청소년 고혈압 관련 유전자의 연관성 분석: Kangwha Study

서일,남정모,김성주,신동직,허남욱,강대룡,Suh, Il,Nam, Chung-Mo,Kim, Sung-Joo,Shin, Dong-Jik,Hur, Nam-Wook,Kang, Dae-Ryong 대한예방의학회 2006 예방의학회지 Vol.39 No.2

Objectives : In this study we examined the association between the genetic markers ACE (A-240T, C-93T, I/D, A2350G), AGT (M235T), AT1R (A1166C), CYP11B2 (T344C, V386A), REN (G2646A), ADRB2 (G46A, C79G, T47C, T1641), GNB3 (C825T) and ADD1 (G460W) and the presence of essential hypertension in adolescents. Methods : The Kangwha Study is an 18-year prospective study that is aimed at elucidating the determinants of the blood pressure level from childhood to early adulthood. For this study, we constructed a case-control dataset of size of 277 and 40 family trios data from the Kangwha Study. For this purpose, we perform a single locus-based case-control association study and a single locus-based TDT (transmission/disequilibrium test) study. Results : In the case-control study, the single locus-based association study indicated that the ADD1 (G460W) (p=0.0403), AGT (M235T) (p=0.0002), and REN (G2646A) (p=0.0101) markers were significantly associated with the risk of hypertension. These results were not confirmed on the TDT study. This study showed that genetic polymorphisms of the ADD1, AGT and REN genes might be related to the hypertension in Korean adolescents. Conclusions : This study provided useful information on genetics markers related to blood pressure. Further study will be needed to confirm the effect of the alpha adducin gene, the angiotensinogen gene and the renin gene on essential hypertension.

한국 기업경영학의 연구동향

김신,천만봉 한국기업경영학회 2012 기업경영연구 Vol.19 No.5

This Study is about the study trends of during the last 19 years that The Korean Corporation management Association was publishing a corporation management until Vol. 19 No. 3(2012. 6) since first issue(1994). The subjects of this study is published a corporation management by the Korean Corporation Management Association it’s around study results. Also, This study is the activity performance and contribution to investigate the systematical study. This Study discussed about the founding motivation and performance of the Korean Corporation Management Association, This study was analyzed time performance and professionally sectoral performance in published the corporation management. The Results are summarized as follows. The Corporation Management of 1990’s was embryonic stage in the Korean Corporation Management Association, In this era was studied about relatively much more accounting and a human resource organization. The Corporation Management of 2000’s can the stabilized and the growth stage to the Korean Corporation Management Association. During this period, First of all, The Corporation Management of the academy journal was enlarged to publish four times per year after 2009. Also the grand prize award of Korean’s Representative CEO began in this period. In addition, This periods began international policy seminar and international symposium of exploration between domestic and foreign scholars for academic exchanges. Also, This period began the field trip of exploration between domestic and overseas corporations for the opportunity to a wide range research and the benchmarking of management practices activities. In 2010, The Corporation Management of Academy journal was selected the scholarship registration journals from the National Research Foundation of Korea. and The Corporation Management of the academy journal was enlarged to published six times per year from 2012. The other hand, In this study classified by journal submission to the research result of the Korean corporation business administration, it were classified by HR, Production Metering, Technological Innovation, MIS, Marketing, e-biz, Finance, Accounting, International Business, Management History, Business Strategy, Small Business, Tourism Management, General Management and the other. Look at these sectorial main research contents, First, HR has been studied the characteristic of Organization, Organizational Culture, and Leadership. And Production Metering were studied DRP system and JIT Production Methods, Quality Management and Productivity. The MIS were studied IS and Technology Acceptance Model(TAM). The other hand, In the Marketing field was studied about the consumer reaction for advertising, Brand recognition, service quality etc. The e-biz field was performing related to e-commerce. In addition, Finance field was performed bank management and financial institutions, corporate governance, date trading of the securities market, real estate market. And an Accounting has made relatively taxation system, international accounting standards, corporate governance improvement. In the field of international business research related to the internationalization of enterprises and FDI, and korean corporations into china. Business strategy was studied related to strategic alliances. And Tourism Management has been performed the service quality of hotel companies and the research related of local government. And The other areas research have been performed a related of employment. However, The limitations of this study, First, In this study has been carried out to the target of the research presented the journal of the corporate management research utilizing limited research. Second, Korean Corporate Management Association was contributed much to the development of Korean Corporate Business Administration grown over past 19th years. But Performed in this study showed the limits the lack of a organize to resources systematically of the society data S... 본 연구는 한국기업경영학회의 1996년 창간호에서부터 제19집 제3호(2012년 6월)까지 지난 19년간의 기업경영학 연구동향에 관한 연구이다. 본 논문의 연구대상은 한국기업경영학회가 발간하는 학술지 「기업경영연구」에 게재된 연구 성과를 중심으로 기업경영학 연구에 있어서 한국기업경영학회의 연구 성과 및 기여도에 대한 부분을 체계적으로 고찰하는데 연구의 목적을 두고 있다. 본 연구는 먼저, 한국기업경영학회의 창립동기와 그동안의 성과와 현황에 대한 내용을 다루었으며, 그리고 「기업경영연구」에 게재된 논문들을 시대별 성과와 전문 분야별 성과로 나누어 분석하였다. 그 결과 다음과 같이 요악할 수 있다. 첫째, 기업경영학의 각 연구 분야에 있어서 학문적 편중성을 개선해야 할 것으로 보인다. 21세기에 들어와서 기업경영학 관련 학문들이 점점 세분화되고 전문화되고 있는 가운데 각 분야별 연구자들의 활발한 연구 활동이 요구되어진다. 둘째, 기업 경영학의 연구에 있어서 국제적인 연구논문의 발표가 필요하다. 우리나라의 기업경영학 연구는 한국기업을 대상으로 하는 것이 대부분이어서 이런 난점을 없애기 위해서는 외국 기업과의 국제 비교분석 같은 분야에 더 많은 논문이 게재되어야 할 것으로 사료된다. 셋째, 외국학자의 적극적인 참여가 필요하다. 기업경영학의 연구내용이 글로벌화 되기 위해서는 연구자들의 국적이 다양해지는 것이 바람직하다고 사료된다. 이는 기업경영학 연구의 글로벌화를 이룰 수 있을 뿐만 아니라 다양한 시각에서 기업경영학 연구를 발전시킬 수 있는 계기를 마련할 수 있다. 넷째, 한국기업경영연구의 체계적인 자료정리가 필요하다. 한국기업경영학회는 1994년 출발 하였지만 2001년 6월에 지금의 명칭으로 개칭 후 전국 규모의 학회로 발전하였다. 그러나 한국기업경영학회는 지난 19년간의 학회역사를 이어오면서 체계적인 학회 자료의 정리에 일부 미흡한 부분이 남아 있었다. 특히 초기의 학회자료에 대한 체계적 정리가 필요할 것으로 사료된다. 끝으로, 한국기업경영학회는 지난 19년 동안 기업경영학에 있어서 많은 연구 성과를 보여주었지만, 학회가 세계적인 학회로 발전하기 위해서는 좀 더 활발한 연구 활동의 촉진이 필요할 것으로 사료된다

Demographic and Genome Wide Association Analyses According to Muscle Mass Using Data of the Korean Genome and Epidemiology Study

Gim Jeong-An,Lee Sangyeob,Kim Seung Chan,Baek Kyung-Wan,Yoo Jun-Il 대한의학회 2022 Journal of Korean medical science Vol.37 No.50

Background: Sarcopenia is commonly found in the elderly due to a decline in muscle mass. Many researchers have performed genome-wide association studies (GWAS) to find genetic risk factors of sarcopenia. Although many studies have discovered sarcopenia associated single nucleotide polymorphisms (SNPs), most of them are studies targeting Caucasians. The purpose of this study was to evaluate genetic correlation according to muscle mass in middle aged Koreans using data of the Korean Genome and Epidemiology Study (KOGES), a large population-based genomic cohort study. Methods: Baseline participants were 10,030 subjects aged 40 to 69 years who were from Ansan or Anseong in Gyeonggi-do, South Korea. Among them, 9,351 subjects with laboratory data available were included in this study. To identify sarcopenia associated variants, those in the top 30% and bottom 30% of muscle mass index (MMI) were compared. A total of 7,452 people with an MMI of 30-70% were excluded. A total of 1,004 people were also excluded due to missing data. Finally, 895 people were selected for this study. The Korea Biobank Array generated 500,568 SNPs for this dataset. Results: When subjects were divided into top 30% and bottom 30% of MMI, the top 30% had 169 men and 308 women and the bottom 30% had 220 men and 198 women. In men, age, body mass index (BMI), waist and hip were significantly (P < 0.005) different between top 30% and bottom 30% MMI groups. In women, age, BMI, waist, hip, and hypertension history were significantly different between the two MMI groups. There were 13 significant SNPs in men and 14 significant SNPs in women. Genes associated with variants in men based on the single-nucleotide polymorphism database (dbSNP) were LRP1B containing rs11679458 and RGS6 containing rs11848300. A gene associated with variants in women was Pi4K2A, which contained rs1189312 as a variant. In addition, rs11189312 was associated with expression quantitative trait loci (eQTL) of ZFYVE27 in skeletal muscles and other SNPs of ZFYVE27 (rs10882883, rs17108378, rs35077384) known to be associated with spastic paraplegia. The eQTL analysis revealed that rs11189312 was a variant associated with SNPs of ZFYVE27. Conclusions: In the demographic study, significant results were found in BMI, waist, hip, history of hyperlipidemia, and sedentary life status in male group, and significant results were found in BMI, waist, hip, and hypertension history in female group. Variant rs11189312 was found to be a novel variant affecting ZFYVE27 expressed in skeletal muscles, suggesting that rs11189312 might be related to sarcopenia as a novel discovery of this study. Further study is needed to determine the association between sarcopenia and ZFYVE27 known to be associated with spastic paraplegia.

A Genome-Wide Association Study Identifies UTRN Gene Polymorphism for Restless Legs Syndrome in a Korean Population

ChulHyun Cho,JiHye Choi,SeungGul Kang,HoKyoung Yoon,YoungMin Park,JoungHo Moon,KiYoung Jung,JinKyu Han,HongBum Shin,HyunJi Noh,YongSeo Koo,Leen Kim,HyunGoo Woo,HeonJeong Lee 대한신경정신의학회 2017 PSYCHIATRY INVESTIGATION Vol.14 No.6

Objective-Restless legs syndrome (RLS) is a highly heritable and common neurological sensorimotor disease disturbing sleep. The objective of study was to investigate significant gene for RLS by performing GWA and replication study in a Korean population. Methods-We performed a GWA study for RLS symptom group (n=325) and non-RLS group (n=2,603) from the Korea Genome Epidemiology Study. We subsequently performed a replication study in RLS and normal controls (227 RLS and 229 controls) to confirm the present GWA study findings as well as previous GWA study results. Results-In the initial GWA study of RLS, we observed an association of rs11645604 (OR=1.531, p=1.18×10-6) in MPHOSPH6 on chromosome 16q23.3, rs1918752 (OR=0.6582, p=1.93×10-6) and rs9390170 (OR=0.6778, p=7.67×10-6) in UTRN on chromosome 6q24. From the replication samples, we found rs9390170 in UTRN (p=0.036) and rs3923809 and rs9296249 in BTBD9 (p=0.045, p=0.046, respectively) were significantly associated with RLS. Moreover, we found the haplotype polymorphisms of rs9357271, rs3923809, and rs9296249 (overall p=5.69×10-18) in BTBD9 was associated with RLS. Conclusion-From our sequential GWA and replication study, we could hypothesize rs9390170 polymorphism in UTRN is a novel genetic marker for susceptibility to RLS. Regarding with utrophin, which is encoded by UTRN, is preferentially expressed in the neuromuscular synapse and myotendinous junctions, we speculate that utrophin is involved in RLS, particularly related to the neuromuscular aspects.

A genome-wide association study of the association between single nucleotide polymorphisms and brachial-ankle pulse wave velocity in healthy Koreans

Xu, EnShi,Shin, Jinho,Lim, Ji Eun,Kim, Mi Kyung,Choi, Bo Youl,Shin, Min-Ho,Shin, Dong Hoon,Lee, Young-Hoon,Chun, Byung-Yeol,Hong, Kyung-Won,Hwang, Joo-Yeon Korean Society of Medical Genetics and Genomics 2017 대한의학유전학회지 Vol.14 No.1

Purpose: Pulse wave velocity (PWV) is an indicator of arterial stiffness, and is considered a marker of vascular damage. However, a genome-wide association study analyzing single nucleotide polymorphisms (SNPs) associated with brachial-ankle PWV (baPWV) has not been conducted in healthy populations. We performed this study to identify SNPs associated with baPWV in healthy populations in Korea. Materials and Methods: Genomic SNPs data for 2,407 individuals from three sites were analyzed as part of the Korean Genomic Epidemiologic Study. Without replication samples, we performed multivariable analysis as a post hoc analysis to verify the findings in site adjusted analysis. Healthy subjects aged between 40 and 70 years without self-reported history or diagnosis of hypertension, diabetes, hyperlipidemia, heart disease, cerebrovascular disease and cancer were included. We excluded subjects with a creatinine level >1.4 mg/dL (men) and 1.2 mg/dL (women). Results: In the site-adjusted association analysis, significant associations (P<$5{\times}10^{-8}$) with baPWV were detected for only 5 SNPs with low minor allele frequency. In multivariable analysis adjusted by age, sex, height, body mass index, mean arterial pressure, site, smoking, alcohol, and exercise, 11 SNPs were found to be associated (P<$5{\times}10^{-8}$) with baPWV. The 5 SNPs (P<$5{\times}10^{-8}$) linked to three genes (OPCML, PRR35 and RAB40C) were common between site-adjusted analysis and multivariable analysis. However, meta-analysis of the result from three sites for the 11 SNPs showed no significant associations. Conclusion: Using the recent standard for genome-wide association study, we did not find any evidence of significant association signals with baPWV.

A genome-wide association study of the association between single nucleotide polymorphisms and brachial-ankle pulse wave velocity in healthy Koreans

EnShi Xu,Jinho Shin,Ji Eun Lim,Mi Kyung Kim,Bo Youl Choi,Min-Ho Shin,Dong Hoon Shin,Young-Hoon Lee,Byung-Yeol Chun,Kyung-Won Hong,Joo-Yeon Hwang 대한의학유전학회 2017 대한의학유전학회지 Vol.14 No.1

Purpose: Pulse wave velocity (PWV) is an indicator of arterial stiffness, and is considered a marker of vascular damage. However, a genome-wide association study analyzing single nucleotide polymorphisms (SNPs) associated with brachial-ankle PWV (baPWV) has not been conducted in healthy populations. We performed this study to identify SNPs associated with baPWV in healthy populations in Korea. Materials and Methods: Genomic SNPs data for 2,407 individuals from three sites were analyzed as part of the Korean Genomic Epidemiologic Study. Without replication samples, we performed multivariable analysis as a post hoc analysis to verify the findings in site adjusted analysis. Healthy subjects aged between 40 and 70 years without self-reported history or diagnosis of hypertension, diabetes, hyperlipidemia, heart disease, cerebrovascular disease and cancer were included. We excluded subjects with a creatinine level >1.4 mg/dL (men) and 1.2 mg/dL (women). Results: In the site-adjusted association analysis, significant associations (P<5×10 –8 ) with baPWV were detected for only 5 SNPs with low minor allele frequency. In multivariable analysis adjusted by age, sex, height, body mass index, mean arterial pressure, site, smoking, alcohol, and exercise, 11 SNPs were found to be associated (P<5×10 –8 ) with baPWV. The 5 SNPs (P<5×10 –8 ) linked to three genes (OPCML, PRR35 and RAB40C) were common between site-adjusted analysis and multivariable analysis. However, meta-analysis of the result from three sites for the 11 SNPs showed no significant associations. Conclusion: Using the recent standard for genome-wide association study, we did not find any evidence of significant association signals with baPWV.

재일 조선불교유학생들의 활동

조아담(A Dam Jo) 동국대학교 불교문화연구원 2008 佛敎學報 Vol.0 No.48

1910년대부터 시작된 불교계의 일본유학은 1920년대 이르러 그 수가 급격히 증가했다. 이는 신지식을 수용하고 인재를 양성하려는 불교계의 의식과 더불어 도성 출입 금지 해제 이후 확산된 일본불교에 대한 호감이 작용한 것으로 보인다. 또한 한국인의 자주성을 말살하고 한국불교를 일본불교에 흡수시키려는 일제의 교육정책의 영향도 있었다. 1920년에 창립된 `조선불교유학생학우회`는 이회광에 의한 한국불교의 임제종 연합기도를 저지하는 등의 활동을 펼쳤으나 1년 후 명칭개정을 통해 해체되었다. 이후 1921년 `재일본조선불교청년회`가 결성되어 국내 불교청년운동과 연계하고 국내불교계를 개혁하려는 의지를 드러냈다. 그들은 순회강연을 통해 신지식의 보급과 계몽에 앞장섰으며, 기관지인 금강저를 발간하고 `원효대성찬앙회` 및 `삼장학회` 등을 통한 불교신앙의 대중화를 도모하는 등 다양한 활동으로 그러한 열정을 표면화했다. 1931년 국내 단체인 `조선불교청년회`가 `조선불교청년총동맹`으로 명칭을 변경한데 이어 전국에 산재된 각 불교청년회가 스스로 그 조직을 해체하고 총동맹의 일원인 동맹체로 전환하였다. 그러한 대세에 합류하여 재일본조선불교청년회는 조선불교청년총동맹의 지부동맹인 `동경동맹`으로 변경되었다. 동경동맹은 정기대회, 신입회원 환영 및 졸업회원 송별회를 개최하고, 연구모임 `동맹연구회` 활동, 기관지 금강저 발간을 지속하는 등 자체적 활동과 더불어 국내 불교계와의 긴밀한 유대를 위해 노력하였다. 이를 통해 1930년 초반부터 등장한 종헌실행문제, 사법개정운동, 중앙불전 폐지 문제 등 중요 현안에 대해 그들의 의사를 적극적으로 표출하기도 하였다. 그러나 국내 총동맹 내분 등 불교청년운동 부진의 영향으로 1934년 동경동맹은 해체되었다. 한편, 1930년에 결성된 항일 비밀결사인 만당 역시 동경에 그 지부를 두고 있었다. 만당의 동경지부는 일본에서 대학을 다니며 불교청년운동을 하던 김법린에 의해 1932년경에 조직되었다. 그 당원은 김법린, 허영호, 장도환, 최범술 등으로 당시 국내외 불교청년운동의 핵심인물들이었다. 그들은 유학 이전부터 해방 후에 이르기까지 매우 다양한 활동을 펼친 것으로 알려져 있다. 1936년 결성된 `조선불교동경유학생회`는 이전의 불교유학생 단체의 전통을 계승하고, 국내 불교계의 후원으로 회관을 만드는 등의 활동을 하였다. 그러나 1940년대에 들어서면서 일제의 침략전쟁에 동조하는 모습을 보이기도 하였다. 대부분 승려의 신분이었던 일본 유학생들은 귀국 후 환속하거나 일본불교의 영향으로 결혼을 하는 등, 이른 바 승려의 대처식육 논란의 중심에 서기도 했으며, 유학파들 가운데 상당수가 중앙교무원의 간부직이나 주지를 맡으면서 일제의 정책에 타협하는 모습을 보이기도 했다. 그러나 유학중 불교를 전공하고 뛰어난 학문적 재능을 드러낸 이들은 강원이나 혜화전문·중앙불교전문학교 등에서 강의와 연구에 몰두하여 해방 후까지도 활발한 학술활동을 펼쳤다. The first Korean Buddhist students studying abroad are known to be Kim Beop-ryong and Kim Seung-beop, who started their studies in 1910s. The number of Korean Buddhist students in Japan increased in 1920s and it seems to be caused by an awakening to the need of learning `new knowledge` in stimulating the Korean Buddhism and a growing favor to the Japanese Buddhism after the lifting of entrance ban to the monks. The Japanese intriguing policy, to abolish independent spirit of Korean people and to merge Korean Buddhism into Japanese Buddhism, also contributed to the increase of the Korean Buddhist students in Japan. The association of Jo-seon Buddhist Students in Japan, founded in 1920, took part in activities like the prevention of trying to unite the order Korean order to Rinzai, the Korean Buddhists led by Yi Hwoi-guang. However, it was dissolved as it changed its name. The Jo-seon Buddhist Youth Association in Japan was founded in 1921 and showed a strong will to join with the Buddhist youth movement in Korean in order to reform the Korean Buddhism. Its passion came to take shape through various activities so it took the initiative in spreading new knowledge and in enlightening people, published its own journal, the Geumgangjeo(which means Diamond Mace) and worked for spreading Buddhism by establishing organizations like the Association in Commemoration of Great Master Wonhyo and the Association for Tipitaka Studies. In 1931, the Jo-seon Buddhist Youth Association in Korea changed its name to General Association of the Jo-seon Buddhist Youth. Accordingly, each of the Buddhist youth associations, scattered over the country, dissolved its organization and became an affiliate of the General Association. Following the general trend, the Jo-seon Buddhist Youth Association in Japan became a member of the General Association, as Tokyo affiliate. The Tokyo affiliate carried its own undertakings, so it held meetings like regular assembly, welcoming and farewell parties, organized the Research Group to study Buddhist teachings and continued to publish its journal, the Geumgangjeo. It also worked for maintaining close relation with the Buddhist movements in Korea, so it actively conveyed their words when important matters became issues since the early 1930s, matters like the execution of the Constitution of the Jo-gye Order, the amendment of Temple Laws, an oppressive measure by Japanese and the abolition of the Jung-ang Buddhist College. However, the Tokyo affiliate was dissolved in 1934 due to the inactivity of the Buddhist youth movement, caused by problems like internal conflicts in the General Association. The Man-dang, a secret anti-Japanese Buddhist organization founded in 1930, had also an affiliate in Tokyo. The Tokyo affiliate of the Man-dang was organized in 1932 by Kim Beop-lin, a student who was actively taking part in the Buddhist youth movement. They played an essential role in the Buddhist youth movement and was known to be dedicated to various activities from the years before studying in Japan to the troubled times after the Liberation. The Association of the Jo-seon Buddhist Students Studying in Tokyo upheld the traditions of the early Buddhist students associations in Japan and built its own hall, supported by the Buddhists organizations in Korea. However, it showed sympathy with Japanese policy of aggression in 1940s. Most of the students, who studied in Japan, were monks and some returned to the laity after their returning to Korea, or married according to the Japanese Buddhist tradition. They were also involved in the vehement discussion on the matter of having a wife and eating meats. Many of them became the leading members of the Business Affairs of the Order or a chief monk of a temple and showed compromising attitudes with the Japanese policy. However, those monks, who distinguished themselves in Buddhist studies with outstanding academic abilities, dedicated themselves to teaching and research at monasteries

Association between urinary arsenic concentration and genetic polymorphisms in Korean adults

Lee Seul-Gi,Eom Sang-Yong,Lim Ji-Ae,Choi Byung-Sun,Kwon Ho-Jang,Hong Young-Seoub,Kim Yong-Dae,Kim Heon,Park Jung-Duck 한국독성학회 2024 Toxicological Research Vol.40 No.1

Arsenic (As) is a human carcinogen widely distributed in the environment. This study evaluated the association between the urinary As concentration and single nucleotide polymorphisms (SNPs) in Korean adults to determine the genetic factors related to As concentration. The study included 496 participants for the genome-wide association study (GWAS) and 1483 participants for the candidate gene approach study. Participants were 19 years and older. The concentrations of total As (Tot As) and total As metabolites (Tmet As, the sum of inorganic As and their metabolites; arsenite, arsenate, monomethylarsonic, and dimethylarsinic acid) in the urine were analyzed. The GWAS identified four SNPs (rs1432523, rs3776006, rs11171747, and rs807573) associated with urinary Tot As and four SNPs (rs117605537, rs3776006, rs11171747, and rs148103384) significantly associated with urinary Tmet As concentration (P < 1 × 10– 4). The candidate gene study identified two SNPs (PRDX2 rs10427027 and GLRX rs3822751) in genes related to the reduction reaction associated with urinary Tot As and Tmet As. This study suggests that genetic factors may play a role in regulating As metabolism in the human body, affecting both exposure levels and its potential health risks in the general Korean population, even at low exposure levels.

Genome-Wide Association Study Identifies Two Novel Loci with Sex-Specific Effects for Type 2 Diabetes Mellitus and Glycemic Traits in a Korean Population

Go, Min Jin,Hwang, Joo-Yeon,Park, Tae-Joon,Kim, Young Jin,Oh, Ji Hee,Kim, Yeon-Jung,Han, Bok-Ghee,Kim, Bong-Jo Korean Diabetes Association 2014 Diabetes and Metabolism Journal Vol.38 No.5

<P><B>Background</B></P><P>Until recently, genome-wide association study (GWAS)-based findings have provided a substantial genetic contribution to type 2 diabetes mellitus (T2DM) or related glycemic traits. However, identification of allelic heterogeneity and population-specific genetic variants under consideration of potential confounding factors will be very valuable for clinical applicability. To identify novel susceptibility loci for T2DM and glycemic traits, we performed a two-stage genetic association study in a Korean population.</P><P><B>Methods</B></P><P>We performed a logistic analysis for T2DM, and the first discovery GWAS was analyzed for 1,042 cases and 2,943 controls recruited from a population-based cohort (KARE, <I>n</I>=8,842). The second stage, de novo replication analysis, was performed in 1,216 cases and 1,352 controls selected from an independent population-based cohort (Health 2, <I>n</I>=8,500). A multiple linear regression analysis for glycemic traits was further performed in a total of 14,232 nondiabetic individuals consisting of 7,696 GWAS and 6,536 replication study participants. A meta-analysis was performed on the combined results using effect size and standard errors estimated for stage 1 and 2, respectively.</P><P><B>Results</B></P><P>A combined meta-analysis for T2DM identified two new (rs11065756 and rs2074356) loci reaching genome-wide significance in CCDC63 and C12orf51 on the 12q24 region. In addition, these variants were significantly associated with fasting plasma glucose and homeostasis model assessment of β-cell function. Interestingly, two independent single nucleotide polymorphisms were associated with sex-specific stratification in this study.</P><P><B>Conclusion</B></P><P>Our study showed a strong association between T2DM and glycemic traits. We further observed that two novel loci with multiple diverse effects were highly specific to males. Taken together, these findings may provide additional insights into the clinical assessment or subclassification of disease risk in a Korean population.</P>

군사학 학문연구 동향 탐색: 한국군사학논총 논문 분석을 중심으로

설현주 미래군사학회 2019 한국군사학논총 Vol.8 No.2

The purpose of this study is to investigate the trends of what kind of research is actually being conducted on the military studies. To do this, the research analyzed the articles published in the Review of Korean Military Studies. As a method for analysis, a topic modeling technique, which is one kind of text mining, was used. As a result, it was found that the research was mainly conducted on nine subjects. In view of the nature and content of the subject, despite the fact that the military studies is a fusion of literature, the paper published in the Review of Korean Military Studies has found that the thesis of the humanities and sociological approach is mainstream. In order to investigate the research trends of military studies and to examine the relationship among the research topics, an association rule mining was conducted. As a result, it was found that the research topics derived from the topic modeling analysis were dealt with in some ways with some relevance. The most peculiar thing is the subject related to politics and diplomacy, which, along with almost all the subjects, are relevant and appear in the study, which is a military studies that talks about war, but political and diplomatic solutions or approaches are important in solving military problems. This study is an exploratory study to identify trends in the field of military studies, and it is expected to be helpful in looking at the achievements of the Korean association of future military affairs of the past decade and in the future development of military science.The purpose of this study is to investigate the trends of what kind of research is actually being conducted on the military studies. To do this, the research analyzed the articles published in the Review of Korean Military Studies. As a method for analysis, a topic modeling technique, which is one kind of text mining, was used. As a result, it was found that the research was mainly conducted on nine subjects. In view of the nature and content of the subject, despite the fact that the military studies is a fusion of literature, the paper published in the Review of Korean Military Studies has found that the thesis of the humanities and sociological approach is mainstream. In order to investigate the research trends of military studies and to examine the relationship among the research topics, an association rule mining was conducted. As a result, it was found that the research topics derived from the topic modeling analysis were dealt with in some ways with some relevance. The most peculiar thing is the subject related to politics and diplomacy, which, along with almost all the subjects, are relevant and appear in the study, which is a military studies that talks about war, but political and diplomatic solutions or approaches are important in solving military problems. This study is an exploratory study to identify trends in the field of military studies, and it is expected to be helpful in looking at the achievements of the Korean association of future military affairs of the past decade and in the future development of military science.