Study of the Flow Behavior and Defect Formation in Forming of Axisymmetrically Flanged and Multi-Scaled Parts

Ji Lai Wang,Ming Wang Fu,Junxi Yu,Xing Wang,Wenbin Yang 한국정밀공학회 2016 International Journal of Precision Engineering and Vol.17 No.10

In microforming, the quality of microparts is one of the most critical issues. Folding caused by the abnormal material flow is one of the most common flow-induced defects in macroforming process. The identified formation mechanism of flow-induced defects in macro-forming process could be affected by the so-called size effects when the part dimension is scaled down to micro scale. Therefore, it is necessary to investigate the influence of size effects on the material plastic flow and deformation behavior in multiscaled deformation scenarios. To explore the formation mechanism of flow-induced defects, FE simulation is used to simulate the forming process. On the other hand, the multi-scaled forming was designed. To study the relationship of the flow-induced defect and sizes effects, forming of the axisymmetric parts with flanged features and different scales was conducted. The microstructure and plastic flow behavior of the deformed parts are also revealed. Based on the experimental and FEM simulation results, the formation of folding defects is mainly affected by the geometries and the sizes of the deformed flanged parts instead of grain sizes. In the cases by using material with coarse grains, the folding defect can be significantly reduced.

Transiting Exoplanet Monitoring Project (TEMP). IV. Refined System Parameters, Transit Timing Variations, and Orbital Stability of the Transiting Planetary System HAT-P-25

Wang, Xian-Yu,Wang, Songhu,Hinse, Tobias C.,Li, Kai,Wang, Yong-Hao,Laughlin, Gregory,Liu, Hui-Gen,Zhang, Hui,Wu, Zhen-Yu,Zhou, Xu,Zhou, Ji-Lin,Hu, Shao-Ming,Wu, Dong-Hong,Peng, Xi-Yan,Chen, Yuan-Yuan Astronomical Society of the Pacific 2018 Publications of the Astronomical Society of the Pa Vol.130 No.988

A Micro Cutter Auto-Alignment System with On-Machine Positioning Error Measurement and Compensation Methods

Shih-Ming Wang,Ji-Jun Lin,Zhe-Zhi Ye,Shambaljamts Tsooj,Chun-Chieh Wang 한국정밀공학회 2014 International Journal of Precision Engineering and Vol. No.

To perform an accurate micro machining process, accurate alignment of the micro cutter with respect to the local coordinate frame for machining is essential. Due to the fragility of the micro tool, traditional cutter alignment method used in industry is no longer proper for micro machining. Utilizing machine vision technology with 2 CCDs, a micro tool positioning error measurement and auto-compensation method and system were proposed. In the measurement method, Power Law Method was first used to enhance the image taken by a CCD. Canny Edge Method and image projection method were then used to identify the contours of the cutter and the workpiece from the image. Finally, the position errors of the cutter were determined through calculating the number of pixels between the cutter and the workpiece. The proposed error compensation system can automatically generate NC codes which will accurately re-locate the cutter based on the measured position errors . Experiments were conducted on a micro machine tool, and the results have shown that the y-dir. positioning error of the cutter was significantly improved from -0.025 mm to 0.001 mm, and the total machining error was reduced from -0.02 mm to -0.001 mm.

Analysis of TRRAP as a Potential Molecular Marker and Therapeutic Target for Breast Cancer

Ji Wang,Ming Shan,Tong Liu,Qingyu Shi,Zhenbin Zhong,Wei Wei,Da Pang 한국유방암학회 2016 Journal of breast cancer Vol.19 No.1

Purpose: This study was designed to assess the protein levels of transformation/transcription domain-associated protein (TRRAP) in invasive ductal breast carcinomas, and investigated the association between TRRAP and the clinicopathological features of breast cancer. Methods: We examined TRRAP protein expression in 470 breast cancer tissues and normal breast tissues by tissue microarray to study the correlation between TRRAP expression and clinicopathological features. This was analyzed using the chi-square test. Kaplan-Meier survival curves and log-rank tests were applied to analyze the survival status. Cox regression was applied for multivariate analysis of prognosis. Results: The data demonstrated that expression of TRRAP was significantly lower in breast carcinomas (36.6%) than in corresponding normal breast tissues (50.8%). In addition, TRRAP protein levels negatively correlated with tumor size, and indicated poor differentiation, increased nodal involvement, and low p53-positive rates. Analysis of survival revealed that lower TRRAP expression correlated with shorter survival time. Univariate analyses identified TRRAP and progesterone receptor as independent protective factors for breast cancer prognosis. However, Ki-67, tumor size, and nodal involvement appeared to be independent risk factors. Conclusion: The findings indicate a significant correlation between TRRAP protein levels and adverse prognosis in breast cancer. Therefore, TRRAP could be a prognostic biomarker for breast cancer. In addition, TRRAP is also a predictive biomarker of breast cancer treatment.

Synergistic Effect of 3A Zeolite on The Flame Retardant Properties of Poplar Plywood Treated with APP1

Ming Zhi Wang,Hai Ping Ji,Li Li 한국목재공학회 2015 목재공학 Vol.43 No.2

To evaluate the influence of 3A zeolite on the flame retardant properties of poplar plywood. Ammonium polyphosphate (APP) and 3A zeolite were used as flame retardants to prepare plywood samples. The combustion properties, such as heat release rate (HRR), total heat release (THR), mean CO and CO2 yield, smoke production rate (SPR), and total smoke production (TSP), were characterized by a cone calorimeter. A synergistic effect was observed between 3A zeolite and APP on reducing the HRR and mean CO yield. The probable flame retardation mechanism was proposed.

Contribution of Macrophage Migration Inhibitory Factor -173G/C Gene Polymorphism to the Risk of Cancer in Chinese Population

Wang, Cheng-Di,Li, Tai-Ming,Ren, Zheng-Ju,Ji, Yu-Lin,Zhi, Liu-Shou Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.11

Background: Macrophage migration inhibitory factor (MIF) -173G/C (rs755622) gene polymorphism has been associated with cancer risk. Previous studies have revealed that MIF -173G/C gene polymorphism may increase cancer in the Chinese population, while results of individual published studies remain inconsistent and inconclusive.We performed this meta-analysis to derive a more precise estimation of the relationship. Materials and Methods: We conducted a search on PubMed, Embase, MEDLINE, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI), Wanfang, Weipu on Dec 31, 2014.Odds ratio (OR) and 95% confidence interval (95% CI) were used to assess the association. A total of eight studies including 2,186 cases and 2,285 controls were involved in this meta-analysis. Results: The pooled results indicated the significant association between MIF -173G/C polymorphism and the risk of cancer for Chinese population (CC + CG vs GG: OR=1.14, 95%CI=1.02-127, pheterogeneity<0.01; P=0.023; CC vs CG+GG: OR=1.12, 95%CI=1.02-1.23, pheterogeneity<001; P=0.017;CC vs GG: OR=1.18, 95%CI=1.04-1.33, pheterogeneity<001; P=0.008; CG vs GG:OR=1.03, 95%CI=0.91-1.15, pheterogeneity<001; P=0.656; C vs G:OR=1.24, 95%CI=1.14-1.25, pheterogeneity<001; P<001). Subgroup analysis showed that in patients with "solid tumors", heterogeneity was very large (OR=0.94,95%CI=0.83-1.06,pheterogeneity=0.044; p=0.297). Within "non-solid tumors", the association became even stronger (OR=6.62, 95 % CI=4.32-10.14, pheterogeneity<0.001; p<0.001). Conclusions: This study suggested that MIF -173G/C gene polymorphism may increase increase cancer in the Chinese population.Furthermore, more larger sample and representative population-based casees and well-matched controls are needed to validate our results.

Associations of TNF-RII rs1061622 With Post-Traumatic Stress Disorder and Their Interplays on Serum Lipids Levels in Adolescents

Ji Cheng Zhang,Jin Hua Wang,Jun Yi Liu,Qi Wei Guo,Jia Lin,Yi Lin Shen,Ke Xin Jia,Jia Jing Cai,Guo Ming Su,Ding Zhi Fang 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.11

Objective To verify effects of rs1061622 at tumor necrosis factor-α receptor II (TNF-RII) gene (<i>TNF-RII</i>) on post-traumatic stress disorder (PTSD) and its interactive effects with PTSD on serum lipids levels in adolescents.Methods PTSD was measured by PTSD Checklist-Civilian Version (PCL-C) in 699 adolescent survivors at 6 months after Wenchuan earthquake in China. A polymerase chain reaction and restriction fragment length polymorphism assay were utilized for <i>TNF-RII</i> rs1061622 genotyping followed by verification using DNA sequencing. Serum triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol were tested using routine methods.Results G (deoxyguanine) allele carriers had higher PCL-C scores than TT (deoxythymidine) homozygotes in female subjects. Female adolescents had higher PCL-C scores than male subjects in TT homozygotes. Predictors of PTSD prevalence and severity were different between G allele carriers and TT homozygotes. Subjects with PTSD had lower TG, TG/HDL-C, TC/HDL-C, and higher HDL-C than adolescents without PTSD in male G allele carriers. G allele carriers had higher TG/HDL-C and TC/HDL-C than TT homozygotes in male adolescents without PTSD, and lower TG and TG/HDL-C in male PTSD patients. G allele carriers had higher TG than TT homozygotes only in female adolescents without PTSD.Conclusion These results suggest reciprocal actions of <i>TNF-RII</i> rs1061622 with other factors on PTSD severity, interplays of <i>TNF-RII</i> rs1061622 with PTSD on serum lipid levels, and novel treatment strategies for PTSD and comorbidities of PTSD with hyperlipidemia among adolescents with different genetic backgrounds of <i>TNF-RII</i> rs1061622 after experiencing traumatic events.

Adaptive polymorphism of tetrameric alpha-amylase inhibitors in wild emmer wheat

Ji-Rui Wang,Mei Deng,Ya-Xi Liu,Xin Qiao,Zhen-Hong Chen,Qian-Tao Jiang,Zhi-En Pu,Yu-Ming Wei,Eviatar Nevo,You-Liang Zheng 한국유전학회 2011 Genes & Genomics Vol.33 No.4

α-Amylase inhibitors are attractive candidates for the control of seed weevils as these insects are highly dependent on starch as an energy source. Wheat tetrameric α-amylase inhibitor (WTAI) is a mixture (60 kDa) of 3 units: WTAI-CM2 plus 2 WTAI-CM3 plus WTAI-CM16, where none of the subunits is active on its own. A total of 334 gene sequences were obtained from 14 populations (131 accessions= genotypes) of wild emmer wheat. The frequencies of SNPs in WTAI-CM2,WTAI-CM3 and WTAI-CM16 were 1 out of 87.6, 101.4, and 108.0 bases, where 5, 5 and 4 SNPs were detected in the coding sequence, respectively. The nucleotide sequence of each unit of tetrameric α-amylase inhibitors were much more conserved than that of dimeric or monomeric inhibitors. The wild emmer wheat populations showed diversity on three WTAI loci,both between and within populations. It was revealed that WTAI were naturally selected for across populations by a ratio of dN/dS as expected. The results of purifying and positive selection hypothesis (p<0.05) also showed that the sequences of WTAI were contributed by natural selection, which ensures the protein function conservation as well as the inhibition diversity with insects amylase enzyme. Ecological factors, singly or in combination, explained a significant proportion of the variations in the SNPs. Ecological factors have an important evolutionary role in gene differentiation at these loci, and tetrameric α-amylase inhibitors are obviously adaptively selected under different environments.

Comparison of Primary Breast Cancer Size by Mammography and Sonography

Wang, Jian-Tao,Chang, Li-Ming,Song, Xin,Zhao, Li-Xin,Li, Jun-Tao,Zhang, Wei-Guo,Ji, Ying-Bin,Cai, Li-Na,Di, Wei,Yang, Xin-Yu Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.22

Purpose: To compare tumor size by mammography and sonography and align with pathological results in primary breast cancer cases. Materials and Methods: We retrospectively reviewed 95 primary breast cancer patients who underwent mammography and sonography from January 2011 to June 2012. The largest tumor diameter was chosen as sizing reference for each imaging modality. The measurements of mammography and sonography were considered concordant if they were within the measurement of pathological results ${\pm}0.5cm$. Pearson's correlation coefficient was calculated for imaging results. Results: The range of the maximum diameter was 0.6cm-10.5cm and mean value was $3.81{\pm}2.04cm$ by pathological results, 0.7cm-12.4 cm and $3.99{\pm}2.19cm$ by mammography, and 0.9cm-11.0cm and $3.63{\pm}2.01cm$ by sonography, respectively. Sonography (R: 0.754), underestimated tumor size, but had a better correlation with pathological tumor size compared to mammography (R: 0.676), which overestimated tumor size. Conclusions: Sonography is superior to mammography in assessment of primary breast cancer.

Mechanism Analysis and Stabilization of Three-Phase Grid-Inverter Systems Considering Frequency Coupling

Wang, Guoning,Du, Xiong,Shi, Ying,Tai, Heng-Ming,Ji, Yongliang The Korean Institute of Power Electronics 2018 JOURNAL OF POWER ELECTRONICS Vol.18 No.3

Frequency coupling in the phase domain is a recently reported phenomenon for phase locked loop (PLL) based three-phase grid-inverter systems. This paper investigates the mechanism and stabilization method for the frequency coupling to the stability of grid-inverter systems. Self and accompanying admittance models are employed to represent the frequency coupling characteristics of the inverter, and a small signal equivalent circuit of a grid-inverter system is set up to reveal the mechanism of the frequency coupling to the system stability. The analysis reveals that the equivalent inverter admittance is changed due to the frequency coupling of the inverter, and the system stability is affected. In the end, retuning the bandwidth of the phase locked loop is presented to stabilize the three-phase grid-inverter system. Experimental results are given to verify the analysis and the stabilization scheme.