Monascus Purpureus의 色素增産과 用途에 관한 硏究(Ⅰ)

盧愼圭,朱鉉圭 건국대학교 1969 學術誌 Vol.10 No.1

Recently unlawful colors are misused as the food activities, and this puts forth, to our great regret, a massive social problem on the national health and hygiene. This study was carried out to investigate the color increment and its associated items of Monascus purpureus, which produces red color as the edible sourse except aniline colors, and the followings are found out. 1. The color produced by Monascus purpureus is red in acid solution but red color disappears and turns yellow in alkaline solution. At pH 4.4∼7.0, the red color appears clear and at pH 6.6, it is clearest.《Table 2》《Fig.1》 As most foods are in general shightly acid, this color is suitable for food color. 2. When the water content of the culture medium is 73∼85%, the color was formed most profoundly. Exessive large amount of water content disturbed extremely the color formation than exessive small amount of water content.《Fig.2,3》《Table 3,4》《Photo. 1,2》 3. As to for period of color formation of Monascus purpureus, the color increases Ncutely in 6~8 days, increses slowly in 11∼12 days, and decreases slowly thereafter, 《Fig.4》《Table 5》 4. As the material of culture medium of Monascus purpureus, polished barley produced more color than rice and wheat.《Photo. 3,4》 5. The favorable pH for color formation on the solid medium was slightly acid and generally the color formation was evident at pH 5.4∼6.6.《Table 1》《Fig. 5》《Photo. 4,5》 6. The optimum period for color formation with liquid culture (8-9days) was shortened by 3∼4days than with olio culture, and the amounts of mycelium were most increased in 7∼8days.《Table 7》《Fig.6》

Stochastic Reward Nets을 이용한 통신 프로토콜 검증기법에 대한 연구

노철우,박현희,윤현주 신라대학교 자연과학연구소 1999 自然科學論文集 Vol.6 No.-

In this paper, we describe validation techniques of communication protocol using Petri Nets. The Techniques which can validate protocol design specification written by SDL are constructed and protocol models are developed. Validation technique steps are as follows : SDL specifications are transformed into SRN, from which reachability graghs are obtained. By analyzing the graphs, validation properties such as reachability, boundness and liveness as well as logical errors in design are verified. SRN models for timer and retransmission, essential components of protocol are developed using SRN properties such as cardinality, multiple inhibitor arc, timed and immediate transitions.

人蔘栽培中 腐敗防止에 관한 硏究 : 特히 連作障害의 原因究明에 대하여

盧愼圭,朱鉉圭 건국대학교 1977 學術誌 Vol.21 No.2

Studies on the microbes and soil components of samples which were under continuous growth of ginseng (sample G.) and samples after harvest of ginseng (sample F.) were made to find the causes of continuous cultivational obstruction, and the compared results based on cultivational annum are as the following. 1) The contents of microbes of sample G were decreased with the increasing of the cultivated annum, and the contents in the sample F. were on the contrary. This results seemed to be caused by insecticides. 2) pH of the sample G. were increased depending on the cultivated annum, and in the sample F it were showed the decreasing of pH. 3) The organic compounds were contained more amount in the sample G. cultivated for 2-3 years than the other soil, but the deviation of the contents were very small. 4) The phsphate was contained more amounts in the sample G. cultivated for 4-5 years than the other soil, and in the sample F. cultivated for 1-2 years it was contained more amounts than the other soil, 5) The components of potassium, calcium and magnesium were contained more amounts in the sample G cultivated for 4-6 years than the other soil, but the variation of the contents contents according to the cultivated annum were not appeared the distinct deviation. The contents of zinc, iron, maganese and C.E.C were not changed during the cultivated annum. 6) The contents of copper was increased depending on the cultivated annum, and in the sample G it was decreased with the cultivated annum. The experimental results obtained from the sample G and the sample F were showed the inter-relation among the rot of ginseng-root, continuous cultivation and the deviation of the contents in the components of the both soil.

소화성 궤양 환자에 대한 염산 베넥세이트(울굿^(�)) 임상 효과

정현용,육은주,이헌영,노홍구,김영건 최신의학사 1993 最新醫學 Vol.36 No.8

Carbamate系 殺蟲濟 MIPC(o-Isopropylphenyl-N-methylcarbamate) 粉濟의 安定性에 關한 硏究

孫炫洲,朴魯東,朴昌奎 서울大學校 農科大學 1980 서울대농학연구지 Vol.5 No.2

Effects of moisture, pH, surface acidity and stabilizers on the stability of MIPC in the 2% dust formulations have been studied. MIPC dust formulations containing different levels of moisture and stabilizers were perpared from locally produced carriers, clay, talc and kaolin. The formulated MIPC dust formulation were subjected to thermo-accelerated test. The results are summarized as follows: 1. As regard to MIPC stability to moisture content, clay or kaolin based MIPC dust formulations was most stable when the carriers were used as received. Talc based MIPC dust was, however, most stable when moisture content of the carrier was adjusted to 1%. 2. Effects of stabilizers were best demonstrated when HMT, urea and PAP were added to talc based MIPC formulations. In general, stabilizing effects of varioul stabilizers were meagre in the clay based dust. The PAP alone had pronounced stabilizing effect in the kaolin based formulations. 3. Among three carriers, clay excelled itself over compatibility with MIPC in the dust formulations. 4. concentration of either HMT or urea at 5% showed greater stabilizing effect compared with those at 3%. 5. Among laboratory formulated MIPC dust formulations, clay I+MIPC+urea(5%), clay I+MIPC+urea(3%), clay II+MIPC+HMT(5%) and talc I+MIPC+urea(5%) proved equal or even superior to the commercial MIPC dust by the thermo-accelerated test.

P200 : Phototrichogram analysis of normal scalp hair characteristics with aging

( Jung Eun Kim ),( Joo Hyun Lee ),( Kwang Hyun Choi ),( Won Soo Lee ),( Gwang Seong Choi ),( Oh Sang Kwon ),( Moon Bum Kim ),( Chang Hun Huh ),( Chull Wan Ihm ),( Young Chul Kye ),( Byung In Ro9 ),( W 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

Background: Phototrichogram analysis of normal scalp hair characteristics in Asian populations is not well characterized. Objectives: To investigate the normal hair characteristics of South Koreans using a phototrichogram. Methods: We enrolled 674 males and 683 females between the ages of 10 and 69. Hair density, thickness and the white hair percentage were measured via phototrichogram. Six scalp sites, including front, top, the peak between top and back, back, and the right and left sides were targeted. Results: The mean hair density, hair thickness, and the white hair percentage were not significantly different between genders at any scalp site. The mean hair density and thickness were significantly different according to scalp sites. Hair density declined with age, especially at the peak between top and back. Males and females showed different patterns of aging in hair density. Hair thickness changed little with age. But, mean hair thickness generally tended to increase until the 20s, reach a plateau between the 20s and 50s, and decrease after the 50s. The mean white hair percentages were 1.84 ± 4.24% in males and 1.66 ± 4.21% in females. The mean white hair percentages were significantly increased in subjects greater than 40 years of age. Conclusion: We described the normal characteristics and aging patterns of scalp hair in a Korean population.

장상피화생과 Helicobactor pylori와의 상관 관계에 관한 연구

이복희,김대수,이현숙,진영주,윤세진,송형근,성노현,정현용,이동호 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

In 1965 Lauren divided advanced gastric carcinoma into two main types-namely, "intestinal" and "diffuse" type carcinoma, which differ not only morphologically but also in their clinical and epidemiological characteristics. Moreover, a different histogenetic process has been postulated by many authors that intestinal type gastric carcinoma might arise from areas with intestinal metaplasia. Since Warren and Marshall reported the presence of Helicobacter pylori in the stomach in 1983, strong evidence has been obtained that there is a close relationship between Helicobacter pylori and chronic gastritis, atrophic gastritis, intestinal metaplasia, and intestinal type gastric carcinoma. To study the relationship between intestinal metaplasia and Helicobacter pylori infection, we performed gastroscopic biopsies and CLO tests taken from patients with epigastric pain. Only 87 patients with macroscopically suspected antral gastritis were included. The prevalence of intestinal metaplasia in gastric antral biopsies increased from 33.3% in the age group<30 years to 63.6% in the age group 60 years. When all patients were divided into two age groups-namely, (i)<50 years(n=41) and (ii)≥ 50 years(n-=46), intestinal metaplasia was found significantly more often in patients ≥ 50 years. ((i) 39.2%, (ii) 54.3%, p<0.0001). The prevalence of Helicobacter pylori in gastric antral biopsies decreased from 66.7% in the age group<30 years to 62.5%, in the age group in the age group 50 to 59 years. When all patients were divided into the same two age groups-namely(i)<50 years and (ii)≥50 years, the prevalence of Helicobacter pylori did not differ between two groups in a statistically significant way. The mean age of intestinal metaplasia positive patients who were also Helicobacter pylori positive was 48±11.0(mean±S.D.)years, whereas the mean age of intestinal metaplasia positive patients who were Helicobacter pylori negative was 52±9.7(mean±S.D.)years. In conclusion. although our data do not prove a causal relationship between Helicobacter pylori infection and the histogenesis of intestinal metaplasia, we suggest that Helicobacter pylori plays an important role in the development of intestinal metaplasia in the gastric mucosa. Whether Helicobacter pylori has to be present at all times during this process or is only necessary as a 'trigger', needs further research.

A Clinical Study of Androgenetic Alopecia (3)

(Joo Hyun Shim),(Sung Wook Ro),(Byung In Ro) 대한피부과학회 2002 Annals of Dermatology Vol.14 No.1

N/A Background: Androgenetic alopecia is considered to be a genetically determined disorder influenced by age and androgen. The proportion of patients with androgenetic alopecia among the total number of patients with alopecia seems to be gradually increasing. Objective: The purpose of this study is to evaluate the family history,clinical and endocrine status of the patients with androgenetic alopecia. Method :1113 patients with androgenetic alopecia who had visited the Department of Dermatology, Yongsan Hospital, College of Medicine,Chung-Ang University during the 3 years (1995.1-1998. 12) have been examined. Results: The results are summarized as follows 1) The incidence of androgenetic alopecia among the total number of alopecia patients was 64.5%, showing recent increment. 2) There were 855 male and 258 female patients being most prevalent in the third decade in both sexes and the patients younger than 30 years old with premature androgenetic alopecia,made up 70.3% of the male patients and 48.8%of the female patients with androgenetic alopecia. 3) While Norwood`s type Iia was the most common and following type II,III vertex,and IV in the male AGA, Ludwig`s type II was the most common in female AGA 4) There was a family history of baldness in 53.5%of first degree relatives in male patients and 51.6%in female patients. 5)Associated diseases were observed in 565(66.8%)of the male patients and 219 (84.8%)of the female patients:diseases associated with androgen such as seborrheic dermatitis and acne vulgaris occupied 39.1%. Conclusion :Based on our findings, those who want to treat androgenetic alopecia at the earlier ages are gradually increasing and it seems to be reasonable to believe that the age, genetic factors, localized effects of androgens on the scalp and the density and/or functional activity of androgen receptors may influence the pathogenesis of androgenetic alopecia. (Ann Dermatol 14(1)11-17,2002).

Spatiotemporal Expression Pattern of Chordin , a Neural Inducer in Zebrafish Embryos

Ro, Hyun Joo,Rhee, Myung Chull 한국유전학회 1997 Genes & Genomics Vol.19 No.4

Along the differentiation of a vertebrate embryo to an adult, Spemann's organizer molecules located at the blastopore lip of Xenopus gastrula turn on a series of genes triggering body pattern formation as well as neural induction. Spemann's organizer molecules are composed of secreted signal molecules such as Vg-1, Activin and Wnt, and transcriptional factors such as goosecoid, Xliml and Xnot. While the expression of goosecoid is stimulated by Activin, Goosecoid-induced gene encoding a secreted signal peptide, chordin has been cloned. Injection of chordin mRNA into ventral side of Xenopus gastrula created another complete body axis at the injected site, suggesting that Chordin is one of molecules involved in body pattern formation triggered by Spemann's orgnizer molecules. To understand molecular mechanisms wherein Chordin initiates vertebrate neural induction, spatio-temporal expression pattern of chordin gene in rebrafish embryos at three different developmental stages (one cell, cleavage and neurula) was analysed with whole-mount in situ hybridization technique. Interestingly, chordin mRNA was detected at low level from one cell and cleavage stage embryos apparently without any preponderance of spatial distribution. In contrast, it is specifically restricted to the dorsal side of neurula stage embryos with highly elevated concentration, which is consitant with previous foundings from other species. At this point, we are performing anti-sense RNA injection experiment to examine the possible function of Chordin along embryonic developmental stages.

Three Cases of Generalized Lichen Nitidus

Ro, Byung In,Lim, Hyun Sang,Seo, Seong Jun,Hong, Chang Kwun,Ro, Sung Wook,Chun, Tae Jong,Shim, Joo Hyun,Kim, Meyung Nam 대한피부과학회 1999 Annals of Dermatology Vol.11 No.4

Lichen nitidus(LN) is an uncommon chronic inflammatory disease of shiny, flat-topped, flesh-colored uniform papules most commonly located on the penis, forearms and wrists, lower abdomen, and thighs. LN almost has localized distribution, but in rare cases, it may become generalized. In Korea, three cases of generalized LN were reported. We report here three cases of generalized lichen nitidus in 31-year-old man, 8-year-old boy, and 6-year-old girl who had generalized numerous pinhead-sized, erythematous to flesh-colored, shiny papules. Microscopically, they had typical appearance of LN.