P270 : Erythema dose - a novel global objective index for facial erythema by computer aided image analysis

( Jae Woo Choi ),( Soon Hyo Kwon ),( Seong Moon Jo ),( Sang Woong Youn ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

Background: Facial erythema is a common but morbid condition caused by several inflammatory disorders. Since most of the current severity indexes lack objectivity and global assessment, the computer aided image analysis (CAIA) have been suggested. Objectives: The purpose of this study is to compare the validity and efficacy of novel CAIA erythema index - erythema dose (ED) with two other CAIA indexes. Methods: For mild, moderated and severe erytherotelangiectatic rosacea patients, their photographs of right cheek were assessed with red-blue difference index in image (RBI), a*, and ED. For each index, the differences between severity groups were analyzed. The correlations between the three indexes were evaluated. To evaluate the capability of differentiating the pathologic erythema from the red component of the normal skin, each index was calculated at both the erythema and normal area. Results: The a* and ED significantly changed according to the severity, while the RBI did not. The ED was different between both mild-moderate and moderate-severe, while the a* only between mild-moderate. There was a strong positive correlation between a* and ED. The difference between erythema and normal skin was more prominent in ED than in a*. Conclusion: We confirmed that the ED is well correlated with both subjective assessment, as well as the other CAIA index a*. The ED has the advantage of specifically visualizing and analyzing the pathologic erythema.

The efficacy and safety of dual-frequency ultrasound for improving skin hydration and erythema: a clinical prospective pilot study

( Hee Joo Yang ),( Young Jae Kim ),( Ik Jun Moon ),( Hae Woong Lee ),( Chong Hyun Won ),( Sung Eun Chang ),( Mi Woo Lee ),( Jee Ho Choi ),( Woo Jin Lee ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2

Background: Inflammatory skin diseases, such as rosacea and acne, are major causes of facial erythema and accompanying skin barrier dysfunction. Several methods to restore the impaired skin barrier and improve facial erythema, such as medication, radiofrequency, laser, and ultrasound therapy have been attempted. Objectives: This study evaluated the efficacy and safety of dual-frequency ultrasound with impulse mode for improving skin hydration and erythema in Asian subjects with rosacea and acne. Methods: Twenty-six subjects with facial erythema received an ultrasound treatment once per week for 4 weeks over both cheeks. The erythema index and transepidermal water loss (TEWL) were measured at each visit. Clinicians assessed the erythema improvement and patients evaluated their satisfaction level. Results: The average decrease in TEWL and erythema index at 6 weeks was 5.37±13.22 gㆍh-1ㆍm-2 (p = 0.020) and 39.73±44.21 (p = 0.010), respectively. The clinician’s erythema assessment and the subject satisfaction questionnaire score significantly improved at final follow-up (p < 0.001; p = 0.003, respectively). No serious adverse effects were observed during the treatment and follow-up periods. Conclusion: The dual-frequency ultrasound with impulse mode appears to be both effective and safe for improving skin hydration and erythema in patients with rosacea and acne.

경구 Ibupenta와 2.5% Indomethacin, 0.25%Desoxymethasone 연고가 UVB로 인한 홍반에 미치는 효과에 대한 연구

조문균 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.2

The large amount of UVB irradiation of human skin cause acute erythema that is induced by prostaglandin. Ibupenta and indomethacin have antiinflammatory effect by inhibiting prostaglandin pathway. The purpose of this study was to investigate the effect of oral ibupenta and topical 2.5% indomethacin, 0.25% desoxymethasone ointment on erythema induced by UVB irradiation. In this study, healthy sixteen male medical students who did not have any experience of tanning on their back during the last year were included in this study. There 32 volunteers were devided into two groups, oral ibupenta was administrated to one group and not to the other. The minimal erythema dose(MED) of each volunteer was measured with colorimeter. According to the individual's MED, 1 MED, 2 MED,and 3 MED of UVB was irradiated to the volunteer's back, the erythemas before and after the applying the topical agents were evaluated with naked eyes and colorimeter. In group I applied by 2.5% indomethacin, 0.25% desoxymethasone without oral ibupenta, erythemas tested with 2.5% indomethacin were statistically significantly supressed according to data measured by colorimeter. In group Ⅱ applied by 2.5% indomethacin, 0.25% desoxymethasone with oral Ibupenta, erythemas tested with 2.5% indomethacin and 0.25% desoxymethasone were statistically significantly supressed according to data measured by colorimeter. The maximal supression of UVB induced erythema was observed in 2.5% indomethacin with oral ibupenta. 'These data indicate that oral ibupenta, as an inhibitor of prostaglandin, is more effective than topical indometahcin or topical desoxymethasone in inhibition of UVB induced erythema. There is a synergistic effect between oral ibupenta and topical desoxymethasone. This result indicate that 2.5% indomethacin with oral ibupenta is useful therapy in acute UVB induced erythema within 24 hours. To evaluate the erythema, colorimeter is supposed to be more sensitive than naked eye score.

정상 피부와 과색소가 침착된 피부의 Melanin양과 Erythema양간의 상관성과 정량적 변화

윤영한 ( Young Han Yun ),김경란 ( Kyeong Ran Kim ),김용숙 ( Yong Sook Kim ),박보름 ( Bo Reum Park ),김기영 ( Ki Young Kim ) 한국미용학회 2009 한국미용학회지 Vol.15 No.3

Colors of human skin are a wide range and variety such as white, brown and black. Melanin and erythema play a important role for definition of skin color. The aim of the study is to assess the content and correlation between melanin and erythema in different body sites in skin. volunteers of males and females in twenties age group of korean were agreed with experiment and content of melanin and erythema on the face, back and abdomen of body were measured in range of 450-870nm by mexameter. The analysis of correlations was used by SPSS 11.0 program. In the result, the highest content of melanin was shown in abdomen of male (137.6~250.4AU) and female (112.2~224.0AU) group, but the highest erythema content of face appears in male (336.1~453.3AU). Melanin content of hyperpigmented skin is relative higher than erythema in compared with normal skin. Good correlation was observed not only in normal back skin of males and females (r=0.744, r=0.831) but also back and abdomen in hyperpigmented skin of males and females (r=0.826, r=0.974), in spite of very low correlation in face of males and females. And the level of melanin and erythema in different skins of twenties age group was shown relatively different values, and level of melanin was lower in face of females than males. So that melanin and erythema content revealed great individuality. In conclusion, primary data of melanin and erythema content in different body skins of korean could be collected. Cleansing and washing with cosmetics and/or soaps in face may be help depigmentation (alkali soluble eumelanin), and measurement of melanin content could be useful for hyperpigmentation parameter.

얼굴 홍반 환자에서 Peroxisome Proliferator Activated Receptor α (PPARα) 활성화제의 효과

김예슬 ( Ye Seul Kim ),정유리 ( You Lee Jung ),염종경 ( Jong Kyung Youm ),박준홍 ( Joon Hong Park ),배유인 ( You In Bae ),박영립 ( Young Lip Park ),이상훈 ( Sang Hoon Lee ) 대한피부과학회 2014 대한피부과학회지 Vol.52 No.9

Background: Long-term use of topical steroids for inflammatory skin diseases can induce complications, and efforts to find a better treatment are being continued. Peroxisome proliferator activated receptor α (PPARα) suppresses the skin``s inflammatory reaction, maintains the homeostasis of the skin, and plays an important role in skin barrier function. Objective: This study analyzed the effects of a skin moisturizer containing PPARα activator on various inflammatory skin diseases causing facial erythema and evaluated the observed improvements. Methods: The PPARa activator used for this study is composed of supercritical extracts from Euryale ferox, Euphorbia lathyris, and Rosa multiflora, which showed significant effects in the transactivation assay compared to Wy14643. Moisturizer containing PPARα was applied to the faces of 31 patients with symmetric facial erythema, with PPARα applied on one-half of the face and a control moisturizer on the other half of the face twice a day for 2 weeks. The percentage of erythema index, erythema index, skin hydration, and transepidermal water loss was checked to evaluate treatment effect. Both patients and clinicians each assessed the improvement of erythema on both sides of a patient``s face. Results: Moisturizer containing PPARα agonist significantly improved erythema index measured with Mexameter MX18(r) and percentage of erythema index by polarization color imaging system (DermaVision-PRO(r)) (p<0.05). However, there was no significant improvement in skin hydration and transepidermal water loss. Improvement of erythema was also shown on both the patient and clinician graded assessments. Conclusion: Topical PPARα agonist applied during clinical practice was relatively safe and effective. This can beapplied clinically to various inflammatory skin diseases causing erythema. (Korean J Dermatol 2014;52(9):608∼ 614)

P288 : The effect of PPARa activator containing moisturizer in patients with facial erythema

( Ye Seul Kim ),( Han Eul Lee ),( Gang Mo Lee ),( Je Min An ),( Young Lip Park ),( Moon Kyun Cho ),( Jong Kyung Youm ),( Sang Hoon Lee ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

Background: Atopic dermatitis, seborrheic dermatitis, irritant or allergic contact dermatitis, rosacea, and acne are skin diseases that cause repeated facial erythema. Topical steroids are used to treat these dermatologic condition and long term use of topical steroids can cause complication such as skin atrophy, telangiectasia, and steroid induced acneiform eruption. PPARα is known to regulate keratinocyte differentiation and proliferation, and also participates in wound healing and skin inflammation. Objectives: This study is about the effect of PPARα activator containing moisturizers in patients with facial erythema by improving anti-inflammatory action and skin barrier function. Methods: 32 patients were included in this study and they were applied with PPARα activator containing moisturizers in one side of the face, and the other side with moisturizers not containing PPARα activator. They were applied twice a day two days a week and the study was double blinded, body-split study. The patients were checked of skin hydration, TEWL, and erythema the first day of hospital visit and 2 weeks after the study. Clinical photo analysis was done for checking erythema index and the result was assessed with doctor and patient survey. Results: Patients applied with PPARα activator containing moisturizer showed significant decrease of erythema measurement using mexameter, and decreased erythema index from photo analysis. No significant difference was noted in skin hydration and TEWL. Conclusion: We confirmed the effect and safety of PPARα activator containing moisturizers and anticipate it as a useful treatment for patients with facial erythema.

Erythema severity scoring by deep neural network

( Chul Hwan Bang ),( Jae Yeon Rhu ),( Jae-heon Chun ),( Jae-woong Yoon ),( Sung Min Oh ),( Joonho Jung ),( Jun Young Lee ),( Young-joo Kim ),( Suk-jun Lee ),( Young Min Park ),( Ji Hyun Lee ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2

Background: Erythema is one of common signs of inflammatory dermatologic diseases. It is one of the measured values which are needed to calculate the Eczema Area and Severity Index score or Psoriasis Area and Severity Index score. However, automated standardization of erythema severity using images has not been investigated yet. Objectives: Our aim was to determine whether the deep convolutional neural networks (CNNs) could assess erythema severity at the level of competence comparable to dermatologists’ scoring. Methods: We made a standard dataset of 4,000 clinical images showing erythema. These images were scored 0 to 4 by three dermatologists. First of all, we trained four CNNs (ResNet V1, ResNet V2, GoogLnet and VGG-Net) with the image dataset, and then examined which CNN was most suitable for erythema scoring. Results: : Among the 4 CNNs, ResNet V1 showed the highest accuracy. Compared to dermatologists’ scoring, the accuracy rates of ResNet V1, ResNet V2, GoogLnet and VGG-Net were 95.33%, 95.12%, 93.59% and 21.55%, respectively. Conclusion: These results suggest some CNNs have a performance capacity for erythema scoring at the level of competence comparable to dermatologists.

FCT 4 : Comparison of fractional, non-ablative, 1550-nm laser and 595-nm, pulsed dye laser for the treatment of facial erythema resulting from acne: a Split-face, Evaluator-blinded, randomized pilot study

( Moo Yeol Hyun ),( Sun Young Choi ),( Kui Young Park ),( Kapsok Li ),( Seong Jun Seo ),( Chang Kwun Hong ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

Background: There are no reliable treatment guidelines for persistent post-inflammatory erythema resulting from acne (acne erythema). Objectives: We compared the effect and safety of a fractional, non-ablative, 1550-nm laser (fractional laser) and a 595-nm pulsed dye laser (PDL) for the treatment of acne erythema. Methods: Twelve Korean patients with facial erythema resulting from acne were enrolled in this pilot study. Sides of the face were randomized to receive treatment with a 1550-nm, erbium-glass fractional laser or a 595-nm PDL for a total of three treatments at four-week intervals. The assessment of effectiveness was mean change from baseline in mexameter scores and investigator and patient clinical assessments. The assessment of safety was based on the frequency of reported adverse events. After laser treatment, statistically significant improvements in erythema index from mexameter measurements. Results: Mean scores of investigator assessments were 3.42 ± 0.67 in fractional laser-treated sites and 3.33 ± 0.65 in PDL-treated sites. Patients assessed their improvement as good or excellent in 91.7% of fractional laser-treated sites and 75% of PDL-treated sites. No serious adverse events were observed with fractional or PDL laser. Conclusion: Both lasers are effective and safe modalities for the treatment of acne erythema; however, these data suggest better clinical efficacy with the use of a 1550-nm, erbiumglass fractional laser.

The efficacy and safety of intradermal botulinum toxin injection for the treatment of erythema and flushing of rosacea patients

( Min Jung Kim ),( Joo Ran Hong ),( Hye In Cheon ),( Min Seok Hur ),( Byung Gon Choi ),( Song Hee Han ),( Hae Jeong Youn ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2

Background: Botulinum toxin (BTX) has been used cosmetic purpose for more than a decade with good clinical efficacy and tolerable safety. Recently, there are reports that intradermal BTX could be effective in the treatment in facial erythema and skin rejuvenation. Objectives: This randomized, double-blinded, placebocontrolled, split-face study aimed to investigate the efficacy and safety of intradermal BTX on cheek in rosacea patients with facial erythema. Methods: This randomized, double-blinded, placebocontrolled, split-face study aimed to investigate the efficacy and safety of intradermal BTX on cheek in rosacea patients with facial erythema. Results: GAIS score by subjects and investigators were significantly higher in BTX-treated side. The erythema index decreased in the BTX-treated side at week 4 and week 8 and skin elasticity was improved in the BTX-treated side at week 2 and week 4. In addition, hydration of skin was also improved at week 2, week 4 and week 8. However, TEWL and melanin index did not show difference compare to the NS-treated side. Conclusion: Intradermal BTX injection improved not only erythema but also skin hydration level and elasticity. This study found that the intradermal BTX injection enable to reduce the erythema and rejuvenate the skin effectively and safely.

The Effect of Topical Indomethacin and Topical Corticosteroid on UVB Induced Erythema

Cho, Moon Kyun,Kim, Young Keun,Whang, Kyu Uang,Jung, Hyun Korean Dermatological Association 1995 Annals of Dermatology Vol.7 No.2