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Takanori Masuda,Takeshi Nakaura,Yoshinori Funama,Tomoyasu Sato,Toru Higaki,Masao Kiguchi,Yoriaki Matsumoto,Yukari Yamashita,Naoyuki Imada,Kazuo Awai 대한영상의학회 2018 Korean Journal of Radiology Vol.19 No.6
Objective: We evaluated the effect of various patient characteristics and time-density curve (TDC)-factors on the test bolus-affected vessel enhancement on coronary computed tomography angiography (CCTA). We also assessed the value of generalized linear regression models (GLMs) for predicting enhancement on CCTA. Materials and Methods: We performed univariate and multivariate regression analysis to evaluate the effect of patient characteristics and to compare contrast enhancement per gram of iodine on test bolus (ΔHUTEST) and CCTA (ΔHUCCTA). We developed GLMs to predict ΔHUCCTA. GLMs including independent variables were validated with 6-fold cross-validation using the correlation coefficient and Bland–Altman analysis. Results: In multivariate analysis, only total body weight (TBW) and ΔHUTEST maintained their independent predictive value (p < 0.001). In validation analysis, the highest correlation coefficient between ΔHUCCTA and the prediction values was seen in the GLM (r = 0.75), followed by TDC (r = 0.69) and TBW (r = 0.62). The lowest Bland–Altman limit of agreement was observed with GLM-3 (mean difference, -0.0 ± 5.1 Hounsfield units/grams of iodine [HU/gI]; 95% confidence interval [CI], -10.1, 10.1), followed by ΔHUCCTA (-0.0 ± 5.9 HU/gI; 95% CI, -11.9, 11.9) and TBW (1.1 ± 6.2 HU/gI; 95% CI, -11.2, 13.4). Conclusion: We demonstrated that the patient’s TBW and ΔHUTEST significantly affected contrast enhancement on CCTA images and that the combined use of clinical information and test bolus results is useful for predicting aortic enhancement.
Effect of Patient Characteristics on Vessel Enhancement at Lower Extremity CT Angiography
Takanori Masuda,Takeshi Nakaura,Yoshinori Funama,Tomoyasu Sato,Toru Higaki,Masao Kiguchi,Yukari Yamashita,Naoyuki Imada,Kazuo Awai 대한영상의학회 2018 Korean Journal of Radiology Vol.19 No.2
Objective: To evaluate the effect of patient characteristics on popliteal aortic contrast enhancement at lower extremity CT angiography (LE-CTA) scanning. Materials and Methods: Prior informed consent to participate was obtained from all 158 patients. All were examined using a routine protocol; the scanning parameters were tube voltage 100 kVp, tube current 100 mA to 770 mA (noise index 12), 0.5-second rotation, 1.25-mm detector row width, 0.516 beam pitch, and 41.2-mm table movement, and the contrast material was 85.0 mL. Cardiac output (CO) was measured with a portable electrical velocimeter within 5 minutes of starting the CT scan. To evaluate the effects of age, sex, body size, CO, and scan delay on the CT number of popliteal artery, the researchers used multivariate regression analysis. Results: A significant positive correlation was seen between the CT number of the popliteal artery and the patient age (r = 0.39, p < 0.01). A significant inverse correlation was observed between the CT number of the popliteal artery and the height (r = -0.48), total body weight (r = -0.52), body mass index (r = -0.33), body surface area (BSA) (r = -0.56), lean body weight (r = -0.56), and CO (r = -0.35) (p < 0.001 for all). There was no significant correlation between the enhancement and the scan delay (r = 0.06, p = 0.47). The BSA, CO, and age had significant effects on the CT number (standardized regression: BSA -0.42, CO -0.22, age 0.15; p < 0.05, respectively). Conclusion: The BSA, CO, and age are significantly correlated with the CT number of the popliteal artery on LE-CTA.
Eisuke Miura,Shin-ichi Masuda,Takanori Ooyama,Satoshi Ishii 한국물리학회 2010 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.56 No.1
The generation of quasi-monoenergetic electron beams containing more than 3 × 108 electrons in a monoenergetic peak for energies from 40 to 60 MeV has been demonstrated. The quasimonoenergetic electron beams have been obtained from a plasma with an electron density of 1.6 × 1019 cm−3 produced by an 8-TW, 50-fs Ti:sapphire laser pulse. It is necessary to control the plasma density precisely and to suppress the nanosecond prepulse with the main pulse for stable generation of quasi-monoenergetic beams. Two-dimensional particle-in-cell simulation results are also shown. The simulation result suggests that quasi-monoenergetic beam generation is brought about by matching the laser propagation length with the gas jet length.
포스터 발표 : 수질관리 ; 경작기간 동안 논으로부터 질소와 인의 유출특성
( Soo Yong Shim ),( Seung Hwan Sa ),( Takanori Masuda ),( Yoshihiko Hosoi ),( Bom Chul Kim ) 대한상하수도학회 2006 공동추계 학술발표회 논문집 Vol.2006 No.-
Our aim was to quantify and characterize total nitrogen (TN) and total phosphorus (TP) in runoff from paddy fields in agricultural areas of Tottori, Japan. Freshwater pollution and eutrophication usually involve excess input of nutrients such as N and P. Nonpoint source water pollution is more difficult to control than point source pollution, and the contribution from agricultural nonpoint sources has been increasing. We investigated the characteristics of pollutant runoff from four paddy fields of different sizes, in 2003 and 2004. The N and P export was investigated during rainfall events by examining the variation in TN and TP in runoff, the correlation between discharge and pollutant concentration and loading, and the event mean concentration (EMC). The average TN and TP concentrations in surface water in May and June were 7.3 and 2.2 ㎎ L(-1), respectively, in 2003, and 12.4 and 2.0 ㎎ L(-1), respectively, in 2004, and were higher than in other months [2003: 1.132 (TN) and 0.206 (TP) ㎎ L(-1); 2004: 1.243 (TN) and 0.284 (TP) ㎎ L(-1). TN and TP loadings tended to increase with increasing discharge in most paddy fields. The EMCs were similar among the four paddy fields, but rainfall events differed. The calculated annual pollutant loadings (TN and TP) per unit area were 0.084 (2003) and 0.010 (2004) ton N y(-1) ha(-1), and 0.029 (2003) and 0.004 (2004) ton P y(-1) ha(-1) in one field; those of the other fields were similar. Thus, pollutant contributions from paddy fields as nonpoint agricultural sources are substantial, and continuous examination of discharge water is important for the control and management of agricultural nonpoint source pollution.
Redox-coupled proton transfer mechanism in nitrite reductase revealed by femtosecond crystallography
Fukuda, Yohta,Tse, Ka Man,Nakane, Takanori,Nakatsu, Toru,Suzuki, Mamoru,Sugahara, Michihiro,Inoue, Shigeyuki,Masuda, Tetsuya,Yumoto, Fumiaki,Matsugaki, Naohiro,Nango, Eriko,Tono, Kensuke,Joti, Yasumas National Academy of Sciences 2016 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.113 No.11
<P>Proton-coupled electron transfer (PCET), a ubiquitous phenomenon in biological systems, plays an essential role in copper nitrite reductase (CuNiR), the key metalloenzyme in microbial denitrification of the global nitrogen cycle. Analyses of the nitrite reduction mechanism in CuNiR with conventional synchrotron radiation crystallography (SRX) have been faced with difficulties, because X-ray photoreduction changes the native structures of metal centers and the enzyme-substrate complex. Using serial femtosecond crystallography (SFX), we determined the intact structures of CuNiR in the resting state and the nitrite complex (NC) state at 2.03- and 1.60-angstrom resolution, respectively. Furthermore, the SRX NC structure representing a transient state in the catalytic cycle was determined at 1.30-angstrom resolution. Comparison between SRX and SFX structures revealed that photoreduction changes the coordination manner of the substrate and that catalytically important His255 can switch hydrogen bond partners between the backbone carbonyl oxygen of nearby Glu279 and the side-chain hydroxyl group of Thr280. These findings, which SRX has failed to uncover, propose a redox-coupled proton switch for PCET. This concept can explain how proton transfer to the substrate is involved in intramolecular electron transfer and why substrate binding accelerates PCET. Our study demonstrates the potential of SFX as a powerful tool to study redox processes in metalloenzymes.</P>
( Soo Yong Shim ),( Seung Hwan Sa ),( Takanori Masuda ),( Yoshihiko Hosoi ),( Bom Chul Kim ) 한국물환경학회 2006 공동 추계학술발표회 Vol.2006 No.-
Our aim was to quantify and characterize total nitrogen (TN) and total phosphorus (TP) in runoff from paddy fields in agricultural areas of Tottori, Japan. Freshwater pollution and eutrophication usually involve excess input of nutrients such as N and P. Nonpoint source water pollution is more difficult to control than point source pollution, and the contribution from agricultural nonpoint sources has been increasing. We investigated the characteristics of pollutant runoff from four paddy fields of different sizes, in 2003 and 2004. The N and P export was investigated during rainfall events by examining the variation in TN and TP in runoff, the correlation between discharge and pollutant concentration and loading, and the event mean concentration (EMC). The average TN and TP concentrations in surface water in May and June were 7.3 and 2.2 ㎎ L(-1), respectively, in 2003, and 12.4 and 2.0 ㎎ L(-1), respectively, in 2004, and were higher than in other months [2003: 1.132 (TN) and 0.206 (TP) ㎎ L(-1); 2004: 1.243 (TN) and 0.284 (TP) ㎎ L(-1). TN and TP loadings tended to increase with increasing discharge in most paddy fields. The EMCs were similar among the four paddy fields, but rainfall events differed. The calculated annual pollutant loadings (TN and TP) per unit area were 0.084 (2003) and 0.010 (2004) ton N y(-1) ha(-1), and 0.029 (2003) and 0.004 (2004) ton P y(-1) ha(-1) in one field; those of the other fields were similar. Thus, pollutant contributions from paddy fields as nonpoint agricultural sources are substantial, and continuous examination of discharge water is important for the control and management of agricultural nonpoint source pollution.
심수용 ( Soo Young Shim ),김범철 ( Bum Chul Kim ),호소이요시히코 ( Yoshihiko Hosoi ),마스다다카노리 ( Takanori Masuda ) 한국물환경학회 2005 한국물환경학회지 Vol.21 No.2
The aim of this study is to quantify and characterize the dissolved organic carbon (DOC) from paddy fields and crop fields in Tottori, Japan. DOC and ultraviolet (UV) absorption were measured in the filtrated water of each sample. The DOC concentration and the SUVA (specific UV absorption) of biodegradation analysis samples were determined around 50 days after their incubation. In the Fukui paddy fields, DOC concentration varied seasonally from 1.1 to 10.1 ㎎ Cl^(-1), becoming higher during heavy runoffs in April, a non-agriculture period. Variations in DOC concentration did not always correspond to rainfall, though. The Obadake paddy fields showed a DOC concentration pattern similar to that of the Fukui paddy fields. The daily DOC discharge per area in the Fukui (up), Fukui (down), Obadake (south) and Obadake (north) paddy fields influent from paddy fields were 0.02, 0.0161, 0.0135 and 0.0027 ㎏ a^(-1) day^(-1), respectively. These differences resulted from differences in agricultural types and customs of farmers according to paddy fields and other kinds of fields. Also, the SUVAs [which are indirect means to evaluate humic substances (hydrophobic fractions)] of the studied influent waters from paddy fields were generally lower than those of the influent waters from crop fields. Nonbiodegradable DOC accounted for 50.2-98% and 46.8-85.5% of the total DOC in the paddy fields and in the crop fields, respectively.