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Software Reliability Modeling and Its Applications: Fundamental Survey
Shigeru Yamada 한국신뢰성학회 2014 한국신뢰성학회 학술대회논문집 Vol.2014 No.5
Software reliability is one of the most important characteristics of software quality. Its measurement and management technologies during the software life-cycle are essential to produce and maintain quality/reliable software systems. In this talk, we discuss software reliability modeling and its applications. As to software reliability modeling, hazard rate and NHPP models are investigated particularly for quantitative software reliability assessment. Further, imperfect debugging and software availability models are also discussed for incorporating practical factors of dynamic software behavior. And three software management problems are discussed as an application technology of software reliability models : Optimal software release problem, Statistical testing-progress control, and optimal testing-effort allocation problem.
Takanori Yamada,박규진,Junichi Node,Kakeru Ozaki,Manami Hiraiwa,Yuka Kitaguchi,Katsuyuki Kaneda,Shigeru Hiramoto,Eiichi Hinoi 한국식품과학회 2019 Food Science and Biotechnology Vol.28 No.4
An imbalance in the sophisticated regulationbetween bone-resorbing osteoclasts and bone-formingosteoblasts leads to the pathogenesis and etiology of certainmetabolic bone diseases including osteoporosis. Certainpolyamines are related to the pathophysiology of some disorders,including Alzheimer’s disease, infectious disease,cancer, and aging. Recently, we demonstrated that oralintake of polyamines (spermidine and spermine) preventedbone loss through preferential disturbance of osteoclasticactivation in ovariectomy-induced mouse model of postmenopausalosteoporosis. Here, we showed that daily oralsupplementation of a diet containing polyamine-rich Saccharomycescerevisiae S631 significantly inhibited osteoclasticactivation as well as reduction of bone volume in thecancellous bone without affecting uterine weight inovariectomized mice. Our findings recommend that dailyoral supplementation with polyamine-rich yeast diet wouldbe beneficial for prophylaxis of metabolic bone diseasesassociated with abnormal osteoclast activation.
Conjugal Transfer of Plasmid DNA from Escherichia coli to Streptomyces lavendulae FRI-5
KITANI, SHIGERU,BIBB, MERVYN J.,NIHIRA, TAKUYA,YAMADA, YASUHIRO 한국미생물 · 생명공학회 2000 Journal of microbiology and biotechnology Vol.10 No.4
Streptomyces lavendulae FRI-5 produces the γ-butyrolactone autoregulator IM-2, which is required for nucleoside antibiotic production. We have developed a system for introducing DNA into S. lavendulae FRI-5 via conjugal transfer from Escherichia coli. Conditions were established for conjugation of the oriT- and attP-containing plasmid pSET152 from E. coli ET12567 (pUZ8002) to FRI-5. Conjugation resulted in integration of the plasmid at the chromosomal øC31 attB site. The frequency of intergeneric conjugation varied with the medium used. The highest frequency (1.6×l0^-5 per recipient) was obtained on ISP medium 2 containing 10mM MgCl_2. Southern blot and phenotypic analyses of exconjugants revealed that S. lavendulae FRI-5 contains a unique øC31 attB site, and that integration of heterologous DNA into the attB site did not interfere with morphological differentiation or IM-2-dependent signal transduction, including the production of a blue pigment. This system will now enable detailed genetic analysis of the regulation of antibiotic production in S. lavendulae FRI-5.
Yasuyoshi Kurokawa,Shigeru Yamada,Shinsuke Miyajima,Akira Yamada,Makoto Konagai 한국물리학회 2010 Current Applied Physics Vol.10 No.3
It was found that the dark conductivity of a stoichiometric a-SiC thin film, which is used as barrier layers in a Si quantum dots superlattice (Si-QDSL), increased drastically after thermal annealing above 800 ℃. This is due to the crystallization of an a-SiC phase in the films. To resolve this problem, CO2gas was introduced during the deposition of stoichiometric a-SiC thin films. As a result, the dark conductivity of the films annealed at either 900 or 1000 ℃ was reduced below 10-9 S/cm, since the introduction of oxygen atoms into the films prevented the a-SiC phase from crystallizing during the annealing. O-containing Si-QDSLs were prepared and the dark conductivity of the O-containing Si-QDSLs was reduced in the range of 10-6–10-7 S/cm and increased with increasing the diameter of Si-QDs, suggesting that the leakage in barrier layers was suppressed and the carrier transport through Si-QDs became predominant.