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윤복연,문덕환,박명희,황용식,함성애,손병철,김대환,이창희,김휘동,이채언 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.5
Objective : This study was conducted to prepare the fundamental data on heavy metal concentration in hair permanents agents and to prevent the health impairment due to heavy metal. Methods and Material : The author determined of 5 heavy metals(Pb, Cr, Mn, Ni, and Cu) concentration hair permanent agents in the market with flameless atomic absorption spectrophotometer. Results : The results were as follows: 1. The geometic mean concentrations of total subjects were 0.04㎍/g for Pb, 0.09㎍/g for Cr, 0.06㎍/g for Mn, 0.03㎍/g for Ni, and 0.04㎍/g for Cu. 2. The most highest mean concentrations of heavy metals in hair permanent agents by using type were Cr for wave agent and straight cream agent, Cu for setting iron agent, Cr and Cu for coating perm agent. 3. Metal most hlghest mean concentrations of heavy in hair permanent agents by type of color was green for Cu. 4. The mean concentration of Cu among 5 heavy metals in hair permanent agents by marker was most highest. 5. There was most statistically significant difference on mean concentration in hair permanent agents between domestic and foreign products. 6. The exposure amount of heavy metal concentration by one time using the permanent agent were 4.O㎍ for Pb, 9.O㎍ for Cr, 6.0㎍ for Mn, 3.O㎍ for Ni and 4.0㎍ for Cu. Conclusion : As above results author suggest to prepare the preventive program of health impairment due to heavy metal by long term chronic exposure to who were using the hair permanent agents hair designer and customers.
치료경험이 있는 A형 혈우병 환자에서 그린모노^�의 약동학 및 안전성 : 전향적 다기관 공동 임상시험
윤휘중,이순용,황태주,손영택 德成女子大學校 藥學硏究所 2001 藥學論文誌 Vol.12 No.1
배 경 : 최근 국내에서 사용 가능해 진 단클론항체를 이용한 고순도의 제 8응고인자 그린모노^R에 대하여, 제품의 약동학적 측면을 관찰하고, 급성 이상반응 발생 측면의 안전성을 관찰하고자 하였다. 방 법 : 과거 응고인자 치료경험이 있는 제 8응고인자치 5% 미만의 A 형 혈우병 환자를 대상으로, 그린모노를 체중 1kg당 50units 정맥주사한 후 약물역동학적 분석을 시행하였다. 약물 투여 후 48시간까지 이상반응을 관찰하고, 약물투여 전 및 48시간 까지 이상반응을 관찰하고, 약물투여 전 및 48시간 후에 일반혈액 검사, 혈액생화학검사, 요검사 등을 측정하여 비교하였다. 제8응고인자 억제인자를 Bethesda assay를 이용하여 투여 전 및 투여 3~7일 후 검사하였다. 결 과 : 15명의 환자중 연구를 완료한 13명의 자료를 분석하였다. Recovery rate는 99±22%(범위, 71~ 136%) 였으며, 2-compartment model을 이용한 beta phase의 반감기는 15.7±6.6시간(범위, 9.7~35.9시간)이었다. 그린모노^ R 투여후 의미있는 이상반응은 없었으며, 검사성적의 의미있는 변화도 발견할 수 없었다. 제8응고인자 억제인자는 시험약 투여 전후 모두 0.6 BU 미만으로 유지되었다. 결 론: 그린모노^R는 약동학적으로 유효하고, 급성이상 반응이 없어, 임상 이용에유용하리라 생각한다.
( Hwi Young Kim ),( Yoon Jun Kim ),( Jeong Hoon Lee ),( Su Jong Yu ),( Jung Hwan Yoon ),( Hyo Suk Lee ),( Chung Yong Kim ),( Jae Youn Cheong ),( Sung Won Cho ),( Neung Hwa Park ),( Byung Lae Park ),( 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background: Hepatitis B virus (HBV) infection is the predominant risk factor for chronic hepatitis B (CHB), liver cirrhosis, and hepatocellular carcinoma. Recently, several genome- wide association studies (GWAS) of chronic hepatitis B (CHB) identified human leukocyte antigen (HLA) loci, including HLA-DP and HLA-DQ in Asian populations, as being associated with the risk of CHB. To confirm and identify the host genetic factors related to CHB infection, we performed another GWAS using a higher-density chip in Korean CHB carriers. Methods: We analyzed 1,400 samples from Korean population (400 CHB cases and 1,000 population controls) using a higherdensity GWAS chip (1,140,419 SNPs). In subsequent replication analysis, we further analyzed in an independent study of a Korean CHB cohort consisting of 2,909 Korean samples (971 cases and 1,938 controls). Logistic regression methods were used for statistical analysis adjusting age and sex as covariates. Results: This study identified two new risk-associated loci for CHB on the HLA region of chromosome 6, e.g., rs652888 on euchromatic histone-lysine methyltransferase 2 (EHMT2, P = 7.07 × 10-13) and rs1419881 on transcription factor 19 (TCF19, P= 1.26 × 10-18). (Fig.1) Conditional analysis with nearby HLA CHB loci that were previously known, confirmed the independent genetic effects of these two loci on CHB. Conclusions: Genome-wide association study and subsequent validation study identified new variants associated with the risk of chronic hepatitis B. These findings may advance the understanding of genetic susceptibility to CHB.
YOON, JUNG HWAN,PARK, JONG KYUNG,KANG, YOUNG HWI,PARK, YONG KYU,NAM, SUK WOO,LEE, JUNG YOUNG,PARK, WON SANG Blackwell Publishing Ltd 2011 APMIS Vol.119 No.11
<P>Yoon JH, Park JK, Kang YH, Park YK, Nam SW, Lee JY, Park WS. Lysyl oxidase G473A polymorphism is closely associated with susceptibility to gastric cancer in a South Korean population. APMIS 2011; 119: 762–8.</P><P>The aim of this study was to determine whether a single nucleotide polymorphism at G473A (rs1800449) within the <I>LOX‐propeptide</I> is associated with susceptibility to gastric cancer. We investigated the genotype and allele frequencies of this gene in tissue specimens from 458 gastric cancer patients and 282 healthy individuals. Polymorphism analysis was performed by amplifying the propeptide region of <I>LOX</I> and digestion with <I>Not</I>I followed by sequencing of the products. The frequencies of the <I>LOX</I> G473A G/G, G/A, and A/A genotypes were 54.4% (249/458), 34.3% (157/458), and 11.3% (52/458), respectively, in gastric cancer patients and 58.9% (166/300), 35.5% (100/282), and 5.7% (16/282), respectively, in the healthy controls. Statistically significant differences in the genotype and allele frequency of <I>LOX</I> rs1800449 were observed between the healthy controls and gastric cancer patients (p = 0.0294 and p = 0.0339). When the data were stratified according to gastric cancer histologic subtype, the risk of diffuse‐type gastric cancer in carriers with an A allele (G/A or A/A genotypes) was statistically higher compared to that of carriers with the G/G genotype (p = 0.0001). Our findings suggest that G473A polymorphism of the <I>LOX</I> gene may be closely associated with susceptibility to the development and differentiation of gastric cancer in South Korean patients.</P>
A case of pneumatosis cystoides intestinalis induced by sunitinib
( Yong Suk Lee ),( Chi Hoon Maeng ),( Jae Jun Han ),( Sun Kyung Baek ),( Si-young Kim ),( Hwi-joong Yoon ) 대한내과학회 2015 대한내과학회 추계학술발표논문집 Vol.2015 No.1
Pneumatosis cystoides intestinalis (PCI) is a rare condition characterized by air-filled cysts within intestinal wall. It has been known that various clinical situations such as enteritis, infection, ileus and drugs have been responsible to PCI, although the exact etiology is not elucidated yet. We report the first case of PCI, to the best of our knowledge, that was induced by sunitinib. A 68-year old female who was diagnosed of unresectable, well differentiated pancreatic neuroendocrine tumor of WHO grade II. She was treated with sunitinib since January 2015. After 3 months of sunitinib treatment, she complained of watery diarrhea. Colonoscopic finding was normal. After a brief period of improved diarrhea, she came back to hospital due to severe diarrhea over a week. The abdomen was severely distended and abdominal CT showed diffuse gas-filled cystic formation along with distal ileal loop and colon mimicking pneumoperitoneum. The patient did not complain of abdominal pain, tenderness, rebound tenderness or fever. Chronic enteritis and diarrhea by sunitnib persisted more than 2 months, and could result in damage of bowel mucosa repeatedly. Intraluminal bowel gas can enter via mucosal defect of the bowel wall and cause extensive gas-filled cysts within the walls. We have to know the various range of side effects of targeted therapy since it was introduced into medical oncology recently and we could encounter unknown and unexpected adverse events from the therapy.