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얼굴 홍반 환자에서 Peroxisome Proliferator Activated Receptor α (PPARα) 활성화제의 효과
김예슬 ( Ye Seul Kim ),정유리 ( You Lee Jung ),염종경 ( Jong Kyung Youm ),박준홍 ( Joon Hong Park ),배유인 ( You In Bae ),박영립 ( Young Lip Park ),이상훈 ( Sang Hoon Lee ) 대한피부과학회 2014 대한피부과학회지 Vol.52 No.9
Background: Long-term use of topical steroids for inflammatory skin diseases can induce complications, and efforts to find a better treatment are being continued. Peroxisome proliferator activated receptor α (PPARα) suppresses the skin``s inflammatory reaction, maintains the homeostasis of the skin, and plays an important role in skin barrier function. Objective: This study analyzed the effects of a skin moisturizer containing PPARα activator on various inflammatory skin diseases causing facial erythema and evaluated the observed improvements. Methods: The PPARa activator used for this study is composed of supercritical extracts from Euryale ferox, Euphorbia lathyris, and Rosa multiflora, which showed significant effects in the transactivation assay compared to Wy14643. Moisturizer containing PPARα was applied to the faces of 31 patients with symmetric facial erythema, with PPARα applied on one-half of the face and a control moisturizer on the other half of the face twice a day for 2 weeks. The percentage of erythema index, erythema index, skin hydration, and transepidermal water loss was checked to evaluate treatment effect. Both patients and clinicians each assessed the improvement of erythema on both sides of a patient``s face. Results: Moisturizer containing PPARα agonist significantly improved erythema index measured with Mexameter MX18(r) and percentage of erythema index by polarization color imaging system (DermaVision-PRO(r)) (p<0.05). However, there was no significant improvement in skin hydration and transepidermal water loss. Improvement of erythema was also shown on both the patient and clinician graded assessments. Conclusion: Topical PPARα agonist applied during clinical practice was relatively safe and effective. This can beapplied clinically to various inflammatory skin diseases causing erythema. (Korean J Dermatol 2014;52(9):608∼ 614)
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