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DC-DC 벅 컨버터의 차동모드 노이즈 분석을 위한 고주파 등가회로 모델
신주현,김우중,차한주,Shin, Juhyun,Kim, Woojung,Cha, Hanju 한국전력공사 2020 KEPCO Journal on electric power and energy Vol.6 No.4
In this paper, we proposed a high frequency equivalent circuit considering parasitic impedance components for differential noise analysis on the input stage during DC-DC buck converter switching operation. Based on the proposed equivalent circuit model, we presented a method to measure parasitic impedance parameters included in DC bus plate, IGBT, and PCB track using the gain phase method of a network analyzer. In order to verify the validity of this model, a DC-DC prototype consisting of a buck converter, a signal analyzer, and a LISN device, and then resonance frequency was measured in the frequency range between 150 kHz and 30 MHz. The validity of the parasitic impedance measurement method and the proposed equivalent model is verified by deriving that the measured resonance frequency and the resonance frequency of the proposed high frequency equivalent model are the same.
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락토바실러스 아시도필러스 CBT LA1 생균과 사균체의 세포부착력, 자가응집력, 소수성 상호작용력, LPS 결합력에 대한 평가
신주현,이중수,서재구,Shin, Joo-Hyun,Lee, Joong-Su,Seo, Jae-Gu The Microbiological Society of Korea 2015 미생물학회지 Vol.51 No.3
프로바이오틱스에 대한 연구는 주로 생균의 효과가 많이 알려져 있지만 가열 처리된 유산균인 사균체의 기능에 대한 연구도 활발히 이루어지고 있다. 본 연구에서는 락토바실러스 아시도필러스 CBT LA1의 사균체의 장관장벽 기능에 대하여 in vitro, in vivo에서 실험하였다. 이를 위하여, 세포표면 소수성 상호작용력(cell surface hydrophobicity), 자가응집력(autoaggregation), 세포에 부착하는 능력(cell adhesion)과 자가응집력(autoaggregation), LPS와의 결합력을 조사하였다. 또한 HT-29 장상피세포에서 LPS로 유도되는 IL-8의 발현을 억제하는 효과를 조사하였다. CBT LA1을 80도에서 121도까지 10분 동안 열을 처리하였을 때, 80도에서 열을 처리한 CBT LA1 사균체가 가장 높은 세포에 부착하는 능력을 보여 주었다. CBT LA1 생균과 비교했을 때, 80도에서 열을 처리한 CBT LA1 사균체는 높은 LPS와의 결합력, 소수성 상호작용력, 자가응집력, HT-29 세포에 부착하는 능력과 IL-8의 발현을 억제하는 능력을 보여주었다. In vivo 실험에서 FITC로 label된 LPS를 투여하였을 때 16시간 후, CBT LA1 사균체를 섭취한 동물의 장관 내 LPS가 가장 많이 제거되었다. 이러한 연구 결과들은 CBT LA1 생균처럼 CBT LA1 사균체도 장관장벽 기능을 가지며 이는, 파마바이오틱스로서 그 가능성을 시사한다. Although studies on probiotics have been performed mostly with viable microbes, the beneficial functions of dead or heat-killed form of probiotic strains have also been examined. In this study, live and heat-killed forms of Lactobacillus acidophilus CBT LA1 were investigated in vitro and in vivo to evaluate the properties necessary for gut barrier protection. Cell surface hydrophobicity (CSH), autoaggregation (AA), cell adhesion, and lipopolysaccharide (LPS)-binding properties were evaluated. In addition, the suppressive effect on LPS-induced interleukin (IL)-8 expression was investigated in HT-29 cells. To identify optimal conditions for CBT LA1 to adhere to HT-29 cells, CBT LA1 cells were heat-treated at 80, 85, 90, 95, 100, or $121^{\circ}C$ for 10 min; cells treated at $80^{\circ}C$ for 10 min showed the highest adhesion. Heat-killed bacteria at $80^{\circ}C$ showed higher levels of LPS-binding, CSH, AA, adhesion to HT-29, and suppression of IL-8 expression than did live CBT LA1. In vivo imaging was performed to evaluate the ability of live or heat-killed CBT LA1 to remove LPS from the intestine in a rat model of infection. At 16 h after infection, fluorescence from FITC-conjugated LPS had mostly disappeared from the intestine of the rats administered with live or heat-killed CBT LA1; the effect was greater with heat-killed CBT LA1 at $80^{\circ}C$. These results suggest that heat-killed CBT LA1 as well as its live form can be applied as a pharmabiotic for protection of the gut barrier.
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신주현 (재)천주교수원교구 수원교회사연구소 2022 교회사학 Vol.- No.21
It was a major mission for Jesuit missionaries to address the Doctrine of Trinity in the Chinese Catholic Church during the late-Ming period. The rise of the doctrine lay in the publication of Jiaoyao jielue in 1615 by Alfonso Vagnoni. Vagnoni’s catechism was the very text that extensively propagated the Doctrine of Trinity for the first time in the history of Chinese Catholic Church. By the era of Matteo Ricci, died in 1610, the Chinese Church was immature when it comes to conveying a systematic introduction of the doctrine to the local catecumens. Formerly Matteo Ricci initiated the introduction of the doctrine in his publication of Tianzhu jiaoyao in 1605, noteworthy as a genre of Doctrina Christiana, but it was limited in explicating the complex discussions on the doctrine. The rise of the Doctrine of Trinity happened after the generation of Ricci, and it tells that the second-generation Church during the late Ming was becoming more mature. It is particularly remarkable that a significant number of Catholic elite converts including the famous “Three Pillars” were active in the period, which was a good reflection of growing church community, both quantitative and qualitative. The rise of the Doctrine of Trinity in mid 1610s reflects the confidence of the second-generation Jesuits in China who were inspired by the growth of the church. 천주교의 핵심교리에 해당하는 삼위일체론에 대한 적극적인 설파는 명말 중국천주교회에서도 중요한 과제였다. 명말 삼위일체론의 부상은 1615년 바뇨니의 『교요해략』 이전과 이후로 나뉜다. 『교요해략』은 중국 천주교사상 최초로 삼위일체론 교리를 전면적으로 드러낸 한문서학서다. 리치 시대까지는 중국에서 문인신자들에게 문서선교 형식의 체계적인 삼위일체론 제시가 이루어지지 않았다. 리치의 『천주교요』는 중국교회에 최초로 삼위일체론을 제시한 Doctrina Christiana로서 의의가 있으나 교리의 전달 차원에서는 제한적이었다. 리치 시대 이후에야 삼위일체론이 교리서 체제에서 전면적으로 부상할 수 있었던 사실은 2세대 교회에 이르러 명말 중국교회가 성숙해졌음을 반영하는 것이라고 할 수 있다. 특히 이 시기가 명말 중국천주교회의 중심적 역할을 했던 삼대지주인 서광계, 양정균, 이지조를 비롯한 명망있는 문인신자들의 입교가 확대된 이후 교회의 양적, 질적 성장이 두드러진 시점이라는 데에 주목할 필요가 있다. 리치 사후 1610년대 중반 이후에야 본격화된 삼위일체론의 부상은 교회의 성장에 고무된 2세대 예수회 선교사들이 드러낸 자신감의 표현이라고 해석된다.
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신주현,오재욱 생화학분자생물학회 2020 BMB Reports Vol.53 No.7
The targeted nuclease clustered, regularly interspaced short palindromic repeats/CRISPR-associated proteins (CRISPR/Cas) system has recently emerged as a prominent gene manipulation method. Because of its ease in programming targeted DNA/protein binding through RNA in a vast range of organisms, this prokaryotic defense system is a versatile tool with many applications in the research field as well as high potential in agricultural and clinical improvements. This review will present a brief history that led to its discovery and adaptation. We also present some of its restrictions, and modifications that have been performed to overcome such restrictions, focusing specifically on the most common CRISPR/Cas9 mediated non-homologous end joint repair.
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신주현,곽기환,이진걸,김태훈 대한비과학회 2017 Journal of rhinology Vol.24 No.1
Adenocarcinomas of the sinonasal tract are relatively rare. Such tumors are divided into salivary and nonsalivary types as classified by the World Health Organization. Nonsalivary sinonasal adenocarcinomas are further classified as intestinal (ITAC) and non-intestinal (non-ITAC), which can be separated even further into high-grade and low-grade. Low grade non-ITACs are more uncommon than ITACs. In this study, we present a case of low-grade non-ITAC in a 61-year-old woman who was successfully treated with wide excision without radiotherapy, and we also provide a review of the literature.
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