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Jun-Li Liu,Jing-Ting Sun,Hui-Lin Hu,Hao-Yuan Wang,Yun-Xi Kang,Tian-Qi Chen,Zhu-Hong Chen,Yu-Xuan Shang,Yu-Ting Li,Bo Hu,Rui Liu 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.1
A growing number of neuroimaging studies have revealed abnormal brain structural and functional alterations in subjects with internet addiction (IA), however, with conflicting conclusions. We plan to conduct a systematic review and meta-analysis on the studies of voxelbased morphometry (VBM) and resting-state functional connectivity (rsFC), to reach a consolidated conclusion and point out the future direction in this field. A comprehensive search of rsFC and VBM studies of IA will be conducted in the PubMed, Cochrane Library, and Web of Science databases to retrieve studies published from the inception dates to August 2021. If the extracted data are feasible, activation likelihood estimation and seed-based d mapping methods will be used to meta-analyze the brain structural and functional changes in IA patients. This study will hopefully reach a consolidated conclusion on the impact of IA on human brain or point out the future direction in this field.
Antimicrobial Aflatoxins from the Marine-Derived Fungus Aspergillus flavus 092008
Hui Wang,Wei-Ming Zhu,Zhenyu Lu,Hai-Jun Qu,Peipei Liu,Chengdu Miao,Tonghan Zhu,Jing Li,Kui Hong 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.8
A new aflatoxin, aflatoxin B2b (1), together with six known compounds, were isolated from the marine-derived fungus Aspergillus flavus 092008 endogenous with the mangrove plant Hibiscus tiliaceus (Malvaceae). The structure of 1 was determined by the spectroscopic and chemical methods. Compound 1 exhibited a moderate antimicrobial activity against Escherichia coli, Bacillus subtilis and Enterobacter aerogenes, with MIC values of 22.5, 1.7 and 1.1 μM, respectively. Compound 1 also showed a weak cytotoxicity against A549, K562 and L-02 cell lines, with IC50 values of 8.1, 2.0 and 4.2 μM, respectively. The results showed that hydration and hydrogenation of Δ8-double bond significantly reduces the cytotoxicity of aflatoxins, while the esterification at C-8 increases the cytotoxicity.
Limonoids from the roots of Trichilia sinensis and their cytotoxicities
Zhu-Nian Wang,Wen-Li Mei,Hui-Qin Chen,Jun Wang,Zhu-Nian Wang,Hao Fu Dai 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.12
Six new compounds (1–4, 8, 10), along with six known limonoids (5–7, 9, 11, 12), were isolated from the roots of Trichilia sinensis. Their structures were elucidated on the basis of extensive spectroscopic methods including 1H NMR, 13C NMR, DEPT, HSQC, HMBC, 1H–1H COSY and ROESY experiments, as well as by comparison with the literature. All the compounds were evaluated for cytotoxicities against K562, SGC-7901 and BEL-7402 cell lines. Compounds 2, 7, 10, 11, and 12 showed weak inhibitory activity to the selected cell lines.
Rich Se Nanoparticles Modified Mo-W18O49 as Enhanced Electrocatalyst for Hydrogen Evolution Reaction
Jun-hui Wang,Jia-Yao Tang,Jia-Yi Fan,Zeda Meng,Lei Zhu,오원춘 한국재료학회 2022 한국재료학회지 Vol.32 No.2
Herein a rich, Se-nanoparticle modified Mo-W18O49 nanocomposite as efficient hydrogen evolution reaction catalyst is reported via hydrothermal synthesized process. In this work, Na2SeSO3 solution and selenium powder are used as Se precursor material. The structure and composition of the nanocomposites are characterized by X-ray diffraction (XRD), high-resolution field emission scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), EDX spectrum analysis and the corresponding element mapping. The improved electrochemical properties are studied by current density, and EIS analysis. The as-prepared Se modified Mo-W18O49 synthesized via Na2SeSO3 is investigated by FE-SEM analysis and found to exhibit spherical particles combined with nanosheets. This special morphology effectively improves the charge separation and transfer efficiency, resulting in enhanced photoelectric behavior compared with that of pure Mo-W18O49. The nanomaterial obtained via Na2SeSO3 solution demonstrates a high HER activity and low overpotential of -0.34 V, allowing it to deliver a current density of 10 mA cm2.
Structurally Related Cytotoxic Effects of Flavonoids on Human Cancer Cells in Vitro
Chang, Hui,Mi, Mantian,Ling, Wenhua,Zhu, Jun-Dong,Zhang, Qianyong,Wei, Na,Zhou, Yong,Tang, Yong,Yuan, Jialin 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.9
Flavonoids exist extensively in the human diet, and a variety of health effects have been ascribed to them. The cytotoxic effects of 23 flavonoids on breast cancer cells (MDA-MB-231 and MCF-7), col-orectal carcinoma cells (LoVo and DLD-l) and prostatic cancer cells (PC3) were investigated. By comparing the cytotoxicity ($EC_{50}$) of selected molecules that differ in only one structure element, we identified several structural properties associated with enhanced cytotoxicity, including the presence of the 2,3-double bond, appropriate hydroxyl numbers, 3-OH, 6-OH and ortho-hydroxylation in ring B. Flavonoids with a 5-OH exhibited lower cytotoxicity than their non-hydroxylated counterparts. Results indicated that 3,6-dihydroxylflavone showed the most potent cytotoxic effect on these cancer cells. The appearance of apoptotic cells with DAPI staining was observed in cancer cells under 3,6-dihydroxylflavone treatment, and the apoptosis analysis by flow cytometry also showed that 3,6-dihydroxylflavone induced apoptotic cell death in these cancer cells. These results revealed the structurally related toxicity of flavonoids on human cancer cells, and indicates that 3,6-dihydroxylflavone is an active compound worthy of development for cancer chemotherapy.
Wang, Jun-Hui,Zeng, Yi-Kai,Gu, Hao,Zhu, Lei,Oh, Won-Chun Materials Research Society of Korea 2020 한국재료학회지 Vol.30 No.12
A facile microwave assisted solvothermal process is designed for fabricating SnS nanoparticles decorated on graphene nanosheet, which used as visible light driven photocatalyst. Some typical characterization techniques such as XRD, FT-IR, SEM with EDX analysis, and TEM and BET analysis are used to analyse the physical characteristics of as-prepared samples. Spherical SnS nanoparticles are uniformly dispersed on the surface of graphene nanosheet due to ammonia, which can prevent the aggregation of graphene oxide. Meanwhile, microwave radiation provides fast energy that promotes the formation of spherical SnS nanoparticles within a short time. The visible light photocatalytic activity of as-prepared SnS-GR nanocomposites is analysed through photodegradation efficiency of methylene blue with high concentration. According to the higher photocatalytic property, the as-prepared SnS-GR nanocomposites can be expected to be an efficient visible light driven photocatalyst. After five cycles for decolorization, the rate decreases from 87 % to 78 % (about 9 %). It is obvious that the photocatalytic activity of SnS-GR nanocomposite has good repeatability.
Review : Recovery Processes of Organic Acids from Fermentation Broths in the Biomass-Based Industry
( Qian Zhu Li ),( Xing Lin Jiang ),( Xin Jun Feng ),( Ji Ming Wang ),( Chao Sun ),( Hai Bo Zhang ),( Mo Xian ),( Hui Zhou Liu ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.1
The new movement towards green chemistry and renewable feedstocks makes microbial production of chemicals more competitive. Among the numerous chemicals, organic acids are more attractive targets for process development efforts in the renewable-based biorefinery industry. However, most of the production costs in microbial processes are higher than that in chemical processes, among which over 60% are generated by separation processes. Therefore, the research of separation and purification processes is important for a promising biorefinery industry. This review highlights the progress of recovery processes in the separation and purification of organic acids, including their advantages and disadvantages, current situation, and future prospects in terms of recovery yields and industrial application.
Seismic performance of Bujian Puzuo considering scale ratio and vertical load effects
Yong-Hui Jiang,Jun-Xiao He,Lei Zhu,Lin-Lin Xie,Shuo Fang 국제구조공학회 2024 Structural Engineering and Mechanics, An Int'l Jou Vol.90 No.5
This study investigated the influence of scale ratio and vertical load on the seismic performance of Puzuo joints in traditional Chinese timber structures. Three low-cyclic reversed loading tests were conducted on three scaled specimens of Bujian Puzuo in Yingxian Wooden Pagoda. This study focused on the deformation patterns and analyzed seismic performance under varying scale ratios and vertical loads. The results indicated that the slip and rotational deformations of Bujian Puzuo were the primary deformations. The scale of the specimen did not affect the layer where the maximum interlayer slip occurred, but it did decrease the proportion of slip deformation. Conversely, the reducing vertical load caused the layer with the maximum slippage and the position of the damaged Dou components to shift upward, and the proportion of slip deformation increased. When the vertical load was decreased by 3.7 times, the maximum horizontal bearing capacity under positive and negative loadings, initial stiffness, and energy dissipation of the specimen decreased by approximately 60%, 58.79%, 69.62%, and 57.93%, respectively. The horizontal bearing capacity under positive loading and energy dissipation of the specimen increased by 35.63% and 131.54%, when the specimen scale was doubled and the vertical load was increased by 15 times.
Roles of mTOR and p-mTOR in Gastrointestinal Stromal Tumors
Li, Jun-Chuan,Zhu, Hong-Yu,Chen, Ting-Xuan,Zou, Lan-Ying,Wang, Xiao-Yan,Zhao, Hui-Chuan,Xu, Jun Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10
Objective: This study aimed to examine the relationship between expression of mammal target of rapamycin (mTOR) and phosphorylation of mTOR (p-mTOR) protein in the PI3K/Akt/mTOR signaling pathways in gastrointestinal stromal tumors and relatiuonships with clinical factors. Methods: Immunohistochemistry was used to detect the expression of the associated proteins mTOR, p-mTOR, and phosphorylation of the tumor suppressor genes PTEN, P27, VEGF, and EGFR in 40 cases of gastrointestinal stromal tumors, with division into a very low and low risk group as well as a moderate and high risk group. Results: The positive rate of mTOR and p-mTOR was significantly increased in the moderate and high risk group compared with the very low and low risk group. The difference was statistically significant (P<0.05). When grouped according to size, the positive mTOR expression rate exhibited a statistical difference (P<0.05), which was significantly increased in the group of tumors larger than 5 cm. The difference in the positive mTOR and p-mTOR expression rate exhibit no statistical significance among the PTEN, P27, VEGF, and EGFR expression subgroups (P>0.05). Conclusion: The different expressions of mTOR and p-mTOR in the signal transduction pathway of gastrointestinal stromal tumor in the different degree-of-risk groups suggested that the mTOR and p-mTOR of the signal transduction pathway serve an important function in the occurrence and development of gastrointestinal stromal tumors.
Percutaneous catheter drainage for abscess after surgery
Wen-Bo Zhu,Xiao-Hui Zhao,Hai-Liang Li,Chen-Yang Guo,Quan-Jun Yao,Xiang Geng,Ke Zhao,Hong-Tao Hu 소화기인터벤션의학회 2022 International journal of gastrointestinal interven Vol.11 No.4
Percutaneous abscess drainage (PAD) has been proven to be a safe, effective, and widely used technique for the treatment of patients with abscesses after gastrointestinal surgery. The indications for PAD are expanding and most postoperative abscesses of the gastrointestinal tract are susceptible to PAD. PAD uses various imaging methods, including ultrasound, computed tomography, and several safe and reliable catheter insertion methods.