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( Sora Lim ),( Seho Cha ),( Jun Hyeong Jang ),( Dahye Yang ),( Joonho Choe ),( Taegun Seo ) 한국미생물 · 생명공학회 2017 Journal of microbiology and biotechnology Vol.27 No.1
Kaposi`s sarcoma-associated herpesvirus (KSHV) is associated with formation of Kaposi`s sarcoma, multicentric Castleman`s disease, and primary effusion lymphoma. Replication and transcription activator (RTA) genes are expressed upon reactivation of KSHV, which displays a biphasic life cycle consisting of latent and lytic replication phases. RTA protein expression results in KSHV genome amplification and successive viral lytic gene expression. Transcriptional activity of viral lytic genes is regulated through epigenetic modifications. In Raji cells latently infected with Epstein-Barr virus, various modifications, such as acetylation and methylation, have been identified at specific lysine residues in histone H4 during viral reactivation, supporting the theory that expression of specific lytic genes is controlled by histone modification processes. Data obtained from chromatin immunoprecipitation and quantitative real-time PCR analyses revealed alterations in the H4K8ac and H4K20me3 levels at lytic gene promoters during reactivation. Our results indicate that H4K20me3 is associated with the maintenance of latency, while H4K8ac contributes to KSHV reactivation in infected TREx BCBL-1 RTA cells.
Ginkgo Biloba 추출물이 미세한 압궤손상으로 인한 혈관손상의 회복에 미치는 영향에 관한 연구
강소라,이동진,차진한,김양우 大韓成形外科學會誌 2000 Archives of Plastic Surgery Vol.27 No.1
Late results of microvascular patency after crush or crush avulsion injury have been relatively poor. A key factor in the poor results may relate to the presence of damaged tissue, but the mechanism of this thrombus formation is still imcompletely understood. One current theory about the origin of thrombus after vessel trauma involves increased exposure of the subendothelial tissue to platelets that adhere and aggregate at the injury site, initiating thrombus formation. Most surgeons have usually used several anticoagulant drugs to prevent thrombosis for 2-3 weeks after trauma or microvascular repair. We thought that Ginkgo biloba extract (EGb 761), which has a number of pharmacologic actions, could promote microvasculature healing and prevent thrombosis. The femoral arteries of rats were dissected. Each group was as follows:-① group A (n=10): intact group (not crushed vessel),② group B (n=10); crushing injury (not EGb 761-treated group),③ group C (n=10); crushing injury (EGb 761-treated group). Group B and C underwent crush injury with the energy of 0.07J. We compared patency rate and histological examination. All arteries were patent at postoperative 14 days, and in histologic finding, group C (group with EGb 761 treatment among the crushed injury group) showed significant improvement of vascular endothelial and medial regeneration.
대학원생 표준 학술능력 진단평가 도입 제안: 시드니대 MASUS 사례를 중심으로
손소라 ( Sora Son ),안미리 ( Milee Ahn ),차현진 ( Hyun-jin Cha ) 한국컴퓨터교육학회 2018 한국컴퓨터교육학회 학술발표대회논문집 Vol.22 No.1
본 연구는 대학원생의 연구 수행을 위한 학술적 역량 진단 및 평가를 기반으로 하여 성취 과정을 지원하는 대학원생의 표준 학술능력 진단평가 도입을 제안하고자함을 목적으로 하였다. 이를 위하여 호주 시드니대학교의 대학생 학업능력 진단평가 모델인 MASUS(Measuring the Academic Skills of University Students A Diagnostic Assessment)를 연구대상으로 선정하고 질적연구 방법 중 도구적(instrumental) 사례 연구를 선택하였다. 이에 따라, 자료 수집 단계에서 시드니대학교 학습지원센터 관계자와의 반구조화된 면대면 인터뷰 및 문헌자료를 정보원으로 하여 자료를 분석함으로써 MASUS의 특징과 시사점을 도출하였다. 이를 기반으로 학문적 소양으로서의 글쓰기 능력의 의미와 중요성을 고찰하고, 이를 통해 대학원생 학술 역량 진단평가 도입의 당위성을 부여하였다. 본 연구를 통해 향후 모든 대학원에서 범용적으로 적용할 수 있는 객관적이고 신뢰도 높은 표준 진단평가 모델을 개발하여 긍정적인 진단문화를 형성할 수 있기를 바라는 바이다.
동해 포항 연안 문치가자미(Pseudopleuronectes yokohamae)의 성숙과 산란
김소라 ( Sora Kim ),차형기 ( Hyung Kee Cha ),이재봉 ( Jae Bong Lee ),이해원 ( Hae Won Lee ),양재형 ( Jae Hyeong Yang ),백혜자 ( Hae Ja Baek ),김성태 ( Sung Tae Kim ) 한국수산과학회(구 한국수산학회) 2016 한국수산과학회지 Vol.49 No.3
Marbled flounder Pseudopleuronectes yokohamae is a commercially important flatfish in the coastal waters of the East Sea off Pohang, Korea. Maturity and spawning dynamics of P. yokohamae were investigated based on samples collected by gill net and long line in the coastal waters off Pohang from January 2013 to December 2014. We analyzed monthly changes in maturity stage, gonadosomatic index (GSI), egg diameter, fecundity, and total length at 50% group maturity. We found that the spawning period was December to February, wherein fecundity ranged from 55,760 eggs at 20.40 cm total length (TL) to 1,559,007 eggs at 46.6 cm TL. The relationship between TL and fecundity (F) was F = 0.0017 TL3.5604 (R2 = 0.6984), and F increased with increasing TL. We estimated the TL at 50% group maturity as 27.4 cm for female and 23.5 cm for male P. yokohamae, respectively. The results from this research will aid in the development of policies on season and minimum catch length for sustainable production of P. yokohamae. We propose that it is necessary to conduct long-term ecological monitoring for this species because biological properties such as spawning ecology and growth performance are being affected by climate change.
박소라(Sora Park),Shalom Sara Thomas,차연수(Youn-Soo Cha),김경아(Kyung-Ah Kim) 한국영양학회 2020 Journal of Nutrition and Health Vol.53 No.6
본 연구에서는 괭생이 모자반 추출물의 소포체 스트레스 억제 효능을 연구하기 위하여 HepG2 간세포에 PA를 처리하여 소포체 스트레스를 유발한 후 추출물을 처리하여 UPR 관련 인자 발현 정도를 측정하였다. PA 750 μM 처리 시 UPR 관련 인자 (p-IRE1α, p-eIF2α, CHOP)의 단백질 발현이 가장 높게 나타나 소포체 스트레스를 효과적으로 유도함을 확인하였고 PA 750 μM를 12시간 처리 시 UPR 관련 인자 (p-IRE1α, p-eIF2α, CHOP)의 단백질 발현이 가장 높음을 확인하였다. 괭생이 모자반 처리 시 PA에 의해 상향 조절된 UPR 관련 인자의 mRNA 및 단백질 발현이 감소하여 PA로 유도된 소포체 스트레스에 대한 억제 효능이 있음을 보여주었다. 또한, 괭생이 모자반은 SIRT2, SIRT6 및 SIRT7의 mRNA의 발현을 증가시킴으로써 괭생이 모자반의 소포체 스트레스 억제 효능이 SIRT에 의한 것으로 확인되었다. 이러한 결과는 괭생이 모자반이 다양한 소포체 스트레스 관련 질병의 예방과 치료에 활용가능성이 있음을 시사한다. Purpose: This study examined the effects of Sargassum horneri extracts on palmitic acid (PA)-induced endoplasmic reticulum (ER) stress in HepG2 cells. Methods: HepG2 cells were treated with varying concentrations of S. horneri extract or PA, and the cell viability was measured by water soluble tetrazolium salts analysis. The effective induction of ER stress and the effects of S. horneri were investigated through an examination of the ER stress-related genes, such as activating transcription factor 4 (ATF4), X-box binding protein (XBP1s), C/EBP homologous protein (CHOP), and 78-kDa glucose-regulated protein (GRP78) by quantitative reverse transcription polymerase chain reaction. The expression and activation levels of unfolded protein response (UPR) associated proteins, such as inositolrequiring enzyme-1α (IRE1α), eukaryotic translation initiation factor 2 alpha submit (eIF2α), and CHOP were examined by western blot analysis. Results: The treatment with PA increased the expression of UPR associated genes significantly and induced ER stress in a 12-hour treatment. Subsequent treatment with S. horneri reduced mRNA expression of ATF4, GRP78, and XBP1s. In addition, the protein levels of phosphate (p)-IRE1α, p-elF2α, and CHOP were also reduced by a treatment with S. horneri. An analysis of sirtuin (SIRT) mRNA expression in the S. horneri and PA-treated HepG2 cells showed that S. horneri increased the levels of SIRT2, SIRT6, and SIRT7, which indicates a possible role in reducing the expression of ER stress-related genes. Conclusion: These data indicate that S. horneri can exert an inhibitory effect on ER stress caused by PA and highlight its potential as an agent for managing various ER stress-related diseases.
박소라(Sora Park),김헌애(Heon-ae Kim),차주완(Joo Wan Cha),박종서(Jong-Seo Park),한혜영(Hye-Young Han) 한국기상학회 2014 대기 Vol.24 No.1
The radar reflectivity is significantly affected by ground clutter, beam blockage, anomalous propagation (AP), birds, insects, chaff, etc. The quality of radar reflectivity is very important in quantitative precipitation estimation. Therefore, Weather Radar Center (WRC) of Korea Meteorological Administration (KMA) employed two quality control algorithms: 1) Open Radar Product Generator (ORPG) and 2) fuzzy quality control algorithm to improve quality of radar reflectivity. In this study, an occurrence of AP echoes and the performance of both quality control algorithms are investigated. Consequently, AP echoes frequently occur during the spring and fall seasons. Moreover, while the ORPG QC algorithm has the merit of removing non-precipitation echoes, such as AP echoes, it also removes weak rain echoes and snow echoes. In contrast, the fuzzy QC algorithm has the advantage of preserving snow echoes and weak rain echoes, but it eliminates the partial area of the contaminated echo, including the AP echoes.
Yun, Sora,Lee, Jun Seung,Do, Mi Sol,Jeon, Young Ji,Cha, Ji Young,Baik, Hyung Suk Oxford University Press 2015 Acta biochimica et biophysica Sinica Vol.47 No.11
<P>The TetR family transcriptional regulator AefR contributes to the regulation of the quorum-sensing system. However, the role of AefR in the regulatory network of the phytopathogen <I>Pseudomonas syringae</I> pathovars is not known. In this study, the phenotype of a <I>P. syringae</I> pv. <I>tabaci</I> 11528 <I>aefR</I> deletion mutant strain was examined. The <I>aefR</I> gene expression and AefR DNA-binding affinity were examined by quantitative real-time polymerase chain reaction and electrophoretic mobility shift assay, respectively. AefR was found to control quorum-sensing genes as well as the efflux genes <I>mexE</I>, <I>mexF</I>, and <I>oprN</I> via an indirect mechanism. AefR binds to its own operator site as well as to the palindromic sequence between positions −28 and −2 corresponding to the transcription start site of <I>aefR</I>, as determined by dye primer sequencing. These results suggest that <I>P. syringae</I> AefR modulates quorum sensing and efflux as well as its own expression, which can be exploited by strategies developed to manage this plant parasite.</P>
Korean noctuoidea, the past and the future
Yeong-Bin Cha,Sora Kim 한국응용곤충학회 2023 한국응용곤충학회 학술대회논문집 Vol.2023 No.10
The superfamily Noctuoidea Latreille, 1809 is the largest group within the order Lepidoptera. This big superfamily have been studied for a long time by numerous authors and literatures. However, these huge number of information make hard to study this important group. In this discussion, we hope to talk a simplified overview of significant literature on Korean noctuid moths, recent trends, and forecast for approaching them more easily.