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Jingwei Shang,Toru Yamashita,Yusuke Fukui,Dongjing Song,Xianghong Li,Yun Zhai,Yumiko Nakano,Ryuta Morihara,Nozomi Hishikawa,Yasuyuki Ohta,Koji Abe 대한신경과학회 2018 Journal of Clinical Neurology Vol.14 No.1
Background and Purpose Cognitive and cerebrovascular diseases are common in the elderly, but differences in the plasma levels and associations of plasma biomarkers in these diseases remain elusive. Methods The present study investigated differences in plasma fatty acids [eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)], adiponectin, reptin, plasma markers of inflammation [high-sensitivity C-reactive protein (hsCRP) and serum amyloid A (serum AA)], and plasma lipids [high-density lipoprotein and low-density lipoprotein (LDL)] in patients with Alzheimer’s disease (AD) (n=266), mild cognitive impairment (MCI) (n=44), vascular dementia (VaD) (n=33), and ischemic stroke (IS) (n=200) in comparison to normal controls (n=130). Results The serological data showed that lower EPA and DHA levels and higher reptin and LDL levels were associated with AD and IS, the reptin/adiponectin ratio was strongly associated with IS, the hsCRP level was more strongly associated with VaD and IS, and the serum AA level was associated with all three cognitive diseases and IS. Conclusions This is the first report of differences in the expression levels of plasma biomarkers and peripheral arterial tonometry among AD, MCI, VaD, and IS patients and normal controls. These different associations indicate that diverse pathological mechanisms underlie these diseases
( Kuni Shiina ),( Shinpei Yamashita ),( Yuta Tezuka ),( Hiroko Sakurai ),( Hisanori Gamada ),( Toru Yoshida ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Iwate Prefectural Senmaya Hospital (Senmaya Hospital) adjoins the coastal area where seriously damaged by the Tsunami on 2011.3.11. From the disaster, we are working as the second-line hospital. We perform this study to verify the role of the second-line hospital of tsumami disaster, for taking better steps to deal with the future disasters. Methods: The data was obtained from patient record of Senmaya Hospital and assessed. Results: The patient surge started on the day of the tsunami. Overall 136 patients from tsunami swept area (60% from Iwate Prefecture and 40% from Miyagi Prefecture, next to Iwate) was admitted to Senmaya Hospital within 1 month after the disaster. Temporally, the number of inpatients decreased on 16th, the next day of the restoration of electricity, but increased again. The average inpatient per month was 1.0-1.8 fold (average 1.3) compared with that of the previous year (before tsunami). The highest number of the inpatients was found in February 2012, the coldest month in the fi rst winter. Then cost-free pneumococcus vaccination was introduced to the population more than 65 years old. The rate of pneumonia on admission and discharge by death were signifi cantly decreased from 2012-2013 winter. Conclusions: The second-line hospital must receive many patients immediately after the disaster and continuously accept the excess of the inpatients at least 1 year. The pneumococcus vaccination was effective to decrease admission and hospital death by pneumonia. The second-line hospital should store additional space, equipments and goods for the immediate and continuous excess of the patients.
Ozone Generation Properties of Screw electrode Ozonizer by Different Outer Electrodes
Fujishima, Tomoyuki,Kawaguchi, Toru,Amano, Takanobu,Yamashita, Takahiko 대한전기학회 2014 The Journal of International Council on Electrical Vol.4 No.3
Methyl bromide which is most popular disinfectant of soil has been prohibited from using except for an indispensable use by 2015. Therefore we pay attention to ozone as a substitute of the methyl bromide for soil sterilization, because the ozone is easily generated by dielectric barrier discharges. We have been developing an ozone generation system which is suitable to the soil sterilization and also investigating the soil sterilization with the generated ozone. So we are investigating influences of ozone generation characteristic on the screw electrode ozonizer by changing of outer electrodes, applied voltages, and flow rates of source gases. This time, in order to investigate the influence of the outer electrode form on ozone generation properties, we used two different outer electrodes; the single electrode of 11cm width and 3-divided-electrodes of $1cm{\times}3$(electrode spaces of 4cm). As results, maximum values of the ozone concentration, the ozone yield and the ozone generation efficiency were obtained when the electrode of 11cm was used for the outer electrode.
임호,Lkhagvadorj Shagdarsuren,김승모,Akihiro Hoshino,Toru Yamashita,전충환 대한기계학회 2016 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.30 No.3
Coal is an important energy source whose consumption increases continuously. One of the many ways to use coal is coal blending, which is a very effective technique in power stations. However, coal blending generates unsuspected problems, one of which is ash deposition that causes slagging and fouling. In fact, most blends accelerate and generate heavier ash depositions than their parent coals. This work investigates the characteristics of ash behavior including fusibility and deposition when blending both bituminous and subbituminous coals in a pulverized coal combustion. Two coals used in Japan were used for this study: bituminous (Bit-A) and subbituminous coal (Sub-A). In order to investigate, the blending ratio was changed. A Thermomechanical analysis (TMA) and a Drop tube furnace (DTF) were used for ash fusibility and deposit, respectively. Ash components were determined using X-ray fluorescence at the coal research center of Idemitsu Kosan Co., Ltd., in Japan. These tests revealed that as the blending ratio of Sub-A increased, fusibility in the TMA and the melting propensity increased. Capture efficiency and energy-based growth increased with the blending ratio, and were highest at 80%. Finally, a new approach based on the relation between ash fusibility and deposit derived for predicting adhesion tendency on blended coals was created by deriving the relation between the fusibility and deposit results that affected slag formation.
Usefulness of the Endotoxin Activity Assay to Evaluate the Degree of Lung Injury
Yuichiro Sakamoto,Satoshi Inoue,Takashi Iwamura,Tomoko Yamashita,Atsushi Nakashima,Hiroyuki Koami,Toru Miike,Mayuko Yahata,Hisashi Imahase,Akiko Goto,Showgo Narumi,Miho Ohta,Chris-Kosuke Yamada 연세대학교의과대학 2014 Yonsei medical journal Vol.55 No.4
Purpose: It has been reported that the Pulse Contour Cardiac Output (PiCCO) is very useful mainly in the field of intensive care and treatment to grasp the pathophysiologicalconditions of pulmonary edema because of its capability of obtainingdata such as Pulmonary Vascular Permeability Index (PVPI) and Extra VascularLung Water (EVLW). Furthermore, a high degree of usability of various markers has been reported for better understanding of the pathological conditions in cases with septicemia. Materials and Methods: The correlation between the cardiorespiratory status based upon the PiCCO monitor (EVLW and PVPI) and inflammatorymarkers including C reactive protein, procalcitonin (PC), and EndotoxinActivity Assay (EAA) were evaluated in 11 severe cases that required treatmentwith a respirator in an intensive care unit. Results: The EAA values were significantly higher in patients with abnormal EVLW at 0.46±0.20 compared to the normal EVLW group at 0.21±0.19 (p=0.0064). In a similar fashion, patients with abnormal PVPI values tended to have higher PC levels at 18.9±21.8 comparedto normal PVPI cases at 2.4±2.2 (p=0.0676). On the other hand, PVPI was significantly higher in the abnormal EAA group at 3.55±0.48 in comparison with the normal EAA group at 1.99±0.68 (p=0.0029). The abnormal EAA group tended to have higher PVPI values than the normal EAA group. Conclusion: The EAA is a measurement method designed to estimate the activity of endotoxins in the whole blood. Our results suggest that the EAA value, which had the greatest correlationwith lung disorders diagnosed by the PiCCO monitoring, reflects inflammatoryreactions predominantly in the lungs.
Yasuhiro Shiga,Go Kubota,Sumihisa Orita,Kazuhide Inage,Hiroto Kamoda,Masaomi Yamashita,Toru Iseki,Michihiro Ito,Kazuyo Yamauchi,Yawara Eguchi,Takeshi Sainoh,Jun Sato,Kazuki Fujimoto,Koki Abe,Hirohito 대한척추외과학회 2017 Asian Spine Journal Vol.11 No.3
Study Design: Controlled laboratory study. Purpose: This study aimed to evaluate the efficacy of platelet-rich plasma (PRP) stored at room temperature (RT), frozen, or after freeze-drying. Overview of Literature: PRP enriches tissue repair and regeneration, and is a novel treatment option for musculoskeletal pathologies. However, whether biological activity is preserved during PRP storage remains uncertain. Methods: PRP was prepared from blood of 12 healthy human volunteers (200 mL/person) and stored using three methods: PRP was stored at RT with shaking, PRP was frozen and stored at –80°C, or PRP was freeze-dried and stored at RT. Platelet counts and growth factor content were examined immediately after preparation, as well as 2, 4, and 8 weeks after storage. Platelet activation rate was quantified by flow cytometry. Results: Platelet counts were impossible to determine in many RT samples after 2 weeks, but they remained at constant levels in frozen and freeze-dried samples, even after 8 weeks of storage. Flow cytometry showed approximately 80% activation of the platelets regardless of storage conditions. Almost no growth factors were detected in the RT samples after 8 weeks, while low but significant expression was detected in the frozen and freeze-dried PRP. Over time, the mean relative concentrations of various growth factors decreased significantly or disappeared in the RT group. In the frozen group, levels were maintained for 4 weeks, but decreased significantly by 8 weeks (p <0.05). The freeze-dried group maintained baseline levels of growth factors for the entire 8-week duration. Conclusions: Freeze-drying enables PRP storage while maintaining bioactivity and efficacy for extended periods.
Takanori Masuda,Takeshi Nakaura,Yoshinori Funama,Tomoyasu Sato,Toru Higaki,Masao Kiguchi,Yoriaki Matsumoto,Yukari Yamashita,Naoyuki Imada,Kazuo Awai 대한영상의학회 2018 Korean Journal of Radiology Vol.19 No.6
Objective: We evaluated the effect of various patient characteristics and time-density curve (TDC)-factors on the test bolus-affected vessel enhancement on coronary computed tomography angiography (CCTA). We also assessed the value of generalized linear regression models (GLMs) for predicting enhancement on CCTA. Materials and Methods: We performed univariate and multivariate regression analysis to evaluate the effect of patient characteristics and to compare contrast enhancement per gram of iodine on test bolus (ΔHUTEST) and CCTA (ΔHUCCTA). We developed GLMs to predict ΔHUCCTA. GLMs including independent variables were validated with 6-fold cross-validation using the correlation coefficient and Bland–Altman analysis. Results: In multivariate analysis, only total body weight (TBW) and ΔHUTEST maintained their independent predictive value (p < 0.001). In validation analysis, the highest correlation coefficient between ΔHUCCTA and the prediction values was seen in the GLM (r = 0.75), followed by TDC (r = 0.69) and TBW (r = 0.62). The lowest Bland–Altman limit of agreement was observed with GLM-3 (mean difference, -0.0 ± 5.1 Hounsfield units/grams of iodine [HU/gI]; 95% confidence interval [CI], -10.1, 10.1), followed by ΔHUCCTA (-0.0 ± 5.9 HU/gI; 95% CI, -11.9, 11.9) and TBW (1.1 ± 6.2 HU/gI; 95% CI, -11.2, 13.4). Conclusion: We demonstrated that the patient’s TBW and ΔHUTEST significantly affected contrast enhancement on CCTA images and that the combined use of clinical information and test bolus results is useful for predicting aortic enhancement.