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Comparative Evaluation of Animal Models for Atopic Dermatitis in NC/Nga Mice
Jun-Won Yun,Hyuk Kim,Hyun-Jin Kang,Jae-Young Koh,Bae-Hwan Kim 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.1
Atopic dermatitis is a chronic and relapsing inflammatory skin disease accompanied by severe itching. Recently, animal models of atopic dermatitis, including NC/Nga mouse and hapten-induced mouse model, have received increasing attention. This study was designed to compare four mouse models for atopic dermatitis: 2,4-dinitrochlorobenzene (DNCB) short-term model, DNCB long-term model, dermatophagoides farina (Df) model, and dermatophagoides pteronyssinus (Dp) model. Repeated application of DNCB, Df, and Dp induced chronic skin inflammation, including thickening of the epidermis with marked hyperkeratosis and parakeratosis, and elevated the serum IgE levels compared than normal mice. Therefore, we suggested that 4 models induce not only AD-like skin lesions but also Th2-dominated immune responses in NC/Nga mice maintained under SPF conditions. Application of DNCB also evoked the increase in number of hindlimb scratching in short-term and long-term model. However, in both Df model and Dp model, there was no significant difference in number of hindlimb scratching between Dp- or Df-treated mice and control mice. The scratching frequency and serum immunoglobulin E (IgE) level in DNCB long-term model are higher than those of DNCB short-term model. Moreover, in DNCB long-term model, an increase in degranulating cutaneous mast cells, together with an increase in serum histamine level, was observed in DNCB-treated mice. And, interleukin-4 (IL-4) in the splenic T cell culture supernatants significantly increased in DNCB-treated mice. Consequently, considering all results, NC/Nga mice model developed through repeated long-term treatment of DNCB may be a good model for studying atopic dermatitis.
Multicenter retrospective analysis of patients with chronic lymphocytic leukemia in Korea
Jun Ho Yi,이경원,이지현,Kwai Han Yoo,Chul Won Jung,Dae Sik Kim,Jeong-Ok Lee,Hyeon Seok Eom,Ja Min Byun,Youngil Koh,Sung Soo Yoon,Jin Seok Kim,Jee Hyun Kong,Ho-Young Yhim,Deok Hwan Yang,Dok Hyun Yoon,Do Hyou 대한혈액학회 2021 Blood Research Vol.56 No.4
Background Chronic lymphocytic leukemia (CLL) is the most common type of adult leukemia in Western countries but is rare in the East Asian countries. Due to its rarity and the lack of feasible novel agents and laboratory prognostic tools, there are limited data on the clinical outcomes of this disease in Asia. To clarify the current treatment status, we performed a multicenter retrospective analysis of patients with CLL in Korea. Methods The medical records of 192 eligible patients between 2008 and 2019 were reviewed for clinical characteristics, treatment courses, and outcomes. The first-line treatment regimens of the patients included in this analysis were as follows: fludarabine/cyclophosphamide/ rituximab (FCR) (N=117, 52.7%), obinutuzumab plus chlorambucil (GC) (N=30, 13.5%), and chlorambucil monotherapy (N=24, 10.8%). Results The median progression-free survival (PFS) was 55.6 months, and the average 2-year PFS rate was 80.3%. PFS was not significantly different between the patients receiving FCR and those receiving GC; however, chlorambucil treatment was associated with significantly inferior PFS (P <0.001). The median overall survival was 136.3 months, and the average 5- and 10-year OS rates were 82.0% and 57.4%, respectively. Conclusion This is one of the largest studies involving Korean patients with CLL. Although the patients had been treated with less favored treatment regimens, the outcomes were not different from those reported in Western studies.
Role of PET/CT Scan and Brain MRI in Patients with Ground-glass Opacity Lung Nodules
( Jun Whi Song ),( Jae Uk Song ),( Kyung Jong Lee ),( Kyeong Man Jeon ),( Won Jung Koh ),( Gee Young Suh ),( Man Pyo Chung ),( Ho Joong Kim ),( O Jeong Kwon ),( Sang Won Um ) 대한결핵 및 호흡기학회 2011 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.112 No.-
( Won Uk Koh ),( Sung Hoon Kim ),( Bo Young Hwang ),( Woo Jong Choi ),( Jun Gul Song ),( Jeong Hun Suh ),( Jeong Gill Leem ),( Jin Woo Shin ) 대한통증학회 2011 The Korean Journal of Pain Vol.24 No.2
Background: Facet joint disease plays a major role in axial low-back pain. Few diagnostic tests and imaging methods for identifying this condition exist. Single photon emission computed tomography (SPECT) is reported that it has a high sensitivity and specificity in diagnosing facet disease. We prospectively evaluated the use of bone scintigraphy with SPECT for the identification of patients with low back pain who would benefit from medial branch block. Methods: SPECT was performed on 33 patients clinically suspected of facet joint disease. After SPECT, an ultrasound guided medial branch block was performed on all patients. On 28 SPECT-positive patients, medial branch block was performed based on the SPECT findings. On 5 negative patients, medial branch block was performed based on clinical findings. For one month, we evaluated the patients using the visual analogue scale (VAS) and Oswestry disability index. SigmaStat and paired t-tests were used to analyze patient data and compare results. Results: Of the 33 patients, the ones who showed more than 50% reduction in VAS score were assigned ``responders``. SPECT positive patients showed a better response to medial branch blocks than negative patients, but no changes in the Oswestry disability index were seen. Conclusions: SPECT is a sensitive tool for the identification of facet joint disease and predicting the response to medial branch block. (Korean J Pain 2011; 24: 81-86)
( Jun Young Park ),( Moon Seok Choi ),( Young Suk Lim ),( Jang Won Park ),( Seung Up Kim ),( Yang Won Min ),( Geum Youn Gwak ),( Yong Han Paik ),( Joon Hyoek Lee ),( Kwang Cheol Koh ),( Seung Woon Pai The Editorial Office of Gut and Liver 2014 Gut and Liver Vol.8 No.1
Background/Aims: Inflammatory pseudotumor (IPT) of the liver is a rare disease characterized by chronic infiltration of inflammatory cells. However, the clinical characteristics and outcomes of IPT remain uncertain. Methods: Clinical features, image findings, and outcomes of 55 patients with histologically proven IPT were evaluated. Results: They consisted of 26 men and 19 women with median age of 65 years. Serum carcinoembryonal antigen and carbohydrate antigen 19-9 levels were normal in 42 patients (93.3%). Enhanced CT scans indicated poorly defined peripheral enhancement (82.5%) at the arterial phase and poorly defined hyperattenuating lesions with internal hypoattenuating areas at the equilibrium phase (77.0%). Gadolinium-enhancement MRI revealed poorly defined peripheral rim-like enhancement (77.8%). Ten patients underwent surgical resection and 35 were treated conservatively with or without antibiotics. No recurrence was noted after surgical resection during follow-up (1 to 48 months). In all patients who received conservative treatment, complete resolution or size reduction was noted during follow-up (1 to 192 months). Conclusions: CT and MRI provide clues to the diagnosis of IPT in patients with liver masses and normal tumor markers. However, due to the lack of pathognomonic findings, the clinician`s suspicion and histological diagnosis are necessary to make an accurate diagnosis of IPT. (Gut Liver 2014,8:58-63)