구순열과 구개열환자의 특성에 관한 분석

나후자,양은진,김선,김수일,김원식 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2

The cleft lip and cleft palate has relatively high incidence among congenital anomalies. The etiological factors of these anomalies have been studied widely, but they are not yet understood perfectly. So, the authors reviewed and analyzed retrospectively 505 cases of cleft lip and cleft palate patients who were treated at the Chungnam Uiversity Hospital during the past 12 years from January 1985 to December 1996 for evaluation of etiological factors of cleft lip and palate, and the results were as follows : 1. The male was affected 1.6 times more frequently in cleft lip with palate, but the female was affected 1.8 time more frequently in cleft palate alone. 2. The incomplete cleft lip was 1.7 times higher than complete type and the ratio of left, right and bilateral was 2.1 : 1 : 0.3, and complete cleft lip with palate was 4 times higher than incomplete type and the ratio of left, right and bilateral was 1.2 : 1 : 0.9. 3. The incomplete cleft palate was 6.6 times higher than complete cleft palate. 4. There was positive family history in 11.8% of all the patients. 5. There was combined congenital anomalies with cleft lip and palate in 18.8% of all patients, and the most frequently involved anomaly was the ear anomaly. 6. U.R.I was the most frequently involved disease and herb medicine was the most frequently administered drug during the frist trimester. 7. In educational level of parents, senior high school was 66.5% of all.

한국인 정신분열병과 HLA-DRB1 대립유전자의 관련성

황나영,김종원,오흥범,조지희,오선영,홍진표,박종익,이동은 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.5

연구목적: 유전이 정신분열병의 중요한 원인이라는 것은 널리 인정되어 왔다. 본 연구는 한국인 정신분열병과HLA-DRB1 유전자좌와의 관련성을 알아보고 외국인 대상의 보고들과 비교함으로써 한국인 정신분열병의 유전적 특성을 밝히고자 시행하였다. 방법: 정신분열병 환자 70명을 대상으로 HLA-DRB1 대립유전자를 고해상도 수준까지 분석하였다. 저해상도 수준의 HLA-DR결과는 정상 한국인 2,000명의 연구 보고와 비교하였으며 고해상도 수준의 HLA-DRB1 결과는 정상 한국인 229명의 연구 보고와 비교하였다. 결과: 저해상도 수준에서는 HLA-DR11이 정신분열병 환자군에서 9.0%, 정산인에서는 3.8%의 빈도를 보여 환자군에서 통계적으로 유의하게 높은 빈도를 보였으며(p=0.005), 고해상도 수준에서는 HLA-DRB1*1101이 환자군에서 9.0%로 정상인의 1.8%보다 유의하게 높은 빈도를 보였다(p<0.001). 결론: 본 연구에서는 한국인 정신분열병과 HLA-DR11(HLA-DRB1*1101)이 양적 상관관계를 보여 백인에서 DR4와 부정적 상관관계를 보인 결과나 일본인에서 DR1(DRB1*0101)과 양적 상관관계를 보인 결과와 상이하였다. 이러한 한국인 정신분열병 환자의 유전적 특성은 가족연구 혹은 더 많은 수의 환자를 대상으로 한 관련연구를 통하여 재확인되어야 할 것이다. 중심단어:정신분열병·HLA-DRB1·관련연구. Objective: A genetic predisposition is widely accepted in schizophrenia. This study was intended to fine any association of HLA-DRB1 alleles with korean schizophrenics and thereby compare the results of other ethni groups. Method: The subjects were 70 unrelated Korean patients. Low and high resolution typing of HLA-DRB1 alleles were performed. The comparison groups were 2,000 unrelated healthy Koreans for low resolution HLA-DR and 229 unrelated healthy Koreans for HLA-DRB1 alleles. Results: Gene frequencies of HLA-DR11(patients 9.0%, healthy control 3.8%, p=0.005) and HLA-DRB1*1101(patients 9.0%, healthy control 1.8%, p<0.001) were significantly higher in Korean schizophrenics. Conclusion: The frequency of HLA-DR11(HLA-DRB1*1101) is significantly higher in Korean schizophrenics than in healthy Koreans. HLA-DR4 and HLA-DR1, which were known to be associated with Caucasian and Japanese schizophrenics, respectively, did not show statistical association with Korean schizophrenics. This association need to be reassured though further studies with families or association study with larger numbers of subjects. KEY WORDS:Schizophrenia·HLA-DRB1·Association study.

제한효소인 Sdi Ⅰ을 생성하는 Streptomyces 분리 균주의 수리동정

배무,서원나,송은숙,이계준 이화여자대학교 생명과학연구소 1994 생명과학연구논문집 Vol.5 No.-

제한효소인 Sdi I을 생산하는 한 균주(Streptomyces sp.264)를 토양으로부터 분리하여 형태적 관찰 및 수리동정을 실시하였다. 50여개의 분류 단위 형질을 분석하였고, 이 실험 결과를 TAXON program에 적용하여 종의 수리동정을 실시하였다. 그 결과 분리균 sp.264는 Streptomyces의 제 19주군집에 속하는 Streptomyces diastatochromogenes의 한 균주로 동정되었다. Numerical identification was applied for Streptomyces sp.264, an isolate producing a new restriction endonuclease Sdi I. The restriction enzyme would appear to be an isoschisomer of Xho I. Fifty taxonomic unit characters were tested and the data obtained were analyzed numerically by using the TAXON program. The isolate was identified to be the jamor cluster 19 of Streptomyces and best matched to S. diastatochromogenes. It was, therefore, concluded that the isolate was identified to be a member of Streptomyces diastatochromogenes.

Heavy Metal Contents, Chemical Composition and Cytotoxic Effect of Largescale Blackfish (Girella punctata)

Eun Na,Yeon Jung Choe,Ji Won Seo,Won Hee Jo,Sung Won An,Jing wen Chen,Sun Young Lim 한국식품영양학회 2019 한국식품영양학회 학술대회논문집(학술심포지움) Vol.2019 No.11

Dietary Intake of Limosilactobacillus reuteri MGEL21002 Prevents Obesity and Type2 Diabetes in Diet-induced Obese Mice

Eun Ji LEE,Ji Eun LIM,Dong Pil KIM,So Young PARK,Dong Nyoung OH,Sung Jin JUNG,Jin Won CHOI,Da Young KIM,Na Young BEEN,Yun Jy HEO,Hyo Jeong SONG,Seok Won KIM,Sun Jay YOON,Won Je JANG,Jong Min LEE 한국생물공학회 2022 한국생물공학회 학술대회 Vol.2022 No.9

Effect of Intraoperative Mitomycin C on the Surgical Outcomes of Ahmed Glaucoma Valve Implantation with Ciliary Sulcus Tube Placement

Na Eun Kim(Na Eun Kim),Sung Sik Kim(Sung Sik Kim),Jihei Sara Lee(Jihei Sara Lee ),Kwanghyun Lee(Kwanghyun Lee),Hyoung Won Bae(Hyoung Won Bae),Sang Yeop Lee(Sang Yeop Lee),Wungrak Choi(Wungrak Choi),Ch 대한안과학회 2023 Korean Journal of Ophthalmology Vol.37 No.3

Purpose: To evaluate the effect of intraoperative mitomycin C (MMC) on the surgical outcomes of ciliary sulcus (CS) Ahmed glaucoma valve (AGV) tube placement. Methods: A retrospective review of medical records of 54 consecutive patients who underwent AGV implantation with tube placed in CS was performed. Consecutive cases operated without the use of intraoperative MMC from 2017 to 2019 were compared with consecutive cases operated with MMC from 2019 to 2021. Surgical failure was defined as intraocular pressure (IOP) exceeding 21 mmHg in two consecutive visits after postoperative 3 months or ≤30% IOP reduction, IOP ≤5 mmHg in two consecutive visits, or loss of light perception. Kaplan-Meier survival analysis and log-rank test were performed to compare the surgical failure rates. Results: A total of 54 eyes of 54 patients were investigated. Mean follow-up period after AGV implantation was 1.4 ± 0.8 years. The MMC group showed significantly lower IOP during the 1st postoperative month (20.5 ± 8.6 mmHg vs. 15.8 ± 6.4 mmHg, p = 0.027), but the difference did not persist 6 months after the surgery (p = 0.805). The mean number of postoperative antiglaucoma medications was significantly lower in the MMC group in the 1st postoperative month (p = 0.047) but no difference was found at 6 months. No statistical difference was noted in the rates of postoperative complications. Kaplan- Meier survival analysis showed comparable survival rates between MMC group and no MMC group (p = 0.356). Conclusions: The intraoperative use of MMC significantly lowered IOP in the 1st postoperative month but did not increase 6 months success rates in patients receiving AGV tube placement in CS.

Phaeohyphomycosis due to Pleurostomophora richardsiae in a Patient with a Hematological Malignancy

Eun Jeong Won,Sook-Ja Park,Uiree Jo,Heungsup Sung,Eun-Ji Choi,Mi-Na Kim 한국균학회 2023 Mycobiology Vol.51 No.6

N/A

Critically Ill Patients with Pandemic Influenza A/H1N1 2009 at a Medical Center in Korea

( Eun Young Choi ),( Jin Won Huh ),( Chae Man Lim ),( Youn Suck Koh ),( Sung Han Kim ),( Sang Ho Choi ),( Won Young Kim ),( Won Kim ),( Mi Na Kim ),( Sang Bum Hong ) 대한결핵 및 호흡기학회 2011 Tuberculosis and Respiratory Diseases Vol.70 No.1

Background: The aim of the study was to describe the characteristics, treatments, and outcomes of critically ill patients with pandemic Influenza A/H1N1 2009 at a major medical center in Korea. Methods: This retrospective observational study examined critically ill adult patients with pandemic Influenza A/H1N1 2009, who were admitted to the AMC between August and December 2009. Results: 27 patients with confirmed pandemic Influenza A/H1N1 2009 were admitted to the intensive care unit (ICU) at the Asan Medical Center (AMC). The median age (IQR) was 59 years (41∼67), and 66.7% of the patients were older than 51 years. A total of 81.5% of the patients had 2 or more co-morbidities. The median time (IQR) from symptom onset to presentation was 2 days (1∼4), and the median time from presentation to ICU admission was 0 days (0∼1.5). All patients received oseltamivir (300 mg/day) and 13 patients received triple combination therapy (oseltamivir, amantadine, ribavirin). Twelve patients required mechanical ventilation on the first day of ICU admission. A total of 6 patients (22.2%) died within 28 days of admission. The patients who died had significantly higher acute physiology and chronic health evaluation (APACHE) II and sequential organ failure assessment (SOFA) scores at presentation. There were no significant differences in age, co-morbidities, or antiviral regimens between survivors and non-survivors. Conclusion: Critical illness related to pandemic Influenza A/H1N1 2009 was common in elderly patients with chronic co-morbidities. All patients were given high-dose oseltamivir or triple combination antiviral therapy. Nonetheless, patients with critical illnesses associated with pandemic Influenza A/H1N1 2009 had a death rate of 22.2%.

Critically Ill Patients with Pandemic Influenza A/H1N1 2009 at a Medical Center in Korea

Choi, Eun-Young,Huh, Jin-Won,Lim, Chae-Man,Koh, Youn-Suck,Kim, Sung-Han,Choi, Sang-Ho,Kim, Won-Young,Kim, Won,Kim, Mi-Na,Hong, Sang-Bum The Korean Academy of Tuberculosis and Respiratory 2011 Tuberculosis and Respiratory Diseases Vol.70 No.1

Background: The aim of the study was to describe the characteristics, treatments, and outcomes of critically ill patients with pandemic Influenza A/H1N1 2009 at a major medical center in Korea. Methods: This retrospective observational study examined critically ill adult patients with pandemic Influenza A/H1N1 2009, who were admitted to the AMC between August and December 2009. Results: 27 patients with confirmed pandemic Influenza A/H1N1 2009 were admitted to the intensive care unit (ICU) at the Asan Medical Center (AMC). The median age (IQR) was 59 years (41~67), and 66.7% of the patients were older than 51 years. A total of 81.5% of the patients had 2 or more co-morbidities. The median time (IQR) from symptom onset to presentation was 2 days (1~4), and the median time from presentation to ICU admission was 0 days (0~1.5). All patients received oseltamivir (300 mg/day) and 13 patients received triple combination therapy (oseltamivir, amantadine, ribavirin). Twelve patients required mechanical ventilation on the first day of ICU admission. A total of 6 patients (22.2%) died within 28 days of admission. The patients who died had significantly higher acute physiology and chronic health evaluation (APACHE) II and sequential organ failure assessment (SOFA) scores at presentation. There were no significant differences in age, co-morbidities, or antiviral regimens between survivors and non-survivors. Conclusion: Critical illness related to pandemic Influenza A/H1N1 2009 was common in elderly patients with chronic co-morbidities. All patients were given high-dose oseltamivir or triple combination antiviral therapy. Nonetheless, patients with critical illnesses associated with pandemic Influenza A/H1N1 2009 had a death rate of 22.2%.

우황청심원(牛黃淸心元)이 정상인의 혈압(血壓), 맥박수(脈搏數), 뇌혈류(腦血流) 및 뇌혈관반응도(腦血管反應度)에 미치는 영향(影響)

윤상필,이상호,김은주,나병조,정동원,신원준,문상관,배형섭,김이동,Yun, Sang-Pil,Lee, Sang-Ho,Kim, Eun-Ju,Na, Byong-Jo,Jung, Dong-Won,Shin, Won-Jun,Moon, Sang-Kwan,Bae, Hyung-Sup,Kim, Lee-Dong 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.3

Objectives: Uwhangchungsim-won(UC) has been used in the treatment of a wide variety of conditions including stroke, hypertension, arterosclerosis, autonomic imbalance, and mental instability, in Korean traditional hospitals. The aim of this study was to evaluate the effect of DC on cerebral hemodynamics and to determine the appropriate dosage. Methods: We studied changes in hyperventilation-induced cerebrovascular reactivity and mean blood flow velocity of the middle cerebral arteries(MCAs) were studied by means of transcranial Doppler ultrasound. Changes in mean blood pressure, pulse rate and expiratory CO2(PECO2) were observed using Cardiocap TM/5. Six healthy young volunteers who were administrated with full doses of DC for group A, and half doses for group B. Six other healthy subjects comprised the control group. The evaluation was performed during basal condition, and repeated at 20, 40, 60, 120, and 180 minutes after administration. Results: Increases of cerebrovascular reactivity and mean blood flow velocity in the middle cerebral artery in group A were significantly different compared with group B and the control group (p<0.1). Mean blood pressure, pulse rate and expiratory CO2 did not change during the observation and were not different among these three groups. We observed that in cerebrovascular reactivity induced hyperventilation, group A was most effective at 40 minutes after administration, and its effectiveness lasted for 120 minutes. Conclusions: This study provides evidence for UC, in full doses, as an agent for dilation of the cerebral arteriols to increase hyperventilation-induced cerebrovascular reactivity as a consequence of faster recovery of blood flow velocity.