COMPARISON OF PV POLICIES BETWEEN CHINA, JAPAN AND KOREA

Sang-Hoon LEE,Nyun-Bae PARK,Eui Chan JEON 한국신재생에너지학회 2011 AFORE Vol.2011 No.-

Purification and refolding of the recombinant subunit B protein of the Aggregatibacter actinomycetemcomitans cytolethal distending toxin

Jeon, Yong-Seon,Seo, Sung-Chan,Kwon, Jin-Hee,Ko, Sun-Young,Kim, Hyung-Seop Korean Academy of Periodontology 2008 Journal of Periodontal & Implant Science Vol.38 No.2

Purpose: Aggregatibacter actinomycetemcomitans is associated with localized aggressive periodontitis. It produces cytolethal distending toxin (CDT), which induces cell cycle arrest in the G2/M phase. The CDT holotoxin is composed of CdtA, CdtB, and CdtC. CdtB has structural homology to human DNase I and is an active component of the CDT complex acting as a DNase. In particular, the pattern homology seen in the CdtB subunit has been associated with specific DNase I residues involved in enzyme catalysis, DNA binding, and metal ion binding. So, to study the functions and regulation of recombinant CdtB, we made up a quantity of functional recombinant CdtB and tested it in relation to the metal ion effect. Materials and Methods: We constructed the pET28a-cdtB plasmid from A. actinomycetemcomitans Y4 by genomic DNA PCR and expressed it in the BL21 (DE3) Escherichia coli system. We obtained the functional recombinant CdtB by the refolding system using the dialysis method and then analyzed the DNase activity and investigated the metal ion effect from plasmid digestion. Results: The recombinant CdtB subunit was expressed as the inclusion bodies. We were able to obtain functional recombinant CdtB subunit using refolding system. We confirmed that our refolded recombinant CdtB had DNase activity and was influenced by the metal ions $Mg^{2+}$ and $Ca^{2+}$. Conclusion: We suggest that the factors influencing recombinant CdtB may contribute to CDT associated diseases, such as periodontitis, endocarditic, meningitis, and osteomyelitis.

Star polymer-assembled thin film composite membranes with high separation performance and low fouling

Jeon, Sungkwon,Park, Chan Hyung,Park, Sang-Hee,Shin, Min Gyu,Kim, Hyun-Ji,Baek, Kyung-Youl,Chan, Edwin P.,Bang, Joona,Lee, Jung-Hyun Elsevier 2018 Journal of membrane science Vol.555 No.-

<P><B>Abstract</B></P> <P>Thin film composite (TFC) membranes have attracted intense interest due to applications in various molecular separation processes including water purification, gas separation, organic solvent separation and saline-gradient energy production. In particular, growing global demands for clean water and reduced energy consumption have raised interest in highly permselective and low fouling TFC membranes for water treatment and desalination. This drive has led to the design of new molecular structures of TFC membranes using advanced materials. Here, we designed a new building block material, a star-shaped polymer, which can be assembled into the selective layer of the TFC membrane <I>via</I> a commercial interfacial polymerization (IP) technique. This ideal 3-dimensional compact globular geometry along with high density end-functional groups enabled the realization of membranes with higher permselectivity as well as superior antifouling properties even compared to commercial membranes. We demonstrate the remarkable versatility of this building block by using the same starting materials to fabricate membranes that can function either as nanofiltration or reverse osmosis membrane depending on the IP process conditions, which is not feasible with the conventional materials used in membrane fabrication.</P> <P><B>Highlights</B></P> <P> <UL> <LI> TFC membranes were fabricated by interfacial polymerization of star polymers (SP). </LI> <LI> RO and NF performances can be obtained by adjusting the polymerization conditions. </LI> <LI> SP assembly produces a highly permselective layer with a unique stratified structure. </LI> <LI> SP-assembled membranes show separation performance exceeding commercial membranes. </LI> <LI> SP-assembled membranes have superior fouling resistance to commercial membranes. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Measurement of Geometric Properties of Printed Patterns and Evaluation of their Printability

Sung Woong Jeon(전선웅),Cheol Kim(김철),Jong-Chan Park(박종찬),Dong Soo Kim(김동수),Chung Hwan Kim(김충환) Korean Society for Precision Engineering 2014 한국정밀공학회지 Vol.31 No.11

Long-term outcomes after noncurative endoscopic resection of early gastric cancer: the optimal time for additional endoscopic treatment

Jeon, Mi Young,Park, Jun Chul,Hahn, Kyu Yeon,Shin, Sung Kwan,Lee, Sang Kil,Lee, Yong Chan Elsevier 2018 Gastrointestinal Endoscopy Vol.87 No.4

<P><B>Background and Aims</B></P> <P>We aimed to evaluate long-term outcomes with noncurative endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) and surveillance strategies such as the optimal time for additional endoscopic treatment in patients with noncurative ESD.</P> <P><B>Methods</B></P> <P>Of 2527 patients who underwent gastric ESD for EGC, 512 (20.3%) patients with noncurative resection were reviewed. Noncurative resection is defined as positive resected margins on histology, lymphovascular infiltration, or beyond the expanded criteria for ESD.</P> <P><B>Results</B></P> <P>The mean ± standard deviation follow-up duration was 79.0 ± 55.7 months. A total of 264 patients (51.6%) and 50 patients (9.8%) underwent surgery and endoscopic treatment after noncurative resection, respectively, whereas 198 patients (38.7%) were observed. Cancer-specific survival and disease-free survival rates were significantly different among the surgery, other endoscopic treatment, and observation groups (96.7%, 86.8%, and 86.2%, respectively; <I>P</I> =.030; and 92.5%, 73.6%, and 63.0%, respectively; <I>P</I> < .001). When patients who underwent surgery were excluded, the disease-free survival rate of recurrence was not significantly different between the endoscopic treatment and observation groups (73.6% vs 63.0%; <I>P</I> = .548). To exclude the potential for the presence of lymph node metastasis, we further analyzed disease-free survival of local recurrence by comparing the patients with only a positive lateral resection margin. The disease-free survival rate was higher in the endoscopic treatment group than in the observation group (89.2% vs 69.1%; <I>P</I> = .023). Moreover, additional endoscopic treatment within 3 months showed significant associations with lower risk of local recurrence on multivariate analysis (hazard ratio, 0.017; 95% confidence interval, 0.002-0.260; <I>P</I> = .003).</P> <P><B>Conclusions</B></P> <P>In patients with noncurative ESD, additional surgery showed a better long-term outcome; moreover, when a positive lateral resection margin was the only noncurative factor, additional endoscopic treatment within 3 months could be considered to improve disease-free survival.</P>

Large Sized Common Iliac Artery Aneurysm with Thrombus Developing a Diagnostic Confusion in a Patient with Sciatica

Jeon, Ik Chan,Kim, Sang Woo,Jung, Young Jin The Korean Pain Society 2014 The Korean Journal of Pain Vol.27 No.4

The causes of sciatica are variable and include musculoskeletal, dermatologic, infectious, neoplastic, and vascular disorders. In many cases, the symptom is usually caused by degenerative disease in the spine with the compression or irritation of spinal nerve. On the other hands, there are also several announced extra-spinal causes including aneurysm, diabetes, and radiation for sciatica in a low rate. Among the extra-spinal cases, aneurysms arising from iliac vessels are sometimes developing a diagnostic confusion with the spinal causes, and delayed diagnosis can lead to poor prognosis. It is very important to pay attention weather the aneurysmal cause is involved in the symptom of sciatica.

J-curve relationship between corrected QT interval and mortality in acute heart failure patients

Chan Soon Park,Hyun-Jai Cho,Eue-Keun Choi,이상은,김민석,김재중,Jin-Oh Choi,Eun-Seok Jeon,Kyung-Kuk Hwang,Shung Chull Chae,Sang Hong Baek,Seok-Min Kang,Byung-Su Yoo,Dong-Ju Choi,Youngkeun Ahn,Kye-Hoon Kim,Myeon 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.6

Background/Aims: This study investigated the prognostic power of corrected QT (QTc) interval in patients with acute heart failure (AHF) according to sex. Methods: We analyzed multicenter Korean Acute Heart Failure registry with patients with AHF admitted from 2011 to 2014. Among them, we analyzed 4,990 patients who were followed up to 5 years. Regarding QTc interval based on 12 lead electrocardiogram, patients were classified into quartiles according to sex. Results: During follow-up with median 43.7 months, 2,243 (44.9%) patients died. The relationship between corrected QT interval and all-cause mortality followed a J-curve relationship. In Kaplan-Meier analysis, both sex had lowest mortality in the second QTc quartile. There were significant prognostic differences between the second and the fourth quartiles in male (log-rank p = 0.002), but not in female (log-rank p = 0.338). After adjusting covariates, the third (hazard ratio [HR], 1.185; 95% confidence interval [CI], 1.001 to 1.404; p = 0.049) and the fourth (HR, 1.404; 95% CI, 1.091 to 1.535; p = 0.003) quartiles demonstrated increased risk of mortality compared to the second quartile in male. In female, however, there was no significant difference across quartiles. QTc interval was associated with 5-year all-cause mortality in J-shape with nadir of 440 to 450 ms in male and 470 to 480 ms in female. Conclusions: QTc interval was an independent predictor of overall death in male, but its significance decreased in female. The relationship between QTc interval and all-cause mortality was J-shaped in both sex.

Consideration of Regulatory Systems for Decommissioning of Nuclear Power Plants

Sang-Kyu Ahn,In-Young Jeon,Jae-Hak Cheong,Kyung-woo Choi,Chan Woo-Jeong,Youn-Keun Lee 한국방사성폐기물학회 2006 방사성폐기물학회지 Vol.4 No.4

우리나라를 포함한 일본 및 미국과 독일, 영국, 프랑스 등 유럽국가의 원자력발전소 해체에 관한 규제제도 조사를 수행하였다. 각국의 해체에 관한 규제제도에 관하여 규제정책, 법규, 인허가 절차, 검사, 대중참여 등의 항목별로 비교분석을 수행하였다. 향후 본 조사결과는 국내의 가동 원자력발전소의 폐로 및 해체에 대비한 국내 제도 개선방향 수립에 참조자료로서 활용될 예정이다. Regulatory systems for decommissioning of nuclear power plants in several countries, such as Japan, United States of America, Germany, United Kingdom, France, and Republic of Korea, are surveyed. In the survey, regulatory policies, legislations, licensing process, inspection and public involvements for decommissioning are identified and compared. Afterwards, the survey results will be utilized as a reference to establish the improvement directions of domestic regulatory system.

Prenatal Exposure to High Cortisol Induces ADHD-like Behaviors with Delay in Spatial Cognitive Functions during the Post-weaning Period in Rats

Sang-Chan Jeon,Hye-Ji Kim,Eun-A Ko,Sung-Cherl Jung 한국뇌신경과학회 2021 Experimental Neurobiology Vol.30 No.1

High levels of cortisol in blood are frequently observed in patients with major depressive disorders and increased cortisol level induces depressivelike symptoms in animal models. However, it is still unclear whether maternal cortisol level during pregnancy is a critical factor resulting in neuropsychiatric disorders in offspring. In this study, we increased cortisol level in rats by repetitively injecting corticosterone subcutaneously (Corti. Mom, 20 mg/kg/day) during pregnancy and evaluated the behavioral patterns of their pups (Corti.Pups) via forced swimming (FS), open field (OF), elevated plus maze (EPM) and Morris water maze (MWM) tests during the immediate post-weaning period (postnatal day 21 to 25). In results, corticosterone significantly increased plasma cortisol levels in both Corti.Moms and Corti.Pups. Unlike depressive animal models, Corti.Pups showed higher hyperactive behaviors in the FS and OF tests than normal pups (Nor.Pups) born from rats (Nor.Moms) treated with saline. Furthermore, Corti.Pups spent more time and traveled longer distance in the open arms of EPM test, exhibiting higher extremity. These patterns were consistent with behavioral symptoms observed in animal models of attention deficit hyperactivity disorder (ADHD), which is characterized by hyperactivity, impulsivity, and inattention. Additionally, Corti.Pups swam longer and farther to escape in MWM test, showing cognitive declines associated with attention deficit. Our findings provide evidence that maternal cortisol level during pregnancy may affect the neuroendocrine regulation and the brain development of offspring, resulting in heterogeneous developmental brain disorders such as ADHD.

Cystoperitoneal Shunting after Fenestration of an Enlarging Arachnoid Cyst

Jeon, Ik-Chan,Kim, Min-Su,Kim, Seong-Ho,Jang, Sung-Ho 영남대학교 의과대학 2008 Yeungnam University Journal of Medicine Vol.25 No.2

A two-month-old girl with a history of an incidental arachnoid cyst in the prenatal period (38 weeks) presented with persistent irritability A follow-up computed tomographic (CT) scan revealed an enlarged arachnoid cyst with hydrocephalus We performed craniotomy and fenestration, but the cyst size did not decrease, and hydrocephalus had worsened on a follow-up CT scan performed 13 months after fenestration. The patient was treated with cystoperitoneal shunting Follow-up magnetic resonance imaging (MRI) performed 5 years later revealed that the arachnoid cyst had decreased in size and that the hydrocephalus had resolved. Enlarging arachnoid cysts are not common, and optimal surgical treatment is uncertain Based on the features of this case, we believe cystoperitoneal shunting is an advisable surgical intervention for patients with enlarging arachnoid cysts presenting with hydrocephalus.