지역사회에서 형성된 사회적 지지와 근로자의 사회심리적 스트레스간의 관련성

임화영,김형수,최영환,장성훈,이건세,정최경희,오원기,최재욱,정춘화 대한산업의학회 2006 대한직업환경의학회지 Vol.18 No.4

Objective: This study was performed to examine the relationship between community-based social support and psychosocial distress in workers. Methods: The study subjects were 596 workers recruited from 11 companies in Chungju city. A structured questionnaire was used to assess sociodemographics, health-related behaviors, job characteristics, job stress, work-based social support, community-based social support and level of psychosocial distress. Results: Hierarchical multiple regression analysis showed that workers with no chronic disease, exercise and sufficient sleep had a higher score of psychosocial distress than those with chronic disease, no exercise, and not enough sleep. Coworker's work-based social support and community-based social support were negatively associated with psychosocial distress. The R square value of total independent variables on psychosocial distress was 0.409, and that of community-based social support on psychosocial distress was 0.052. Conclusion: This study showed that community-based social support served as a protective factor against psychosocial distress in some workers. We recommend the establishment of a worksite stress reduction program in occupational level as well as community-based social support.

Somatic mutations of the <i>ERBB4</i> kinase domain in human cancers

Soung, Young Hwa,Lee, Jong Woo,Kim, Su Young,Wang, Young Pil,Jo, Keon Hyun,Moon, Seok Whan,Park, Won Sang,Nam, Suk Woo,Lee, Jung Young,Yoo, Nam Jin,Lee, Sug Hyung Wiley Subscription Services, Inc., A Wiley Company 2006 International journal of cancer: Journal internati Vol.118 No.6

<P><B>Abstract</B></P><P>The EGFR family consists of 4 receptor tyrosine kinases, EGFR (ERBB1), ERBB2 (HER2), ERBB3 (HER3) and ERBB4 (HER4). Recent reports revealed that the kinase domains of both <I>EGFR</I> (<I>ERBB1</I>) and <I>ERBB2</I> gene were somatically mutated in human cancers, raising the possibility that the other ERBB members possess somatic mutations in human cancers. Here, we performed mutational analysis of the <I>ERBB4</I> kinase domain by polymerase chain reaction–single‐strand conformation polymorphism assay in 595 cancer tissues from stomach, lung, colon and breast. We detected the <I>ERBB4</I> somatic mutations in 3 of 180 gastric carcinomas (1.7%), 3 of 104 colorectal carcinomas (2.9%), 5 of 217 nonsmall cell lung cancers (2.3%) and 1 of 94 breast carcinomas (1.1%). The 12 <I>ERBB4</I> mutations consisted of 1 in‐frame duplication mutation and 8 missense mutations in the exons, and 3 mutations in the introns. We simultaneously analyzed the somatic mutations of <I>EGFR</I>, <I>ERBB2, K‐RAS</I>, <I>PIK3CA</I> and <I>BRAF</I> genes in the 12 samples with the <I>ERBB4</I> mutations and found that 1 gastric carcinoma with <I>ERBB4</I> mutation also harbored <I>K‐RAS</I> gene mutation. Our study demonstrated that in addition to <I>EGFR</I> and <I>ERBB2</I>, somatic mutation of the kinase domain of <I>ERBB4</I> occurs in the common human cancers, and suggested that alterations of ERBB4‐mediated signaling pathway by <I>ERBB4</I> mutations may contribute to the development of human cancers. © 2005 Wiley‐Liss, Inc.</P>

Apoptosis of neuronal cells in the brains of postembryonic silkworms Bombyx mori (Lepidoptera: Bombycidae)

Young KIM, Mi,MIN, Kang Kim,Ok CHOI, Chang,Young SONG, Hwa,SEOK, Chang Lee,Woo KIM, Bong,KANG, Pil Don,Hoo JEON, Soung,Pil CHO, Byung,Jae BAE, Yeon,KO, Young-Gyo,HEE, Bong Lee Biology Centre AS CR 2009 EUROPEAN JOURNAL OF ENTOMOLOGY Vol.106 No.3

Mutational analysis of <i>caspase 1</i>, <i>4</i>, and <i>5</i> genes in common human cancers

Soung, Young Hwa,Jeong, Eun Goo,Ahn, Chang Hyeok,Kim, Sung Soo,Song, Sang Yong,Yoo, Nam Jin,Lee, Sug Hyung Elsevier 2008 Human pathology Vol.39 No.6

<P><B>Summary</B></P><P>Mounting evidence indicates that deregulation of apoptosis is involved in the mechanisms of cancer development. Mutations of genes encoding caspases, the executioners of apoptosis, have been detected in human cancers, indicating inactivation of apoptosis by the mutations of <I>caspase</I> is an important mechanism in cancer development. The aim of this study was to see whether genes encoding human <I>caspases 1</I>, <I>4</I>, and <I>5</I> are mutated in human cancers. We analyzed the entire coding region and all splice sites of human <I>caspase 1</I>, <I>4</I>, and <I>5</I> genes for the detection of somatic mutations in 337 human cancers, including 103 colorectal, 54 gastric, 60 breast, 60 hepatocellular, and 60 lung carcinomas by a single-strand conformation polymorphism assay. We detected 2 (0.6%) <I>caspase-1,</I> 2 (0.6%) <I>caspase-4,</I> and 15 (4.4%) <I>caspase-5</I> mutations in the 343 cancers. The mutations were detected in 11 gastric carcinomas (2 <I>caspase-1</I> and 9 <I>caspase-5</I> mutations), 6 colorectal carcinomas (2 <I>caspase-4</I> and 4 <I>caspase-5</I> mutations), 1 breast carcinoma (1 <I>caspase-5</I> mutation), and 1 lung carcinoma (1 <I>caspase-5</I> mutation). The mutations consisted of 11 mutations in exons and 8 mutations in noncoding sequences. The 11 mutations in the exons consisted of 3 missense, 1 silent, and 7 frameshift mutation(s). Of note, most (6/9) of the <I>caspase-5</I> mutations in the coding sequences were detected in microsatellite instability (MSI)-positive cancers. These data indicate that somatic mutations of <I>caspase-1</I> and <I>caspase-4</I> genes are rare in common solid cancers. In addition, the data indicate that <I>caspase-5</I> gene is commonly mutated in the MSI-positive cancers, and suggest that inactivation of <I>caspase-5</I> may play a role in the tumorigenesis of MSI-positive cancers.</P>

Mini Review : Crosstalk between integrin and receptor tyrosine kinase signaling in breast carcinoma progression

( Young Hwa Soung ),( John L. Clifford ),( Jun Chung ) 생화학분자생물학회 2010 BMB Reports Vol.43 No.5

This review explored the mechanism of breast carcinoma progression by focusing on integrins and receptor tyrosine kinases (or growth factor receptors). While the primary role of integrins was previously thought to be solely as mediators of adhesive interactions between cells and extracellular matrices, it is now believed that integrins also regulate signaling pathways that control cancer cell growth, survival, and invasion. A large body of evidence suggests that the cooperation between integrin and receptor tyrosine kinase signaling regulates certain signaling functions that are important for cancer progression. Recent developments on the crosstalk between integrins and receptor tyrosine kinases, and its implication in mammary tumor progression, are discussed. [BMB reports 2010; 43(5): 311-318]

Studies on the Anticarcinogenic of Undaria pinnatifida Fractions

Soung-Young Park,Young-Hwa Jung,Bok-Mi Jeoung,Song-Ja Bae 한국생명과학회 2004 한국생명과학회 심포지움 Vol.43 No.-

Invited Mini Review : Emerging roles of exosomes in cancer invasion and metastasis

( Young Hwa Soung ),( Thalia Nguyen ),( Hans Cao ),( Janet Lee ),( Jun Chung ) 생화학분자생물학회 2016 BMB Reports Vol.49 No.1

Recent evidence has indicated that nano-sized vesicles called “exosomes” mediate the interaction between cancer cells and their microenvironment and play a critical role in the development of cancers. Exosomes contain cargo consisting of proteins, lipids, mRNAs, and microRNAs that can be delivered to different types of cells in nascent as well as distant locations. Cancer cell-derived exosomes (CCEs) have been identified in body fluids such as urine, plasma, and saliva from patients with cancer. Although their content depends on tumor type and stage, CCEs merit consideration as prognostic and diagnostic markers, as vehicles for drug delivery, and as potential therapeutic targets because they could transport various oncogenic elements. In this review, we summarize recent advances regarding the role of CCEs in cancer invasion and metastasis, as well as its potential clinical applications. [BMB Reports 2016; 49(1): 18-25]

Roles of integrins in regulating metastatic potentials of cancer cell derived exosomes

Young Hwa Soung,Shane Ford,Shane Ford,Jun Chung 대한독성 유전단백체 학회 2019 Molecular & cellular toxicology Vol.15 No.3

Purpose of review: Exosomes are nano-sized extracellular vesicles ranging from 30-150 nm in diameter. Exosomes interact with nearby or distantly localized recipient cells by involving ligand/receptor binding at the surface of recipient cells or fusion with plasma membrane of recipient cells. A number of recent literatures support the role of integrins in mediating metastatic process of cancer cell derived exosomes. While exosomes need to dock on the surface of recipient cells to transmit signals or transfer their contents, the process of docking and uptake of exosomes by recipient cells is poorly understood. This review discusses the recent reports that suggest the potential roles of exosomal integrins in mediating docking and uptake of exosomes, and how these processes are related to metastatic potentials of cancer cell derived exosomes. Recent findings: Exosomal integrins (α6β4, α6β1, αvβ5, αvβ3, αvβ6) and exosomal integrin ligands (vinculin, fibronectin) have been recently reported to play roles in cancer metastasis. As exosomes are involved in cell-to-cell communication, integrins and their ligands in cancer cell derived exosomes can contribute to progression by selecting target tissues and triggering integrin mediated signaling cascades to form new metastatic niche. Recent studies also suggest that exosomal integrins and their ligands can be targeted for developing exosome based diagnostics and therapies.

소라페닙 치료 실패 후 세포독성화학요법으로 완전반응을 보인 폐전이를 동반한 간세포암 1예

박화선 ( Hwa-sun Park ),장재영 ( Jae Young Jang ),백민영 ( Min Young Baek ),김용권 ( Yong Kwon Kim ),윤현진 ( Hyun Jin Youn ),백수영 ( Su Young Back ),정승원 ( Soung Won Jeong ),이세환 ( Sae Hwan Lee ),김상균 ( Sang Gyune Kim ) 대한간암학회 2017 대한간암학회지 Vol.17 No.1

Hepatocellular carcinoma (HCC) is the 2nd most common cause of cancer related death in Korea and well-known malignancy with poor prognosis. Sorafenib is the first-line molecular targeted agent in patients with extra-hepatic spread of HCC. However, complete response is extremely rare in patients treated with sorafenib and the disease control rate is only 43%. We report a 53-year-old man with advanced HCC with pulmonary metastasis who showed complete response by cytotoxic chemotherapy with doxorubicin and cisplatin with relatively tolerable adverse effects after failure of treatment with sorafenib. (J Liver Cancer 2017;17:72-76)

미역귀 분획물의 항균ㆍ암세포 성장저지 효과

박성영(Soung-Young Park),정영화(Young-Hwa Jung),신미옥(Mi-Ok Shin),정복미(Bok-Mi Jung),배송자(Song-Ja Bae) 한국식품영양과학회 2005 한국식품영양과학회지 Vol.34 No.6

본 연구에서는 미역귀를 추출, 각 용매별로 분획하여 항균 효과와 암세포 성장억제 및 QR 유도활성 효과 등의 생리활성을 연구하였다. 미역은 일반적으로 콜레스테롤 배출 작용, 중금속(Cd) 및 방사능 물질(Sr)의 체내 흡수 억제, 배출 작용과 정장 작용이 있으므로 식이섬유 식품으로서 효과가 많다. 미역의 뿌리부분이며 식품개발품으로 소외되고 있는 미역귀를 이용하여 식중독 및 식품부패원인균 등을 이용한 항균 활성을 측정해 보았으며 특히 식중독원인균인 Staphylococus aureous에 시료의 UPMM층의 항균효과가 보였고 단백질식품부패균인 Serratia marcescens에는 UPMB와 UPMM, UPMH 등에서 전반적으로 항균효과가 보였다. 또 4종의 인체 암 세포주 HeLa, HT-29, MCF-7 및 HepG2에 대한 암세포 성장억제 실험을 한 결과 사용한 4종의 암세포주에서 모두 정도의 차이는 있으나 시료첨가 농도에 의존적으로 성장저지 효과가 나타났다. 특히 시료의 methanol 분획층인 UPMM에서 괄목할 만한 높은 효과를 나타내었으며 HeLa, HT-29 및 HepG2세포에서는 UPMM의 농도를 500 ㎍/mL 첨가 시 이미 97.71, 98.63 및 90.32%의 높은 암세포 성장억제 효과를 나타내었다. 한편, 사용한 4가지 암세포주 중 유일하게 quinone reductase를 가지고 있는 HepG2를 이용한 quinone reductase 유도 활성여부를 측정한 결과 UPMH의 첨가농도 320 ㎍/mL에서 대조군보다 2.36배의 높은 QR유도효과를 나타내었다. 이와 같은 실험결과에서 식품이나 건강 및 약리적 효과가 있는 식품으로 알려진 미역귀의 기능성 식품으로서의 개발이 기대되어진다. In this study, we investigated antimicrobial and cytotoxicity effects of Undaria pinnatifida Sporophyll, which using methanol, dichloromethane and ethanol were extracted and fractionated into four different types: methanol (UPMM), hexane (UPMH), butanol (UPMB) and aqueous (UPMA). The antimicrobial activity was increased in proportion to its concentration by the paper disc method. Among the solvent fractions, UPMM and UPMB showed relatively strong antimicrobial activities in the order. Among various partition layers, the methanol partition layer (UPMM) was showed the strongest cytotoxic effects on all cancer cell lines. We also observed quinone reductase (QR) induced effects in all fraction layers of UP on HepG2 cells. The QR induced effects of UPMH on HepG2 cells at 320 ㎍/mL concentration indicated 2.36 with a control value of 1.0.