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Effect of Cadmium concentration on plant growth characteristics of Jatropha curcas L.
Yang-Gyu Ku,Won Park,Cho-Rong Kim,Ha-Young Jang,Ha-Na Park,Hyun-Sung Kim,Jeong-Min Oh,Jin-Ki Bang,Young-Seok Jang,Sung-Ju Ahn 한국작물학회 2008 한국작물학회 학술발표대회 논문집 Vol.2008 No.10
Cadmium (Cd) is one of heavy metals that can be easily absorbed by plant roots, and transported from soil to shoots. The effect of Cd concentration (0~200 μM) on the physiological responses, Cd content of shoot and root, and antioxidant enzymes by oil plants Jatropha curcas (cv. Biji Jarak) were investigated in hydroponics system for two weeks. Stomatal conductance was significantly depressed by Cd treated plants. However, the leaf chlorophyll content was unaffected by Cd treated plants. Cd contents in the roots of Jatropha were accumulated higher than those of shoots. Jatropha treated plants at 100 and 200 μM was found to accumulate more than 100 mg kg-1 of Cd in shoots. Jatropha plants had a high ablity to uptake Cd from soil and transport it from soil to shoot as a Cd hyperaccumulator plant because of plants accumulating more than 100 mg kg-1 of Cd in shoots are considered to define as Cd hyperaccumulator. These results confirm that Jatropha is a suitable candidate for the phytoremediation of high-level cadmium contaminated soils.
A Study on the Eclipse Estimation and Management of the COMS for On-station Operation
Sang-Cherl Lee,Koon-Ho Yang,Bong-Kyu Park,Bang-Yeop Kim 한국항공우주학회 2008 한국항공우주학회 학술발표회 논문집 Vol.- No.-
The COMS will be located at 128.2 deg East in geostationary orbit with three missions, one is a continuous monitoring of imagery and extracting of meteorological products, another is a monitoring of marine environments around Korean peninsular. The other is experimental telecommunication with Ka band payload. In space, especially geostationary orbit. various space circumstances, especially eclipse should be considered to operate the COMS in safety. The eclipse management which has two types of the Sun eclipse that causes a geostationary satellite to be in the shadow. The most common one is caused by the Earth blocking the sunlight and happens near equinoxes. The Earth caused eclipses can continue up to 45 days around equinox with the satellite being in the shadow up to 72 minutes each day. The eclipse estimation which is classified with the Sun eclipse by the Moon. the Sun eclipse by the Earth and the Moon eclipse by the Earth, are required for the purpose of the payloads and satellite operation. On station, two sub-system are concerned by the Sun eclipse, the one is AOCS because the Sun is used in normal mode for yaw estimation, the other is electrical power subsystem, because there is no more the Sun on the solar array to provide the power. We estimate entry and exit of eclipse of partial and total eclipse from geometrical relationship between the Sun, the Moon, the Earth and the COMS. This estimation is based on the stationkeeping simulation plan which will be done with 7 days period.
Biological and molecular characterization of feline caliciviruses isolated from cats in South Korea
Yang, Dong-Kun,Park, Yu-Ri,Yoo, Jae Young,Choi, Sung-Suk,Park, Yeseul,An, Sungjun,Park, Jungwon,Kim, Heui-Jin,Kim, Jongho,Kim, Ha-Hyun,Hyun, Bang-Hun The Korean Society of Veterinary Science 2020 大韓獸醫學會誌 Vol.60 No.4
Feline calicivirus (FCV) infection results in a common upper respiratory disease associated with oral ulceration in cats. Although FCV infection has been reported in cats worldwide, the biologic and genetic features of South Korean FCV are unclear. We aimed to investigate the biological and genetic features of South Korean FCV isolates. Crandell-Rees feline kidney (CRFK) cells were used to isolate FCV from 58 organ homogenate samples. The FCV isolates were confirmed by cytopathic effects, immunofluorescence, electron microscopy, and reverse transcription polymerase chain reaction assays. Viral genetic analysis was carried out with VP2 gene and complete genomes of FCVs. Five viruses propagated in CRFK cells were confirmed to be FCVs. The FCV17D283 isolate showed the highest viral titer of 107.2 TCID50/mL at 36 h post-inoculation. Korean FCV isolates did not grow well in Vero, BHK-21, A72, or Madin-Darby canine kidney cells. The FCV17D03 and FCV17D283 isolates had the highest genetic similarity (80.1% and 86.9%) with the UTCVM-H1 and 14Q315 strains, which were isolated in the United States and South Korea in 1995 and 2014, respectively. We isolated five FCVs from cats and detected important genetic differences among them. FCV isolates did not show any virulent effects in mice.
Bang, Jun Soo,Oh, Da Hee,Choi, Hyun Mi,Sur, Bong-Jun,Lim, Sung-Jig,Kim, Jung Yeon,Yang, Hyung-In,Yoo, Myung Chul,Hahm, Dae-Hyun,Kim, Kyoung Soo BioMed Central 2009 Arthritis research & therapy Vol.11 No.2
<P><B>Introduction</B></P><P>The objective of this study was to determine the anti-inflammatory, nociceptive, and antiarthritic effects of piperine, the active phenolic component in black pepper extract.</P><P><B>Methods</B></P><P>The <I>in vitro </I>anti-inflammatory activity of piperine was tested on interleukin 1β (IL1β)-stimulated fibroblast-like synoviocytes derived form patients with rheumatoid arthritis. The levels of IL6, matrix metalloproteinase (MMPs), cyclo-oxygenase 2 (COX-2), and prostaglandin E2 (PGE<SUB>2</SUB>) were investigated by ELISA and RT-PCR analysis. The analgesic and antiarthritic activities of piperine were investigated on rat models of carrageenan-induced acute paw pain and arthritis. The former were evaluated with a paw pressure test, and the latter by measuring the squeaking score, paw volume, and weight distribution ratio. Piperine was administrated orally to rats at 20 and 100 mg/kg/day for 8 days.</P><P><B>Results</B></P><P>Piperine inhibited the expression of IL6 and MMP13 and reduced the production of PGE<SUB>2 </SUB>in a dose dependant manner at concentrations of 10 to 100 μg/ml. In particular, the production of PGE<SUB>2 </SUB>was significantly inhibited even at 10 μg/ml of piperine. Piperine inhibited the migration of activator protein 1 (AP-1), but not nuclear factor (NF)κB, into the nucleus in IL1β-treated synoviocytes. In rats, piperine significantly reduced nociceptive and arthritic symptoms at days 8 and 4, respectively. Histological staining showed that piperine significantly reduced the inflammatory area in the ankle joints.</P><P><B>Conclusions</B></P><P>These results suggest that piperine has anti-inflammatory, antinociceptive, and antiarthritic effects in an arthritis animal model. Thus, piperine should be further studied with regard to use either as a pharmaceutical or as a dietary supplement for the treatment of arthritis.</P>
Synthesis of Water Soluble Analogs of Arylsulfonylimidazolidinone (JSH-2282)
Bang, Seong-Cheol,Lee, Ki-Cheul,Sharma, Vinay K.,Sharma, Niti,Yang, Hyun-Sun,Jung, Sang-Hun Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.7
To improve the water solubility of arylsulfonylimidazolidinone (JSH-2282), a potent anti-cancer agent, two urea derivatives, sodium (S)-2-(3-(4-(5-((S)-2-oxo-4-phenylimidazolidin-1-ylsulfonyl)indoline-1-carbonyl)-phenyl)ureido)succinate (2a) and sodium (S)-2-(3-(4-(5-((S)-2-oxo-4-phenylimidazolidin-1-ylsulfonyl)indoline-1-carbonyl)phenyl)ureido)pentanedioate (2b), were synthesized and studied for solubility and anti-cancer activity.
The Role of Alkoxy Group on the A Ring of Isoflavones in the Inhibition of Interleukin-5
Yang, Hyun-Mo,Shin, Hye-Rim,Bang, Seong-Cheol,Lee, Ki-Cheol,Hoang, Le Tuan Ahn,Lee, In-Jeong,Kim, Young-Soo,Jung, Sang-Hun 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.8
Novel isoflavones were found to be potent inhibitors of interleukin-5 (II-5). 5-Benzyloxy-3-(4-hydroxyphenyl)-4H-chromen-4-one (2a, 87.8% inhibition at 50 ${\mu}M$, $IC_{50}$ = 15.3 ${\mu}M$) was ini- tially identified as a potent inhibitor of IL-5. Its activity was comparable to that of budesonide or sophoricoside (1a). The benzyloxy group appeared to be critical for the enhancement of the IL-5 inhibitory activity. To identify the role of this hydrophobic moiety, 5-cyclohexylmethoxy (2d), 7-cyclohexylmethoxy (2e), 5-cyclohexylethoxy (2f), 5-cyclohexylpropoxy (2g), 5-(2-methylpropoxy) (2h), 5-(3-methylbutoxy) (2i), 5-(4-methylpentoxy) (2j) and 5-(2-ethylbutoxy) (2k) analogs were prepared and tested for their effects on the bioactivity of IL-5. Compounds 2d ($IC_{50}$ = 5.8 ${\mu}M$), 2e ($IC_{50}$ = 4.0 ${\mu}M$) and 2j ($IC_{50}$ = 7.2 ${\mu}M$) exhibited the most potent activities. Considering the cLog P values of compounds 2 and the different three dimensional structures of 2d and 2e, the alkoxy group on ring A contributed to their cell permeability for the enhancement of activity, rather than playing a role in the ligand motif binding to the receptor. The optimum alkoxy group should be one that provides cLog P values of compounds 2 in the range of 4.13 to 4.39.