다발성 대장암의 치료

백옥주,오승엽,서광욱 대한대장항문학회 2009 Annals of Coloproctolgy Vol.25 No.1

Purpose: The detection of synchronous and metachronous colon cancer is important for the surgical treatment. The aim of this study is to review the clinicopathological characteristics of multiple colon cancers. Methods: A retrospective analysis was performed with 43 patients with multiple colon cancers who underwent surgical treatment from June 1996 to May 2008. Patients with familial adenomatous polyposis and cancer from inflammatory bowel disease were excluded. Results: There were 43 cases of multiple colon cancers. Synchronous colon cancers were present in 30 patients and metachronous colon cancers were present in 18 patients. The mean age was 61.33±11.44, and the male-to-female ratio was 23:20. The index cancer and the second cancers in synchronous colon cancers, as well as the first colon cancer in metachronous colon cancers showed, significantly more distal tumor locations. However, the second cancers in metachronous colon cancers showed no significant differences in tumor location. As for stage, a more advanced stage was noted in the index cancer than in the second cancers in synchronous cancer. However, an early stage was noted for the first colon cancer in metachronous cancers. Seventeen patients with synchronous cancer and 14 patients with metachronous colon cancer underwent a total or a subtotal colectomy. Conclusion: Detection of synchronous colon cancer was important for deciding the extent of surgical resection. Patients with colon cancer should be considered for frequent colonoscopy follow-up for early detection of metachronous colon cancer. Purpose: The detection of synchronous and metachronous colon cancer is important for the surgical treatment. The aim of this study is to review the clinicopathological characteristics of multiple colon cancers. Methods: A retrospective analysis was performed with 43 patients with multiple colon cancers who underwent surgical treatment from June 1996 to May 2008. Patients with familial adenomatous polyposis and cancer from inflammatory bowel disease were excluded. Results: There were 43 cases of multiple colon cancers. Synchronous colon cancers were present in 30 patients and metachronous colon cancers were present in 18 patients. The mean age was 61.33±11.44, and the male-to-female ratio was 23:20. The index cancer and the second cancers in synchronous colon cancers, as well as the first colon cancer in metachronous colon cancers showed, significantly more distal tumor locations. However, the second cancers in metachronous colon cancers showed no significant differences in tumor location. As for stage, a more advanced stage was noted in the index cancer than in the second cancers in synchronous cancer. However, an early stage was noted for the first colon cancer in metachronous cancers. Seventeen patients with synchronous cancer and 14 patients with metachronous colon cancer underwent a total or a subtotal colectomy. Conclusion: Detection of synchronous colon cancer was important for deciding the extent of surgical resection. Patients with colon cancer should be considered for frequent colonoscopy follow-up for early detection of metachronous colon cancer.

결장암 위치에 따른 예후 및 재발양상의 비교

박진석,유창식,김찬욱,정광용,신의섭,윤상남,임석병,김진천 대한대장항문학회 2009 Annals of Coloproctolgy Vol.25 No.4

Purpose: We aimed to compare the prognosis and the recurrence patterns of sporadic primary colon cancers according to the location of the cancer. Methods: One thousand four-hundred eighty-three (1,483) stage II, III colon cancer patients who had undergone a consecutive curative resection between January 1989 and December 2003 were analyzed. Hereditary, synchronous, metachronous, and recurrent colon cancers were excluded. The right colon was defined as being from the cecum to the transverse colon, and the left colon was defined as being from the splenic flexure colon to the rectosigmoid colon. The median follow-up time was 63 (3-228) mo. Results: Poorly differentiated and mucinous cell type tumors were more frequent in the right colon. T3 tumors were more frequent in the right colon. Lymph-node-positive tumors were more frequent in the left colon. The recurrence rate was higher in the left colon, but the patterns of recurrence were not different according to the tumor’s location. By univariate analysis, age, preoperative serum CEA level, T-stage, N-stage, lymphovascular invasion, postoperative chemotherapy, and tumor location were significant prognostic factors associated with recurrence. By multivariate analysis, sex, preoperative serum CEA level, T-stage, N-stage, postoperative chemotherapy, and tumor location were significant prognostic factors associated with recurrence. The 5-yr disease-free survival rates were 84.0% for right colon cancer and 77.1% for left colon cancer (P= 0.005). The recurrence rates for cancers in the sigmoid colon and the rectosigmoid colon were higher than those for cancers in the cecum and the ascending colon. Conclusion: The tumor’s location was an independent prognostic factor for recurrence, but the pattern of recurrence did not vary with the tumor’s location. Purpose: We aimed to compare the prognosis and the recurrence patterns of sporadic primary colon cancers according to the location of the cancer. Methods: One thousand four-hundred eighty-three (1,483) stage II, III colon cancer patients who had undergone a consecutive curative resection between January 1989 and December 2003 were analyzed. Hereditary, synchronous, metachronous, and recurrent colon cancers were excluded. The right colon was defined as being from the cecum to the transverse colon, and the left colon was defined as being from the splenic flexure colon to the rectosigmoid colon. The median follow-up time was 63 (3-228) mo. Results: Poorly differentiated and mucinous cell type tumors were more frequent in the right colon. T3 tumors were more frequent in the right colon. Lymph-node-positive tumors were more frequent in the left colon. The recurrence rate was higher in the left colon, but the patterns of recurrence were not different according to the tumor’s location. By univariate analysis, age, preoperative serum CEA level, T-stage, N-stage, lymphovascular invasion, postoperative chemotherapy, and tumor location were significant prognostic factors associated with recurrence. By multivariate analysis, sex, preoperative serum CEA level, T-stage, N-stage, postoperative chemotherapy, and tumor location were significant prognostic factors associated with recurrence. The 5-yr disease-free survival rates were 84.0% for right colon cancer and 77.1% for left colon cancer (P= 0.005). The recurrence rates for cancers in the sigmoid colon and the rectosigmoid colon were higher than those for cancers in the cecum and the ascending colon. Conclusion: The tumor’s location was an independent prognostic factor for recurrence, but the pattern of recurrence did not vary with the tumor’s location.

폐쇄성 좌측 대장암에서 스텐트 삽입 후 단단계 복강경 대장 절제술의 단기 예후: 비폐쇄성 좌측 대장암의 복강경 대장 절제술군과의 비교

김현실,김성근,안창혁,강원경,이윤석,이인규,김형진,이상철,조현민,박종경,오승택,김준기 대한대장항문학회 2009 Annals of Coloproctolgy Vol.25 No.6

Purpose: Laparoscopic surgery has been considered to be contraindicated for treating malignant colorectal obstruction. Stent insertion for obstructive colorectal cancer has recently allowed laparoscopic surgery to be performed by means of preoperative bowel decompression and bowel preparation. The aim of this study is to evaluate the safety and the feasibility of a one-stage laparoscopic resection for obstructive left-sided colon cancer after stent insertion by comparing the results to those for nonobstructive left-sided colon cancer. Methods: Between May 2006 and January 2009, a laparoscopic colorectal operation was performed on 18 consecutive patients with obstructive left-sided colon cancer after placement of a self-expandable stent by one colorectal surgeon, and the results were compared retrospectively to those for 43 patients with non-obstructive left-sided colon cancer who had undergone a laparoscopic procedure with the same surgeon. The collected data were the clinicopathologic characteristics, the perioperative complications, the oncologic outcomes, the postoperative recovery results, and the survival rate. Results: The obstructive left-sided colon cancer group had significant benefits in retrieved lymph nodes (18.8±5.3 vs. 14.0± 8.7, P=0.036), and distal resection margin (5.5±3.0 cm vs. 3.6±2.4 cm, P=0.011). There were no significant differences in other clinicopathological characteristics and oncologic outcomes, including the overall 3-yr survival rate, between the two groups. Conclusion: Preoperative stent decompression followed by a laparoscopic colorectal resection is a safe and feasible option for treating obstructive left-sided colon cancer. A further large-scale prospective study should be performed to evaluate the long-term outcome of a one-stage laparoscopic resection using stent insertion in cases of obstructive left-sided colon cancer. Purpose: Laparoscopic surgery has been considered to be contraindicated for treating malignant colorectal obstruction. Stent insertion for obstructive colorectal cancer has recently allowed laparoscopic surgery to be performed by means of preoperative bowel decompression and bowel preparation. The aim of this study is to evaluate the safety and the feasibility of a one-stage laparoscopic resection for obstructive left-sided colon cancer after stent insertion by comparing the results to those for nonobstructive left-sided colon cancer. Methods: Between May 2006 and January 2009, a laparoscopic colorectal operation was performed on 18 consecutive patients with obstructive left-sided colon cancer after placement of a self-expandable stent by one colorectal surgeon, and the results were compared retrospectively to those for 43 patients with non-obstructive left-sided colon cancer who had undergone a laparoscopic procedure with the same surgeon. The collected data were the clinicopathologic characteristics, the perioperative complications, the oncologic outcomes, the postoperative recovery results, and the survival rate. Results: The obstructive left-sided colon cancer group had significant benefits in retrieved lymph nodes (18.8±5.3 vs. 14.0± 8.7, P=0.036), and distal resection margin (5.5±3.0 cm vs. 3.6±2.4 cm, P=0.011). There were no significant differences in other clinicopathological characteristics and oncologic outcomes, including the overall 3-yr survival rate, between the two groups. Conclusion: Preoperative stent decompression followed by a laparoscopic colorectal resection is a safe and feasible option for treating obstructive left-sided colon cancer. A further large-scale prospective study should be performed to evaluate the long-term outcome of a one-stage laparoscopic resection using stent insertion in cases of obstructive left-sided colon cancer.

The Prognosis and Recurrence Pattern of Right- and Left-Sided Colon Cancer in Stage II, Stage III, and Liver Metastasis After Curative Resection

Yasuyuki Nakamura,Daisuke Hokuto,Fumikazu Koyama,Yasuko Matsuo,Takeo Nomi,Takahiro Yoshikawa,Naoki Kamitani,Tomomi Sadamitsu,Takeshi Takei,Yayoi Matsumoto,Yosuke Iwasa,Kohei Fukuoka,Shinsaku Obara,Tak 대한대장항문학회 2021 Annals of Coloproctolgy Vol.37 No.5

Purpose: Primary tumor location of colon cancer has been reported to affect the prognosis after curative resection. However, some reports suggested the impact was varied by tumor stage. This study analyzed the prognostic impact of the sidedness of colon cancer in stages II, III, and liver metastasis after curative resection using propensity-matched analysis.Methods: Right-sided colon cancer was defined as a tumor located from cecum to splenic flexure, while any more distal colon cancer was defined as left-sided colon cancer. Patients who underwent curative resection at Nara Medical University hospital between 2000 and 2016 were analyzed.Results: There were 110 patients with stage II, 100 patients with stage III, and 106 patients with liver metastasis. After propensity matching, 28 pairs with stage II and 32 pairs with stage III were identified. In the patients with stage II, overall survival (OS) and recurrence-free survival (RFS) were not significantly different for right- and left-sided colon cancers. In the patients with stage III, OS and RFS were significantly worse in right-sided colon cancer. In those with liver metastasis, OS of right-sided colon cancer was significantly worse than left-sided disease, while RFS was similar. Regarding metachronous liver metastasis, the difference was observed only in the patients whose primary colon cancer was stage III. In each stage, significantly higher rate of peritoneal recurrence was found in those with right-sided colon cancer.Conclusion: Sidedness of colon cancer had a significant and varied prognostic impact in patients with stage II, III, and liver metastasis after curative resection.

Cyclooxygenase-2 Expression Is Related to the Epithelial-to-Mesenchymal Transition in Human Colon Cancers

장태정,전규하,정기훈 연세대학교의과대학 2009 Yonsei medical journal Vol.50 No.6

Purpose: Down-regulation of E-cadherin is a hallmark of the epithelial-to-mesenchymal transition (EMT). EMT progression in cancer cells is associated with the loss of certain epithelial markers and the acquisition of a mesenchymal phenotype, as well as migratory activities. Cyclooxygenase-2 (COX-2) expression is associated with tumor invasion and metastasis in colon cancer. This study investigated the relationship between E-cadherin and COX-2 in colon cancer cells and human colon tumors. Materials and Methods: Colon cancer cell lines and immunohistochemistry were used. Results: E-cadherin expression was inversely related to the expressions of COX-2 and Snail in colon cancer cells. Ectopic expression of COX-2 or Snail reduced E-cadherin and induced a scattered, flattened phenotype with few intercellular contacts in colon cancer cells. Treatment of cancer cells with phorbol 12-myristate 13-acetate increased the expressions of COX-2 and Snail, decreased 15-hydroxyprostaglandin dehydrogenase expression, and increased the cells’ motility. In addition, exposure to prostaglandin E2 increased Snail expression and cell motility, and decreased E-cadherin expression. Membranous E-cadherin expression was lower in adenomas and cancers than in the adjacent, non-neoplastic epithelium. In contrast, the expressions of Snail and COX-2 were higher in cancers than in normal tissues and adenomas. The expressions of COX-2 and Snail increased in areas with abnormal E-cadherin expression. Moreover, COX-2 expression was related to higher tumor stages and was significantly higher in nodal metastatic lesions than primary cancers. Conclusion: This study suggests that COX-2 may have a role in tumor metastasis via EMT. Purpose: Down-regulation of E-cadherin is a hallmark of the epithelial-to-mesenchymal transition (EMT). EMT progression in cancer cells is associated with the loss of certain epithelial markers and the acquisition of a mesenchymal phenotype, as well as migratory activities. Cyclooxygenase-2 (COX-2) expression is associated with tumor invasion and metastasis in colon cancer. This study investigated the relationship between E-cadherin and COX-2 in colon cancer cells and human colon tumors. Materials and Methods: Colon cancer cell lines and immunohistochemistry were used. Results: E-cadherin expression was inversely related to the expressions of COX-2 and Snail in colon cancer cells. Ectopic expression of COX-2 or Snail reduced E-cadherin and induced a scattered, flattened phenotype with few intercellular contacts in colon cancer cells. Treatment of cancer cells with phorbol 12-myristate 13-acetate increased the expressions of COX-2 and Snail, decreased 15-hydroxyprostaglandin dehydrogenase expression, and increased the cells’ motility. In addition, exposure to prostaglandin E2 increased Snail expression and cell motility, and decreased E-cadherin expression. Membranous E-cadherin expression was lower in adenomas and cancers than in the adjacent, non-neoplastic epithelium. In contrast, the expressions of Snail and COX-2 were higher in cancers than in normal tissues and adenomas. The expressions of COX-2 and Snail increased in areas with abnormal E-cadherin expression. Moreover, COX-2 expression was related to higher tumor stages and was significantly higher in nodal metastatic lesions than primary cancers. Conclusion: This study suggests that COX-2 may have a role in tumor metastasis via EMT.

Serum Antioxidant Minerals and Colon Cancer Progression

Jiyoung Kim,Mi Kyung Kim,Kyu Yong Choi,Won Chul Lee,황혜진,황진아,Yang Cha Lee-Kim,Jung Hwa Park 대한암예방학회 2010 Journal of cancer prevention Vol.15 No.3

In Korea, colon cancer is one of the most fasting growing cancers in the last decade. Although a colonoscopy is served as a preventive tool by detecting a colon cancer precursor of adenoma, unremoved adenoma increases the likelihood of later developing colon cancer. Thus, understanding adenoma will give the important information of progress in colon cancer. However, there are few studies for colorectal adenoma along with colon cancer in Korea. The objective of this study was to investigate the serum antioxidant mineral levels in adenoma and colon cancer compared to healthy controls. We examined the selenium, copper and zinc by using atomic absorption spectrophotometer. Selenium was significantly lower in both adenoma and cancer groups, compared to the controls (p<0.05). In contrast, copper was significantly higher in both adenoma and colon cancer patient groups, compared to the controls (p<0.0001) while there was no difference in zinc among the different stages of colon cancer. Our finding indicated that non-cancerous benign stage of adenoma and malignant colon cancer had comparable serum selenium and copper levels, which significantly different from healthy controls. These findings suggest that certain mineral levels can be used as early stage indicator for colon cancer progression.

Expression of Epidermal Growth Factor Receptor in Colon Cancer

Yoo, Seung Jin,Park, Seung Cheol,Chang, Suk Kyun,Kim, Eung Kook,Song, Young Tack,Choo, Sang Yong CATHOLIC MEDICAL CENTER 1994 Bulletin of the Clinical Research Institute Vol.22 No.2

Recently, epidermal growth factor receptor (EGFR) has been examined in many tumors such as lung cancer, breast cancer, brain tumor, and stomach cancer. And it has been known to be associated with the development and progression of such tumors. However, there is no agreement of the expression of EGfR with clinical staging and the histological differentiation of colon cancer, of which incidence is increasing progressively in Korea. This study was initiated to clarify the importance of expression of EGFR on clinical staging and clinicopathologic parameters including the depth of invasion, the histologic differentiation of cancer cells, tumor site, tumor size, and the blood level of carcinoembryonic antigen (CEA). The expression of EGFR was examined immunohistochemically using monoclonal antibody against EGPR in total of 49 colon cancer tissues in the patients undertaken colectomy due to colon cancer and 10 metastatic lymph nodes in the same patients, and 18 human benign tumors such as polyps and adenomas, and 13 normal colon tissues in the patients undertaken colectomy due to traumatic colon injury or inflammatory disease. The results were as follows: 1. The immunoreactivity of EGFR was detected in 36.7% (18/49) of the colon cancers, while it was observed in 5.6% (1/18) of the benign tumors, the incidence between the two being significantly different (P<0.05). However, there was no expression of EGFR in normal colon tissues. And the immunoreactivity of EGFR in metastatic lymph nodes was detected in 40.0% (4/10) of the metastatic lymph nodes. 2. The immunoreactiyity of EGFR of human colon cancers was gradually increased from 12.5% (1/8) of Dukes-Astle-Coller's stage A, 22.2% (2/9) of stage BI, 16.7% (2/12) of stage B2, 42.9% (3/7) of stage CI to 76.9% (10/13) of stage C2 (P<0.05). And the immunoreactivity of EGFR was related to their depth of invasion of cancer cells (P<0.05). 3. There was no relation between the immunoreactivity of EGFR, cancer size, cancer site and the level of carcinoembryonic antigen (P<0.05). 4. The EGFR was expressed only in moderately-differentiated cancers and well-differentiated cancer, while not expressed in poorly-deffernetiated cancer(P<0.05). 5. The immunohistochemical staining intensity of EGFR receptor was gradually increased according to progression of clinical stages (P<0.05). These results suggested that the expression of EGFR may play an important role in the growth and differentiation of colon cancer. And the expression of EGFR using immunohisto-chemical stain was useful for diagnosis and treatment of colon cancer, and it also may serve as a prognostic indicator.

대장암에서 표피성장인자수용체의 발현

박승철(Seung Chull Park),김정수(Jeong Soo Kim),전해명(Hae Myung Jeon),김재광(Jae Kwang Kim),김응국(Eung Kook Kim) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.4

N/A Recently, epidermal growth factor receptor(EGFR) has been examined in many tumors such as lung cancer, breast cancer, brain tumor and stomach cancer. And it has been known to be associated with the development and progression of such tumors. However, there is no agreernent of the expression of EGFR with clinical staging and .ne histological differentiation of colon cancer of which incidence is increasing progressively in Korea. This study was initiat- ed to clarify the importance of expression of EGFR on clinical staging and clinicopathologic parameters including the depth of invasion, the histologic differentiation of cancer cells, tumor site, tumor size and the blood level of carcinoembryonic antigen(CEA). The expression of EGFR was examined immunohistochemically using monoclonal antibody against EGFR in total of 49 colon cancer tissues in the patients undertaken colectomy due to colon cancer and 10 metastatic lymph nodes in the same patients and 18 bnign tumors such as polyps and adenomas and 13 normal colon tissues in the patients undertaken colectomy due to t.raumatic colon injury or inflammatory disease. The immunoreactivity of EGFR was detected in 36.7% (18/49) of the colon cancers, while it was observed in 5.6%(1/18) of the benign tumors, the incidence between the two being signif- icantly different(P<0.05). However, there was no expression of EGFR in normal colon tis- sues. And the immunoreactivity of EGFR in metastatic lymph nodes was detected in 40.0% (4 /10) of the metastatic lymph nodes. The immunoreactivity of EGFR of human colon cancers was gradually increased from 12.5%(1/8) of Dukes-Astler-Coilers stage A, 22.2%(2/9) of stage Bl, 16.7%(2/12) of stage B2, 42.9%(3/7) of stage Cl to 76.9%(10/13) of stage C2(P <0.05). And the immunoreactivity of EGFR was related to their depth of invasion of cancer cells(P<0.05). There was no relation between the immunoreactivity of EGFR, cancer size, cancer site and level of carcinoembryonic antigen(P>0.05). The EGFR was expressed only in moderately-differentiated cancers and well-different.iated cancers, while not expressed in poor- ly-defferentiated cancers(P<0.05). The immunohistochemical staining intensity of EGFR was gradually increased according to clinical stages(P<0.05). These results suggested that the expression of EGFR may p)ay an !mportant role in the growth and differentiation of colon cancer. And the expression of EGFR using immunohistochemical stain was useful for diagnosis and treatment of colon cancer and it also may serve as a prognostic indicator.(Korean J Gastroenterol 1994; 26: 637 646)

Array-비교유전체보합법을 이용한 결장암세포주에서의 유전체 변이 연구

김미진(Mi Jin Kim),박수연(Soo Yeun Park),한후재(Hoo Jae Hann) 대한해부학회 2009 Anatomy & Cell Biology Vol.42 No.4

한국인 결장암세포주 세 개를 대상으로 array-비교유전체 보합법을 시행한 결과 다양한 염색체 이상 및 유전자의 증폭과 결실이 발견되었다. 기존의 결장암 연구에서 알려져 있는 염색체 1p, 1q, 2q, 8p, 8q 부위의 증가와 염색체 4q, 12q, 20p 부위의 감소를 본 연구에서도 확인하였고, 14q32.33, 16p13.3, 16q24.3 부위의 증가와 9q13, Yq11.233 부위의 감소는 본 연구를 통하여 새롭게 발견되었다. 또한 본 연구를 통하여 다양한 유전자의 변화를 확인하였다. 세 개의 결장암세포구 모두에서 공통적으로 증가한 유전자는 1q22, 1q32.1, 2q35, 8p12, 8q22.3, 14q32.33, 16p13.3, 16q24.3에 위치하고, 감소한 유전자는 9q13, 14q32.33, 20p12.1, Yq11.223에 위치한다. 다른 대장암 연구에서도 확인된 ELF 3, AAMP 유전자의 증가를 본 연구에서도 확인하였고, 다른 암 연구에서 암을 유발하는 것으로 알려진 GON4L, TIMM17Q, RNPEP, TMBIM1, GPBAR1, PPP1R13B 그리고 SOX8 유전자를 본 연구를 통해 결장암에서도 증가하는 것으로 처음 확인하였다. 또한 암발생과 관련된 염색체 부위에서 확인되었지만, 그 기능이 밝혀지지 않은 PNKD, ODF1, CBWD3, C20orf133그리고 RBMY2SP 유전자를 확인하였다. 새롭게 밝혀진 이들 유전자들은 결장암의 발생 또는 진행과 관련된 후보 유전자일 것으로 판단되며, 향후 기능적 연구를 통해 그 관련성 규명이 요구된다. Cancer development is accompanied by genetic events like losses, gains amplification of certain chromosome regions or alterations of chromatin structure. Array-based CGH(Array-CGH) is a highly comprehensive, sensitive and fast technique to allow investigation of general changes in target oncogenes and tumor suppressor genes. Recently, the prevalence of colon cancer is rapidly increasing in Korea an now it is the fourth leading cause of cancer death. So, the purpose of this study is to examine genomic alterations in colon cancer cell lines and to search novel genes which might be related to the development of colon cancer. In this study, genomic alterations are analyzed by using array-CGH in three colon cell lines from Korean, SNU-81, SNU-407 and SNU-1047. We observed numerous chromosomal imbalances from all cell lines. The common chromosomal gains were observed in 1p36.33, 1q22, 1q32.1, 2q35, 8p22.3, 14q32.33, 16p13.3, and 16q24. Common chromosomal losses were found in 4q22.1, 9q13, 14q21.1, 14q32.33, 20p12.1, Xq21.1, and Yq11.223. Gains of 1p, 2q, 8p, and 8q or losses of 4q, 14q and 20p are already known to be associated with the colon cancer development. For gene alterations, we could see gains of some genes such as ELF3 and AAMP, which were already reported to be associated with colon cancer. Also, we could find some gene alterations which were known to be associated with other cancer types. These genes were GON4L, RNPEP, TMBIM1, TIMM17A, GPBAR1, PPP1R13B and SOX8. Besides, we found alterations of new genes such as PKND and LEPROTL1. The association of these genes with colon cancer is first demonstrated here. These genes may be the novel candidate genes functioning in the development of colon cancer. In conclusion, array-CGH demonstrated the complexity of genetic aberrations in several colon cell lines. These data about the patterns of genomic alterations could be a basic step for understanding more detailed genetic events in the carcinogenesis and also provide information about possible target genes for diagnosis and treatment in colon cancer.

Elevated Mean Platelet Volume is Associated with Presence of Colon Cancer

Li, Jia-Ying,Li, Ying,Jiang, Zheng,Wang, Rui-Tao,Wang, Xi-Shan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23

Background: Colon cancer is the second most common cancer in developed countries. Activated platelets play a key role in inflammation and atherothrombosis, with mean platelet volume (MPV) is an early marker of platelet activation. The aim of the study was to clarify the relevance of MPV in patients with colon cancer. Materials and Methods: We measured MPV levels in 128 patients with colon cancer before and after surgery, and 128 controls matched for age, gender, body mass index (BMI) and smoking status. The odds ratios (ORs) and 95% confidence intervals (CIs) for colon cancer were calculated using multivariate logistic regression analyses across MPV quartiles. Results: Patients with colon cancer had higher MPV compared with controls. Surgical tumor resection resulted in a significant decrease in MPV levels (11.4 fL vs 10.7 fL; p<0.001). A positive correlation between MPV and tumor-nodule-metastases (TNM) stage was found. Furthermore, after adjusting for other risk factors, the ORs (95%CIs) for colon cancer according to MPV quartiles were 1.000, 2.238 (1.014-4.943), 3.410 (1.528-7.613), and 5.379 (2.372-12.198), respectively. Conclusions: The findings show that patients with colon cancer have higher MPV levels compared with controls, and these are reduced after surgery. In addition, MPV was found to be independently associated with the presence of colon cancer. Further studies are warranted to assess the utility of MPV as a novel diagnostic screening tool for colon cancer.