Bortezomib과 Dexamthasone으로 치료한 골수외 형질세포종 4예

백종현,이은영,장리라,손창배,신은경,서정아,이지숙,이호섭,이상민,신성훈,김양수 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Despite the use of aggressive local and systemic treatment including autologous stem cell transplantation in multiple myeloma, extramedullary recurrences are common and the prognosis of these patients is poor. Many novel drugs such as thalidomide, lenalidomide and bortezomib improve the response of treatment of multiple myeloma, but some reports failed to describe thalidomide has effect in extramedullary plasmacytoma. Recent data report on the successful treatment plasmacytomas with bortezomib in patients with advanced multiple myeloma. We treated 4 relapsed or refractory extramedullary plasmacytomas with bortezomib at our institution. We recognized all these extramedullary plasmacytomas decreased and showed more than partial response. This report lends support to the efficacy of bortezomib in the treatment of plasmacytoma and describes the safe use of bortezomib. Responses may, however, be of short duration. Therefore, despite our limited experience, we propose that bortezomib may be considered a therapeutic option for such patients who have risk of radiation therapy

Effectiveness of a Community-Based Intensive Case Management Model on Reducing Hospitalization for People With Severe Mental Illness in Seoul

Jee Hoon Sohn,Sung Joon Cho,Hae Woo Lee,Hyun Kim,Seung Yeon Lee,Yoomi Park,Hwo Yeon Seo,Eun Soo Kim,Jee Eun Park,Bong Jin Hahm 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.12

Objective To overcome the limited effectiveness of standard case management services, the Seoul Intensive Case Management program (S-ICM) for patients with serious mental illnesses was introduced in 2017. This study aimed to evaluate its effectiveness in reducing the length of hospital stay.Methods Monitoring data from April 2019 to March 2020 were retrieved from the Seoul Mental Health Welfare Center. A total of 759 participants with serious mental illnesses were included. The average length of admission per month was compared between the pre-ICM (previous year) and during-ICM periods. For post-ICM observation subgroup, average length of admission per month was compared between pre-ICM, during-ICM, and post-ICM periods. To determine the relative contributions of risk factors for during-ICM and post-ICM admission, multivariate logistic regression analyses were performed.Results The average admission stay for pre-ICM period was significantly longer than that for during-ICM period (1.47 vs. 0.26 days). Among the predictors for during-ICM admission, pre-ICM psychiatric admission was the most important risk factor, followed by medical aid beneficiary and suicidal behavior. In the subgroup analysis of the post-ICM observation period, the pre-ICM, during-ICM, and post-ICM average admission stays were 1.45, 0.29, and 0.57 days/month, respectively. There was a significant difference in the average length of stay between the pre-ICM and during-ICM periods and between the pre-ICM and post-ICM periods. Post-ICM admission risks included pre-ICM admission, S-ICM duration <3 months, and chronic unstable symptoms.Conclusion The results suggest that the S-ICM effectively reduces psychiatric hospitalization duration, at least over a short-term period.

골프 샷의 임팩트 전·후 GRF Peak 값의 크기와 타이밍에 관한 해석

손지훈(Sohn, Jee-Hoon) 한국체육과학회 2011 한국체육과학회지 Vol.20 No.5

The aim of this research is to explore the concept of adequate weight shift. Weight shift is an important factor that influences golf shot performance. In this research, I investigate the GRF peak value and timing differences between athletes and novices. Six athletes with a 1.17 average handicap and seven university faculty members, with a 20.29 average handicap, participated in this research. All were right-handed. Time phase between events and right and left foot GRF peak value for all events were measured. Center of mass speed and acceleration were also calculated. For statistical analysis, the paired T-test was used. In the case of the athletes group, all participants show the same pattern: LPEAK occurs just before IMP. RPEAK occurs between MBS and BST. In the case of the novice group, they show five different patterns of LPEAK and four different patterns of RPEAK. The athletes group’s left foot GRF is as large as 1.47 times at MDS event and 1.54 times at IMP event, compared to the novice group. However, right foot GRF is smaller at all events except MBS. Also, COM speed decreases radically between MDS and LPEAK.

대도시 중심부 쪽방촌 주민의 알코올 사용 장애 유병률과 작업상실일

손지훈(Jee Hoon Sohn),조성준(Sung Joon Cho),안성희(Seung-Hee Ahn),성수정(Su Jeong Sung),유지민(Ji Min Ryu),박지은(Ji Eun Park),조맹제(Maeng Je Cho) 대한사회정신의학회 2016 사회정신의학 Vol.21 No.2

연구목적 : 본 연구는 대도시 중심부 쪽방촌 주민의 알코올 사용 장애 유병률과 작업상실일(Work-loss day)을 평가하여 해당 인구의 알코올 관련 문제의 기능 손실 기여도를 보고자 하였다. 방 법 : 서울 중심권역인 창신동과 돈의동의 쪽방 밀집 지역의 주민에 대하여 정신보건센터를 중심으로 구청 및 지역 내 관련기관의 협력을 받아 한국어판 Composite International Diagnostic Interview(K-CIDI)와 World Health Organization Disability Assessment Schedule II(WHODAS-II)를 포함한 조사를 실시하였다. 가가호호 직접 방문하여 해당지역의 전수 조사를 목표로 하였으며, 969명의 대상자 중 581명이 마무리를 하였다. 결 과 : 알코올 의존과 남용에 대한 평생 유병률은 각각 24.8%, 10.2%였으며, 1년 유병률은 각각 18.4%와 5.3%로 조사되었다. 알코올 의존에 대한 주요 위험인자로는 남성, 60세 이하의 나이, 노숙의 경험, 알코올 문제의 가족력과 우울증상 등이 유의한 결과를 보였다. 1년내 알코올 의존을 보인 군에서는 31%의 작업상실일(Work-loss day)이 관찰되었으며, 여러 변수를 보정한 분석에서 알코올 사용 장애가 독립적으로 초래하는 작업상실률%는 6.66%였다. 외에도 우울증상, 만성 질환, 등급을 받은 장애의 여부 등은 유의한 수준의 작업상실일지수%의 예측인자로, 현재 고용 상태는 보호요인으로 관찰되었으며, 그 기여도는 알코올 의존보다 큰 것으로 조사되었다. 결 론 : 조사가 진행된 쪽방촌 지역은 알코올 사용 장애 문제 유병률이 높았으며, 작업상실일 및 작업상실률% 또한 유의한 수준으로 관찰되었다. 하지만, 이에 대한 기여도는 우울증상, 만성 질환, 등급을 받은 장애의 여부 등이 알코올 의존보다 높았다. 그러므로 알코올 사용 장애가 언급된 요인들의 결과일 수도 있겠다. Objective : The aim of this study was to estimate the prevalence of alcohol use disorder and its effect on work-loss days among the people living in Single-Room-Occupancy (SRO) areas of central Seoul. Methods : Door to door household survey was conducted with all single-room-occupants in the study area. Of 969 people living in the area, 581 subjects completed interview with Korean Version of Composite International Diagnostic Interview as well as WHO disability assessment schedule-II. Results : Lifetime prevalence of alcohol dependence was 24.8% and alcohol abuse was 10.2%. One year prevalence of alcohol dependence was 18.4% and alcohol abuse was 5.3%. Main risk factors of alcohol dependence were male gender, younger age than 60 years, experience of homelessness, family history of alcoholism and depressive symptoms. People with alcohol dependence showed monthly work-loss of 31%. But only 6.7 percentage points of work-loss could be directly attributed to the alcohol dependence. Employments status, registered disability, chronic health problem and depressive symptom were stronger predictors of work-loss days (%) than alcohol dependency. Conclusion : Alcohol use problem was highly prevalent in single-room occupant areas with significant loss of work-days. But depressive symptoms, unemployment and physical health account for more work-loss days than alcohol dependence, and it might be possible that alcohol use disorders being the result of those factors.

골프 Fat shot에 대한 운동역학적 분석

손지훈(Jee-Hoon Sohn) 한국콘텐츠학회 2013 한국콘텐츠학회논문지 Vol.13 No.10

Fat shot은 골프에서 공보다 뒤땅을 먼저 치게 되는 샷의 공식 용어이다. 본 연구에서는 fat shot과 정상적인 샷의 동작을 비교?분석하였다. K 대학교 교원 5명을 연구대상자로 선정하였으며, 개인별 fat shot이 최소 5개 체크될 때까지, 샷을 계속하게 하였다. AD, MBS, TBS, MDS, IMP, MF를 분석 시점으로 설정하였고, 구간 소요시간, 지면반력 패턴, 백스윙 크기, 팔꿈치 각도, 코킹 각도, 골반과 몸통의 회전, 골반 선속도?각속도 등을 분석하였다. 변인별 차이를 확인하기 위해 대응표본 검증을 실시하였다. Fat shot의 주요 원인으로 간주되는 다운스윙에서의 빠른 코킹 풀림, 다운스윙 초기의 오른 팔꿈치 신전, 뒷발에 체중을 실은 채로 하는 스윙 등의 형태는 나타나지 않았다. 백스윙 크기와 X-Factor 크기, 골반과 몸통의 회전각도, 골반의 회전각속도에서도 두 샷 간 차이가 나지 않았다. 그러나 정상적인 샷에 비해 Fat shot은 다운스윙 초반이 아닌, 후반부 임팩트 바로 직전의 다소 급격한 체중 이동 형태와 다운스윙 과정 중 골반의 타겟 방향으로의 급격한 가?감속, 그리고 골반의 수직 상방으로의 다소 작고 늦은 타이밍의 움직임 속도 패턴을 나타내었다. When the golf club hits the ground prior to making contact with the golf ball, we define it as fat shot. The aim of this research was to investigate the difference between normal shot and fat shot in golf. Five candidates playing as recreational golfer participated in this research and they were all right-handed people. Time phase between each event, wrist cocking angle, elbow extension-flexion angle, backswing height, pelvis angle, thorax angle, L-GRF, R-GRF, pelvis linear velocity, pelvis angular velocity and COG path were calculated. For statistical analysis the paired T-test was used. An early un-cocking, an early right elbow extension and impact with leaving their weight behind foot were not reasons of fat shot. Backswing height, X-Factor, pelvis angle and thorax rotation angle were not different between normal shot and fat shot. But we could find a pattern of abrupt pelvic movement and weight shift to target direction just before impact in case of fat shot. In addition fat shot showed time-delayed and small value of pelvis linear velocity pattern to upward during downswing phase as against normal shot.

골프 스윙 시 선수와 비선수의 두부 분절 움직임 패턴 비교: 골프 헤드업에 관한 해석

손지훈 ( Sohn Jee-hoon ),구도훈 ( Koo Do-hoon ) 한국융합과학회 2022 한국융합과학회지 Vol.11 No.8

연구목적 본 연구는 골프 샷의 명언 중 하나인 'Do not head up'에 대한 운동학적 분석을 수행하고 그것을 해석하는 것에 목적이 있다. 연구방법 엘리트 골프 선수 8명과 비선수 10명의 5번 아이언 샷을 측정한 뒤, 스윙 구간 전체에서 머리 움직임 변화를 분석하였다. 스윙 구간은 어드레스(AD), 미들 오브 백스윙(MBS), 백스윙 탑(BST), 미들 오브 다운스윙(MDS), 임팩트(IMP), 미들 오브 폴로스루(MF)로 구분하였다. 적외선 기반 3차원 동작분석 시스템을 사용하였다. 머리 분절 좌우 관자놀이에 부착한 2개의 적외선 반사 마커 중심을 머리의 움직임으로 정의하였다. 골프 스윙 시 정의된 머리 분절의 3차원적 움직임을 집단 간 비교하였다. 결과 선수의 경우 머리의 움직임이 백스윙 시 우측(-y 축 방향), 하방(-z 축 방향)으로 움직임이 나타나고, 다운스윙 시 좌측(+y 축 방향), 후방(-x 축 방향), 하방(-z 축 방향) 의 방향으로 3차원 공간에서 머리 움직임이 나타났다. 비선수들은 백스윙 시 이미 머리 위치가 높아지면서 임팩트 시 머리 위치가 충분히 내려오지 못하는 패턴을 보였다. 선수들은 다운스윙 시 일관된 머리 움직임이 타나났으나, 비선수의 경우는 피험자 간 각기 다른 패턴의 머리 움직임을 보였다. 결론 골프 코칭 시 '머리를 들지 마라라는 격언으로는 부족하다. 골프 스윙 동작 시 머리 움직임의 3차원적 피드백이 제공되어야 올바른 머리 움직임을 바탕으로 골프 스윙이 이루어질 수 있을 것이다. Purpose The purpose of this study is to analyze the head movements of elite golfers and non-players during golf swings to interpret the meaning of head-ups kinematically. Method After measuring the 5th iron shot of 8 elite golfers and 10 non-players, the change in head movement was analyzed throughout the swing section. Swing sections were divided into address (AD), middle of back swing (MBS), back swing top (BST), middle of down swing (MDS), impact (IMP), and middle of through (MF). An infrared-based three-dimensional motion analysis system was used. The center of the two infrared reflective markers attached to the left and right temples of the head segment was defined as the movement of the head. The three-dimensional movements of the head segment defined during the golf swing were compared between groups. Result In the case of the eltie golfers, the movement of the head appeared in the right(-y axis direction) and downward directions(-z axis direction) during the backswing, and the movement of the head appeared in the three-dimensional space to the left(+y axis direction), post direction(-x axis direction), and downward(-z axis direction) directions during the downswing. Non-elite golfers showed a pattern in which the head position was not sufficiently lowered during impact as the head position was because of already increased haead position during the backswing. The elite golfers showed consistent head movements during downswing, but in the case of non-athletes, they showed different head movements between subjects. Conclusion When coaching golf, the adage Do not head up is not enough. In the case of a golf swing motion, three-dimensional feedback of the head movement might be provided so that the golf swing can be achieved based on the correct head movement.

의도적인 드로우 샷과 페이드 샷이 골프 스윙 역학에 미치는 영향에 관한 연구

손지훈 ( Jee Hoon Sohn ),류재진 ( Jae Jin Ryue ),이기광 ( Ki Kwang Lee ),임영태 ( Young Tae Lim ) 한국운동역학회 2010 한국운동역학회지 Vol.20 No.2

Intentional draw and fade shots could be good weapons for lowering golf score. But how to make such shots? To investigate deterministic variables generating different projectile paths of shots in square stance was the purpose of this study. Ten right-handed male collegiate athletes, showing 1.3 of averaged handicap, participated in this study. They were asked to intentionally perform three different shots such as the straight shot(control condition), draw shot, and fade shot. Swing path, pelvis rotation angle, thorax rotation angle and left forearm supination angle were determined for dependent variables on impact event at each trial. For statistical analysis one-way repeated measures ANOVA were used. The results showed that swing path was one of main factor making differences among three kind of shots. Straight shot vs. Draw shot, Straight shot vs. Fade shot and Draw shot vs. Fade shot showed differences on swing path. And left forearm supination angle revealed significant difference between draw shot and fade shot, showing a significant larger angle of draw shot than fade shot. No other significant difference was detected for the other variables. We found that the shot characteristics were influenced primarily by swing path and left forearm supination angle.

골프 선수들의 실제 샷, 빈 스윙, 배트 스윙 비교 연구

손지훈(Sohn, Jee-Hoon) 한국체육과학회 2013 한국체육과학회지 Vol.22 No.5

Practice swings are considered useful methods to increased one"s golf skills. Golf swing bats, as a swing aid, are considered useful apparatus among amateur golfers. In this research, we investigate the differences among real shot, practice swing and golf bat swing. Five professional golfers with a 2 average handicap, participated in this research. Time phase between events and COG height for all events were calculate. Pelvis rotation angle, pelvis lineal velocity, pelvis angular velocity, thorax rotation angle to the target, elbow"s flexion-extension angle, and left wrist cocking angle for all events were analyzed. Also, left foot GRF and right foot GRF were measured. For statistical analysis, one way repeated measures ANOVA was used. There were no significant differences in motion and tempo during the backswing phase between real shot and practice swing. But cocking angle, thorax angle and L-GRF at MF event were different. Real shot"s time duration, IMP to MF, was longer than practice swing because of ball collision. There were some significant differences in motion and tempo during the downswing phase between real shot and bat swing. Bat swing took longer time than real shot during TBS-MDS phase. At MF event, cocking angle, L-GRF, right elbow angle, thorax angle and pelvis angular velocity were different between real shot and bat swing.

골프에서 힘 조절이 샷의 거리와 정확성에 미치는 영향

손지훈(Jee Hoon Sohn),이기광(Ki Kwang Lee) 한국사회체육학회 2011 한국사회체육학회지 Vol.0 No.46

The aim of this research is to explore the concept of adequate power control to optimize distance and precision in golf shot. To control one`s own swing power is an important factor that influences golf shot performance. In this research, The author investigated the golf shot characteristics(distance, radius, club head speed, ball speed, smash factor) and motion variables(stance width, backswing height, cocking angle, X-Factor, pelvis linear velocity, pelvis angular velocity, GRF pattern) at five different condition(70%, 80%, 90%, MAX, RD). Seven athletes with a 1.43 average handicap participated in this research. All were right-handed. For statistical analysis, One-way repeated measures ANOVA was used. Golf shot with feel of a round was similar to 90% power shot. RD condition showed short distance but smaller radius against MAX condition. To control swing power, athletes changed stance width, backswing height, weight shift pattern and pelvis movement radically to target path. They didn`t change cocking angle and X-Factor at BST event.

스포츠공학 연구 동향 탐색을 통한 운동역학 분야 확장 방향 모색

손지훈 ( Sohn Jee-hoon ),양종현 ( Yang Jong-hyun ) 한국융합과학회 2022 한국융합과학회지 Vol.11 No.8

연구목적 본 연구는 스포츠공학 분야에서 가장 저명한 학술지를 분석하여 스포츠공학 분야의 최근 연구 동향을 탐색하는 것에 목적이 있다. 연구방법 이를 위해 ISEA에서 발간하는 Sport Engineering 저널에 출판되어 있는 최근 3년간(2020~2022)의 논문 62편 중 56편의 연구 내용을 분석하였다. 결과 스포츠공학 분야의 주된 연구 분야는 장비 개발 및 검증이었으며, 실험적 연구가 가장 높은 비중을 차지했다. 공학 분야와 관련된 논문이 주를 이루었지만 비율이 매년 감소하였고, 운동역학 분야는 증가하는 추세를 보였다. 결론 스포츠공학은 현재 공학 계열이 주도하고 있는 전도유망한 신생 연구 분야이다. 한국에서도 체육 계열, 특히 운동역학 분야에서 세계적 스포츠공학 분야의 흐름을 받아들이고, 관련 연구를 시작해 나갈 필요가 있다. Purpose The purpose of this studyﾠis to explore the recent research trends in the field of sports engineering by analyzing thesis data of the most prominent academic journal in this field. Methods Out of 62 papers published in the last three years (2020-2022) in the Sport Engineering Journal published by ISEA, 56 were analyzed. Result The main field of research of sports engineering was equipment development and verification; however, experimental research accounted for the highest proportion. Although papers related to engineering were predominant, the ratio decreased every year; and the field of sports biomechanics gained popularity. Conclusion Sports engineering is a promising field of research led by the engineering. In Korea, it is necessary to accept the flow of global sports engineering and start related research in the field of physical education, especially related to sport biomechanics.