적혈구를 이용한 항암제의 배송시스템 및 제제설계 = Development of Delivery System by Use of Red Cells

다국어 초록 (Multilingual Abstract)

Drug delivery system by use of red cells was established to sustain the release of daunorubicin. Daunorubicin could be rapidly entrapped into red cellls by addition of distilled water containing daunorubicin and adenosine triphosphate(ATP). Daunorubicin could be entrapped into red cells within 2 minutes. This modified method induced no hemolysis and could sustain the level of intracellular ATP as same as normal red cells. Therefore, this method shows very efficient to make a red cell delivery system which has release pattern withour hemolytic leakage within a desire time since the hemolysis during the release would reflect the loss of intracellular ATP that might result on the decrease of the viability in vivo. Additionally this method would supply rapid and efficient for the dispensing because the short time and small volume are needed for the entrapping procedure.