레일 표면결함 자동검출을 위한 장치와 AI 네트워크 개발

최영태 ( Choi Yeong-tae ),지구철 ( Ji Koochul ),오소원 ( Oh Sowon ),최일윤 ( Choi I L-yoon ) 한국구조물진단유지관리공학회 2024 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.28 No.1

레일표면결함 자동 검출을 위한 결함 유형 분류

오소원(Sowon Oh),최영태(Yeong-Tae Choi),최일윤(Il Yoon Choi) 한국철도학회 2023 한국철도학회 학술발표대회논문집 Vol.2023 No.11

Comparison between Pediatric Crohn’s Disease and Ulcerative Colitis at Diagnosis in Korea: Results from a Multicenter, Registry-Based, Inception Cohort Study

( Sowon Park ),( Ben Kang ),( Seung Kim ),( Sujin Choi ),( Hyo Rim Suh ),( Eun Sil Kim ),( Ji Hyung Park ),( Mi Jin Kim ),( Yon Ho Choe ),( Yeoun Joo Lee ),( Jae Hong Park ),( Eell Ryoo ),( Hong Koh ) 대한소화기기능성질환·운동학회 2022 Gut and Liver Vol.16 No.6

Background/Aims: We aimed to compare the differences in pediatric Crohn’s disease (CD) and ulcerative colitis (UC) at diagnosis in Korea. Methods: This was a multicenter, registry-based, inception cohort study conducted at five centers in Korea between 2013 and 2017. Baseline demographics, clinical characteristics, and results from laboratory, endoscopic, radiologic examinations were compared between pediatric CD and UC patients who were <19 years old at diagnosis. Results: A total 307 patients were included (227 CD [73.9%] and 80 UC [26.1%]). The male to female ratio was 2.49:1 for CD, and 1.49:1 for UC (p=0.019). Median age at diagnosis was 14.4 years (interquartile range, 12.4 to 16.2) for CD, and 14.4 years (interquartile range, 11.7 to 16.5) for UC (p=0.962). Hematochezia was the only dominant symptom in UC patients compared to CD patients (86.2% vs 30.8%, p<0.001). White blood cell counts, platelet counts, erythrocyte sedimentation rate, and C-reactive protein levels were significantly higher, and serum albumin level was significantly lower in CD patients than in UC patient. Anti-Saccharomyces cerevisiae antibody was positive in 44.5% and 16.2% of CD and UC patients, respectively (p<0.001), and antineutrophil cytoplasmic antibody was positive in 15.0% and 58.8% of CD and UC patients, respectively (p<0.001). Terminal ileal involvement was prominent in CD, while rectal involvement was more prominent in UC. Small bowel involvement and perianal perforating diseases were also more prominent in CD. Conclusions: This is the first a multicenter study in Korea to compare the differences between pediatric CD and UC at diagnosis in Korea. A large-scale, national study is expected to better clarify these findings in the future. (Gut Liver 2022;16:921-929)

Study on the Emerging VOCs Analysis Method using Purge&Trap GC/MS in Raw Water and Treated Water

Sowon Kang(강소원),Hyunseung Cho(조현승),Taekkyun Choi(최택균),Sunku Park(박선구),Hakseok Kim(김학석),Sangrak Lee(이상락),Juhyun Park(박주현) 환경독성보건학회 2021 한국독성학회 심포지움 및 학술발표회 Vol.2021 No.5

Volatile Organic Compounds (VOCs) are unsaturated hydrocarbons that cause odors and ozone through volatilization into the atmosphere. In this study, the analysis method of VOCs was performed using Purge & Trap gas chromatography/mass spectrometry. Analysis method was discussed and optimized. The results of 14 VOCs have shown that Method Detection Limit (MDL) was in the range from 0.0098 μg/L to 0.6519 μg/L and Limit of Quantification (LOQ) was in the range from 0.0313 μg/L to 2.0762 μg/L. The results of accuracy and precision ranged from 85.9 % to 114.8 % and 1.0 % to 3.3 %. Investigation of the matrix effects on tap water has shown that this method is suitable for VOCs analysis. Raw water and treated water of 15 water treatment plants were studied by developed method. As a results, Chloromethane was detected in the range from N/D to 1.924 μg/L of raw water and in the range from N/D to 4.595 μg/L of treated water. Detection frequency was 50.0 % of raw water and 86.6 % of treated water. In the case of Chloromethane in raw water, the frequency of detection was decreased during the period of wet season. In addition, in the case of water treatment plant that does not use a coagulant or uses river-side filtered water, the formation of chloromethane was less in treated water. These results are intended to be used as scientific basis data for the preparation of the water quality environment policy system in the future.

One-step flame method for the synthesis of coated composite nanoparticles

Sheen, Sowon,Yang, Sangsun,Jun, Kimin,Choi, Mansoo Springer-Verlag 2009 JOURNAL OF NANOPARTICLE RESEARCH Vol.11 No.7

Crystallinity control of flame generated composite nanoparticles by laser irradiation

Sheen, Sowon,Yang, Sangsun,Jun, Kimin,Pikhitsa, Peter V.,Choi, Mansoo Elsevier 2012 Powder technology Vol.229 No.-

Catalytic properties of size-controlled colloidal platinum using nanosecond pulse laser

Jeonghun Lee,Sowon Choi,Hyunsung Jung,Jaegeun Lee 한국표면공학회 2023 한국표면공학회 학술발표회 초록집 Vol.2023 No.11-1

정책담론분석을 위한 정책논변과 문화층위의 결합 모형 -입학사정관제 사례-

최태현 ( Taehyon Choi ),선소원 ( Sowon Seon ) 한국정책학회 2015 韓國政策學會報 Vol.24 No.2

오늘날 정책결정과정에서 참여와 숙의가 강조됨에 따라 다양한 정책 관련 이해당사자들간의 정책 담론을 논리적 차원 뿐 아니라 가치와 신념체계의 차원에서도 분석할 필요성이 높아지고 있다. 기존의 분석들, 특히 정책 담론 분석 모형의 하나로 자주 적용되어 온 정책논변모형은 담론의 논리구조에 다소 치중된 모형이라는 한계가 있다. 이 논문에서는 참여적 숙의민주주의라는 조건에서 대립하는 주장들의 논리구조와 더불어 가치 및 근본 가정의 구조를 이해하기 위해 정책논변모형과 문화의 층위모형을 결합한 하나의 분석모형을 제시하였다. 그리고 제시된 모형을 교육정책 중 하나인 입학사정관제의 도입을 둘러싼 담론에 적용하여 예시적으로 분석하였다. 마지막으로 모형을 적용한 분석과 관련된 방법론적 논점들을 검토하였다. 통합적 분석 모형을 통해 다양하고 복잡한 정책 담론을 주장,가치, 근본 가정의 층위에서 체계적으로 분석하고, 그 결과 사회적 숙의를 통해 가치와 근본 가정 차원에서의 타협점을 발견하여 이해당사자들이 합의할 수 있는 대안을 창출하기 위한 정보를 제공해 줄 수 있을 것으로 기대된다. As participation and deliberation become a legitimate practice in policy decision making processes, there has been increasing need to consider diverse stakeholders’ value and belief systems as well as their logics in policy argumentation. The policy argumentation model, which has been frequently used to analyze policy discourse, exclusively focuses on the logical structure of policy discourse. In this article, we proposed a model of policy discourse analysis in which the policy argumentation model and the three-tier model of organizational culture are integrated to consider both logical and value structures of a policy argument. We applied the model to the case of the adoption of the admission officer system in Korea. Finally, we discussed methodological issues in applying the proposed model. Through a policy discourse analysis using the model, it is expected that stakeholders can find a common ground at the value and assumption levels and develop an agreeable solution.

원유 시료에서 분리한 장알균속 세균의 다중약물 유출 펌프(Multidrug Efflux Pump) 유전자의 분포도와 항생제 내성 패턴

강소원,이상진,최성숙,Kang, SoWon,Lee, SangJin,Choi, SungSook 한국미생물학회 2013 미생물학회지 Vol.49 No.2

원유시료에서 분리한 장알균속 세균 245균주의 항생제 내성에 관여하는 다중약물 유출 펌프 유전자 분포도와 항생제 내성 패턴을 연구하였다. 그 결과 245 장알균속 균주의 ampicillin에 대한 내성률은 44.1%, erythromycin에 대한 내성률은 79.2%, tetracycline에 대한 내성률은 76.3%, chloramphenicol에 대한 내성률은 36.3%였으며 vancomycin과 ciprofloxacin에 대해서는 모두 감수성임을 알 수 있었다. 내성 관련 유전자 중 MFS타입의 eme(A)는 82.1%의 장알균에 분포하였으며, ABC 타입의 유전자인 efr(A)는 72.7%, efr(B)는 77.1%, lsa는 71.8%의 장알균에 분포하였다. 특히 이러한 유전자의 기원 세균인 Enterococcus faecalis의 경우 eme(A)는 92.5%, efr(A)는 87.4%, efr(B)는 88.4%, lsa는 88.4%의 분포도를 나타내었다. 한편 동일한 장알균속이지만 종이 다른 장알균에서 eme(A)는 E. faecium 4균주, E. avium 7균주, E. durans 4균주 및 E. raffinosus 2균주에 분포하고 있었다. efr(A)는 E. faecium 2균주와 E. durans 2균주에 분포하였으며, efr(B)는 E. faecium 4균주, E. avium 5균주 및 E. durans 4균주에 분포하였다. 본 연구는 우리나라 원유시료에서 분리한 장알균속의 여러 종의 세균에서 동일한 다중약물 유출 펌프(multidrug efflux pump)의 분포에 대한 첫 번째 보고라 사료되며 E. faecalis 이외의 장알균속에서 이러한 유전자의 분포는 서로 다른 종간의 유전자의 수평적인 이동의 가능성을 시사한다. The major aim of this study was to investigate the distribution of genes that encode multidrug efflux pumps in Enterococci spp. isolates from bovine milk samples and antibiotic resistance patterns of these strains. Of the 245 isolates, 44.1% showed ampicillin resistance, 79.2% showed erythromycin resistance, 76.3% showed tetracycline resistance and 36.3% showed chloramphenicol resistance. In case of vancomycin and ciprofloxacin, all of the isolates were susceptible to these antibiotics. Of the 245 enterococcal isolates, 82.1% have MFS type eme(A) gene, 72.7% have ABC type efr(A) gene, 77.1% have ABC type efr(B) gene, and 71.8% have ABC type lsa gene. In case of Enterococcus faecalis, the original strain for these genes, 92.5% have eme(A), 87.4% have efr(A), 88.4% have efr(B), and 88.4% have lsa. Interestingly, in case of different species of Enterococci, eme(A) was also detected in four strains of E. faecium, seven strains of E. avium, four strains of E. durans and two strains of E. raffinosus. efr(A) was also detected in two strains of E. faecium and two strains of E. durans and efr(B) was also detected in four strains of E. faecium, five strains of E. avium and four strains of E. durans. This means the possibility of co-transfer of resistance genes between Enterococci species in natural environment. These results are the first report describing the presence of same multidrug efflux pumps in different species of Enterococci in Korea.

원유시료에서 분리한 대장균의 퀴놀론 항생제 내성 기전

강소원,이상진,최성숙,Kang, Sowon,Lee, Sangjin,Choi, Sungsook 한국미생물학회 2014 미생물학회지 Vol.50 No.3

원유시료에서 분리한 대장균의 quinolone 항생제 내성비율과 그 내성 결정인자를 분석하였다. 원유시료에서 대장균을 분리하고 quinolone 항생제인 nalidixic acid와 ciprofloxacin에 대한 MIC값을 결정하였으며 내성균을 대상으로 염색체상에 있는 quinolone 내성 결정부위(quinolone resistant determining region, QRDR)인 gyrA, gyrB, parC, pareE의 염기서열 분석, 플라스미드상에 존재하는 내성유전자(plasmid mediated quinolone resistant, PMQR) qnrA, qnrB, qnrS, aac(6')-lb-cr, qepA의 분석 및 약물 유출펌프 유전자인 acrB의 발현을 비교 분석하였다. 그 결과 총 487개의 대장균군 세균중 9개의 균이 nalidixic acid에 내성임을 확인하였으며($MIC{\geq}64{\mu}g/ml$) 이중 6개 균주가 ciprofloxacin에도 내성임을 확인하였다(MIC $4-16{\mu}g/ml$)). 9개의 내성 균주 모두 QRDR의 gyrA 영역 codon 83에 변이(S83L)를 갖고 있었으며 그 중 2균주는 codon 83과 87 (S83L and D87N)에 이중 돌연변이를 갖고 있었다. 한편 9균주 중 3개의 균주에서 parC 영역 codon 80 (S80I)에 변이를 갖고 있었다. 플라스미드 상에 존재하는 내성유전자인 qnrA, qnrB, qnrS, aac(6')-lb-cr 및 qepA 유전자는 존재하지 않았으며 AcrAB-TolC efflux pump 유전자인 acrB 유전자가 대조균인 E. coli ATCC 25922와 비교하여 ciprofloxacin 내성 균주 6균주 중 4균주에서 유의적으로 과발현(2.15-5.74배) 되고 있음을 확인하였다. The aim of this study was to investigate the prevalence of quinolone resistant E. coli from raw bulk milk and to characterize the resistance determinants. In this study, the gyrA, gyrB, parC, and parE quinolone resistance determining regions (QRDR) were sequenced from quinolone resistant E. coli isolates. Also, the presence of plasmid-mediated quinolone resistance (PMQR) and the expression of efflux pump genes based on quantitative real-time PCR (qRT-PCR) were investigated. Of the 487 coliform bacteria, 9 strains showed nalidixic acid resistance, and 6 of the 9 nalidixic acid resistant isolates were also ciprofloxacin resistant. These 9 strains had a single mutation at codon 83 (S83L) in gyrA, 2 of them had double mutations at codon 83 and 87 (S83L and D87N) in gyrA and 3 of the 9 isolates had single mutations at codon 80 (S80I) in parC. None of the 9 isolates harbored PMQR determinants. Compared with wild-type E. coli ATCC 25922, an over-expression of the acrB gene (2.15-5.74 fold), encoding the pump component of the AcrAB-TolC efflux pump was observed in 4 of 6 ciprofloxacin resistant isolates. This study identified the quinolone resistance mechanism of E. coli isolated from raw milk samples in Gyeonggi-do.