Alkyl/Vinyl-표면개질된 Nanosilicas의 LSR-나노콤포지트 HVDC 전기적 및 기계적 특성

함성호(Seong Ho Ham),송창훈(Chang Hun Song),최승민(Seung Min Choi),장희수(Hee Soo Jang),유재우(Jae Woo Yoo),윤영빈(Young Been Yoon),이병훈(Byung Hun Lee),김찬성(Chan Seong Kim),조승민(Seung Min Jo),이지희(Ji Hee Lee),박재준,김영선(Young 대한전기학회 2020 대한전기학회 학술대회 논문집 Vol.2020 No.7

나노 실리카의 친수성 표면은 다양한 비율의 알킬실란 및 비닐 실란 커플 링 제로 변형시킴으로써 소수성 특성으로 변화된다. 실리콘 고무 나노 복합체에서 고전압 직류(HVDC) 항복 전압 및 인장 특성에 대한 개질 된 나노 실리카의 효과를 중전기 장비에 적용하기 위해 연구 하였다. 표면 개질은 푸리에-변형 적외선 분광법 (FT-IR) 분석에 의해 확인되고 알킬 / 비닐 커플 링제의 중량은 열 중량 분석 (TGA)에 의해 측정된다. 실리콘 고무 나노 복합물은 액체 실리콘 고무(LSR)와 개질 된 나노 실리카를 혼합함으로써 제조된다. LSR대 나노 실리카의 혼합비는 20 중량 %로 고정된다. LSR 매트릭스에서 나노 실리카 입자의 균일 한 분산을 관찰하기 위해, 투과 전자 현미경 (TEM)이 사용되고 표면-개질 된 나노 실리카는 20 내지 100 nm 크기의 나노 클러스터 형태로 잘 분산되어있는 것으로 밝혀졌다. 알킬 실란 : 비닐 실란의 표면 개질 비가 50 일 때 전기적 특성 (± HVDC 파괴 강도 및 유전 특성)및 기계적 특성 (인장 강도 및 파단 신율)이 추정되며 ± HVDC 파괴 강도 및 인장 강도가 최대 : 50 중량 %.

건조단계 수중함 품질정보를 이용한 함 탑재장비 신뢰성 분석

장호성 ( Ho Seong Chang ),이관우 ( Kwan Woo Lee ),최영호 ( Young Ho Choi ),손윤준 ( Yoon Jun Son ),함영훈 ( Young Hoon Ham ) 한국품질경영학회 2017 한국품질경영학회 학술대회 Vol.2017 No.1

가상대장내시경검사를 이용해 진단한 장관포상기종 1예

함주호 ( Joo Ho Ham ),김태호 ( Tae Ho Kim ),한석원 ( Sok Won Han ),조근종 ( Keun Jong Cho ),최선욱 ( Son Ook Choi ),백정선 ( Jung Sun Pack ),양성은 ( Seong Eun Yang ),김상희 ( Sang Hee Kim ),양승아 ( Seung Ah Yang ),이윤정 ( Yune 대한소화기학회 2007 대한소화기학회지 Vol.50 No.5

Pneumatosis cystoides intestinalis (PCI) is a rare condition characterized by multiple gas filled cysts in the intestinal wall. The diagnosis of PCI is usually made by colonoscopy, histology, or radiologic findings. We report a case of PCI in a 35-year-old man. The patient initially complained of watery diarrhea and abdominal bloating for 2 weeks. Simple abdominal X-ray demonstrated numerous, small, round, air densities on the right upper abdomen along the ascending and proximal transverse colon. Colonoscopy revealed numerous, 5-20 mm sized, sessile poly-poid, balloon-like distended, protruding subepithelial masses covered with normal colonic mucosa from cecum to proximal transverse colon. We performed a CT colonoscopy and confirmed PCI with multiple air-filled cystic masses along the colonic wall from cecum to proximal transverse colon. The patient was treated with antibiotics and oxygen inhalation for 2 weeks. Follow-up CT colonoscopy revealed marked regression in the number and size of the air-filled cystic masses. Herein, we report the first case of the PCI in Korea diagnosed by CT colonoscopy. Follow-up evaluation with CT colonoscopy was performed after the treatment of the PCI. CT colonoscopy is a useful non-invasive diagnostic tool for the diagnosis of pneumatosis cystoides intestinalis. (Korean J Gastroenterol 2007;50:334-339)

경남지역 사육 염소 큐열 항체 양성률 조사

성민호 ( Min-ho Seong ),박종식 ( Jong-sik Bak ),윤도경 ( Do-kyung Youn ),김형수 ( Hyeong-su Kim ),고병효 ( Byeong-hyo Ko ),함정민 ( Jeong-min Ham ),정명호 ( Myeong-ho Jeong ) 한국동물위생학회(구 한국가축위생학회) 2020 韓國家畜衛生學會誌 Vol.43 No.4

Coxiella burnetii is the causative agent of Q fever which is a zoonosis occuring in both humans and animals worldwide. The purpose of this study was to investigate the seroprevalence of C. burnetii in Korean native goat in Gyeongnam province, Korea. A total of 1,365 goat blood samples from 273 farms in Gyeongnam province were collected between 2018 and 2019. Among them, 177 (13.0%) samples out of 71 (26.0%) farms were seropositive for C. burnetii by ELISA. Seroprevalence were 15.4% and 10.9% in 2018 and 2019, respectively. According to the region, seroprevalence in western, central, eastern, northern and southern areas of Gyeongnam province were 16.6%, 17.8%, 8.0%, 11.6% and 10.8%, respectively. Seroprevalence was increased with breeding scale (Head<10:7.0%, 10≤Head<50:8.7%, 50≤Head<100:13.6%, 100≤Head:28.8%). Seroprevalence according to the season showed highest in summer (18.9%) and lowest in winter (9.4%). These results indicated that C. burnetii infection is widespread among Korean native goats of Gyeongnam province in Korea and further study needs to prevent the circulation of other livestock with Korean native goat.

A 90-Day Repeated Oral Dose Toxicity Study of Alismatis Rhizoma Aqueous Extract in Rats

Lee, Mu-Jin,Jung, Ho-Kyung,Lee, Ki-Ho,Jang, Ji-Hun,Sim, Mi-Ok,Seong, Tea-Gyeong,Ahn, Byung-Kwan,Shon, Jin-Han,Ham, Seong-Ho,Cho, Hyun-Woo,Kim, Yong-Min,Park, Sung-Jin,Yoon, Ji-Young,Ko, Je-Won,Kim, Jo Korean Society of ToxicologyKorea Environmental Mu 2019 Toxicological Research Vol.35 No.2

Alismatis rhizoma (AR), the dried rhizome of Alisma orientale (Sam.) Juzep, is a well-known, traditional medicine that is used for the various biological activities including as a diuretic, to lower cholesterol and as an anti-inflammatory agent. The present study was carried out to investigate the potential toxicity of the Alismatis rhizoma aqueous extract (ARAE) following 90-day repeated oral administration to Sprague-Dawley rats. ARAE was administered orally to male and female rats for 90 days at 0 (control), 500, 1,000 and 2,000 mg/kg/day (n = 10 for male and female rats for each dose). Additional recovery groups from the control group and high dose group were observed for a 28-day recovery period. Chromatograms of ARAE detected main compounds with four peaks. Treatment-related effects including an increase in the red blood cells, hemoglobin, hematocrit, albumin, total protein, and urine volume were observed in males of the 2,000 mg/kg/day group (p < 0.05). However, the diuretic effect of ARAE was considered, a major cause of hematological and serum biochemical changes. The oral no-observed-adverse-effect level (NOAEL) of the ARAE was > 2,000 mg/kg/day in both genders, and no target organs were identified.

What controls phase-locking of ENSO to boreal winter in coupled GCMs?

Ham, Yoo-Geun,Kug, Jong-Seong,Kim, Daehyun,Kim, Young-Ho,Kim, Dong-Hoon Springer-Verlag 2013 Climate dynamics Vol.40 No.5

Intestinal Metastasis of Osteosarcoma Presenting with Intussusception - A Case Report -

Seong-Ho Yoo,Min-A Kim,KyuJoo Park,JoonKoo Han,SangHoon Lee,ChongJai Kim,EuiKeun Ham 대한병리학회 2002 Journal of Pathology and Translational Medicine Vol.36 No.4

Metastatic osteosarcoma most commonly affects the lungs and other bones. Intestinal intussusception caused by metastatic osteosarcoma is very rare. We report a case of metastatic osteosarcoma of the intestine in a 39-year-old female. She underwent surgical resection of the left femur due to osteosarcoma and received additional chemotherapy 3 years ago. Pulmonary metastasis was found two years later and the patient complained of abdominal pain, nausea and vomiting after 8 months following excision of the lung nodules. Abdominal computed tomography revealed intussusception with a suspected polypoid mass in the distal portion of the jejunum. The histologic findings of the resected bowel were those of osteosarcoma. This is the first case of documented intestinal metastasis of osteosarcoma in Korea. It is suggested that the tumor metastasis to the small intestine should be considered in patients with previous osteosarcoma, when the patient presents with acute abdominal symptoms and intussusception.

적혈구를 이용한 Daunorubicin의 배송시스템에 관한 연구

함성호,송경,손동환,고건일,김재백 圓光大學校 藥品硏究所 1993 藥品硏究所報 Vol.8 No.1

The delivery system of daunorubicin(DNR) by the entrapment in red blood cells(RBC) was established to sustaine the release in the circulatory system by the intravenous injection. In spite of the well establishment for the entrapment method of drugs into RBC, it was not reported to consider the viability of RBC and the simple and easy method of the entrapment for the dispensing. The two entrapment methods(preswelling technique and ionopore, amphotericin B) were re-examined and evaluated for the new entrapping conditions without hemolysis. The addition of 4 ml of 60% HBSS into 1 ml of 50% RBC suspension didn't induced the hemolysis and increased hematocrit level as 28%. In this condition DNR could be entrapped into RBC within 15min. And also the amphotericin B treatment below 10ug/ml induced the non-hemolysis to entrap DNR into RBC within 10 min. Under these conditions intracellular ATP level was decreased as 18%. However membrane fluidity and the shape factor of RBC were maintained. Even though these parameters were maintained as the normal range, DNR release rate from RBC was affected by the hemolysis during the release test in HBSS, PBS and individual serum. For the maintenance of intracellular ATP, ATP and sodium pyruvate were added into all of solutions to need during the entrapment procedure because this hemolysis during the release test would reflect the loss of intracellular ATP that would be postulate the decrease of the viability in-vivo. The addition of ATP increased the intracellular level, which presented the non-hemolytic release rate. From these results, the simple method for the entrapment was evalusted. As it were, under the non-hemolytic condition and the maintenance of intracellular ATP, DNR could be rapidly entrapped with non-hemolysis by the addition of the sterile distilled water containing DNR and ATP. This new method would supply the more rapid and efficiency for the dispensing because the short time and the small volume were needed for the entraping procedure. The osmotic fragility for RBC was maintained like the native RBCs, too.

적혈구를 이용한 항암제의 배송시스템 및 제제설계

함성호,고건일,김재백,손동환 圓光大學校 藥品硏究所 1995 藥品硏究所報 Vol.10 No.1

Drug delivery system by use of red cells was established to sustain the release of daunorubicin. Daunorubicin could be rapidly entrapped into red cellls by addition of distilled water containing daunorubicin and adenosine triphosphate(ATP). Daunorubicin could be entrapped into red cells within 2 minutes. This modified method induced no hemolysis and could sustain the level of intracellular ATP as same as normal red cells. Therefore, this method shows very efficient to make a red cell delivery system which has release pattern withour hemolytic leakage within a desire time since the hemolysis during the release would reflect the loss of intracellular ATP that might result on the decrease of the viability in vivo. Additionally this method would supply rapid and efficient for the dispensing because the short time and small volume are needed for the entrapping procedure.

2021년 한국포도막학회 회원 설문 조사

김성호(Seong Ho Kim),박정현(Jung Hyun Park),유나경(Na-Kyung Ryoo),공민귀(Mingui Kong),송수정(Su Jeong Song),함돈일(Don Il Ham),한국포도막학회(Korean Uveitis Society ) 대한안과학회 2022 대한안과학회지 Vol.63 No.11

목적: 2021년 한국포도막학회 회원의 포도막염에 대한 진료와 치료 경향에 대한 설문 조사의 결과를 보고하고자 한다. 대상과 방법: 국내 포도막염의 실제 진료와 치료 경향을 파악하기 위해 2021년 11월 한국포도막학회에서 회원 300명에게 총 11문항의설문 조사를 시행하였고, 다지 선다형 또는 양자택일형의 문항에 대한 답변의 비율을 비교하였다. 결과: 응답률은 59.7% (179명)였고, 응답자 중 망막 세부 전공을 선택한 경우가 92.7%로 가장 많았고, 응답자 중 과반수 이상에서외래 진료 환자 중 포도막염 환자의 비율은 10% 미만이라고 하였다(66.9%). 앞포도막염 환자에서 추가로 시행하는 영상검사로는 안저 사진 촬영 및 빛간섭단층촬영을 시행하는 경우가 가장 많았다(83.8% vs. 73.2%). 전신검사가 필요한 경우 시행하는 항목으로는일반혈액검사, 일반화학검사, erythrocyte sedimentation rate, C-reactive protein 순이었다. 스테로이드 국소 치료의 경우 테논낭하주사를 가장 선호하였으며(74.9%), 전신 경구 스테로이드 제제 사용 시 대다수 0.5-1 mg/kg으로 시작하였다(83.7%). 스테로이드 불응성 포도막염 환자의 치료 시 2차 약제로는 사이클로스포린의 사용을 선호하였다(36.2%). 결론: 본 설문 조사의 결과를 통해 실제 국내 포도막염 환자들에 대한 진단과 치료 경향을 알 수 있었다. 본 연구의 여러 가지 제한점이있으나, 한국포도막학회에서 공식적으로 시행한 첫 포도막염 실제 진단과 치료 행태 조사라는 연구 의의가 있겠다. Purpose: To report the results of a 2021 questionnaire survey assessing the current trends and practice patterns in the treatment of uveitis, conducted by the Korean Uveitis Society (KUS). Methods: To understand the current treatment and trends for uveitis in Korea, a total of 11 questions were surveyed in November 2021 among 300 members of the KUS. This survey comprised 11 multiple choice and dichotomy questions. Results: Of 300 participants, 179 responded, and the response rate was 59.7%. Among the respondents, 92.7% were retina specialists and 66.9% reported less than 10% of uveitis patients among outpatients. As imaging tests performed in patients with anterior uveitis, fundus photography and optical coherence tomography were typically performed (83.8% vs. 73.2%, respectively). The frequently performed blood tests for general screening were complete blood count, blood chemistry test, erythrocyte sedimentation rate, and C-reactive protein (89.9% vs. 86.2% vs. 85.5% vs. 82.4%, respectively). Regarding local steroid treatment, subtenon injection was the most preferred (74.9%). Regarding systemic oral corticosteroids, 83.7% of respondents commonly used initial doses of 0.5-1 mg/kg. Cyclosporine, methotrexate, mycophenolate mofetil, and azathioprine were used for steroid-refractory uveitis patients in that order (36.2% vs. 34.8% vs. 21.7% vs. 7.3%, respectively). Concerning the currently used biologic agent, adalimumab was the most preferred, at 96.7%. Conclusions: This survey highlights the recent trends and practice patterns in the treatment of uveitis in Korea.