Techniques for Formulation of Nanoemulsion Drug Delivery System: A Review

Manish Kumar,Ram Singh Bishnoi,Ajay Kumar Shukla,Chandra Prakash Jain 한국식품영양과학회 2019 Preventive Nutrition and Food Science Vol.24 No.3

Nanoemulsion drug delivery systems are advanced modes for delivering and improving the bioavailability of hydrophobic drugs and the drug which have high first pass metabolism. The nanoemulsion can be prepared by both high energy and low energy methods. High energy method includes high-pressure homogenization, microfluidization, and ultrasonication whereas low energy methods include the phase inversion emulsification method and the self-nanoemulsification method. Low energy methods should be preferred over high energy methods as these methods require less energy, so are more efficient and do not require any sophisticated instruments. However high energy methods are more favorable for food grade emulsion as they require lower quantities of surfactant than low energy methods. Techniques for formulation of nanoemulsion drug delivery system are overlapping in nature, especially in the case of low energy methods. In this review, we have classified different methods for formulation of nanoemulsion systems based on energy requirements, nature of phase inversion, and self-emulsification.

Elucidating Energy Requirements in Alternative Methods of Robo Production

Akinoso, Rahman,Are, Oluwayemisi Teslima Korean Society for Agricultural Machinery 2018 바이오시스템공학 Vol.43 No.2

Purpose: This study was designed to elucidate the energy-utilization patterns for five methods of robo production. Methods: Robo (fried melon cake) was produced using five different methods, and the energy used for each unit operation was calculated using standard equations. The sensory attributes of the products were determined by panelists. Data were analyzed using descriptive analysis and analysis of variance at p < 0.05. Results: The energy demands for processing 2.84 kg of melon seed into robo (fried melon cake) using processes 1 (traditional method), 2, 3, 4, and 5 (improved methods) were 50,599.5, 21,793.6, 20,379.7, 21,842.9, and 20,429.3 kJ, respectively. These are equivalent to energy intensities of 1,7816.7, 7,673.8, 7,175.9, 7,691.2, and 7,193.4 kJ/kg, respectively. For the traditional process, the frying operation consumed the highest energy (21,412.0 kJ), and the mixing operation consumed the lowest energy (675.0 kJ). For the semi-mechanized processes, the molding operation consumed the highest energy (6,120.0 kJ), and the dry milling consumed the lowest energy (14.4 kJ). Conclusions: The energy-consumption patterns were functions of the type of unit operation, the technology involved in the operations, and the size of the equipment used in the whole processing operation. Robo produced via the milling of dried melon seed before oil expression was rated highest with regard to the aroma and taste quality, as well as the overall acceptability of the sensory evaluation, and required the lowest energy consumption. Full mechanization of the process line has potential for further reduction of the energy demand.

Elucidating Energy Requirements in Alternative Methods of Robo Production

Rahman Akinoso,Oluwayemisi Teslima Are 한국농업기계학회 2018 바이오시스템공학 Vol.43 No.2

Purpose: This study was designed to elucidate the energy-utilization patterns for five methods of robo production. Methods: Robo (fried melon cake) was produced using five different methods, and the energy used for each unit operation was calculated using standard equations. The sensory attributes of the products were determined by panelists. Data were analyzed using descriptive analysis and analysis of variance at p < 0.05. Results: The energy demands for processing 2.84 kg of melon seed into robo (fried melon cake) using processes 1 (traditional method), 2, 3, 4, and 5 (improved methods) were 50,599.5, 21,793.6, 20,379.7, 21,842.9, and 20,429.3 kJ, respectively. These are equivalent to energy intensities of 1,7816.7, 7,673.8, 7,175.9, 7,691.2, and 7,193.4 kJ/kg, respectively. For the traditional process, the frying operation consumed the highest energy (21,412.0 kJ), and the mixing operation consumed the lowest energy (675.0 kJ). For the semi-mechanized processes, the molding operation consumed the highest energy (6,120.0 kJ), and the dry milling consumed the lowest energy (14.4 kJ). Conclusions: The energy-consumption patterns were functions of the type of unit operation, the technology involved in the operations, and the size of the equipment used in the whole processing operation. Robo produced via the milling of dried melon seed before oil expression was rated highest with regard to the aroma and taste quality, as well as the overall acceptability of the sensory evaluation, and required the lowest energy consumption. Full mechanization of the process line has potential for further reduction of the energy demand.

Comparison among methods of effective energy evaluation of corn silage for beef cattle

Wei, Ming,Chen, Zhiqiang,Wei, Shengjuan,Geng, Guangduo,Yan, Peishi Asian Australasian Association of Animal Productio 2018 Animal Bioscience Vol.31 No.6

Objective: This study was conducted to compare different methods on effective energy evaluation of corn silage for beef cattle. Methods: Twenty Wandong bulls (Chinese indigenous yellow cattle) with initial body weight of $281{\pm}15.6kg$, were assigned to 1 of 5 dietary treatments with 4 animals per treatment in a randomized complete block design. Five dietary treatments included group 1 with corn silage only diet, group 2 with corn silage-concentrate basal diet (BD) and 3 groups with 3 test diets, which were the BD partly substituted by corn silage at 10%, 30%, and 60%. The total collection digestion trial was conducted for 5 d for each block after a 10-d adaptation period, and then an open-circuit respiratory cage was used to measure the gas exchange of each animal in a consecutive 4-d period. Results: The direct method-derived metabolizable energy and net energy of corn silage were 8.86 and 5.15 MJ/kg dry matter (DM), expressed as net energy requirement for maintenance and gain were 5.28 and 2.90 MJ/kg DM, respectively; the corresponding regression method-derived estimates were 8.96, 5.34, 5.37, and 2.98 MJ/kg DM, respectively. The direct method-derived estimates were not different (p>0.05) from those obtained using the regression method. Using substitution method, the nutrient apparent digestibility and effective energy values of corn silage varied with the increased corn silage substitution ratio (p<0.05). In addition, the corn silage estimates at the substitution ratio of 30% were similar to those estimated by direct and regression methods. Conclusion: In determining the energy value of corn silage using substitution method, there was a discrepancy between different substitution ratios, and the substitution ratio of 30% was more appropriate than 10% or 60% in the current study. The regression method based on multiple point substitution was more appropriate than single point substitution on energy evaluation of feedstuffs for beef cattle.

TGA를 이용한 Chlorinated Poly Vinyl Chloride(CPVC)의 활성화 에너지 평가

박형주 한국화재소방학회 2019 한국화재소방학회논문지 Vol.33 No.1

The activation energy of CPVC (Chlorinated Poly Vinyl Chloride) used for non-metallic synthetic resin piping infire-fighting was measured by thermogravimetric analysis (TGA). The activation energy was determined using by TGAkinetic methods, such as Kissinger and Flynn-Wall-Ozawa method. The calculated activation energy was 128.07 kJ/mol(Kissinger method) and 145.60 kJ/mol (Flynn-Wall-Ozawa method). The difference in activation energies calculated by theKissinger method and Flynn-Wall-Ozawa method was not considered to be significant considering that the different analysismethods. The combustion characteristics will be tested in a future study through an evaluation of thermal deterioration usingan accelerated deterioration and air oven aging test and the lifetime of CPVC will be predicted. 열중량 분석법(TGA)을 이용하여 소방용 합성수지 배관으로 사용되는 CPVC의 활성화 에너지를 측정하였다. 열중량 분석법을 이용한 활성화 에너지는 Kissinger method와 Flynn-Wall-Ozawa method를 이용하여 계산하였다. 활성화에너지를 계산한 결과 Kissinger method에 의해 128.07 kJ/mol, Flynn-Wall-Ozawa method에 의해 145.60 kJ/mol로 나타났다. Kissinger method와 Flynn-Wall-Ozawa method에 의해 계산된 활성화 에너지의 차이는 해석 방법이 다르다는 점을 감안했을 때 큰 차이가 없다고 판단된다. 향후 가속열화을 이용한 열적 열화평가 및 공기오븐노화시험을 통한CPVC의 연소특성을 시험하고, 수명을 예측하고자 한다.

내진 설계를 위한 에너지 소산량 산정법의 활용

임혜정,박홍근,엄태성 한국지진공학회 2003 한국지진공학회논문집 Vol.7 No.6

기존의 비선형 정적 및 동적 해석에서는 철근콘크리트 구조물의 에너지 소산능력을 정확히 고려하지 못하고 있다. 최근 연구에서는 휨지배 철근콘크리트 부재의 에너지 소산능력을 정확히 평가할 수 있는 식이 개발되었으며, 본 연구에서는 이 평가방법을 이용하여 에너지 소산능력을 정확히 고려할 수 있는 비선형 정적 및 동적 해석 방법을 개발하였다. 비선형 정적 해석을 위하여 에너지 스펙트럼 곡선을 개발하고 이를 적용하여 능력스펙트럼법을 개선하였으며, 또한 비선형 동적 해석을 위하여 철근콘크리트 부재의 단순화된 에너지 기초 주기거동모델을 개발하였다. 제안된 모델은 부재의 강성에 기초한 기존의 주기거동모델과는 달리 완전한 주기거동 발생시 소산되는 에너지를 정확하게 반영할 수 있다. 본 연구에서는 제안된 방법에 따라 비선형 정적 및 동적 해석법의 절차를 정립하였으며 이를 적용한 컴퓨터 해석 프로그램을 개발하였다. 제안된 해석 방법은 부재의 단면형태, 철근비, 배근형태 등 설계 변수에 따른 에너지 소산능력을 정확하게 고려하고 지진발생시 에너지 소산능력이 구조물의 성능에 미치는 효과를 반영할 수 있다. Traditional nonlinear static and dynamic analyses do not accurately estimate the energy dissipation capacity of reinforced concrete structure. Recently, simple equations which can accurately calculate the energy dissipation capacity of flexure-dominated RC members, were developed in the companion study. In the present study, nonlinear static and dynamic analytical methods improved using the energy-evaluation method were developed. For nonlinear static analysis, the Capacity Spectrum Method was improved by using the energy-spectrum curve newly developed. For nonlinear dynamic analysis, a simplified energy-based cyclic model of reinforced concrete member was developed. Unlike the existing cyclic models which are the stiffness-based models, the proposed cyclic model can accurately estimate the energy dissipating during complete load-cycles. The procedure of the proposed methods was established and the computer program incorporating the analytical method was developed. The proposed analytical methods can estimate accurately the energy dissipation capacity varying with the design parameters such as shape of cross-section, reinforcement ratio and arrangement, and can address the effect of the energy dissipation capacity on the structural performance under earthquake load.

폭발성 물질의 폭발에 따른 폭발압력 평가

윤용균 대한화약발파공학회 2018 화약발파 Vol.36 No.4

Explosions of vapor cloud formed due to the leakage from installations with flammable fuels have often occurred in Korea and foreign countries. In this study, TNT equivalency method and Multi-Energy method for vapor cloud explosion blast modelling are described and demonstrated in a case study. As TNT equivalency method is simple and direct, it has been widely used for modelling a vapor cloud explosion blast. But TNT equivalency method found to be difficult to select a proper correlation between the amount of combustion energy produced from the vapor cloud explosion and the equivalent amount of TNT to model its blast effects. Multi-Energy method assumes that the strength of vapor cloud explosion blast depends on the layout of the space where the vapor cloud is spreading. Strictly speaking, the explosive potential of a vapor cloud is dependent upon the density of the obstructed regions. In this study, Flixborough accident are analyzed as a case study to assess the applicability of TNT equivalency method and Multi-Energy method. TNT equivalency method and Multi-Energy method found to be applicable if coefficient of TNT equivalency and coefficient of strength of explosion blast are selected properly. 인화성 물질을 보유하고 있는 시설물에서 인화성 물질이 유출되어 형성된 증기운의 폭발이 국내와 해외에서 자주 발생하고 있다. 본 연구에서는 증기운 폭발에 따른 폭풍 효과를 모사하기 위해서 TNT 등가법과 다중에너지법을 적용하였다. TNT 등가법은 단순하고 직접적인 적용이 가능하기 때문에 증기운 폭발을 해석하기 위해서지금까지 널리 사용되고 있다. 그러나 TNT 등가법은 증기운 폭발로부터 발생하는 연소에너지와 이를 TNT 등가량으로 환산하는데 필요한 적절한 상관관계를 선택하는 것이 어렵다는 근본적인 단점을 가지고 있다. 다중에너지법에서는 증기운 폭발의 강도가 증기운이 확산되는 지역에서의 확산 경로의 레이아웃에 따라 달라진다고 가정한다. 즉 증기운의 잠재적 폭발력은 혼잡지역의 혼잡정도에 따라 달라진다. 본 연구에서는 TNT 등가법과 다중에너지법의 적용성을 평가하기 위해서 Flixborough 폭발사고를 사례연구로 분석하였다. 분석 결과 TNT 등가계수와 폭발강도계수를 현장상황에 맞게 적절히 선택하는 경우 TNT 등가법과 다중에너지법은 증기운 폭발 사고를 분석하는데 적합할 것으로 예상된다.

Effects of particle size and adaptation duration on the digestible and metabolizable energy contents and digestibility of various chemical constituents in wheat for finishing pigs determined by the direct or indirect method

Yuanfang Fan,Panpan Guo,Yuyuan Yang,Tian Xia,Ling Liu,Yongxi Ma 아세아·태평양축산학회 2017 Animal Bioscience Vol.30 No.4

Objective: This experiment was conducted as a 3×2×2 factorial design to examine the effects of particle size (mean particle size of 331, 640, or 862 μm), evaluation method (direct vs indirect method) and adaptation duration (7 or 26 days) on the energy content and the apparent total tract digestibility (ATTD) of various chemical components in wheat when fed to finishing pigs. Methods: Forty-two barrows (Duroc×Landrace×Yorkshire) with an initial body weight of 63.0±0.8 kg were individually placed in metabolic cages and randomly allotted to 1 of 7 diets with 6 pigs fed each diet. For the indirect method, the pigs were fed either a corn-soybean meal based basal diet or diets in which 38.94% of the basal diet was substituted by wheat of the different particle sizes. In the direct method, the diets contained 97.34% wheat with the different particle sizes. For both the direct and indirect methods, the pigs were adapted to their diets for either 7 or 26 days. Results: A reduction in particle size linearly increased the digestible energy (DE) and metabolizable energy (ME) contents as well as the ATTD of gross energy, crude protein, organic matter, ether extract (EE) and acid detergent fiber (ADF) (p<0.05), and had a trend to increase the ATTD of dry matter of wheat (p = 0.084). The DE, ME contents, and ATTD of gross energy, crude protein, dry matter and organic matter were higher (p<0.05) when determined by the direct method, but the ATTD of ADF, EE, and neutral detergent fiber were higher when determined by the indirect method (p<0.05). Prolongation of the adaption duration decreased the ATTD of neutral detergent fiber (p<0.05) and had a trend to increase the ATTD of EE (p = 0.061). There were no interactions between particle size and the duration of the adaptation duration. The ATTD of EE in wheat was influenced by a trend of interaction between method and adaptation duration (p = 0.074). The ATTD of ADF and EE in wheat was influenced by an interaction between evaluation method and wheat particle size such that there were linear equations (p<0.01) about ATTD of ADF and EE when determined by the direct method but quadratic equations (p = 0.073 and p = 0.088, respectively) about ATTD of ADF and EE when determined by the indirect method. Conclusion: Decreasing particle size can improve the DE and ME contents of wheat; both of the direct and indirect methods of evaluation are suitable for evaluating the DE and ME contents of wheat with different particle sizes; and an adaptation duration of 7 d is sufficient to evaluate DE and ME contents of wheat in finishing pigs.

BEAT 프로그램을 이용한 건물에너지 retrofit 요소들 간의 에너지 절감 관계분석

김현수(Kim, Hyeonsoo),최기원(Choi, Ki-won),장지훈(Jang, Ji-hoon),강경모(Kang, Kyung-mo),이승복(Leigh, Seung-Bok) 대한건축학회 2017 大韓建築學會論文集 : 構造系 Vol.33 No.2

Recently, Korean government is successively driving energy saving policies. Nevertheless, the use of energy is continuously increasing, and shift toward a low-energy society is somewhat out of our expectation. The major goal of building energy retrofit is to optimize energy consumption in existing buildings which are under deterioration. Many of these old buildings with lower efficiency spend more energy than newly built ones. Thus, this paper suggests a reasonable guideline for energy retrofit. A government office building located in Kangdonggu, Seoul is selected as the subject building, and a modified bin-method called BEAT(Building Energy Analysis Tool) program is used for the analysis. The primary goal of this research is to find the best combination of influencing factors that can improve energy efficiency in old buildings. Such factors stem from design components of Building, System and also Operational facets of a building. By applying the input standards from "Green remodeling guidelines", heating energy can be reduced by 38.28% in the winter and 38.50% of cooling energy in the summer. Most of the factors contributed to reducing energy consumption except for SC(Shading Coefficient) and Internal lighting to heating energy. This is due to the blockage of solar heat gain and decrement of internal heat respectively, which results in a higher demand for heating in the winter. Finally, the total energy(HVAC+Lighting+Office equipment) on a yearly basis, can be reduced by 38.89% when all the considering factors are applied in combination. The study will further move to analyze the best solution for building energy retrofit.

에너지 관련 법상 에너지 이용 효율화 방안에 관한 연구

이재삼 가천대학교 법학연구소 2013 가천법학 Vol.6 No.2

오늘날 우리 생활과 밀접한 관계를 가지고 있는 에너지와 관련된 문제들을 법제적으로 고찰하였는바, 현실적으로 중요하게 인식되고 있는 에너지의 헌법적 규정화와 현행 에너지법의 통합화 방안을 제시하였으며, 현실적으로 에너지의 고갈과 부족현상에 따른 에너지 이용의 효율화를 위한 대안으로써 에너지 이용 효율의 규제를 강조하였다. 또한 에너지의 이용에 따른 환경오염의 증가를 방지하기 위한 대안을 제시하였다.특히 에너지 이용의 효율화를 위한 다음의 제고방안이 강조되어야 할 것으로 사료되는 바이다.첫째, 오늘날 인간의 생존권 실현에 없어서는 아니 될 에너지 자원의 절대적인 필요성이 제기되면서 헌법적인 차원에서의 에너지 절약과 효율적 이용에 관련된 관념의 정립이 필요하다. 즉 국가의 균형 있는 국민경제의 성장과 안정, 적정한 소득의 분배 유지, 시장의 지배와 경제력의 남용 방지, 경제주체간의 조화를 통한 경제의 민주화를 위한 규제와 조정을 위한 국가의 에너지 통제와 조정 등 헌법적 차원에서의 에너지 규정의 제도적 보장이 이루어져야 할 것이다. 결국 국민의 에너지 이용권과 부족함이 없는 에너지 환경을 향유할 수 있는 권리와 국가의 책무 및 에너지의 절약 내지는 효율화 규정 등 헌법적 차원의 에너지 입법화가 필요하다. 둘째, 현행 에너지법, 에너지이용합리화법 등 에너지 관련 각 법률들이 에너지 이용의 효율화를 위한 국가와 사용자의 의무를 규정하고 있는바, 각 법률 간의 관계가 연계를 이루어지지 않고 분산되어 있어서 그 효율성이 저하되고 있는 실정이다. 따라서 에너지 관련 법률체계상 에너지 기본법을 토대로 에너지의 이용 효율화를 위한 에너지의 계획·관리·규제·정보·연구·개발 등 기능적인 법체계와 현재 국내외의 에너지 수급·규제와 에너지 과다소비의 방지에 대한 규제가 미약하므로 현행 에너지의 합리적 이용 여건을 반영하는 통합적인 법체계의 정립이 필요하다.셋째, 에너지의 고갈과 부족 현상에 따른 에너지의 절약의 일환인 에너지 소비의 능동적 효율화가 필요하다. 즉 에너지 사용의 능동적 효율화를 기하므로써 에너지의 측정, 모니터링 및 통제를 통해 지속적인 변화에 영향을 주어야 하며, 에너지 저소비형 정책 및 에너지 절감 제도가 필요하다. 따라서 모든 가전제품 등에 대한 에너지 규제와 기준을 강화시킴으로써 에너지 이용 효율화의 실효성 확보의 수단이 필요하다.넷째, 에너지 이용으로 인한 심각한 환경오염으로 이어지는 문제점과 그의 방지에 대한 구체적인 규정의 연계성이 부족하므로 에너지 소비에 따른 환경 오염 방지의 관련 규정이 필요하다고 할 수 있다. Today, after considering issues related with energy which is close to human life in a legislative way, the constitutional regularization of energy and the plan of unifying current energy-related regulations, which seem so important, were proposed, and for the alternative way of efficiency in energy usage resulted by lack and depletion of energy, regulation on efficiency of energy usage was emphasized. First, it is necessary to establish the concept on constitutional energy saving and efficiency as the absolute necessity of energy resources which are vital for human beings’ existence is being issued. In other words, systemic guarantee of constitutional energy regulation such as following should be settled; growth and stability of national economy, maintenance of distributing reasonable income, prevention of market control and abusing economic power, national controlling of energy for restriction and control for economic democratization through the harmony among main economic players. This is, constitutional energy legalization is necessary since civil rights to use energy, rights and national duty to enjoy energy environment without lack of energy, and compulsory regulation of energy saving, or at least efficiency of energy are necessary. In addition, regulation and control for energy efficiency is certainly needed. Second, laws related with energy such as current energy regulation and energy usage rationalization regulate the duty of the nation and the user for efficiency of energy usage, but there is a question about the efficiency since they are dispersed without connection among those. Thus, based on fundamental law of energy, it is necessary to settle functional legal system such as planning, manageing, regulating, informing, studying, and developing energy for energy efficiency and integrated legal system reflecting current energy supply and usage in and out of the country. Third, regulation of energy usage and energy over-use prevention, which are part of energy saving followed by today’s shortage and depletion of energy, are weak. Article 14 of current enforcement ordinance of efficiency in energy usage clearly states the limitation and prohibition of energy usage, and by reinforcing regulation and criteria about other electrics and goods, means to retain effectiveness of efficient energy usage are to be studied. Fourth, the relationship between energy and the environment seems separated because of the lack of detailed connectivity of the problem due to the environmental pollution from energy usage and the restrictions to prevent those, and the limitation of environment pollution from energy usage is vague. Still, there is no doubt that the main reason for global warming is from the emission of green-house gases through energy usage. Thus, energy is closely related with environmental issues regarding that it causes various types of environmental damages in producing, distributing and using energy. Especially, the usage of fossil fuel causes environmental problems such as air pollution, acid rain, environmental damage and global warming so that for the preparation of this, energy saving and energy efficiency should be reinforced and comprehensive management, study, and development of alternative bio-energy should be continuously made.