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Yang, Deok-Hwan,Kim, Mi-Hyun,Lee, Youn-Kyung,Hong, Cheol Yi,Lee, Hyun Ju,Nguyen-Pham, Thanh-Nhan,Bae, Soo Young,Ahn, Jae-Sook,Kim, Yeo-Kyeoung,Chung, Ik-Joo,Kim, Hyeoung-Joon,Kalinski, Pawel,Lee, Je-J Springer International 2011 Annals of hematology Vol.90 No.12
<P>For wide application of a dendritic cell (DC) vaccination in myeloma patients, easily available tumor antigens should be developed. We investigated the feasibility of cellular immunotherapy using autologous alpha-type 1-polarized dendritic cells (관DC1s) loaded with apoptotic allogeneic myeloma cells, which could generate myeloma-specific cytotoxic T lymphocytes (CTLs) against autologous myeloma cells in myeloma patients. Monocyte-derived DCs were matured by adding the 관DC1-polarizing cocktail (TNF관/IL-1관/IFN-관/IFN-관/poly-I:C) and loaded with apoptotic allogeneic CD138(+) myeloma cells from other patients with matched monoclonal immunoglobulins as a tumor antigen. There were no differences in the phenotypic expression between 관DC1s loaded with apoptotic autologous and allogeneic myeloma cells. Autologous 관DC1s effectively took up apoptotic allogeneic myeloma cells from other patients with matched subtype. Myeloma-specific CTLs against autologous target cells were successfully induced by 관DC1s loaded with allogeneic tumor antigen. The cross-presentation of apoptotic allogeneic myeloma cells to 관DC1s could generate CTL responses between myeloma patients with individual matched monoclonal immunoglobulins. There was no difference in CTL responses between 관DC1s loaded with autologous tumor antigen and allogeneic tumor antigen against targeting patient's myeloma cells. Our data indicate that autologous DCs loaded with allogeneic myeloma cells with matched immunoglobulin can generate potent myeloma-specific CTL responses against autologous myeloma cells and can be a highly feasible and effective method for cellular immunotherapy in myeloma patients.</P>
레거시 시뮬레이터를 활용한 FLIGHTLAB<SUP>®</SUP> 모델 기반의 조종성 평가 환경 설계 연구
양창덕(Chang Deok Yang),이승덕(Seung Deok Lee),조환희(Hwan Heui Cho),정동우(Dong Woo Jung) 한국항공우주학회 2016 韓國航空宇宙學會誌 Vol.44 No.6
고-신뢰도 모델을 이용한 조종성 평가 시뮬레이션 환경은 비행제어시스템의 설계/평가에 필수적으로 요구된다. 한국항공우주산업㈜에서는 소형민수헬기 핵심기술 개발과 관련하여 자동비행조종장치 소프트웨어 개발과제를 수행 중에 있으며 제어법칙 설계를 위한 비행동역학 모델 및 해석을 위해 상용 도구인 FLIGHTLAB을 이용하고 있다. 본 연구에서는 기존에 개발된 레거시 시뮬레이터를 FLIGHTLAB 모델과 연동하고 이를 조종성 평가에 활용한 내용을 다루었다. 본 논문에서는 외부 연동을 위한 FLIGHTLAB 모델의 설정, 연동프로그램 개발 및 연동 방안에 대한 내용을 수록하였다. 또한 본 논문에서는 레거시 시뮬레이터와의 연동을 통해 ADS-33E-PRF의 호버 및 pirouette MTE 기동비행을 수행하고 평가 결과를 수록하였다. The handling quality simulator including high fidelity flight mechanics model is indispensable component to design and verify the flight control system. Korea Aerospace Industries, LTD. (KAI) has been performing LCH (Light Civil Helicopter) core technology development program regarding automatic flight control system (AFCS) software development. And KAI has been developing flight mechanics model using FLIGHTLAB to design and evaluate the AFCS flight control law. This paper presents the handling quality assessment environment development results through the combining FLIGHTLAB with a legacy simulator. And this paper details the FLIGHTLAB model, application development process and FLIGHTLAB interface design. The developed handling quality assessment environment has been demonstrated with the ADS-33E hover and pirouette MTE (Mission Task Element) maneuver simulation.
Yang, Seung-Hwan,Lee, Chun-Gu,Lee, Won-Kyu,Ashtiani, Alireza Araghi,Kim, Joon-Yong,Lee, Sang-Deok,Rhee, Joong-Yong Korean Society for Agricultural Machinery 2012 바이오시스템공학 Vol.37 No.1
Purpose: Utilizing air thermal energy during over-heated time in the greenhouse is a necessary component to save greenhouse heating costs for nighttime. However, there is no practical way to implement the related principles. Methods: In this study, a heating and cooling system which utilizes the surplus air thermal energy in a greenhouse was developed. Available air thermal energy and heating load for this experimental glasshouse were estimated based on temperature conditions of the plant growth and weather data. Results: Estimated values were 400 MJ/day for maximum surplus air thermal energy and 340 MJ/day for maximum heating energy which were target values of the design as well. The system consists of a heat pump, fan-coil units and heat storage tanks which are divided into low and high temperature tanks. Moreover, a new control logic was developed for surplus air thermal energy utilization. Conclusions: This paper explains the details of conceptual design process of the system. Results of test operations showed that the developed system performed the recovery and supply of the thermal energy according to design purposes.