大羌活湯의 消炎 鎭痛作用에 관한 硏究

金度植,林起龍,李炳柱,엄기진,文永熙 조선대학교 약학연구소 1992 藥學硏究誌 Vol.14 No.1

Experimental studies were conducted to investigate for the effect of Daeganghwal-Tang(DHT) extract on the anti-inflammatory activity, analgesic activity, subacute toxicity and acute toxicity. The following results have been obtanied ; In the anti-inflammatory activity in rats, DHT extract (300,600㎎/㎏ p.o) was shown remarkable preventive effect in the edema induced by Freund's complete adjuvant and 5% acetic acid. In analgesic activity test in mouse, DHT extract(300,600㎎/㎏ p.o) was shown significant analgegic activity in mouse induced by 0.7% acetic acid. In acute toxicity test in mouse, DHT extract showed10% mortelity at DHT extract 1.200㎎/㎏ i.p. and 2,000㎎/㎏ p.o.. In subacute toxicity test in mouse. DHT extract was not showed toxicity for 19 day. Uric acid in the serum of the treated rats by Freund's complete adjuvant were slightly decreased by comparing with the control group. During the administration of DHT extract, The body weight increased, but the liver and spleen weight was not changed by comparing with the control group. .

말라리아의 임상적 고찰

최경숙,박무림,정병학 圓光大學校 醫科學硏究所 2001 圓光醫科學 Vol.16 No.1-2

연구배경: 국내의 말라리아는 1970년대 말부터 근절되었으나, 1993년을 기점으로 급증하는 추세이어서, 이에 대한 역학적, 임상증상이나 경과 및 치료결과에 대하여 분석하고, 서구문헌과 비교해보고자 하였다. 방 법: 1998년 10월부터 2001년 8월까지 고열과 오한을 주소로 원광대학병원에 입원하여 말라리아로 확진된 28례의 환자들에 대하여 후향적으로 의무기록을 조사하였다. 본 연구결과를 토대로 서구의 연구결과와 비교하였다. 통계학적인 분석은 SPSS 9.0 통계 프로그램의 Chi-square test를 이용하였다. 결 자: 총 28례에서 원인원충은 전 례 모두 P. vivax이었고, 27례에서 발병 1년 이내에 전역한 경력이 있었고, 여자1례는 경기도 북부지역이나 외국여행의 경력이 없는 상태에서 진단되었다. 토착형 말라리아는 6월부터 10월 사이에 집중적으로 발생하였고, 고열과 오한(100%), 설사(14%), 오심이나 구토(35%), 심박수 항진(28%), 간종대(21%), 비장종대(39%)의 소견이 관찰되었다. 혈액검사상 평균혈색소는 12.4±1.8 g/dl이었고, 평균혈소판 수는 99,860±64,740/u1이었으며, 간기능의 이상을 보인 경우는 11례(39%)이었다. 혈뇨는 5례(18%), 총빌리루빈치의 상승은 10예(36%)에서 관찰되었다. 전 예에서 chloroquine phosphate를 3일간 1500 ㎎을 투여하고, 이후 primaqulne 15 ㎎을 매일 14일간 투여하여 28례 전 예에서 발열과 오한이 사라지면서 이상소견을 보였던 검사들도 정상화되어 가는 양상을 보였고, 치료중 나타난 약제의 부작용은 없었다. 서구의 Stanley 등의 연구결과와 비교하였을 때 빈혈, 백혈구 감소의 빈도가 더 높았다. 결 론: 최근 국내 말라리아의 발생은 급증하고 있어 이에 대한 적극적인 관리가 필요하고, 발열을 주소로 내원한 환자에서 반드시 말라리아를 감별진단하여야 한다. 또한 국내 토착형 말라리아에 대한 유전적인 소인 등의 연구가 추가적으로 필요할 것으로 사료된다. Background: Vivax malaria, which was once thought to be eradicable since more than 20 years ago, has made a dramatic resurgence since 1993 in the northern parts of Kyeonggi-do. We analyzed the cases of malaria who were treated in Wonkwang University Hospital with regards to epidemiology, clinical manifestations, and treatment outcome. Method: We retrospectively analyzed, clinical data of 28 confirmed cases of malaria treated in the same hospital from October, 1998 to August, 2001. We also compared out data to meta-analysis reports from western contries. Results: Twenty-eight cases of malaria were enrolled. All cases were diagnosed as vivax malaria. All 28 patients had fever and chills. Hematologic abnormalities were the most common laboratory findings. Our patients showed anemia, thrombocytopenia, leukopenia and elevation of transaminase more frequently than western patients. Conclusion: The number of malaria cases has been increasing by year. Early diagnosis, treatment, and prevention of malaria are important. To prevent indigenous malaria, anyone who travels to endemic areas should receive proper education and chemoprophylaxis, considering the pattern of drug resistance. Further genetic studies are desired to determine the subspecies of plasmodium vivax.

3 차원 데이터획득 뇌 FDG-PET 의 정확도 평가

최창운,이경한,최용,임상무,김상은,이정림,홍성운,김병태 대한핵의학회 1999 핵의학 분자영상 Vol.33 No.3

Purpose: To assess the quantitative accuracy and the clinical utility of 3D volumetric PET imaging with FDG in brain studies, 24 patients with various neurological disorders were studied. Materials and Methods: Each patient was injected with 370 MBq of 2-[18F]fluoro-2-deoxy-D-glucose. After a 30 min uptake period, the patients were imaged for 30 min in 2 dimensional acquisition (2D) and subsequently for 10 min in 3 dimensional acquisition imaging (3D) using a GE AdvanceTM PET system. The scatter corrected 3D (3D SC) and non scatter-corrected 3D images were compared with 2D images by applying ROIs on gray and white matter, lesion and contralateral normal areas. Measured and calculated attenuation correction methods for emission images were compared to get the maximum advantage of high sensitivity of 3D acquisition. Results: When normalized to the contrast of 2D images, the contrasts of gray to white matter were 0.75±0.13 (3D) and 0.95±0.12 (3D SC). The contrasts of normal area to lesion were 0.83±0.05 (3D) 0.96±0.05 (3D SC). Three nuclear medicine physicians judged 3D SC images to be superior to the 2D with regards to resolution and noise. Regional counts of calculated attenuation correction was not significantly different to that of measured attenuation correction. Conclusion: 3D PET images with the scatter correction in FDG brain studies provide quantitatively and qualitatively similar images to 2D and can be utilized in a routine clinical setting to reduce scanning time and patient motion artifacts. (Korean J Nucl Med 1999;33:327-36)

Adenoacanthoma and Fibrous Osteodystrophy in a German Shepherd Dog

Rim, Byung Moo 全北大學校 1984 論文集 Vol.26 No.-

2년전에 후지에서 종양절제 수술을 행한 병력을 가지고 있는 10세된 German Shepherd 견이 전신쇠약 기립불능 체온상승 호산성 백혈구 증가등의 임상증세를 보여 치료하였으나 호전되지 않아 안락사 시켜 검안하였다. 이 개는 전신골격이 육안덧으로나 현미경적으로 fivrous osteodystorophy 소견을 보였으며, 폐장과 유방에서 발견되는 다발성 전이성 종양괴가 병리조직학적으로 희귀한 종양인 adenoacanthom 와 유사한 소견을 나차내었기로 문헌과 비교 검토하여 증예보고 하는 바이다.

Effects of Lonicera Japonica Extract as a Biological Response Modifier

Rim, Byung Moo,Rim, Chae Woong,Choi, Jin Young,Chung, Yun Shin,Jeong, Hyun Gook A.R. Liss 1992 ENVIRONMENTAL MUTAGENS AND CARCINOGENS Vol.12 No.1

Acute Gastric Dilation in an Adult Female Rhesus Monkey (Macaca mulata)

Rim, Byung Moo,Choi, In Hyuk 全北大學校 1982 論文集 Vol.24 No.-

전주동물원에서 약 2년간 건강한 가운데 사육되어 오던 성숙한 암컷 원숭이(Macaca mulata)가 갑작스럽게 복부팽대를 나타내면서 증세발현후 수시간만에 폐사하였다. 이 원숭이의 체중은 14.5kg으로 검안시 신체조건은 대단히 양호하였으며 유일한 육안적인 소견은 다량의 가스로 위장이 확장된 것이었다. 조직병리학적인 관찰에서도 급성 위확장증의 일반소견을 보였기로 문헌과 비교 검토하여 증예 보고하는 바이다. An adult female rhesus monkey (Macaca mulata) developed sudden abdominal distension and died within a few hours. At necropsy the monkey's physical condition was found to be excellent. Body weight was 14.5kg and the only notable gross lesion was the presence of large amount of gas in the distended stomach. Histopathologic examination of tissues obtained from this animal revealed the features of acute gastric dilatation.

The Protective Effect of Ginseng and Aloe Extract against Cigarette Smoke-induced Hepatotoxicity

Rim, Byung-Moo,Lim, Chae-Woong Korean Society of ToxicologyKorea Environmental Mu 1996 Toxicological Research Vol.12 No.2

The preventive effects of ginseng and aloe extract on cigarette smoke-induced hepatotoxicity to Spague-Dawley rats were investigated. The experimental rats were exposed smoke by inhalation for 5 weeks, 3 times per day, and 15 minutes each time. Also ginseng and aloe extract (Group G+A), aloe (Group A) or ginseng (Group G) were administered to each group, but the positive control rats (Group C) were exposed smoke without any other special treatments. Group C showed decreased food intake and increased water consumption. Also the reduction of body weight and the increase in serumAST, ALT, triglyceride and alkaline phosphatase were observed. The relative liver weights of group C were increased and the hepatic parenchyma revealed light brownish red grossly. On histopathologic observation, the hepatocytes of group C animals exhibited diffuse swelling which narrowed the, sinusoidal lumen and disarrayed the hepatic cord-like arrangement. Diffuse necrosis of the hepatocytes was also observed. However, degeneration and necrosis of the hepatocytes were milder in group G+A. In the case of group A, the damage was moderate, while the group G showed marginal improvement from group C. Electronmicroscopically, peroxisome increased and mitochodria decreased in group C. Various hepatic damages related to smoking in group C revealed recovering tendency in group G+A. This study indicated that daily administration of ginseng and aloe could decrease and even prevent cigarette smokeinduced hepatotoxicity.

ACUTE MAMMALIAN TOXICITY OF O-CHLOROBENZYLIDENE MALONONITRILE(CS)

Rim, Byung-Moo,Rim, Chae-Woong The Korean Society of Toxicology Korea Environment 1989 Toxicological Research Vol.5 No.1

Acute inhalation intoxication of CS (O-chlorobenzylidene malononitrile) occurred among the 192 animals in confined animal cages of farm as the result of prolonged exposure. A total of 8 animals (3 silver foxes, 3 fitches and 2 minks) died in 15 hours after the exposure. Distinct evidences of pulmonary atelectasis were observed as with hepatorenal damages. The lethal toxicity of CS was considered to be due to early severelung damages leading to asphyxia, accompanying acute toxic hepatitis and nephritis.

Ultrastructural Studies on the Effects of Korean Panax Ginseng on the Theca Interna of Rat Ovary

Rim, Byung Moo 전북대학교 의과학연구소 1980 全北醫大論文集 Vol.4 No.1

휜쥐에 고려인삼 추출물을 60일간 투여하는 동안 steroid물질을 산생하는 난소내 난포막 내층 세포의 미세구조상의 변화를 구명하기 위해 본 연구를 실시하였던 바 다음과 같은 결과를 얻었다. 인삼 투여 동물의 난포막 내층 세포에 나타난 세포질성 변화로는 mitochondria의 수, 크기 및 그 치밀도가 증가되었으며, smooth surfaced endoplasmic reticulum, rough surfaced endoplasmic reticulum 및 Golgi체의 크기도 증가되었다. 역시 핵과 핵소체도 다소 증대되었으며, 한편 lipid과립의 수가 감소됨에 비해 dense body는 그 수가 증가되었다. 이상의 변화는 steroid산생세포의 기능한진상을 나타내는 결과로 결국 인삼 투여는 동물의 난포막 내층의 steroid산생세포에 대하여 자극의 효과가 있음을 형태학적으로 입증해 주었다.

Clinical and Hematologic Variables in Animals with Experimentally Induced Leptospirosis

Rim, Byung Moo,Rim, Chae Woong,Choi, Sam Im 한국수의공중보건학회 1992 예방수의학회지 Vol.16 No.1