Peroxiredoxin 6 expression is inversely correlated with nuclear factor-κB activation during Clonorchis sinensis infestation

Pak, J.H.,Son, W.C.,Seo, S.B.,Hong, S.J.,Sohn, W.M.,Na, B.K.,Kim, T.S. Pergamon ; Elsevier Science Ltd 2016 FREE RADICAL BIOLOGY AND MEDICINE Vol.99 No.-

Clonorchis sinensis is a carcinogenic human liver fluke. Its infection promotes persistent oxidative stress and chronic inflammation environments in the bile duct and surrounding liver tissues owing to direct contact with worms and their excretory-secretory products (ESPs), provoking epithelial hyperplasia, periductal fibrosis, and cholangiocarcinogenesis. We examined the reciprocal regulation of two ESP-induced redox-active proteins, NF-κB and peroxiredoxin 6 (Prdx6), during C. sinensis infection. Prdx6 overexpression suppressed intracellular free-radical generation by inhibiting NADPH oxidase2 and inducible nitric oxide synthase activation in the ESP-treated cholangiocarcinoma cells, substantially attenuating NF-κB-mediated inflammation. NF-κB overexpression decreased Prdx6 transcription levels by binding to two κB sites within the promoter. This transcriptional repression was compensated for by other ESP-induced redox-active transcription factors, including erythroid 2-related factor 2 (Nrf2), hypoxia inducible factor 1α (HIF1α), and CCAAT/enhancer-binding protein β (C/EBPβ). Distribution of immunoreactive Prdx6 and NF-κB was distinct in the early stages of infection in mouse livers but shared concomitant localization in the later stages. The intensity and extent of their immunoreactive staining in infected mouse livers are proportional to lesion severity and infection duration. The constitutive elevations of Prdx6 and NF-κB during C. sinensis infection may be associated with more severe persistent hepatobiliary abnormalities mediated by clonorchiasis.

한국 재래산양의 이유 후 초기사료개발을 위한 기초 연구

조익환,황보순,손장호,송해범,안종호,최일신,이주삼 ( l . H . Jo,S . Hwangbo,J . H . Son,H . B . Song,J . H . Ahn,I . S . Choe,J . S . Lee ) 한국영양사료학회 1998 韓國營養飼料學會誌 Vol.22 No.3

Decomposition of excess sludge in a membrane bioreactor using a turbulent jet flow ozone contactor

Hwang, B.K.,Son, H.S.,Kim, J.H.,Ahn, C.H.,Lee, C.H.,Song, J.Y.,Ra, Y.H. Korean Society of Industrial and Engineering Chemi 2010 Journal of industrial and engineering chemistry Vol.16 No.4

<P>We have investigated the decomposition of excess sludge generated in a membrane bioreactor using a turbulent jet flow ozone contactor (TJC), which induced both hydrodynamic cavitation and ozonation reactions. We monitored the effects of various TJC operating parameters on the properties of the sludge, including the particle sizes, the particle size distribution, and the levels of soluble COD, total COD, and mixed liquor suspended solids. The TJC enhanced the degree of sludge reduction while consuming less energy, relative to conventional ozonation treatment systems, because of the synergic effects of hydrodynamic cavitation and zonation. The hydrodynamic cavitation generated in the TJC increased the ozone mass transfer efficiency, which in turn promoted the rate of disintegration and solubilization of the sludge particles. Crown Copyright (C) 2010 Published by Elsevier B.V. on behalf of The Korean Society of Industrial and Engineering Chemistry. All rights reserved.</P>

한국 소재 대학교에 재학 중인 재외국민대학생의 문화지능과 학습참여도가 우울에 미치는 영향

강보미,강유빈,고미영,김찬송,남의정,박소은,박정연,백도윤,이혜린,한보혜,신주현,손지희 이화여자대학교 간호과학대학 2019 이화간호학회지 Vol.- No.53

Purpose: This study aims to identify the impact that cultural intelligence and learning engagement of Korean overseas students in Korea have in depression, also, to propose direction for further research, and to suggest a nursing intervention program that aims to the reduction of depression in overseas students. Methods:. The selected participants of the present study were Korean Overseas University Students enrolled in a special admission for overseas students. Data were obtained through the use of SPSS Window 25 and analyzed using descriptive statistics, t-test, ANOVA, Scheffe test, Pearsons correlation coefficient, and multiple linear regression analysis. Results: Depression in Korean overseas university students is influenced by the education system(ß=-.193, p=.046) and continent of residency(ß=0.197, p=.03). It is necessary to take into account the differences of education systems as well as the cultural differences from where they come from for the purpose of reducing depression rates in overseas Koreans. Conclusion: The results of this study show that depression in Korean overseas students is related to the differences in continents of residency and the education systems. Consequently, the development and implementation of a nursing intervention program considering both factors, the continent and education system, has become a necessity that relates to the reduction of depression in Korean overseas students.

Dual-end-functionalized tin (Sn)-phyllosilicates for the esterification of oleic acid

Nam, B.,Lee, H.U.,Park, S.Y.,Son, B.C.,Lee, G.W.,Park, J.Y.,Lee, Y.C. Korean Society of Industrial and Engineering Chemi 2016 Journal of industrial and engineering chemistry Vol.41 No.-

<P>We designed dual-end-functionalized tin (Sn)-phyllosilicate, where the -SH functional groups were subsequently oxidized for -SO3H/SO4H functionalities in a Bronsted acid with/without NH2 functional groups in a Bronsted base. Dual-end-functionalized tin (Sn)-phyllosilicates [MTES:APTS = 1.0:0.11, MTES:TEOS = 1.0:0.11 and 1.0:0.43, v/v] were fabricated where the inorganic framework of Sn species can function as a Lewis acid. The Sn-phyllosilicates with dual acids were applied to esterify oleic acid and produce oleic acid-methyl-ester to test their feasibility as fatty-acid-conversion solid catalysts. In the absence of amine groups, the increase in ratio of tetraethyl orthosilicate (TEOS) to (3-mercaptopropyl)-trimethoxysilane (MTES) for the synthesis of Sn-phyllosilicates (MTES:TEOS = 1.0:0.11 and 1.0:0.43, v/v) increased the recovery of Sn-phyllosilicate in the solvent media and gradually decreased the oleic acid methyl-ester production efficiency (%) of the oleic acid conversion. At the fixed 2.0 wt% Sn-phyllosilicate (MTES:APTS = 1.0:0.11, v/v) loading and oleic acid:MeOH weight ratio = 1:1, an 80 degrees C reaction temperature and 4 h reaction time were determined to be the optimal conditions for the oleic acid methyl-ester production, which had 90% oleic acid conversion efficiency. When the Sn-phyllosilicate (MTES:APTS = 1.0:0.11, v/v) loading was increased from 0.1 to 5.0 wt% at 80 degrees C and 4 h, the fatty-acid conversion efficiency (%) of oleic acid gradually increased from 39.16 to 92.23%. In contrast, Sn-phyllosilicate (MTES:TEOS = 1.0:0.43) had the lowest oleic acid conversion efficiency (%) but the highest catalyst recovery. In summary, this study presents a facile method to produce oleic acid conversion catalysts on an industrial scale. (C) 2016 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.</P>

가스배관재의 피로균열진전거동과 파괴저항특성곡선에 관한 연구

손종동(J. D. Son),임만배(M. B. Lim) 한국동력기계공학회 2007 동력시스템공학회지 Vol.11 No.1

Facile surfactant driven fabrication of transparent WO₃ photoanodes for improved photoelectrochemical properties

Kim, J.H.,Lee, B.J.,Wang, P.,Son, M.H.,Lee, J.S. Elsevier 2016 Applied Catalysis A Vol.521 No.-

<P>A facile polymer-assisted direct deposition method is reported for fabrication of transparent WO3 films for photoelectrochemical water oxidation. Addition of Triton X114 as a polymer additive brings a significant impact on morphology, optical property and crystallinity of WO3 film that leads to improved photoelectrochemical activity. An optimum amount of Triton X 114 added during the WO3 synthesis makes a photoanode with near glass-like transparency with activity improvement. Moreover, bulk charge separation efficiency as high as 80% at 1.23 V-RHE is obtained by Triton X 114 addition by forming preferentially (200) oriented WO3 crystals of better bulk charge transfer property. (C) 2016 Elsevier B.V. All rights reserved.</P>

Enhancement of contraction and L-type Ca²⁺ current by murrayafoline-A via protein kinase C in rat ventricular myocytes

Chidipi, B.,Son, M.J.,Kim, J.C.,Lee, J.H.,Toan, T.Q.,Cuong, N.M.,Lee, B.H.,Woo, S.H. North-Holland ; Elsevier Science Ltd 2016 european journal of pharmacology Vol.784 No.-

<P>We previously reported that murrayafoline-A (1-methoxy-3-methyl-9H-carbazole, Mu-A) increases the contractility of ventricular myocytes, in part, via enhancing Ca2+ influx through L-type Ca2+ channels, and that it increases the Ca2+ transients by activation of protein kinase C (PKC). In the present study, we further examined the cellular mechanisms for the enhancement of contractility and L-type Ca2+ current (I-ca,I-L) by Mu-A. Cell shortening and I-Ca,I-L were measured in rat ventricular myocytes using a video edge detection method and perforated patch-clamp technique, respectively. We found that the positive inotropic effect of Mu-A was not affected by pre-exposure to the beta-adrenoceptor antagonist propranolol, the protein kinase A (PIGS) inhibitors KT5720 or H-89, or the phospholipase C inhibitor U73122. Interestingly, the Mu-A-mediated increases in cell shortening and in the rate of contraction were completely suppressed by pre-treatment with the PKC inhibitor GF109203X. The stimulatory effect of Mu-A on I-Ca,I-L was not altered by inhibition of PKA (KT5720), G-protein coupled receptors (suramin), or alpha(1)-adrenoceptor (prazosin). However, pre-exposure to the PKC inhibitor, GF109203X or chelerythrine, abolished the Mu-A-induced increase in I-Ca,I-L. Pre-exposure to the Ca2+-calmodulin-dependent protein kinase II (CaMKII) inhibitor KN93 slightly reduced the stimulatory effects on contraction and I-Ca,I-L by Mu-A. Phosphorylation of PKC was enhanced by Mu-A in ventricular myocytes. These data suggest that Mu-A increases contraction and I-Ca,I-L via PKC in rat ventricular myocytes, and that the PKC-mediated responses in the presence of Mu-A may be partly mediated by CaMKII. (C) 2016 Elsevier B.V. All rights reserved.</P>

Bar-coated high-performance organic thin-film transistors based on ultrathin PDFDT polymer with molecular weight independence

Nketia-Yawson, B.,Lee, H.S.,Son, H.J.,Kim, B.,Noh, Y.Y. Elsevier Science 2016 ORGANIC ELECTRONICS Vol.29 No.-

<P>We report high-performance organic thin-film transistors (OTFTs) with an ultrathin active layer of difluorobenzothiadiazole-dithienosilole copolymer (PDFDT) form by using the wire bar-coating process. The top-gate/bottom contact (TG/BC) OTFTs based on bar-coated PDFDT polymer as channel material and poly(methyl methacrylate) (PMMA) as gate dielectric show a hole mobility of up to 2.2 cm(2) V-1 s(-1) with a current ON/OFF ratio (I-on/I-off) of 10(4)-10(5), with the mobility being two times larger than that of the spincoated PDFDT based OTFTs. The higher mobility of the bar-coated PDFDT polymer films can be attributed to the well-organized fibril structures of the polymer chains. Importantly, two different molecular weight polymers (M-n = 23 and 34 kDa) were employed to conduct these experiments and both batches showed about the same performance, which mitigates the typical batch-to-batch variation in OTFT performance. Furthermore, we explored the operational stability of the bar-coated OTFTs in ambient air and nitrogen environments. The bias-stress and cycling tests between the ON/OFF states of the bar-coated devices showed high stability in both nitrogen and air. Conclusively, here we demonstrate that (i) a simple barcoating process is a better method to control and obtain good polymer morphology in comparison to spin-coating, and (ii) the PDFDT polymer has great potential to provide good reproducibility and stability in large-area OTFT devices. (C) 2015 Elsevier B.V. All rights reserved.</P>

노인의 병원 선택 경험

김단비,김민지,김해솔,김희정,박윤선,손유경,송예진,유예림,이다예,이서영,이지현,강숙정,김부연 이화여자대학교간호학회 2020 이화간호학회지 Vol.- No.54

Purpose: The purpose of this descriptive study was to examine hospital choice factors among elderly patients to understand their experience and use as data to move towards senior-friendly hospitals. Methods: The individual in-depth interviews were conducted from August 13th to 18th, 2019. The participants consisted of eight senior citizens aged 65 and above that suffered from chronic illnesses and had regular hospital visits. Results: This study found that when elderly patients choose the hospital, they considered ‘awareness such as brand name of the hospital', ‘quality of medical service',‘convenience', ‘healthcare team / hospital employee', ‘personal experience', ‘children’s recommendation’ and etc,. The significant point was that all these factors were related to personal experiences from specific hospitals. Conclusion: This study analyzed the hospital choice factors of the elderly patients with high hospital utilization rates and found that the results were mainly affected by the distinct characteristics of elderly patients. The implications of this study are that we proposed further research directions and means for the improvement of the hospital. We suggest hospitals to increase labor allocation for elderly patients with difficulties dealing with unmanned systems such as kiosk and strengthen the role of healthcare providers as instructors for higher satisfaction.