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Shin, J.I.,Song, K.S.,Kim, H.,Cho, N.H.,Kim, J.,Kim, H.S.,Lee, J.S. Blackwell Publishing Ltd 2011 British journal of dermatology Vol.164 No.6
<P><B>Summary</B></P><P><B>Background </B> Because inflammatory cytokines are known to be potent inducers of matrix metalloproteinases (MMPs), and MMPs themselves can promote inflammation, we speculated that MMP activation might be involved in the pathogenesis of Henoch–Schönlein purpura (HSP) vasculitis.</P><P><B>Objectives </B> To investigate the gene expression profile of all known MMPs and tissue inhibitors of metalloproteinases (TIMPs) in children with HSP and to examine the role, if any, of MMPs in the pathogenesis of HSP.</P><P><B>Methods </B> Peripheral blood samples were obtained from 10 patients with HSP (nine were in the acute stage, one had HSP nephritis) and four healthy controls. Peripheral blood samples were also taken from the nine patients with HSP when they reached the convalescent stage of the disease. From these samples, total RNA was purified and gene expressions were measured using real‐time polymerase chain reaction.</P><P><B>Results </B> MMP‐8 expression was decreased in patients with arthralgia (<I>P </I>=<I> </I>0·038), and MMP‐3 (<I>P </I>=<I> </I>0·03) and TIMP‐4 expressions (<I>P </I>=<I> </I>0·016) were elevated in HSP patients with nephritis. Soft tissue oedema was associated with decreased expressions of MMP‐26 (<I>P </I>=<I> </I>0·038) and MMP‐28 (<I>P </I>=<I> </I>0·038). MMP‐1, MMP‐8, MMP‐9, MMP‐10, MMP‐13, MMP‐16 and MMP‐26 levels were significantly higher in patients in the acute stage of HSP than in normal controls (<I>P </I><<I> </I>0·05). MMP‐9 (<I>P </I>=<I> </I>0·097) and MMP‐19 (<I>P </I>=<I> </I>0·054) levels decreased to borderline significance in patients in the convalescent stage compared with those in the acute stage. The duration of steroid administration was negatively correlated with MMP‐1, MMP‐2, MMP‐7, MMP‐10, MMP‐12, MMP‐19, MMP‐23 and TIMP‐1 levels (<I>P </I><<I> </I>0·05), suggesting a suppressive effect of steroids on the expressions of MMPs and TIMPs.</P><P><B>Conclusions </B> This is the first study to describe the expression profile of all known MMPs and TIMPs in children with HSP, and our results suggested that abnormal levels of MMP and TIMP activity may have a role in the pathogenesis of HSP.</P>
Shin, Ji‐,Ae,Kim, Jae‐,Jin,Choi, Eun‐,Sun,Shim, Jung‐,Hyun,Ryu, Mi Heon,Kwon, Ki Han,Park, Hee‐,Min,Seo, Jin‐,Young,Lee, Soo‐,Yeon,Lim, Do‐,Won,Cho, Nam Wiley Subscription Services, Inc., A Wiley Company 2013 Head & neck Vol.35 No.7
<P><B>Abstract</B></P><P><B>Background</B></P><P>The aims of this study were to evaluate the apoptotic activities and molecular mechanisms of methanol extracts of <I>Dianthus chinensis</I> (MEDC) and <I>Acalypha australis</I> L. (MEAL) in human oral cancer cells.</P><P><B>Methods</B></P><P>The apoptotic effects and related molecular mechanisms of MEDC and MEAL on oral cancer cells were evaluated using MTS assay, DAPI staining, immunostaining, Western blotting, and reverse transcriptase–polymerase chain reaction.</P><P><B>Results</B></P><P>Sp1 was overexpressed in oral tumor tissues compared with normal oral mucosa. Downregulation of Sp1 inhibited the growth of SCC‐15 and YD‐15 oral cancer cells. MEDC and MEAL inhibited cell growth and induced apoptosis in both cell lines by decreasing the expression of Sp1. In addition, treatment of cells with MEDC and MEAL decreased Mcl‐1 expression, which is a downstream target of Sp1.</P><P><B>Conclusion</B></P><P>Our results indicate that MEDC and MEAL are bioactive natural products that can potentially induce apoptosis of tumor cells that overexpress the Sp1 protein. © 2012 Wiley Periodicals, Inc. Head Neck, 2013</P>
Shin, J.I.,Lim, H.Y.,Kim, H.W.,Seung, B.J.,Ju, J.H.,Sur, J.H. ACADEMIC PR 2016 JOURNAL OF COMPARATIVE PATHOLOGY Vol.155 No.1
<P>This study was designed to investigate the role of obesity in canine malignant mammary tumours (CMMTs), by assessing aromatase expression and the regulatory roles of immune mediators such as cyclo-oxygenase-2 (COX2), prostaglandin E-2 (PGE(2)), nuclear factor kappa beta (NF-kappa B), hypoxia inducible factor-1 alpha (HIF-1 alpha cc) and adipokines (i.e. leptin) in lean, optimal body weight, overweight and obese animals. Clinicopathological data, including the breed, body weight, body condition score and age and neutering status, were collected, together with histopathological characteristics (i.e. histological types, grading and lymphatic invasion). To determine the expression of each factor, immunohistochemistry was conducted with 60 samples of malignant CMMTs. CMMTs from overweight and obese animals had significantly elevated levels of PGE(2), and aromatase expression correlated significantly with PGE(2), NF-kappa B and leptin expression. However, no significant difference was observed in terms of histopathological characteristics. The results suggest that PGE(2), a known obesity-related immune mediator, could be upregulated in CMMTs from overweight and obese animals. In addition, PGE(2), NF-kappa B and leptin influenced the expression of aromatase, as observed in women. (C) 2016 Elsevier Ltd. All rights reserved.</P>
An estimation method for 2-port S-parameters using 4-port connection circuit with leakage couplings
Shinji Ohno,Toshikazu Sekine,Yasuhiro Takahashi 대한전자공학회 2015 ITC-CSCC :International Technical Conference on Ci Vol.2015 No.6
An estimation method for S-parameters of 2-port circuit by using connection circuits with leakage couplings is presented. In our method, two ports of 4- port connection circuit are terminated with unknown 2- port circuit or known loads. And the S-parameters between remaining two ports are measured. Advantages of our method is that the S-parameters of 2-port circuit are to be estimated only by solving the linear least squares problem. Our method can be applied to determine the S-parameters of the circuit with a difficult port to connect the probe of the instrument as the IC package and to determine the S-parameters of the circuit ground is not common.
( Shinji Ishii ),( Suguru Fukahori ),( Kimio Asagiri ),( Yoshiaki Tanaka ),( Nobuyuki Saikusa ),( Naoki Hashizume ),( Motomu Yoshida ),( Daisuke Masui ),( Naoko Komatsuzaki ),( Naruki Higashidate ),( 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2017 Journal of Neurogastroenterology and Motility (JNM Vol.23 No.4
Background/Aims The aim of this study is to investigate the degree of delayed gastric emptying (DGE) and evaluate how the severity of DGE affects gastroesophageal reflux disease (GERD) in neurologically impaired (NI) patients utilizing 24-hour multichannel intraluminal impedance pH measurements (pH/MII) and <sup>13</sup>C-acetate breath test (<sup>13</sup>C-ABT) analyses. Methods <sup>13</sup>C-ABT and pH/MII were conducted in 26 NI patients who were referred to our institution due to suspected GERD. At first, correlation analyses were performed to investigate the correlation between the <sup>13</sup>C-ABT parameters and the clinical or pH/MII parameters. Thereafter, all patients were divided into 2 groups (DGE and severe DGE [SDGE] group) according to each cut off half emptying time (t<sub>1/2</sub>, 90-170 minutes). Each pH/MII parameter was compared between the 2 groups in each set-up cutoff t<sub>1/2</sub>. Results The mean t<sub>1/2</sub> of all patients was 215.5 ± 237.2 minutes and the t<sub>1/2</sub> of 24 (92.3%) patients were > 100 minutes. Significant moderate positive correlations were observed between both t1/2 and lag phase time and the non-acid reflux related parameters. Furthermore, the patients in the SDGE group demonstrated higher non-acid reflux related parameters than those of the DGE groups when the cutoff was t<sub>1/2</sub> ≥ 140 minutes. Conclusion The present study demonstrated that GE with t<sub>1/2</sub> ≥ 140 minutes was related to an increase of non-acid exposure reaching up to the proximal esophagus in NI patients, and indicating that NI patients with SDGE might have a high risk of non-acid GERD. (J Neurogastroenterol Motil 2017;23:533-540)
Shinji Inoue,Shigeru Yamada 대한산업공학회 2018 대한산업공학회 추계학술대회논문집 Vol.2018 No.11
Reflecting the debugging process or environment in testing phase on software reliability models is often discussed as one of the approaches for improving the accuracy of model-based software reliability assessment. We propose a few specific models for software reliability measurement by considering several debugging processes based on the notion of a phase-type probability distribution. Further we show numerical examples of our models, and discuss the usefulness of a phase-type modeling approach by using actual fault counting data.
Shinji Matsumoto,Hideki Shimada,Takashi Sasaoka 한국지질과학협의회 2017 Geosciences Journal Vol.21 No.3
The disintegration of rocks by weathering plays an important role in the occurrence of Acid Mine Drainage (AMD), which is the environmental problem caused by the exposure of sulfide minerals to water and oxygen. The weathering of rocks is, generally, classified into physical or chemical weathering. However, there are few studies that focus on the complex interaction between physical and chemical weathering of rocks and on the effects of the interaction on the occurrence of AMD. This paper elucidates the complex interrelation between physical and chemical weathering of rocks as well as the progress of AMD through leaching test and weathering test with argillaceous rocks taken in open-cast coal mine in Indonesia in addition to sample analysis before and after the wetting and drying cycle: the rock samples were exposed to oxygen and water during the cycle. The results indicated that the argillaceous rocks which consist of sulfide and/or sulfate caused chemical weathering with micro-cracks on the surface of rocks through the dissolution of soluble iron and sulfur during the occurrence of AMD. Additionally, physical weathering of rocks due to clay minerals was accelerated by chemical weathering with the development of cracks with the occurrence of AMD in the argillaceous rocks containing kaolinite and pyrite. Although weathering of rocks also accelerated AMD, it was concluded that the sulfur content, the form of sulfur and iron in rocks, and the supply of oxygen significantly contributed to the occurrence of AMD.