Medetomidine과 Atipamezole의 상호 작용이 개의 뇌파에 미치는 영향

장환수,장광호,이주명,강원모,박승훈,이만기,장인호 한국임상수의학회 2001 한국임상수의학회지 Vol.18 No.3

We investigated the effects of interactions of medetomidine and atipamezole on electroencephalography (EEG) in seven dogs. The dogs were sedated with medetomidine at dose of 30$\mu\textrm{g}$/kg, IM. Atipamezole was injected 15 min later at dose of 30$\mu\textrm{g}$/kg, IV. Recording electrode was positioned at Cz, which was applied to International 10-20 system. Heart rates, arterial blood pressures and behavioral changes were also measured. EEG was recorded in 6 stages(S1: before medetomidine injection, S2: prior to head-down movement after medetomidine injection, S3: 5 minutes after medetomidine injection, S4: 10 minutes after medetomidine injection, S5: 15 minutes after medetomidine injection, S6: prior to head-up movement after atipamezole injection), and heart rates and arterial pressures were recorded at S1, S5 and S6. All results were compared with those of control(S1). After medetomidine injection, the power spectra of EEG were gradually decreased and those of the frequency over 13 Hz were significantly decreased(p<0.05), which were still in the significantly decreased state after atipamezole injection. In the band powers (Band1; 1-2.5 Hz, Band2; 2.5-4.5 Hz, Band3; 4-8Hz, Band4; 8-13 Hz, Band5; 13-20 Hz, Band6; 20-30 Hz, Band7; 30-50 Hz, Band8; 1-50 Hz), band 1, 2, 3, 4, 8 were not significantly changed in any stages. Band 5, 6, 7 were significantly decreased in S 3, 4, 5, 6. That is, medetomidine affects the frequency band over 13 Hz on EEG, and atipamezole does not restored the decreased band powers until dogs showed head-up movement.

Clinical Antagonistic Effect of Atipamezole in Cats Anesthetized with Tiletamine-Zolazepam and Medetomidine

Kim, Hyung-Ung,Park, Chang-Sik,Jun, Moo-Hyung,Jeong, Seong-Mok,Kim, Myung-Cheol 충남대학교 형질전환복제돼지연구센터 2007 논문집 Vol. No.10

연구의 목적은 고양이에서 zoletil^(?)과 medetomidine 약물 마취 시 atipamezole의 임상적 길항 효과를 보기 위함이다. 마취를 하고 다시 회복 되는 동안에 체온, 심박수, 호흡수를 측정하였다. 이 연구에서는 12 마리의 건강한 한국 잡종 고양이를 사용하였다. 각 6마리씩 무작위로 선별하여 대조군(zoletil^(?)과 medetomidine, ZM)과 실험군(zoletil^(?), medetomidine과 길항제인 atipamezole, ZMA) 두 군으로 나누었다. 모든 고양이들은 투여 전 15분, 주사후 5분, 25분, 105분에 평가하였으며, 길항제인 atipamezole은 마취 주사 후 20분에 근육 주사 하였다. 회복 시간, 심박수, 호흡수는 두 군간 유의성이 있는 결과를 보였고 체온은 유의성을 나타내지 않았다. 두 군 모두 zoletil^(?)과 medetomidine 마취 주사 후 4분 내에 횡와 되는 결과를 보였고 마취 시간도 3시간 가까이 지속해 고양이에 있어서 이들 약물이 좋은 마취 효과가 있음을 보여 주었다. 회복 시 마취 부작용은 거의 보이지 않았다. 고양이가 마취에서 회복되어 기립 자세를 하기까지 걸리는 시간이 ZM 군에서는 210.8±45.6 시간으로 나타났고, ZMA 군에서는 154.2±21.1 시간으로 나타났다. 길항제를 투여한 ZMA 군에서 회복시간이 거의 한 시간 가까이 단축되어 ZMA군이 ZM군보다 회복이 빠르다는 결과를 보였다. 본 연구에서 atipamezole은 medetomidine-tiletamine/zolazepam으로 병용 마취된 고양이에서 유용한 회복효과를 발휘하였다. The purpose of the study is to evaluate the clinical antagonistic effect of atipamezole(0.25 mg/kg,IM) in cats anesthetized with tiletamine-zolazepam (zoletil^(?), 10 mg/kg, IM) and medetomidine (0.05 mg/kg, IM). Twelve healthy 1 year old Korean mixed breed cats were used for this study. They were 4 males and 8 females. These cats were randomly assigned to two groups. One was control group (Zoletil^(?) + medetomidine, ZM), and the other was treatment group (Zoletil^(?)+medetomidine and antagonism by atiparnezole, ZMA). All cats were examined 15 minutes before,5, 25, 65 and 105 minutes after administration of tiletarnine-zolazepam and medetomidine. Atipamezole was injected intramuscularly 20 minutes after ZM administation. Recovery time, heart rate, respiratory rate, total plasma protein and blood glucose were significantly different between ZM group and ZMA group (P < 0.05). However, rectal temperature was not significantly different between ZM group and ZMA group. Two groups were able to induce sternal recumbency within 2 minutes and lateral recumbency within 4 minutes after the anesthetics injection. Mean sternal position time (mean ± SD) was 174.0± 44.6 and 116.2 ± 27.3 minutes, and mean standing position time was 210.8 ± 45.6 and 154.2 ± 21.1 minutes in ZM and ZMA group, respectively. In these two groups, adverse effects during recovery time from anesthesia were not seen. As a result, the ZMA group had a faster recovery than the ZM group. Thus it was concluded that atipamezole could exert a useful reversal effect in cats anesthetized with rnedetornidine-tiletamine/zolazepam combination.

Isofourane으로 마취된 개에 medetomidine, medetomidine-buprenorphine, medetomidine-fentanyl의 경막외 투여 시 심혈관계 반응과 진통효과의 비교

장화석,김혜진,최치봉,이정선,김휘율,Chang, Hwa-Seok,Kim, Hye-Jin,Choi, Chi-Bong,Lee, Jung-Sun,Kim, Hwi-Yool 대한수의학회 2007 大韓獸醫學會誌 Vol.47 No.1

The aim of this study was to compare the reaction of the cardiovascular system, and the anesthetic effect among 3 experimental groups, epidural administration of medetomidine as a single agent, the combination of buprenorphine and medetomidine, and the combination of fentanyl and medetomidine. Twenty one dogs were anesthetized with isoflurane and allowed to breathe spontaneously. Epidural, arterial, and venous catheters were inserted. The tip of epidural catheter was positioned at the level of the space between the sixth and seventh lumbar vertebra. After a stable plane of anesthesia was achieved, these dogs were each administered one of the following treatments epidurally : medetomidine $10{\mu}g/kg$ (Group M), a combination of medetomidine $5{\mu}g/kg$ and buprenorphine $10{\mu}g/kg$ (Group M/B), and a combination of medetomidine $5{\mu}g/kg$ and fentanyl $10{\mu}g/kg$ (Group M/F). Heart rate (HR), Respiratory rate (RR), End-tidal carbon dioxide (EtCO2), and arterial blood pressure were measured before drug administration (base line) and 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, and 60 min postinjection. Blood gas analysis was performed before injection and 5, 15, 25, 35, 45, 60 min postinjection. Isoflurane was discontinued 80 min postinjection and pain/motor function were evaluated up to 260 min postinjection every 15 min. At the early stage of drug introduction (until 5 min), the HR was decreased significantly in all 3 groups compared with base line. In Group M, HR was significantly decreased compared with the other 2 groups. With time (starting 20 min after drug introduction), the HR was decreased significantly in Group M/B in respect to base line. However, no significant difference was seen number-wise in all 3 groups. During 60 min after drug introduction, the systolic, diastolic and mean arterial pressures were highest in Group M and lowest in Group M/F. Among 3 groups, drug action and motor loss duration were longest in Group M/F. Analgesic effect observed in the M/F group was the most prominent and long-lasting, compared to those seen in the other 2 groups. Given the fact that the recovery of motor function takes place in a short period of time after analgesic effects disappeared, additional use of M/F depending on the patient's condition would be a good way to achieve effective pain management. However, proper care should be taken to ensure the function of cardiovascular system in the patient because the administration of M/F under isoflurane anesthesia results in a significant decline in arterial blood pressure ($65{\pm}10mmHg$).

Effects of Medetomidine and Tramadol Administration on the Minimum Alveolar Concentration of Isoflurane in Dogs

김경미,정종태,박현정 한국임상수의학회 2010 한국임상수의학회지 Vol.27 No.6

This study was to evaluate the effects of tramadol and medetomidine administration on minimum alveolar concentration (MAC) of isoflurane in dogs. MAC of isoflurane was determined in four occasions; 1 ml saline (Control),2 μg/kg medetomidine (M2), 4 mg/kg tramadol (T4), 2 μg/kg medetomidine-4 mg/kg tramadol combination (M2T4). Heart rate, blood pressure, respiratory rate, end-tidal carbon dioxide concentration, saturation of hemoglobin with oxygen and body temperature were recorded. After administration of M2 (0.81 × 0.18%), T4 (0.81 × 0.14%) and M2T4(0.62 × 0.12%), less isoflurane was required than the control value (1.13 × 0.19%). Significantly lower heart rate than the control value was detected after treatment of M2, T4, and M2T4. When only M2T4 was administered, blood pressure was significantly higher than the control value. In conclusion, administrations of tramadol, medetomidine and medetomidine-tramadol combination decreased the MAC of isoflurane in dogs. Especially, medetomidine-tramadol combinations could be useful as a premedication because of the anesthetic sparing effect and moderate changes in cardiovascular system.

Medetomidine Sedation and Its Antagonism by Yohimbine in Dogs

허경희,이재연,최경하,조진행,박창식,김명철 한국임상수의학회 2010 한국임상수의학회지 Vol.27 No.4

The purpose of this study was to determine the antagonistic effects of yohimbine on sedation induced in dogs with medetomidine. Six mixed breed dogs were repeatedly used at a 2 weeks withdrawal time in this study. The dogs received 40 μg/kg of medetomidine followed 15 minutes later by 0.2 ml/kg saline solution (group M) or 0.11 mg/kg yohimbine (group MY). All the dogs were examined before and 5, 15, 30, 45, 60, 75, 90, 120 and 150minutes after the injection of medetomidine, and the induction and recovery times, vital signs, blood biochemistry and anesthetic quality were recorded. There were significant differences in the recovery of anesthesia between the groups. In both groups the heart rate decreased rapidly down to five minutes after the administration of medetomidine. The activity of ALT, AST and the protein concentration did not change significantly in either group and there was no significant difference between them at any time. Response to noise, muscle tone and analgesic score in the MY group at 30 minutes were significantly lower than those of the M group. When recovering from anesthesia, the dogs treated with yohimbine took less time to achieve sternal recumbency and less time to be able to stand and walk. It was concluded that yohimbine reversed effectively medetomidine sedation in dogs.

Antagonistic Effects of Atipamezole and Yohimbine against Anesthesia with Medetomidine and Ketamine Combination in Pigs

이재연,김명철 한국임상수의학회 2011 한국임상수의학회지 Vol.28 No.3

The aims of the present study were to investigate the anesthetic and hemodynamic effects of medetomidineketamine combination and to compare antagonistic effects of atipamezole and yohimbine on the recovery of pig from anesthesia induced by medetomidine-ketamine combination. Landrace and Yorkshire cross-bred pigs were evaluated in the present study. Pigs (n = 8) received three different treatments (one treatment per 14 days in a random order). All pigs were injected intramuscularly with medetomidine, and ketamine in a single syringe. Intravenous injections of atipamezole (MKA), yohimbine (MKY), or a control saline solution (MK) were administered 20 minutes after the medetomidine-ketamine combination injection. The intravenous antagonist injections quickly reversed the medetomidine-ketamine induced sedation in the pigs, resulting in a significantly shorter duration of anesthesia in the MKA and MKY groups compared to the MK group. Mean arterial pressure (MAP) levels were significantly lower in the MKA and MKY groups compared to the MK group. Scores for posture and responses to noxious stimuli after atipamezole and yohimbine administration were significantly lower in the MKA and MKY groups than in the MK. In conclusion, the sedative effects and increases in blood pressure induced by a medetomidine-ketamine combination were quickly and smoothly reversed by atipamezole or yohimbine.

Medetomidine에 유발된 정좌반사소실에 대한 Tricyclic Isoxazole 유도체들의 항우울성에 관한 3D-QSAR 분석

명평근(Pyung-Keun Myung),성낙도(Nack-Do Sung),최민성(Min-Sung Choi) 大韓藥學會 2011 약학회지 Vol.55 No.2

To search the minimum structural requirement of tricyclic isoxazole analogues (1~30) as new class potent antidepressant, thee-dimensional quanti- tative-structure relationship (3D-QSAR) models between substituents (R1~R5) of tricyclic isoxazoles and their antidepressant activity against medetomidine-induced loss of righting were performed and discussed quantitatively using comparative molecular field analysis (CoMFA) and comparative molecular similarity indies analysis (CoMSIA) methods. The correlativity and predictability (r2=0.484 and q2=0.947) of CoMSIA-2 model were higher than those of the rest models. The inhibitory activity against medetomidine-induced loss of righting was dependent on electrostatic field (43.4%), hydrophobic field (35.3%), and steric field (21.2%) of tricyclic isoxazoles. From the CoMSIA-2 contour maps, it is predicted that the antidepressant activity of potent antidepressants against medetomidine-induced loss of righting will be able to increase by the substituents (R1~R5) which were in accord with CoMSIA field.

Anesthetic and Cardiorespiratory Effects of Medetomidine-Ketamine-Butorphanol and Xylazine-Ketamine-Butorphanol in Dogs

이태훈,이재연,정성목,김명철 한국임상수의학회 2012 한국임상수의학회지 Vol.29 No.3

This study examined the anesthetic and cardiopulmonary effects of xylazine or medetomidine in combination with ketamine-butorphanol in dogs. Five dogs were used in both the medetomidine-ketamine-butorphanol (MKB) group and the xylazine-ketamine-butorphanol (XKB) group. The procedures for the two groups were performed 4 weeks apart. MKB group showed a shorter duration for anesthesia than XKB group. Other factors were not statistically significant between the two groups. The MKB group showed signs of bradycardia, therefore cautious patient monitoring is necesessary. The XKB showed a longer anesthetic time and less adverse effects, however the MKB combination was more expensive and had less advantages. In conclusion, the results suggested the recommended use of both MKB and XKB in procedures that need approximately 50 minutes. If patients have a risk of bradycardia, one should be cautious of using a medetomidine-xylazine-butorphanol combination. Both MKB and XKB did not have much adverse effects; however MKB did not have advantages when compared to XKB. Therefore, XKB may be more effective when compared to MKB.

Effect of Medetomidine and Combination of Medetomidine/tiletamine/ zolazepam and Medetomidine/tiletamine/zolazepam/tramadol on Echocardiographic Cardiac Contractility in Dogs

서상일,김태준,이은찬,현창백 한국임상수의학회 2015 한국임상수의학회지 Vol.32 No.5

This study evaluated the myocardial performance on echocardiography after the sedation/anesthesia of medetomidine (D), the combination of medetomidine and tiletamine/zolazepam (DZ), and the combination of medetomidine, tiletamine/zolazepam and tramadol (DZT) in Beagle dogs. Ten healthy adult Beagle dogs (weighing 8.6 ± 1.0 kg) were enrolled in this study. Heart rate (HR), fractional shortening (%FS), left ventricular ejection fraction (%LVEF), stroke volume (SV), cardiac output (CO), left ventricular internal diameter in systole (LVIDs) and left ventricular internal diameter in diastole (LVIDd) using M-mode echocardiography were measured prior to anesthesia, then every 10 min for 60 min. The HR, %FS, %LVEF, SV and CO were significantly decreased during sedation/ anesthesia with D, DZ and DZT combination of anesthesia. Although those anesthetic protocols provided acceptable quality of sedation/anesthesia, levels of cardiovascular suppression were substantial and persistent and thus the continuous monitoring on vital signs should be accompanied in any situation. Close attention is required for dogs with pre-existing heart diseases, when those anesthetic protocols were applied.

개에서 Halothane 마취시 전마취제로서 xylazine/fentanyl/azaperone과 medetomidine/midazolam 및 이들 길항제와의 병용이 마취효과 및 심맥관계에 미치는 영향

양한석,권오경,우흥명,남치주,Yang, Han-seok,Kweon, Oh-kyeong,Woo, Heung-myeong,Nam, Tchi-chu 대한수의학회 1999 大韓獸醫學會誌 Vol.39 No.3

This study was performed to evaluate anesthetic and cardiovascular effects of xylazine/fentanyl/azaperone and medetomidine/midazolam as preanesthetics and their combinations with antagonists in halothane-anesthetized dogs. Eight clinically healthy dogs($4.54{\pm}2.16kg$) were used at the interval of more than 14 days between experiments in turn for propionyl promazine(PP 0.3mg/kg, IM), xylazine/fentanyl/azaperone(XFA 2mg/kg, 0.0137mg/kg, 0.11mg/kg, IM), medetomidine/midazolam(MM 0.02mg/kg, 0.3mg/kg, IM), combination of XFA and their antagonists (yohimbine 0.05mg/kg, naloxon 0.0005mg/kg, IV) and combination of MM and their antagonist(atipamezole 0.08mg/kg IM). The sedation induction times in XFA($2.56{\pm}1.01min$) and MM($5.44{\pm}2.07min$) groups were significantly better than that of PP group($10.75{\pm}2.38min$)(p < 0.05). The thiopental sodium dose required for tracheal intubation in XFA($2.38{\pm}3.38mg/kg$) and MM($3.91{\pm}3.47mg/kg$) groups were significantly less than that of PP group($12.57{\pm}2.13mg/kg$)(p < 0.05). All time indices expressing the recovery(pedal reflex recurrence time, extubation time, arousal time, standing time and walking time) were significantly shorter in the combination groups of XFA or MM with their antagonists than in PP, XFA and MM groups(p < 0.05). The suppressions of cardiovascular function of XFA and MM were more than that of PP. Heart rate and cardiac output were recovered by the antagonists of XFA and MM, but mean arterial pressure were not recovered by the antagonists. PP induced apnea in 4 out of 8 dogs, but XFA in none and MM in one. The present study suggested that for rapid sedation, prevention of apnea after intubation and rapid recovery after halothane cessation, combinations of xylazine/fentanyl/azaperone or medetomidine/midazolam with their antagonists are recommendable as preanesthetic method in gas anesthetised dogs with normal cardiovascular function.