Roles and Mechanisms of Eosinophilic Inflammation in Asthma and Allergic Diseases

Hirohito Kita 대한 소아알레르기 및 호흡기학회 2000 소아알레르기 및 호흡기학회지 Vol.10 No.부록1

Cross-Sectional and Longitudinal Associations between Forearm Bone Mineral Density and Anthropometry in Adult Japanese Men and Women

Hirohito Sone 대한골대사학회 2024 대한골대사학회지 Vol.31 No.1

Background: No consensus exists regarding which anthropometric measurements are related to bone mineral density (BMD), and this relationship may vary according to sex and age. A large Japanese cohort was analyzed to provide an understanding of the relationship between BMD and anthropometry while adjusting for known confounding factors. Methods: Our cohort included 10,827 participants who underwent multiple medical checkups including distal forearm BMD scans. Participants were stratified into four groups according to age (≥50 years or <50 years) and sex. The BMD values were adjusted for confounding factors, after which single and partial correlation analyses were performed. The prevalence of osteopenia was plotted for each weight index (weight or body mass index [BMI]) class. Results: Cross-sectional studies revealed that weight was more favorably correlated than BMI in the older group (R=0.278 and 0.212 in men and R=0.304 and 0.220 in women, respectively), whereas weight and BMI were weakly correlated in the younger age groups. The prevalence of osteopenia exhibited a negative linear relationship with weight among older women ≥50 years of age, and an accelerated increase was observed with decreasing weight in older men weighing <50 kg and younger women weighing <60 kg. When weight was replaced with BMI, the prevalence was low in most subgroups classified by weight. Conclusions: Weight, rather than BMI, was the most important indicator of osteopenia but it might not be predictive of future bone loss.

Regulation and Role of EZH2 in Cancer

Hirohito Yamaguchi,Mien-Chie Hung 대한암학회 2014 Cancer Research and Treatment Vol.46 No.3

Polycomb repressive complex 2 (PRC2) is the epigenetic regulator that induces histone H3lysine 27 methylation (H3K27me3) and silences specific gene transcription. Enhancer ofzeste homolog 2 (EZH2) is an enzymatic subunit of PRC2, and evidence shows that EZH2plays an essential role in cancer initiation, development, progression, metastasis, and drugresistance. EZH2 expression is indeed regulated by various oncogenic transcription factors,tumor suppressor miRNAs, and cancer-associated non-coding RNA. EZH2 activity is alsocontrolled by post-translational modifications, which are deregulated in cancer. The canonicalrole of EZH2 is gene silencing through H3K27me3, but accumulating evidence showsthat EZH2 methlyates substrates other than histone and has methylase-independentfunctions. These non-canonical functions of EZH2 are shown to play a role in cancerprogression. In this review, we summarize current information on the regulation and rolesof EZH2 in cancer. We also discuss various therapeutic approaches to targeting EZH2.

Roles and Mechanisms of Eosinophilic Inflammation in Asthma and Allergic Diseases

(Hirohito Kita) 대한 소아알레르기 호흡기학회(구 대한소아알레르기 및 호흡기학회) 2000 Supplement Vol.10 No.2

Partially Corrugated Waveguide Laser Diodes for Analog CATV Application

Hirohito Yamada,Tetsuro Okuda,Thshitaka Torikai 한국통신학회 1997 OPTOELECTRONICS & COMMUNICATIONS CONFERENCE Vol.2 No.1

REVIEW : Review of Pure Endoscopic Full-Thickness Resection of the Upper Gastrointestinal Tract

Hirohito Mori,Hideki Kobara,Noriko Nishiyama,Shintaro Fujihara,Tsutomu Masaki 대한소화기학회 2015 Gut and Liver Vol.9 No.5

Colored Ring-Shaped Thread Tag Clippings to Identify the Accurate Location of Multiple Polyps Resected via Endoscopic Mucosal Resection

( Hirohito Mori ),( Hideki Kobara ),( Tsutomu Masaki ) 대한소화기학회 2017 Gut and Liver Vol.11 No.1

Evaluating Spinal Canal Lesions Using Apparent Diffusion Coefficient Maps with Diffusion-Weighted Imaging

Kanamoto Hirohito,Norimoto Masaki,Eguchi Yawara,Oikawa Yasuhiro,Orita Sumihisa,Inage Kazuhide,Abe Koki,Inoue Masahiro,Kinoshita Hideyuki,Umimura Tomotaka,Matsumoto Koji,Masuda Yoshitada,Furuya Takeo,K 대한척추외과학회 2020 Asian Spine Journal Vol.14 No.3

Study Design: Observational study.Purpose: To evaluate healthy volunteers and patients with spinal canal lesions using apparent diffusion coefficient (ADC) maps with diffusion-weighted imaging.Overview of Literature: Decompression surgery for lumbar spinal stenosis (LSS) is selected on the basis of subjective assessment and cross-sectional magnetic resonance imaging (MRI). However, there is no objective standard for this procedure.Methods: We performed 3T MRI in 10 healthy volunteers and 13 patients with LSS. The ADC values in the spinal canal were evaluated at 46 vertebrae (L4/5 and L5/S1 for each participant), and the reduced and conventional fields of view were compared.Results: The ADC values were 2.72±0.12 at L4/5 in healthy volunteers, 2.76±0.19 at L5/S1 in healthy volunteers, 1.77±0.58 at L4/5 in patients with LSS, and 2.35±0.29 at L5/S1 in patients with LSS. The ADC value at L4/5 in patients with LSS was significantly lower than that at L5/S1 in patients with LSS and that at L4/5 and L5/S1 in healthy volunteers (<i>p</i> <0.05). With an ADC cutoff value of 2.46 to identify LSS, this approach provided an area under the curve of 0.81, sensitivity of 0.92, and specificity of 0.76 (<i>p</i> <0.05).Conclusions: Preoperative examination using ADC maps permits visualization and quantification of spinal canal lesions, thus proving the utility of ADC maps in the selection of decompression surgery for LSS.

Structural changes in the cruise network by ship size in Northeast Asia

Ito Hirohito,Hanaoka Shinya,Sugishita Kashin 한국해운물류학회 2022 The Asian journal of shipping and Logistics Vol.38 No.4

Several ports want cruise ships to call at their ports for economic benefits. However, the main cause of concern is the complexity of port selection behavior for cruise lines. Tracking cruise ship movement data may help them understand the port selection behavior of cruise lines. This study aimed to examine the structural changes in the cruise network by ship size in Northeast Asia from 2014 to 2019 using network science methods with automatic identification system data. We identified five key findings. First, the number of nodes and edges in the mega- and small-size ship networks was growing rapidly. Second, the small-size network was growing with unique characteristics of low density and average clustering coefficient, and high average shortest path length and diameter. Third, the hub ports of Shanghai in the megaand Hiroshima and Kobe in the small-size had gained more degrees over time. Fourth, owing to the deployment of new mega-ships in Shanghai, existing large- and mid-ships were shifting to different ports. Finally, modularity of all sizes increased over time, and the community structure became clearer. © 2022 The Authors. Production and hosting by Elsevier B.V. on behalf of The Korean Association of Shipping and Logistics, Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)

한위 허창과 그 툰전,툰영 구역

염택유인 ( Shiozawa Hirohito ) 중국사학회 2002 中國史硏究 Vol.21 No.-

許昌는 後漢王朝末期의 國都이고 또한, 漢魏의 結節点으로써 重要한 都市임에도 불구하고 그 樣相은 전혀 알려져 있지 않다. 그래서 本稿에서는 都市許昌과 許昌을 內包하는 地域空間의 樣相을 探究하기로 한다. 먼저 旣刊의 報告書 및 筆者自身이 2001年, 2002年에 행한 踏査結果를 基礎로 許昌故城(張潘故城)의 現狀을 整理했다(圖1). 그런데, 許昌故城은 어디까지나 城壁에 둘러싸인 空間이기 때문에, 筆者가 探究의 目的으로하는 都市空間의 一部에 불과하다. 여기에서 말하는 都市空間이란, 어떤 特定한 都市와 地域的·?經濟的으로 密接한 關係를 가지는 地域空間을 指稱해서 말하는 것이다. 따라서 許昌의 都市空間探究에는 視點을 許昌故城에 限定하지 않고, 우선 許昌을 內包하고 許昌과 密接한 關係를 가지는 地域空間의 檢出을 考察의 前提로 할 必要가 있다. 이 檢出에는 潁川郡域에 이르는 廣域의 檢索範圍를 設定하고, 遺蹟과 墓葬, 地名傳承을 資料로 이용했지만, 該當地域에 있어서의 活用資料의 方法論的인 有用性과 問題点을 指摘한 다음에 데이타로써 活用했다. 이 作業에 의해 檢出된 都市空間은, 許晶故城을 中心으로 半徑25km의 範圍였다(圖2). 그 範圍內에서는 許昌內外城, 屯營, 屯田, 狩獵·禁苑, 墓葬, 藝葬, 練兵, 郊의 七區域을 想定했다. 許昌을 둘러싼 問題에서 特히 注目되어지는 것은 屯田(民屯田)의 施行과 兵戶制의 出現이고, 여기에 屯營·屯田區域이 想定가능했던 것은 許昌이란 都市의 樣相을 생각하는데에 있어서 매우 重要하다. 다음에 여기에 想定된 屯田·屯營區域을 文獻을 어떻게 링크시켜서 고찰할 것일까 하는 것이 問題가 된다. 첫번째의 問題点은 屯田區域의 樣相이고, 本稿에서는 許下屯田의 施行區域과 고 管理管轄 및 거기에 動員된 屯田民에 관해서 考察했다. 屯田想定區域은 ?陵縣望田村一帶와 許昌市南部부터 長葛縣東南部一帶까지로 나눌 수 있다. 한편 屯田官에 關한 史料를 보면 典農中郎將·?典農都尉와 典農校尉·校尉丞의 二系統으로 나눌 수 있지만, 許昌에 대해서는 就任官의 史料檢索에서 潁川典農中郎將과 潁川典農都尉가 놓여져 있었다고 생각된다. 업에 있어서의 努郡典農도 똑같이 理解할 수 있지만, 그 事例에서는 中郎將 ?都騎 各定員一名인 것을 알수 있다. 또 『水經注』에는 潁川(許昌)典農都尉의 所在(許昌市, 舊潁陰縣)가 실려 있다. 以上의 点에 더해서 許昌의 田域을 나타내는 諸史料를 總合해서 생각하면, 望田區域은 潁川典農中郎將, 許昌市近郊區域은 潁川典農都尉의 管轄區域으로 각각 理解할 수 있다 한편, 屯田民에 대해서는 屯田의 開始時期와 許昌入城의 經緯, 生産效率등에서 보면 現地召募의 一般民과 潁·汝의 黃巾余衆으로 구성된 該當地域民이었다고 생각된다. 두번째의 問題点은 屯營區城의 所在와 그 樣相이다 이 問題에서는 許昌故城과 ?陵議台村一帶의 屯營區域과의 位置關係가 注目된다. 許昌故城은 漢의 都城이며, 洛陽으로부터 移住한 많은 漢의 官僚와 그 家族이 居住하고 있었다고 생각된다. 한편, 曹操의 兵團은 營(屯營)의 形態로 駐留하고 있었음을 史料로 알 수 있다. 朝廷內는 曹操라고 해도 身邊에 危險을 느끼는 空間이었고, 許昌故城과 議台屯營區域의 存在에서 漢의 官僚와 魏의 臣僚가 許昌이란 都市空間에 있어서 居住空間을 달리하고 있었다고 생각할 수 있다. 曹操를 비롯한 魏의 諸營은 許昌外城에서도 確認되지만, 墓葬區와의 交錯關係도 근거하여 判斷하면, 曹操兵團은 議台區域을 本據地로 했었다고 생각된다. 또한, 『文選』에 보이는 兵戶의 集團住宅的인 施設의 存在도 該當區域의 狀況와 結付시켜서 생각하는 것이 可能하다. 以上, 臨戰下의 國都 許昌은 廣域의 都市空間을 想定하는 것에서, 처음으로 그 樣相을 理解할 수 있었다. 그리고, 許昌은 屯田經營과 兵團駐留라고 하는 軍事基地的인 色彩가 强한 都市이면서, 또한 漢과 魏와의 結節点에 있어서는 同一都市空間속에 있으면서 漢과 魏가 그 活勳의 空間을 달리 하고 있었던 都市였다.