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Cisapride가 금식기 담낭의 수축운동에 어떤 영향을 미치는가?
송영진,장이찬,윤효영,이상전 충북대학교 의과대학 충북대학교 의학연구소 1996 忠北醫大學術誌 Vol.6 No.1
Cisapride의 식사후 담낭의 수축운동에 대한 영향을 규명하고자 20-30대의 건강인 12명(남자 6명, 여자 6명)을 대상으로 placebo, cisapride 10㎎ 혹은 20㎎을 경구복용한 후 담낭체적의 변화를 초음파로 측정하여 다음과 같은 결과를 얻었다. Placebo를 복용한 군에서는 검사기간중 완만한 체적의 변동이 있었으나, cisapride를 복용한 후에는 담낭체적이 지속적으로 현저하게 증가되었다. 이러한 담낭체적의 증가는 placebo를 복용한 군과 비교해 볼 때, cisapride 10㎎을 복용한 군에서는 60분후부터, 20㎎을 복용한 군에서는 50분후부터 통계학적 유의성이 있었으며(p<0.05), 이러한 경향은 검사종료시까지 지속되었다. 그리고 최대체적은 cisapride 10㎎을 복용한 군에서는 120분후에 최초체적의 145%에, cisapride 20㎎을 복용한 군에서는 90분후에 최초체적의 162%에 도달하였다(Fig. 2). 한편 체적곡선 아래의 면적은 cisapride 10㎎을 복용한 군은 31325 ±2518, 20㎎을 복용한 군은 33355 ±4726로, placebo를 복용한 군(23510 ±2864)보다 유의하게 컸다(p<0.05) 이상의 결과에서 cisapride의 경구섭취는 금식기 담낭의 수축운동을 억제하는 이완효과가 있음을 알 수있었다. 그리고 이러한 담낭수축억제효과는 장기간 cisapride를 복용하는 환자에서 담석형성이 촉진되는 효과가 있을 수 있고, 반대로 담석존재시 선통 발작을 억제하거나 예방하는 효과가 있을 수도 있다는 것을 시사한다. Cisapride(C23H29CIFN304) is one of the well-known prokinetic agents. It operates upon whole gastrointestinal tract, from lower esophageal sphincter to anal sphincter, and holds the most promise for patients with colonic motility disorders. It is known to function as an indirect cholinergic stimulant through increased release of acetylcholine in the intramural plexuses. Unlike metoclopramide, it does not have the antidopaminergic effects on the central nervous system. But its effect on the biliary system is not clearly elucidated. This study was performed in 12 healthy volunteers, and focused on the change of gallbladder volume after cisapride ingestion during fasting period. With the interval of 2-4days, placebo, 10㎎ or 20㎎ of cisapride were given. Cisapride inhibited the contraction of gallbladder compared with placebo. The results suggest that cisapride can induces the possible cholelithiasis, but, on the other hand, it can be used as the possible spasmolytic agent in the gallstone disease.
旣成服 製作을 위한 치수分布에 관한 硏究〔Ⅳ〕 : 25歲~60歲 以上 女性의 體型別 치수分布
宋泰玉,李全淑,兪熹子 梨花女子大學校 韓國生活科學硏究院 1979 韓國生活科學硏究院 論叢 Vol.24 No.-
旣成服 製作에 필요한 우리나라 女性의 體型分類를 目的으로 1,108名의 25세~60세 이상의 旣婚女性을 對象으로 11部位의 値數를 計側하여 그 分布를 究明하였다. 옷의 種類에 따라 體型을 分類하였고, 옷의 種類에 따라 부위의 치수를 측정하여 年齡別 平均置와 標準偏差를 구하고 相關關係를 구하였다. 본문의 <표 17,18,19>에서 옷의 종류별, 體型別 衣服製作 個數를 表示하면 <표21>과 같다. This study is done as one of the serials of "Study on the Distribution of size Korean Woman for Ready-made Clothes." 11items of 1,108 Korean married women from 25 to 60 years of ages that were grouped in 7 classes were maesured. In results of Analysis of the measureing data, the grading and distribution of cloth size obtaioned as follows.
성균관대학교 멀티미디어 원격교육 시스템(배움 한마당) 개발에 관한 연구
김석수,권해문,이상권,김상진,전진호,황대준 成均館大學校 科學技術硏究所 1997 論文集 Vol.48 No.1
We propose SKKU Multimedia Distance Education System for distance education between nature science campus(Suwon) and social science campus(Seoul) in Sung Kyun Kwan University on DooRae (Distributed Object Oriented Multimedia Application Crafting Environment for Collaboration) framework (or platform). We support ONE : N study mode for a group lecture and discussion between two campus, and also we support mediation for floor mode of a group lecture and brain storming for floor mode of discussion. The communication portocol of this system is composed of TCP/IP and UDP, and the network type is composed of WAN(El line)for between the Suwon campus and Seoul campus, ATM LAN for each campus(local site). And, this system supports the application development of the collaborative multimedia environment connected with the various network in the CBM (Computer based Multimedia) based. Also, it does not restrict on space between a teacher(s) and a student(s) into cyberspace which made by network. This system has an interaction, late comer, a question and an answer, multi-session, application sharing and whiteboard which resembles chalkboard. Also, various supplementary functions such as video conference and voice conference for this system are what makes face-to-face education effective. Also it supports real or non-real type. The operation system developed on windows 95.
Song Hee Lee(Song Hee Lee),Young Taek Oh(Young Taek Oh),Do-Yeon Lee(Do-Yeon Lee),Eunbyeol Cho(Eunbyeol Cho),Byung Su Hwang(Byung Su Hwang),Junhyun Jeon(Junhyun Jeon) 한국식물병리학회 2022 Plant Pathology Journal Vol.38 No.6
Plants produce chemicals of immense diversity that provide great opportunities for development of new antifungal compounds. In search for environmentfriendly alternatives to the fungicide of current use, we screened plant extracts obtained from more than eight hundred plant materials collected in Korea for their antifungal activity against the model plant pathogenic fungus, Magnaporthe oryzae. This initial screening identified antifungal activities from the eleven plant extract samples, among which nine showed reproducibility in the follow-up screening. These nine samples were able to suppress not only M. oryzae but also other fungal pathogens. Interestingly, the plant extracts obtained from Actinostemma lobatum comprised five out of eight samples, and were the most effective in their antifungal activity. We found that butanol fraction of the A. lobatum extract is the most potent. Identification and characterization of antifungal substances in the A. lobatum extracts would provide the promising lead compounds for new fungicide.
VDUP1 Is Required for the Development of Natural Killer Cells
Lee, Kee Nyung,Kang, Hyung-Sik,Jeon, Jun-Ho,Kim, Eun-Mi,Yoon, Suk-Ran,Song, Hyunkeun,Lyu, Chil-Youl,Piao, Zheng-Hao,Kim, Sun-Uk,Han, Ying-Hao,Song, Su-Sung,Lee, Young-Ho,Song, Kyu-Sang,Kim, Yong-Man,Y Elsevier 2005 Immunity Vol.22 No.2
<P><B>Summary</B></P><P>Vitamin D<SUB>3</SUB> upregulated protein 1 (VDUP1) is a stress-response gene that is upregulated by 1,25(OH)<SUB>2</SUB>D<SUB>3</SUB> in tumor cells. The in vivo roles of VDUP1 were investigated by producing mice lacking VDUP1 (VDUP1<SUP>−/−</SUP> mice). VDUP1<SUP>−/−</SUP> mice showed minimal changes in the development of T and B cells, but there was a profound reduction in the numbers of natural killer (NK) cells. As well, these mice showed decreased NK activity. In the VDUP1<SUP>−/−</SUP> mice, the expression of CD122 was reduced, demonstrating that VDUP1 is required for CD122 expression and NK maturation. In addition, severe lymphoid hyperplasia in the small intestine was observed in VDUP1<SUP>−/−</SUP> mice. Taken together, these results suggest that VDUP1 is a critical factor for the development and function of NK cells in vivo.</P>
Design Optimization, Modeling, and Control of Unmanned Aerial Vehicle Lifted By Coandă Effect
Lee, Hyunyong,Han, Seonhye,Lee, Hyoju,Jeon, Jaehyeok,Lee, Choonghan,Kim, Yong Bum,Song, Seung Hwan,Choi, Hyouk Ryeol IEEE 2017 IEEE/ASME transactions on mechatronics Vol.22 No.3
<P>The Coanda effect is a natural phenomenon, which is that flowing fluid on a certain surface is pulled to the surface due to the viscosity of the fluid. This phenomenon can be utilized to produce the lift force of a flying object. This paper presents a new type of unmanned aerial vehicle (UAV) lifted by the Coanda effect, called SCoanda. We introduce the empirical study of its design and implementations. The principle of the Coanda effect is briefly explained in the first section. The design optimization and control of the UAV, and implementation issues are explained. The structural design of SCoanda is devised to use the maximum lift force produced by the Coanda effect. Since there are a plenty of cases about the shape of SCoanda, it has been limited to oval. It is investigated through computational fluid dynamics. As the result, an optimized design is determined among several candidates and appropriate structural materials are selected via tests. Also, dynamic modeling is suggested under several conditions of SCoanda before simulations are conducted to build up a controller and determine gains according to the dynamic modeling. Finally, the UAV is manufactured and its performances are successfully demonstrated in the indoor and the outdoor environments.</P>