plasmacytosis suggests that plasma cells develop in response to the tumor and are producing antibody, possibly "blocking" antibody.
자궁경부의 전암성 병변 및 편평상피암의 바이러스성 성인에 관한 연구 - 헤르페스 및 유두종 바이러스 항원의 면역화학적 관찰 -
안긍환(GH Ahn),박성희(SH Park),김용일(YI Kim),이상국(SK Lee),이효표(HP Lee),강순범(SB Kang) 대한산부인과학회 1984 Obstetrics & Gynecology Science Vol.27 No.14
자궁경부 이형성 33예, 상피내암 19예, 침윤성 편평상피암 40예와 대조군 자궁경부 43예를 대상으로 면역 과산화효소법을 이용하여 헤르페스 바이러스와 유두종 바이러스 항원의 출현빈도를 검색한 바 다음과 같은 결론을 얻었다. 1. 헤르페스 바이러스 항원은 이형성 28예중 4예(p<0.01), 상피내암 16예중 1예에서 국소적으로 나타났으며 상피내암에서는 주위 이형성 부위에 나타났다. 헤르페스 바이러스 항원은 중간세포의 세포질 혹은 드물게는 핵에 적갈색 과립상으로 염색되어 나타났다. 대조군 및 침윤성 편평상피암에는 헤르페스 바이러스 항원이 나타나지 않았다. 2. 유두종 바이러스 항원은 이형성 24에중 3예에서 나타났으며 표층세포 핵에 국한해서 나타났으며 일부표층부 중간세포의 핵에도 나타났다(0.05) Thirty-three cases of cervical dysplasia (mild, moderate, and severe), 19 cases of carcinoma in situ(CIS), 43 cases of squamous cell carcinoma of the uterine cervix, were examined for the presence of Herpes simplex virus type 2 (HSV-2) and papillomavirus genus-specific structural antigens(HPV) with a peroxidase-antiperoxidase method on formalin-fixed, paraffin-embedded tissue. HSV-2 antigen was detected in 4 of 28 cases of cervical dysplasia (mild, moderate, and severe) and 1 of 16 cases of CIS. In CIS the HSV-2 antigen was detected in the area of severe dysplasia adjacent to CIS. The HSV-2 antegen was found mainly in the cytoplasm of the intermediate cells. None of the control normal cervical tissue or squamous cell carcinoma of the uterine cervix showed HSV-2 antigen. HPV antigen was detected in 3 of 24 cases of cervical dysplasia (mild, moderate, and severe). The antigen-positive nuclei were found mainly in the superficial cells and partly in the intermediate cells just beneath the superficial cells with the antigen. The HPV antigen was not detected in CIS, squamous cell carcinoma, and control normal cervical tissue. In one case of severe dysplasia both HSV-2 and HPV antigen were detected in two separate areas. The results of this study provide immunohistochemical confirmation for the relationship of herpes simplex virus type-2 and human papilloma virus to cervical dysplasia.
Intralobar Pulmonary Sequestration: 수술 1예 보고
양기민,안긍환,김용일 대한흉부심장혈관외과학회 1971 Journal of Chest Surgery (J Chest Surg) Vol.4 No.1
Intralobar pulmonary sequestration is rare congenital lung disease, in which systemic artery supplies a congenitally cystic portion of the lung. Patient was 19 years old male whose complaints were fever, chest pain and sputum. Chest film showed a round homogenous density and air-fluid level at the left lower lung field and on bronchogram, contrast materials did not enter the abscess pocket. By operation multiple lung abscess pockets at the lower lobe were noted. An aberrant artery, measuring 0.4cm. in diameter and 2 cm. in length, arised from the aorta just above the diaphragm and entered the pusterior basal segment of left lower lobe. After division of the artery, left lower lobectomy was done ana postoperative hospital course was uneventful. Pathologic findings were multiple lung cysts which were not connected to the left lower lobe bronchi and an aberrant artery which showed elastic lamillation and mild sclerotic change.