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Ahn, Nam-Shik,Hu, Hongbo,Park, Jin-Sung,Park, Joon-Suk,Kim, Jong-Sik,An, Sungwhan,Kong, Gu,Aruoma, Okezie I.,Lee, Yong-Soon,Kang, Kyung-Sun Elsevier 2005 Mutation research. Fundamental and molecular mecha Vol.579 No.1
<P><B>Abstract</B></P><P>Although 2,3,7,8-tetrachlorodibenzo-<I>p</I>-dioxin (TCDD) has a variety of carcinogenic and noncarcinogenic effects in experimental animals, its role in human carcinogenicity remain controversial. A simian virus 40-immortalized cell line from normal human breast epithelial cells with stem cells and luminal characteristics (M13SV1) was used to study whether TCDD can induce AIG positive colony formation and cause increased cell numbers in a inverted U-shaped dose–response manner. TCDD activated Akt, ERK2, and increased the expression of CYP1A1, PAI-2, IL-lb mRNA, and ERK2 protein levels. TCDD was able to increased phosphorylation and expression of ERK2 in same dose–response manner as AIG positive colony formation. Thus, TCDD induced tumorigenicity in M13SV1, possibly through the phosphorylation of ERK2 and/or Akt. Further, cDNA microarray with 7448 sequence-verified clones was used to profile various gene expression patterns after treatment of TCDD. Three clear patterns could be delineated: genes that were dose-dependently up-regulated, genes expressed in either U-shape and/or inverted U-shape. The fact that these genes are intrinsically related to breast epithelial cell proliferation and survival clearly suggests that they may be involved in the TCDD-induced breast tumorigenesis.</P>
A Dose Verification Method for Proton Therapy by Using a Plastic Scintillation Plate
김동욱,임영경,Jungwook Shin,Sungwhan Ahn,신동호,윤명근,이세병,Sung-Yong Park,DaeYong Kim,곽정원,김진성 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.55 No.2
An interesting issue in proton therapy is how to reduce the time needed for percent depth dose (PDD) measurement and how to prepare a two-dimensional dose measurement tool for a proton scanning beam. Currently, three-dimensional water phantom systems are used for range verification in the scattering beam mode of proton therapy. However, this approach is very slow and is in appropriate for use with a proton scanning beam. At the National Cancer Center in Korea (NCC), we have developed a simple and easy-to-handle range verification system that consists of a plastic scintillation plate, a PMMA (poly methyl methacrylate) phantom, a charge-coupled device camera, and a one-dimensional moving table. In the present study, the linearity of the signal with the dose, the background signal measurement and correction, and the influence of the ionization density on the signal were investigated using our new system. The measured yield depended linearly on the dose, and the dose range measurements had a spatial resolution of about 1 mm.
ALGEBRAIC CORRECTION FOR METAL ARTIFACT REDUCTION IN COMPUTED TOMOGRAPHY
KIWAN JEON,SUNG-HO KANG,CHI YOUNG AHN,SUNGWHAN KIM 한국산업응용수학회 2014 Journal of the Korean Society for Industrial and A Vol.18 No.2
If there are metals located in the X-ray scanned object, a point outside the metals gas its range of projection angle at which projections passing through the point are disturbed by the metals. Roughly speaking, this implies that attenuation information at the point is missing in the blocked projection range. So conventional projection completion MAR algorithms to use the undisturbed projection data on the boundary of the metaltrace is less efficient in reconstructing the attenuation coefficient in detailed parts, in particular, near the metal region. In order to overcome this problem, we propose the algebraic correction technique (ACT) to utilize a prereconstructed interim image of the attenuation coefficient outside the metal region which is obtained by solving a linear system designed to reduce computational costs. The reconstructed interim image of the attenuation coefficient is used as prior information for MAR. Numerical simulations support that the proposed correction technique shows better performance than conventional inpainting techniques such as the total variation and the harmonic inpainting.
김둘선,강성환,김준영,안주현,이창희,정기영,박윤철,김고운,조남웅,Kim, Dul-Sun,Kang, Sungwhan,Kim, Jun-Young,Ahn, Jou-Hyeon,Lee, Chang-Hui,Jung, Keeyoung,Park, Yoon-Cheol,Kim, Goun,Cho, Namung 한국전기화학회 2013 한국전기화학회지 Vol.16 No.3
나트륨 유황전지(NAS)는 대용량 에너지 저장시스템(energy storage system, ESS) 중 하나로서, 최근 풍력에너지, 태양에너지, 해양에너지 등 그린재생에너지의 사용증가로 ESS에 대한 수요가 급증함에 따라 NAS 전지에 대한 관심이 고조되고 있다. NAS 전지는 에너지 밀도가 높고(납 축전지밀도의 3배), 사이클 수명이 길고, 자가방전이 없어 대용량 전력저장 시스템에 적합하다. NAS 전지는 양극으로 황(Sulfur), 음극으로 나트륨(Na), 고체전해질 및 분리막으로 ${\beta}$"-알루미나($Al_2O_3$)로 구성되어 있고, 양극 활물질인 황은 부도체이기 때문에 도전재인 탄소섬유(carbon felt)에 함침시켜 양극으로 사용해야 함으로, 양극재 구성 및 특성은 전지성능에 상당한 영향을 미치게 된다. 따라서 본 논문에서는 NAS 전지의 구성, 다황화나트륨($Na_2S_x$, 방전생성물) 및 양극재의 특성, 전지 성능에 미치는 영향인자들에 대해서 알아보고자 한다. Sodium sulfur (NAS) battery is a high energy storage system (ESS). These days, as the use of renewable green energy like wind energy, solar energy and ocean energy is rapidly increasing, the demand of ESS is increasing and NAS battery is considered to be one of the most promising ESS. Since NAS battery has a high energy density(3 times of lead acid battery), long cycle life and no self-charge and discharge, it is a good candidate for ESS. A NAS battery consists of sulfur as the positive electrode, sodium as the negative electrode and ${\beta}$"-alumina as the electrolyte and a separator simultaneously. Since sulfur is an insulator, carbon felt should be used as conductor with sulfur and so the composition and property of the cathode could largely influence the cell performance and life cycle. Therefore, in this paper, the composition of NAS battery, the property of carbon felt and sodium polysulfides ($Na_2S_x$, intermediates of discharge), and the effects of these factors on cycle performance of cells are described in detail.