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김제시 간척지역 천부 지하수내 철 환원작용 특성에 대한 고찰
김지훈,정태진,류종식,김락현,Kim, Ji-Hoon,Cheong, Tae-Jin,Ryu, Jong-Sik,Kim, Rak-Hyeon 대한자원환경지질학회 2013 자원환경지질 Vol.46 No.1
간척지를 포함하고 있는 연구지역에서 육지에서 해안지역으로 근접할수록 측정된 지하수의 산화환원 전위 (Eh)와 용존 산소량 (DO)은 낮게 관찰되었다 (Eh: 0.57 V ${\rightarrow}$ 0.13 V, DO; 9.7 mg/l ${\rightarrow}$ 1.3 mg/l). 이는 연구지역 지하수의 산화환경이 육지에서 해안가로 근접할수록 호기성 환경에서 아혐기성/혐기성 환경으로 변화한다는 것을 의미한다. 또한 지하수 수질 분석 결과에 의하면 철이온 (Fe)이 지하수에 많이 포함되어 있으며 (> 20 mg/l), 대부분의 2가 철로 존재한다. 이러한 연구지역 해안가 지하수들의 특징들은 지하수들이 철의 환원작용 (Fe reduction)이 일어날 수 있는 혐기성 환경에 위치하고 있음을 지시해준다. 철 환원작용이 일어나기 위해서는 3가 철의 공급원이 필요한데, 관측정 퇴적물의 철이온 추출실험에 의하면 연구지역의 퇴적물은 철 환원작용에 필요한 3가 철이온에 대한 충분한 공급원 역할을 할 수 있다. 따라서 분석한 지하수 및 퇴적물의 결과들을 종합해석하면, 연구지역에서 일어나는 철 환원작용은 갯벌의 간척활동과 많은 관련을 가지고 있는 것으로 추정된다. The study area is located on the western coastal region of Korea, partly had been reclaimed lands. Groundwaters of the coastal area show lower Eh and DO values (Eh: 0.57 V ${\rightarrow}$ 0.13 V, DO; 9.7 mg/l ${\rightarrow}$ 1.3 mg/l), and higher Fe concentrations (> 20 mg/l) than those of the inner land (< 0.3 mg/l), indicating that the redox condition of groundwater changes from oxic into suboxic/anoxic conditions as it flows from the inland toward the coastal area. In addition, Fe speciation of groundwater from the coastal area demonstrates that the most dissolved Fe exist as $Fe^{2+}$, reflecting that groundwater is under the anoxic condition to sufficiently occur Fe reduction. According to the result of Fe extraction with the sediment samples from three wells (A, B, C), the sediments provide enough $Fe^{3+}$ to occur the Fe reduction in the groundwater. Integrated all results of the groundwater and sediment, we infer that the Fe reduction to occur in groundwater is associated with the reclamation processes of the study area.
김동수,이용규,김상순,김용기,이민기,이광욱,김상욱,박규현,양웅석,김상호,문한규,허윤,도창호,손덕현,최장락,강필증 대한내과학회 1990 대한내과학회지 Vol.39 No.2
Insulinoma is characterized by fasting hypoglycemia, various neuropsychiatric symptoms, and those caused by secondary to hypoglycemia. A 21-year-old female was admitted due to frequent loss of consciousness and dull mentality for a year and three months. She was diagnosed as insulinoma on the basis of Whipple's triad, celiac, and mesenteric angiography, abdominal C.T, scan, and the inappropriately elevat level of the insulin and C-peptide in the serum. When we transferred her to the Department of General Surgery for the remaval of insulinoma, a large mass was revealed in the pancreatic head portion with the invasion of the adjucent structures. Thus they performed Whipple's operation. Histologic examinations by light and electron microscopy showed islet cell tumor and many secretary granules in the cytoplasm. A brief review of the literature was made.
Kim, Soo Hyeon,Cho, Young-Rak,Kim, Hyeon-Ju,Oh, Joa Sub,Ahn, Eun-Kyung,Ko, Hye-Jin,Hwang, Byung Joon,Lee, Seo-Jin,Cho, Yongwan,Kim, Yong Kee,Stetler-Stevenson, William G.,Seo, Dong-Wan American Society of Hematology 2012 Blood Vol.120 No.24
<B>Abstract</B><P>In cancer, VEGF-induced increase in vascular permeability results in increased interstitial pressure, reducing perfusion and increasing hypoxia, which reduce delivery of chemotherapeutic agents and increase resistance to ionizing radiation. Here, we show that both TIMP-2 and Ala + TIMP-2, a TIMP-2 mutant without matrix metalloproteinase inhibitory activity, antagonize the VEGF-A-induced increase in vascular permeability, both in vitro and in vivo. Like other agents known to preserve endothelial barrier function, TIMP-2 elevates cytosolic levels of cAMP and increases cytoskeletal-associated vascular endothelial cadherin in human microvascular endothelial cells. All of these effects are completely ablated by selective knockdown of integrin α3β1 expression, expression of a dominant negative protein tyrosine phosphatase Shp-1 mutant, administration of the protein tyrosine phosphatase inhibitor orthovanadate, or the adenylate cyclase inhibitor SQ22536. This TIMP-2-mediated inhibition of vascular permeability involves an integrin α3β1-Shp-1-cAMP/protein kinase A-dependent vascular endothelial cadherin cytoskeletal association, as evidenced by using siRNAs to integrin α3β1 and Shp-1, or treatment with Shp-1 inhibitor NSC87877 and protein kinase A inhibitor H89. Our results demonstrate the potential utility for TIMP-2 in cancer therapy through “normalization” of vascular permeability in addition to previously described antiangiogenic effects.</P>
KIM, JAE HYEON,KIM, HYEON-JU,KIM, JIN-KYU,AHN, EUN-KYUNG,KO, HYE-JIN,CHO, YOUNG-RAK,LEE, SANG-JIN,BAE, GYU-UN,KIM, YONG KEE,PARK, JONG WOO,OH, JOA SUB,SEO, DONG-WAN Spandidos Publications 2015 ONCOLOGY REPORTS Vol.34 No.1
<P>Ligularia fischeri (LF) has been used as an edible herb and traditional medicine for the treatment of inflammatory and infectious diseases. In the present study, we report the effects and molecular mechanism of the ethanolic extract of LF on cell proliferation, invasion and tube formation in human umbilical vein endothelial cells (HUVECs). LF-mediated inhibition of cell proliferation was accompanied by reduced expression of cell cycle-related proteins such as cyclin-dependent kinases (Cdks) and cyclins, leading to pRb hypophosphorylation and G1 phase cell cycle arrest. We also show that LF treatment inhibited cell invasion and tube formation in HUVECs. These anti-angiogenic activities of LF were associated with the inactivation of mitogenic signaling pathways, induction of vascular endothelial (VE)-cadherin distribution at cell-cell contacts and inhibition of matrix metalloproteinase (MMP) expression. Collectively, our findings demonstrate the pharmacological functions and molecular mechanisms of LF in regulating endothelial cell fates, and support further development as a potential therapeutic agent for the treatment and prevention of angiogenesis-related disorders including cancer.</P>