항갑상선제로 치료한 그레이브스병 환자의 관해예측인자

남일송,윤여일,김선규,김용현,이주영,목지오,윤석기,김철희,김영선,변동원,서교일,유명희 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background: Most cases of Graves' disease have been treated by antithyroid drugs in Korea. The major drawbacks of antithyroid drugs are the relative high rate of relapse and the inconvinience of long term therapy. Measurement of TBII and TRH stimulation test have been considered as the most reliable tests predicting relapse, but the predictive power is not high enough to use in clinical situation. This study was performed to find good prognostic indicators in Graves' disease patients after the discontinuation of antithyroid drug therapy. Subjects and methods : We restrospectively evaluated 96 patients with Graves' disease who showed normal TRH test at the end of antithyroid drug therapy and were followed for more than one year. Serum T3, T4, T3/T4 ratio, TBII, Anti-TPO Ab and TGAb levels were measured at the time of diagnosis and at the end of therapy. Two to three months after withdrawal of antithyroid medication, serum TSH and free T3 responses to TRH were examined. These parameters were compared between the relapse group and the remission group. Results : Among the 96 patients, 22 patients(22.9%) relapsed(Group Ⅱ) and 74 patients(77.1%) remained in remmision(Group Ⅰ). No significant difference was observed between the relapse and the remission group in clinical parameters, serum T3, T4, TSH, T3/T4 ratio, TBⅡ and Anti-TPO Ab determined before and after treatment. Serum TSH and free T3 levels measured after TRH stimulation were also similar in both groups. Serum TGAb levels determined at the end of treatment were significantly higher in the remission group(p<0.05). Relapse following the discontinuation of therapy occured within 24 months in 72.7% of the relapsed cases. After 24 months, relapse rate was reduced significantly. Conclusion : These results suggest that high serum TGAb levels could be a favorable prognostic indicator for the long term remission of Graves' disease treated with antithyroid drugs, and may suggest that Hashimoto's thyroiditis is combined with Graves' disease in those patients.

성격요인과 아동기 부모-자녀결합형태 및 가족환경과의 관련성에 관한 연구

김용관,이중용,한농교 大韓神經精神醫學會 1994 신경정신의학 Vol.33 No.1

Various theories of personality and psychopathology say that early experiences with the parents significantly influence later personality development and psychopathology. However, there has been relatively little research investigating into this relationship. In order to investigate the relations among personality factors, parent-child bonding patterns and family environment in childhood, the authors administered 16 Personality Factor Questionnaire, Parental Bonding Instrument, and questionnaire for demographic data to 398 healthy university students. The results were summarized as follows: 1) Male subjects show higher scores in imagination(M) and lower in liberalism(Q1) than female subjects. Maternal age at birth of subjects is positively correlated with self-control(Q3) and superego(SUP), and negatively with anxiety(ANX). 2) Male subjects show higher scores in maternal care than female, and levels of parental education are positively correlated with parental care. The sibling number is negatively correlated with materanl overprotection. 3) Ego Strength(C), superego(G), self-control(Q3), superego(SUP) is positively correlated with parental care and negatively correlated with parental overprotection. Surgency(F), shrewdness(N), extraversion(EXT), independence(IND) have similar tendencies. Guilt-proneness(O), anxiety(Q4), anxiety(ANX) is positively correlated with parental overprotection and negatively with parental care. Warmth(A) is correlated with paternal bonding, suspiciousness(L) is correlated with maternal bonding pattern, and self-sufficiency(Q2) in negatively correlated with parental care. 4) Groups classified by parental bonding pattern indicate that optimal group(Group Ⅰ) is correlated with more positive aspects of personality factors, and the affectionless control (Group Ⅳ) is correlated with more negative aspects of personality factors. These results support the hypothesis that early parent-child relationships and family environment influence on later personality development. Further studies with more controlled design are needed to confirm our results.

구강내 결손부에 적용된 연조직 재건술식들에 대한 임상적 고찰

김욱규,이승환,황대석,김용덕,신상훈,김종렬,정인교 부산대학교 병원 암연구소 2007 부산대병원학술지 Vol.- No.21

To evaluate criteria, indications, and prognosis of the various reconstructive methods on the patients with intraoral soft tissue defect who had been treated at Dept. of Oral and Maxillofacial Surgery, Pusan National University Hospital from 2003 to 2005, we have reviewed the clinical data of the patients and analysed. The results were as follows: 1. Tongue flaps have been mainly applied on anterior portion of palate and maxilla. The survival rate was high percent, but the cooperation of patient was inevitable for the success. 2. Palatal mucosa rotational flaps were available on relative large defect on palate, oroantral fistula site. The side effect was a scaring band from secondary healing on denuded donor palate site. Sometimes the band came to be a hinderance to swallowing, phonation. 3. The application of free skin graft on entire maxilla site , palate was possible. The skin from thigh, abdomen could be applicable on fixed or movable tissues. The advantages of abdominal skin were easy harvest and direct donor site closure. 4. Forearm free flap was a workhorse flap for everywhere in intraoral defects. We had used the flap on cheek, floor of mouth, tongue without any significant complications. But the application of the flap was required for long operation time, which was disadvantageous to the old, weak patients. 5. Cervical platysmal flap could be easily applicable for buccal cheek, floor of mouth after excision of the cancer lesion. the design of the flap could be made simultaneously on neck dissection, but the danger of cancer remnants on the flap always might be remained. 6. Buccal fat pad pedicled flap must have been a primary flap for repair of oroantral fistula especially on posterior maxilla. The flap survival will be expected if the considerations for above reconstructivε methods on site, size, condition of defects primarily could be made.

공공 건설공사 중 부도에 따른 공사지연 방지 방안 : Focused on Apartment Houses

김백용,조영준,구교진,현창택 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1

The purpose of this study was to reduce the factor of construction delay in the owner's aspect by analyzing the actual condition of field supervision positively such as construction delay sample and process at the distressed company's construction site. As we analyze the examples of construction delay and reopening into various types, to minimize construction delay after the dishonor of a contractor we propose "Cooperation and reliance fixing between the contract parties through the improvement of order method, Contracting system and Construction management system".

국내 공공부문 설계시공일괄입찰방식의 낙찰자 선정방법 개선에 관한 연구

김만철,서용철,구교진,현창택 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1

Design-Build is considered as the project delivery system to manage construction process more efficiently than design-bid-build. So Korea government has encouraged Design-Build in public sector. But single selection method of weighted criteria doesn't provide the greatest value to owner. Therefore, there is a need to improve selection method to meet owner's needs and project characteristics. This study proposes four types of selection method. Each of selection method is focused on price, qualification, time. The use of these selection methods enable owner to provide the greatest value.

Casein micelle의 구조와 성질

김영교 高麗大學校自然資源科學硏究所 1993 自然資源科學硏究 Vol.1 No.-

This review is an attempt to bring what is known about casein micelles together into a coherent sum-mary. The casein micelles of milk are the colloidal particles of casein camplex, and dispersed in milk with forming a colloidal phase. The nature of the casein micelles has been investignated in many labo-ratories, and with good reason, for this colloidal complex is the essence of many problems encoun-tered in dairy technology. The attempt is, therefore, made to summarize the camposition of casein mice-lles, some properties of individual caseins and calloidal-calcium phosphate, and inter-action between casein micelle components which is the forces res-ponsible for the stability of the casein micelles. On the other hand, many models for casein micelles. On the other hand, many models for casein micelle structure are proposed, however, some of the ear-lier models and theories no longer appear workable. In this review, a few models are selectively intro-duced and discussed.

청소년의 무도수련이 개인과 가족가치관에 미치는 영향

김의영,김교준,오세용 龍仁大學校 武道硏究所 2001 武道硏究所誌 Vol.12 No.1

The purpose of this study was to investigate the effects of Martial Arts training on building the juvenile personal value system, nation value system, and colleague value system. For the design of this study, the hypothetical model of study method was used and the questionnaire was distributed around the area of Seoul and Kyunggido. Total of 1,200 subjects answered on the survey asking about the participation on the training of Martial Arts, the kinds of Martial Arts, the period and its duration of training, the frequency of participation, and the companion. The results of this study were as follows: First, the juveniles who participated on the Martial Arts training showed the positive and active attitudes toward their success as well as their birth. Second, the juveniles who participated on the Martial Arts training showed the progressive trend toward the filial piety, traditional ethics, social ethics, and sexual ethics.

약물치료에 순응도가 낮은 마취고위험군의 전립선비대증에서 TUNA의 임상적 경험

성용완,최은용,김덕교 大韓泌尿器科學會 2001 Korean Journal of Urology Vol.42 No.10

구강내 악성흑색종에 대한 임상연구

김욱규,허진호,황대석,김용덕,신상훈,김종렬,정인교 부산대학교 병원 암연구소 2008 부산대병원학술지 Vol.- No.23

The prognosis of oral malignant melanoma is poor compared with cutaneous melanoma. It may be related to the difficulty of wide enough resection, the early hematogenous matastases, higher stage at initial diagnosis, tendency to growth vertically. In the view of histological differences between oral mucosa and skin, it is impossible use Clark’s and Breslow’s classifications for prognosis. The great problem is that there is still no consensus on the treatment due to rarity. Because data collection from case reports is considered to be the best source of information and should be pooled to anlalyze key determinants of outcome, We reported on 6 cases of primary malignant melanoma of the oral cavity which were diagnosed and treated in Pusan National University Hospital recently and reviewed the literature. Immunohistochemical study on S100 Protein, GP 100 (HMB-45) with biopsy was usable to confirm the melanoma. Neck dissection including wide excision is recommended if lymph node involvement is suspected. Additionally, adjuvant chemotherapy could be supporting therapy.

악안면 영역에서의 유리 전완피판술 적용례분석

김욱규,송원욱,황대석,김용덕,신상훈,김종렬,정인교 부산대학교 병원 암연구소 2009 부산대병원학술지 Vol.- No.25