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Shin, J.I.,Lim, H.Y.,Kim, H.W.,Seung, B.J.,Ju, J.H.,Sur, J.H. ACADEMIC PR 2016 JOURNAL OF COMPARATIVE PATHOLOGY Vol.155 No.1
<P>This study was designed to investigate the role of obesity in canine malignant mammary tumours (CMMTs), by assessing aromatase expression and the regulatory roles of immune mediators such as cyclo-oxygenase-2 (COX2), prostaglandin E-2 (PGE(2)), nuclear factor kappa beta (NF-kappa B), hypoxia inducible factor-1 alpha (HIF-1 alpha cc) and adipokines (i.e. leptin) in lean, optimal body weight, overweight and obese animals. Clinicopathological data, including the breed, body weight, body condition score and age and neutering status, were collected, together with histopathological characteristics (i.e. histological types, grading and lymphatic invasion). To determine the expression of each factor, immunohistochemistry was conducted with 60 samples of malignant CMMTs. CMMTs from overweight and obese animals had significantly elevated levels of PGE(2), and aromatase expression correlated significantly with PGE(2), NF-kappa B and leptin expression. However, no significant difference was observed in terms of histopathological characteristics. The results suggest that PGE(2), a known obesity-related immune mediator, could be upregulated in CMMTs from overweight and obese animals. In addition, PGE(2), NF-kappa B and leptin influenced the expression of aromatase, as observed in women. (C) 2016 Elsevier Ltd. All rights reserved.</P>
Shin, J.I.,Song, K.S.,Kim, H.,Cho, N.H.,Kim, J.,Kim, H.S.,Lee, J.S. Blackwell Publishing Ltd 2011 British journal of dermatology Vol.164 No.6
<P><B>Summary</B></P><P><B>Background </B> Because inflammatory cytokines are known to be potent inducers of matrix metalloproteinases (MMPs), and MMPs themselves can promote inflammation, we speculated that MMP activation might be involved in the pathogenesis of Henoch–Schönlein purpura (HSP) vasculitis.</P><P><B>Objectives </B> To investigate the gene expression profile of all known MMPs and tissue inhibitors of metalloproteinases (TIMPs) in children with HSP and to examine the role, if any, of MMPs in the pathogenesis of HSP.</P><P><B>Methods </B> Peripheral blood samples were obtained from 10 patients with HSP (nine were in the acute stage, one had HSP nephritis) and four healthy controls. Peripheral blood samples were also taken from the nine patients with HSP when they reached the convalescent stage of the disease. From these samples, total RNA was purified and gene expressions were measured using real‐time polymerase chain reaction.</P><P><B>Results </B> MMP‐8 expression was decreased in patients with arthralgia (<I>P </I>=<I> </I>0·038), and MMP‐3 (<I>P </I>=<I> </I>0·03) and TIMP‐4 expressions (<I>P </I>=<I> </I>0·016) were elevated in HSP patients with nephritis. Soft tissue oedema was associated with decreased expressions of MMP‐26 (<I>P </I>=<I> </I>0·038) and MMP‐28 (<I>P </I>=<I> </I>0·038). MMP‐1, MMP‐8, MMP‐9, MMP‐10, MMP‐13, MMP‐16 and MMP‐26 levels were significantly higher in patients in the acute stage of HSP than in normal controls (<I>P </I><<I> </I>0·05). MMP‐9 (<I>P </I>=<I> </I>0·097) and MMP‐19 (<I>P </I>=<I> </I>0·054) levels decreased to borderline significance in patients in the convalescent stage compared with those in the acute stage. The duration of steroid administration was negatively correlated with MMP‐1, MMP‐2, MMP‐7, MMP‐10, MMP‐12, MMP‐19, MMP‐23 and TIMP‐1 levels (<I>P </I><<I> </I>0·05), suggesting a suppressive effect of steroids on the expressions of MMPs and TIMPs.</P><P><B>Conclusions </B> This is the first study to describe the expression profile of all known MMPs and TIMPs in children with HSP, and our results suggested that abnormal levels of MMP and TIMP activity may have a role in the pathogenesis of HSP.</P>
Shin, Ji‐,Ae,Kim, Jae‐,Jin,Choi, Eun‐,Sun,Shim, Jung‐,Hyun,Ryu, Mi Heon,Kwon, Ki Han,Park, Hee‐,Min,Seo, Jin‐,Young,Lee, Soo‐,Yeon,Lim, Do‐,Won,Cho, Nam Wiley Subscription Services, Inc., A Wiley Company 2013 Head & neck Vol.35 No.7
<P><B>Abstract</B></P><P><B>Background</B></P><P>The aims of this study were to evaluate the apoptotic activities and molecular mechanisms of methanol extracts of <I>Dianthus chinensis</I> (MEDC) and <I>Acalypha australis</I> L. (MEAL) in human oral cancer cells.</P><P><B>Methods</B></P><P>The apoptotic effects and related molecular mechanisms of MEDC and MEAL on oral cancer cells were evaluated using MTS assay, DAPI staining, immunostaining, Western blotting, and reverse transcriptase–polymerase chain reaction.</P><P><B>Results</B></P><P>Sp1 was overexpressed in oral tumor tissues compared with normal oral mucosa. Downregulation of Sp1 inhibited the growth of SCC‐15 and YD‐15 oral cancer cells. MEDC and MEAL inhibited cell growth and induced apoptosis in both cell lines by decreasing the expression of Sp1. In addition, treatment of cells with MEDC and MEAL decreased Mcl‐1 expression, which is a downstream target of Sp1.</P><P><B>Conclusion</B></P><P>Our results indicate that MEDC and MEAL are bioactive natural products that can potentially induce apoptosis of tumor cells that overexpress the Sp1 protein. © 2012 Wiley Periodicals, Inc. Head Neck, 2013</P>
Shinji Takahashi,Hiroyuki Inose,Koji Tamai,Masayoshi Iwamae,Hidetomi Terai,Hiroaki Nakamura 대한척추신경외과학회 2023 Neurospine Vol.20 No.3
Osteoporotic vertebral fractures (OVFs) can hinder physical motor function, daily activities, and the quality of life in elderly patients when treated conservatively. Vertebral augmentation, which includes vertebroplasty and balloon kyphoplasty, is a commonly used procedure for OVFs. However, there have been reports of complications. Although serious complications are rare, there have been instances of adjacent vertebral fractures, cement dislocation, and insufficient pain relief due to cement failure, sometimes necessitating revision surgery. This narrative review discusses the common risks associated with vertebral augmentation for OVFs, such as cement leakage and adjacent vertebral fractures, and highlights the risk of revision surgery. The pooled incidence of revision surgery was 0.04 (0.02– 0.06). The risks for revision are reported as follows: female sex, advanced age, diabetes mellitus, cerebrovascular disease, dementia, blindness or low vision, hypertension, hyperlipidemia, split type fracture, large angular motion, and large endplate deficit. Various treatment strategies exist for OVFs, but they remain a subject of controversy. Current literature underscores the lack of substantial evidence to guide treatment strategies based on the risks of vertebral augmentation. In cases with a high risk of failure, other surgeries and conservative treatments should also be considered as treatment options.
A tool support for verifying consistency between UML diagrams by SMV
Shinji HARADA,Tomoyuki YOKOGAWA,Hisashi MIYAZAKI,Yoichiro SATO,Michiyoshi HAYASE 대한전자공학회 2009 ITC-CSCC :International Technical Conference on Ci Vol.2009 No.7
We develop a tool to support verification of consistency between designs described by UML diagrams. This tool translates an XML data exported from a UML drawer into an input of SMV (called SMV program). This tool provides afront-end which parses an XML data and generates an intermediate data. This tool also provides a back-end which generates an SMV programfrom the intermediate data. We show the availability of our tool by applying it to an example.
A Proposal for Prototype-Free Production Preparation Processes Utilizing 3DCG Animations
Shinji Shinoda,Kazuhiro Shimozawa,Akira Niwa,Takeshi Kawase,Toshiyuki Matsumoto,Tadahiro Mizumachi 대한산업공학회 2009 Industrial Engineeering & Management Systems Vol.8 No.2
As the use of 3DCAD data became widespread in designing products in manufacturing, attempts have been made to shorten lead time and reduce cost of production preparation utilizing 3DCAD data for launching assembly lines. In order to create assembly plans not only efficient but easy for operators to operate (‘easy-tooperate’), this study presents approaches, methods, and systems for creating 3DCGAs (3 Dimensional Computer Graphic Animations) which automatically utilize a prototype-free production preparation methodology. Characteristics of this study include that it proposes the methodology for creating assembly operation 3DCGAs automatically, for all the possible assembly operations corresponding each of the possible assembly sequences first. Using the created 3DCGAs, the study next considers assembly methods by evaluating how easy or ‘operator friendly’ they are in implementing, and devises tools or jigs to be used, and plans efficient assembly line organization. The concept of the methodology was formed by focusing on the value-adding assembly steps at which parts turn into products directly. The study also validates the effectiveness of the presented methodology by employing the methods used in actual production preparation process in businesses, and proves that an efficient assembly line can be organized in a shorter period of time utilizing the developed system and by preparing easy-to-operate and efficient plans in 3DCGAs at the design stage.