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      • CUSTOMER ENGAGEMENT IN VIRTUAL TOURISM COMMUNITIES: MEDIATING CUSTOMER IDENTIFICATION AND PURCHASING BEHAVIORS

        Xiaoyun Han,Lianlian Hua,Lin Hu 글로벌지식마케팅경영학회 2018 Global Marketing Conference Vol.2018 No.07

        Despite the increasing attention to customer engagement (CE) by practitioners and academics, extant studies have largely been restricted to conceptualized relationships without empirical testing (So, King, & Sparks, 2014). Drawing on social identity theory and social exchange theory, this study develops a research model delineating the relationship between customer identification (CI), CE and customer purchasing behaviors in virtual communities. The model was tested with structural equation modeling and survey data from 513 members of two virtual tourism communities. Results indicate that both customer-community identification and customer-customer identification (constituting two classifications of CI) have directly positive effect on customer engagement attitude, on which the duration of membership in a community has a moderating effect. Additionally, customer-customer identification influences customer engagement behavior directly and positively, of which customer engagement attitude is the psychological foundation. Finally, customer engagement attitude and customer engagement behavior will promote customers’ purchasing behaviors. The contribution of this paper is that CE has been empirically validated to compose of customer engagement attitude and customer engagement behavior these two separate variables, and CI is testified to be an antecedent rather than a dimension of CE, in line with the standpoints proposed by Algesheimer, Dholakia, and Herrmann (2005).Through the current investigation, empirical studies into the concept connotation and formation mechanism of CE are enriched, and the insight into customer behavior management and CE marketing is intensified.

      • KCI등재

        Feature Engineering Method Using Double-Layer Hidden Markov Model for Insider Threat Detection

        Xiaoyun Ye,Sung-Sam Hong,Myung-Mook Han 한국지능시스템학회 2020 INTERNATIONAL JOURNAL of FUZZY LOGIC and INTELLIGE Vol.20 No.1

        In the past, most Hidden Markov models based on time series only used the original HMM model. The single-layer models (HMMs) structure has a big problem, and it isn’t straight-forward to play its due role when it is necessary to make fine adjustments to the scene. So it was impossible to entirely and flexibly perform user behavior. This paper performs feature extraction and analysis of user behavior data of time series. The data labels should be added after the parameters obtained by statistical methods for clustering to obtain the first hidden state, and the layers are further layered according to working hours and outside working hours. The experimental results show that the method has strong applicability and flexibility, and can quickly detect abnormal behavior.

      • Kinetics of Levulinic Acid Produced from Glucose Using Modified HZSM-5

        Xiaoyun Li,Lifei Yao,Lijie Jiang,Min Liang,Yu Qiu,Yuyang Tian,Shujun Han,Chuanling Si,Youngsoo Bae 강원대학교 산림과학연구소 2018 강원대학교 산림과학연구소 학술대회 Vol.2018 No.09

        Levulinic acid is a valuable platform chemical which could be used as raw material to synthesis various chemicals and fuels. In this work, citric acid modified HZSM-5 and aluminum ion modified HZSM-5 were prepared and used in the production of levulinic acid from glucose. The modified HZSM-5 was characterized by XRD, SEM, FTIR, BET, TG and pyridine FTIR. The Brønsted acid sites density of citric acid modified HZSM-5 was higher than aluminum ion modified HZSM-5. More importantly, the kinetics of levulinic acid production catalyzed by citric acid modified HZSM-5 and aluminum ion modified HZSM-5 were investigated, respectively. The Saeman model was applied to predict the concentration of levulinic acid, and the values calculated by the model agreed well with the experimental data. The rate of production of levulinic acid with citric acid modified HZSM-5 was higher than that of aluminum ion modified HZSM-5. The model supplied a profound understanding in the conversion of glucose into levulinic acid with modified H-ZSM-5 zeolite.

      • KCI등재

        액체/액체 계면에서 테트라사이클린 전이반응의 전기화학적 분석 및 응용

        리우샤오원 ( Xiaoyun Liu ),한혜연 ( Hye Youn Han ),고은서 ( Eunseo Goh ),이혜진 ( Hye Jin Lee ) 한국공업화학회 2017 공업화학 Vol.28 No.5

        편극화된 물/1,2-dichloroethane (1,2-DCE) 계면에서 이온화가 가능한 테트라사이클린(tetracycline, TC) 화학종 전이 반응을 순환전압전류법과 시차펄스전위법을 이용하여 조사하였다. 물의 pH 변화에 따라 전하 상태가 다른 TC 이온 화학종이 물/1,2-DCE 계면에서 전이하는 전위 값을 측정하여 TC 이온의 상 분배 도표를 얻었다. 이를 통해 각 pH에 따라 수용액 또는 유기 용액 층에서 좀 더 우세한 TC 이온 화학종 형태를 확인하였다. 이와 함께 상기 계면에서 TC 전이반응의 형식 전이 전위, 분배 계수 및 Gibbs 에너지 값을 포함한 열역학적 정보를 얻었다. 또한 TC 이온을 정량 분석가능한 센서로 제작하기 위해 고분자 박막에 단일 마이크로 홀을 만들고 유기성의 polyvinylchloride-2-nitropheny-loctylether(PVC-NPOE) 젤을 도포하여 물/젤 계면을 형성하였다. 물/1,2-DCE 계면에서 TC 이온의 전이 반응과 매우 유사하게 수용액의 pH가 4.0일 때 TC 이온의 농도 변화에 따라 전류 값이 증가하는 것을 순환전압전류법으로 관찰하였다. 시차펄스벗김전위법을 이용하여 상기 물/젤 계면에서 완충 수용액에 존재하는 TC 화학종을 5 μM까지 검출할 수 있었으며, 5 μM에서 30 μM까지 정량분석 할 수 있었다. The transfer reaction characteristics of tetracycline (TC) across a polarized water/1,2-dichloroethane (1,2-DCE) interface was studied via controlling both pH and ionic strength of the aqueous phase in conjunction with cyclic and differential pulse voltammetries. Formal transfer potential values of differently charged TC ionic species at the water/1,2-DCE interface were measured as a function of pH values of the aqueous solution, which led to establishing an ionic partition diagram for TC. As a result, we could identify which TC ionic species are more dominant in the aqueous or organic phase. Thermodynamic properties including the formal transfer potential, partition coefficient and Gibbs transfer energy of TC ionic species at the water/1,2-DCE interface were also estimated. In order to construct an electrochemical sensor for TC, a single microhole supported water/polyvinylchloride- 2-nitrophenyloctylether (PVC-NPOE) gel interface was fabricated. A well-defined voltammetric response associated with the TC ion transfer process was achieved at pH 4.0 similar to that of using the water/1,2-DCE interface. Also the measured current increased proportionally with respect to the TC concentration. A 5 μM of TC in pH 4.0 buffer solution with a dynamic range from 5 μM to 30 μM TC concentration could be analyzed when using differential pulse stripping voltammetry.

      • SCIESCOPUSKCI등재

        Morphological, Physiological and Biochemical Responses of Gerbera Cultivars to Heat Stress

        Wen Chen,Xiaoyun Zhu,Weiqing Han,Zheng Wu,Qixian Lai 한국원예학회 2016 원예과학기술지 Vol.34 No.1

        Heat stress is an agricultural problem for Gerbera jamesonii, and it often causes poor seedling growth, reduced flower yield and undesirable ornamental characteristics of flowers. However, little is known about the effect of heat stress on the morphological, physiological and biochemical characteristics of gerbera plants. Here, the responses of six cultivars of Gerbera jamesonii to heat stress were investigated. Under a 1-d heat treatment at 45°C, the leaves of gerbera cultivars showed yellowing, wilting, drying and death to varying degrees. The heat treatment also resulted in increased electrical conductivity, decreased soluble protein and chlorophyll contents, and the accumulation of malondialdehyde (MDA) and proline in leaves. Moreover, heat tolerance differed among the six tested gerbera cultivars. Our results demonstrated that among the six gerbera cultivars, ‘Meihongheixin’ is a heat-resistant cultivar, whereas ‘Beijixing’ is a heatsensitive one. ‘Shijihong’ and ‘Linglong’ are relatively heat-resistant cultivars, and ‘Dadifen’ and ‘Taiyangfengbao’ are relatively heat sensitive.

      • SCIESCOPUSKCI등재

        Morphological, Physiological and Biochemical Responses of Gerbera Cultivars to Heat Stress

        Chen, Wen,Zhu, Xiaoyun,Han, Weiqing,Wu, Zheng,Lai, Qixian Korean Society of Horticultural Science 2016 원예과학기술지 Vol.34 No.1

        Heat stress is an agricultural problem for Gerbera jamesonii, and it often causes poor seedling growth, reduced flower yield and undesirable ornamental characteristics of flowers. However, little is known about the effect of heat stress on the morphological, physiological and biochemical characteristics of gerbera plants. Here, the responses of six cultivars of Gerbera jamesonii to heat stress were investigated. Under a 1-d heat treatment at $45^{\circ}C$, the leaves of gerbera cultivars showed yellowing, wilting, drying and death to varying degrees. The heat treatment also resulted in increased electrical conductivity, decreased soluble protein and chlorophyll contents, and the accumulation of malondialdehyde (MDA) and proline in leaves. Moreover, heat tolerance differed among the six tested gerbera cultivars. Our results demonstrated that among the six gerbera cultivars, 'Meihongheixin' is a heat-resistant cultivar, whereas 'Beijixing' is a heat-sensitive one. 'Shijihong' and 'Linglong' are relatively heat-resistant cultivars, and 'Dadifen' and 'Taiyangfengbao' are relatively heat sensitive.

      • KCI등재

        Exosomes from adipose-derived stem cells overexpressing Nrf2 accelerate cutaneous wound healing by promoting vascularization in a diabetic foot ulcer rat model

        Xue-Li Zhou,Xiaoyun Xie,Weishuai Lian,Rongfeng Shi,Shilong Han,Haijun Zhang,Ligong Lu,Maoquan Li 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-

        Diabetic foot ulcers (DFU) increase the risks of infection and amputation in patients with diabetes mellitus (DM). The impaired function and senescence of endothelial progenitor cells (EPCs) and high glucose-induced ROS likely exacerbate DFUs. We assessed EPCs in 60 patients with DM in a hospital or primary care setting. We also evaluated the therapeutic effects of exosomes secreted from adipose-derived stem cells (ADSCs) on stress-mediated senescence of EPCs induced by high glucose. Additionally, the effects of exosomes and Nrf2 overexpression in ADSCs were investigated in vitro and in vivo in a diabetic rat model. We found that ADSCs that secreted exosomes promoted proliferation and angiopoiesis in EPCs in a high glucose environment and that overexpression of Nrf2 increased this protective effect. Wounds in the feet of diabetic rats had a significantly reduced ulcerated area when treated with exosomes from ADSCs overexpressing Nrf2. Increased granulation tissue formation, angiogenesis, and levels of growth factor expression as well as reduced levels of inflammation and oxidative stress-related proteins were detected in wound beds. Our data suggest that exosomes from ADSCs can potentially promote wound healing, particularly when overexpressing Nrf2 and therefore that the transplantation of exosomes may be suitable for clinical application in the treatment of DFUs.

      • KCI등재

        Recent advances in extracellular vesicles for therapeutic cargo delivery

        김효인,Park Jinbong,Zhu Yin,Wang Xiaoyun,Han Yohan,Zhang Duo 생화학분자생물학회 2024 Experimental and molecular medicine Vol.56 No.-

        Exosomes, which are nanosized vesicles secreted by cells, are attracting increasing interest in the field of biomedical research due to their unique properties, including biocompatibility, cargo loading capacity, and deep tissue penetration. They serve as natural signaling agents in intercellular communication, and their inherent ability to carry proteins, lipids, and nucleic acids endows them with remarkable therapeutic potential. Thus, exosomes can be exploited for diverse therapeutic applications, including chemotherapy, gene therapy, and photothermal therapy. Moreover, their capacity for homotypic targeting and self-recognition provides opportunities for personalized medicine. Despite their advantages as novel therapeutic agents, there are several challenges in optimizing cargo loading efficiency and structural stability and in defining exosome origins. Future research should include the development of large-scale, quality-controllable production methods, the refinement of drug loading strategies, and extensive in vivo studies and clinical trials. Despite the unresolved difficulties, the use of exosomes as efficient, stable, and safe therapeutic delivery systems is an interesting area in biomedical research. Therefore, this review describes exosomes and summarizes cutting-edge studies published in high-impact journals that have introduced novel or enhanced therapeutic effects using exosomes as a drug delivery system in the past 2 years. We provide an informative overview of the current state of exosome research, highlighting the unique properties and therapeutic applications of exosomes. We also emphasize challenges and future directions, underscoring the importance of addressing key issues in the field. With this review, we encourage researchers to further develop exosome-based drugs for clinical application, as such drugs may be among the most promising next-generation therapeutics.

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