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Hypothalamic AMPK as a Regulator of Energy Homeostasis
Huynh, My Khanh Q.,Kinyua, Ann W.,Yang, Dong Joo,Kim, Ki Woo Hindawi Publishing Corporation 2016 Neural plasticity Vol.2016 No.-
<P>Activated in energy depletion conditions, AMP-activated protein kinase (AMPK) acts as a cellular energy sensor and regulator in both central nervous system and peripheral organs. Hypothalamic AMPK restores energy balance by promoting feeding behavior to increase energy intake, increasing glucose production, and reducing thermogenesis to decrease energy output. Besides energy state, many hormones have been shown to act in concert with AMPK to mediate their anorexigenic and orexigenic central effects as well as thermogenic influences. Here we explore the factors that affect hypothalamic AMPK activity and give the underlying mechanisms for the role of central AMPK in energy homeostasis together with the physiological effects of hypothalamic AMPK on energy balance restoration.</P>
On 5-Axis Freeform Surface Machining Optimization: Vector Field Clustering Approach
My Chu A,Bohez Erik L J,Makhanov Stanlislav S,Munlin M,Phien Huynh N,Tabucanon Mario T Society for Computational Design and Engineering 2005 International Journal of CAD/CAM Vol.5 No.1
A new approach based on vector field clustering for tool path optimization of 5-axis CNC machining is presented in this paper. The strategy of the approach is to produce an efficient tool path with respect to the optimal cutting direction vector field. The optimal cutting direction maximizes the machining strip width. We use the normalized cut clustering technique to partition the vector field into clusters. The spiral and the zigzag patterns are then applied to generate tool path on the clusters. The iso-scallop method is used for calculating the tool path. Finally, our numerical examples and real cutting experiment show that the tool path generated by the proposed method is more efficient than the tool path generated by the traditional iso-parametric method.
Dynamic stability of cholesterol and desmosterol in human milk from four asian countries
김지은,My Tuyen Thi Nguyen,김용기,정지아,Dan Li,Mai Xuan Hong To,Huynh Khanh Trang Nguyen,Beenish Israr,Thanh Van Le,안현주,김재한 한국식품과학회 2022 Food Science and Biotechnology Vol.31 No.12
Cholesterol is one of the functional nutrients in human milk, which is indispensable for infant growth. In this study, the concentration of cholesterol and desmosterol in human milk from four Asian countries (n = 578), including Korea, China, Vietnam, and Pakistan, were investigated. The average cholesterol concentrations of Korea and China were similar ranging between 90.2–91.6 mg/L, but those from Vietnam and Pakistan were higher at 113.8 and 175.7 mg/L, respectively. The relative standard deviations were 31–36%, except for Pakistan (51%), showing a broad distribution of 48 to 612 mg/L. Desmosterol concentrations were similar, ranging between 11.2 and 12.8 mg/L except for Pakistan, which was lower than other countries at 9.4 mg/L. In addition, the cholesterol and desmosterol concentrations during the lactation periods were not significantly different in all four Asian countries. Mothers’ BMI did not significantly impact the cholesterol and desmosterol concentration in maternal milk within the same country.
Endoscopic Evaluation of Biliary Strictures: Current and Emerging Techniques
Roy Huynh,Corinne Owers,Christopher Pinto,Thuy-My Nguyen,Titus Kwok 대한소화기내시경학회 2021 Clinical Endoscopy Vol.54 No.6
The diagnosis of biliary strictures in clinical practice can be challenging. Discriminating between benign and malignant biliarystrictures is important to prevent the morbidity and mortality associated with incorrect diagnoses. Missing a malignant biliarystricture may delay surgery, resulting in poor prognostic outcomes. Conversely, it has been demonstrated that approximately20% of patients who undergo surgery for suspected biliary malignancies have a benign etiology on histopathology. Traditionaltissue sampling using endoscopic retrograde cholangiography does not always produce a definitive diagnosis, with a considerableproportion of cases remaining as indeterminate biliary strictures. Recent advances in endoscopic techniques have the potential toimprove the diagnostic and prognostic accuracy of biliary strictures.
김혜권,유광수,Thi My Le Huynh,문형준,Van Giap Nguyen,박봉균 대한수의학회 2017 Journal of Veterinary Science Vol.18 No.2
There are high levels of co-incidence of porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2) in porcine tissue. This study established a duplex nested reverse transcriptase polymerase chain reaction (RT-PCR) method that targets the genomic RNA of type 2 PRRSV and the mRNA of PCV2 in infected tissues. The method amplified discriminative bands of 347 bp and 265 bp specific for type 2 PRRSV and PCV2, respectively. The limits of detection of the duplex nested RT-PCR were 101.5 TCID50/mL for type 2 PRRSV and 102 infected cells/mL for PCV2. The kappa statistic, which measures agreement between methods, was 0.867, indicating a good level of agreement. This RNA-based duplex RT-PCR approach can be another way to detect type 2 PRRSV and PCV2 simultaneously and with improved convenience.
La Nam Phat,Tran Quoc Thang,Huynh Cam Nguyen,Dang Thi My Duyen,Dao Xuan Tien,Bui Dang Dang Khoa,Pham Tan Khang,Nguyen Thi Huong Giang,Hoang Minh Nam,Mai Thanh Phong,Nguyen Huu Hieu 한국화학공학회 2021 Korean Journal of Chemical Engineering Vol.38 No.11
Recycling biomass to cellulose aerogel (Cell-A) provides a promising approach to develop adsorbent materials for spilled-oil recovery. In this work, Cell-A was fabricated from Vietnamese water hyacinth via crosslinking methods using PVA as a crosslinker and freeze-drying process. Various cellulose to PVA ratios were investigated to obtain the optimal synthesis condition. The Cell-A was additionally modified by dip-coating in poly(dimethylsiloxane) (PDMS) and pyrolyzing to form PDMS-coated cellulose aerogels (Cell-AP) and carbon aerogels (CA), respectively. Results of the oil adsorption tests show that pyrolysis produced aerogels with greater adsorption capacity with an optimal mass ratio of 15 : 1 cellulose to PVA. Furthermore, the pseudo-second-order model was found to be more accurate than the pseudo-first-order model for the study of oil absorption kinetics. As a result, the modified cellulose aerogel is promising for replacing earth-unfriendly polymer-based oil sorbents due to their high oil absorption capacity.
SCN1A Gene Mutation and Adaptive Functioning in 18 Vietnamese Children with Dravet Syndrome
Thi Thu Hang Do,Diem My Vu,Thi Thuy Kieu Huynh,Thi Khanh Van Le,손은화,Thieu Mai Thao Le,Huu Hao Ha,Chi Bao Bui 대한신경과학회 2017 Journal of Clinical Neurology Vol.13 No.1
Background and Purpose Dravet syndrome is a rare and severe type of epilepsy in infants. The heterogeneity in the overall intellectual disability that these patients suffer from has been attributed to differences in genetic background and epilepsy severity. Methods Eighteen Vietnamese children diagnosed with Dravet syndrome were included in this study. SCN1A variants were screened by direct sequencing and multiplex ligation-dependent probe amplification. Adaptive functioning was assessed in all patients using the Vietnamese version of the Vineland Adaptive Behavior Scales, and the results were analyzed relative to the SCN1A variants and epilepsy severity. Results We identified 13 pathogenic or likely pathogenic variants, including 6 that have not been reported previously. We found no correlations between the presence or type of SCN1A variants and the level of adaptive functioning impairment or severity of epilepsy. Only two of nine patients aged at least 5 years had an adaptive functioning score higher than 50. Both of these patients had a low frequency of convulsive seizures and no history of status epilepticus or prolonged seizures. The remaining seven had very low adaptive functioning scores (39 or less) despite the variability in the severity of their epilepsy confirming the involvement of factors other than the severity of epilepsy in determining the developmental outcome. Conclusions Our study expands the spectrum of known SCN1A variants and confirms the current understanding of the role of the genetic background and epilepsy severity in determining the developmental outcome of Dravet syndrome patients.
Ann W Kinyua,고창만,Khanh V Doan,양동주,My Khanh Q Huynh,모상현,최윤희,김기우 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
4-hydroxy-3-methoxycinnamic acid (ferulic acid, FA) is known to have numerous beneficial health effects, including anti-obesity and anti-hyperglycemic properties. However, the molecular networks that modulate the beneficial FA-induced metabolic effects have not been well elucidated. In this study, we explored the molecular mechanisms mediating the beneficial metabolic effects of FA. In mice, FA protected against high-fat diet-induced weight gain, reduced food intake and exhibited an overall improved metabolic phenotype. The food intake suppression by FA was accompanied by a specific reduction in hypothalamic orexigenic neuropeptides, including agouti-related protein and neuropeptide Y, with no significant changes in the anorexigenic peptides proopiomelanocortin and cocaine and amphetamine-regulated transcript. FA treatment also inhibited fat accumulation in the liver and white adipose tissue and suppressed the expression of gluconeogenic genes, including phosphoenolpyruvate carboxylase and glucose-6-phosphatase. Furthermore, we show that FA phosphorylated and inactivated the transcription factor FoxO1, which positively regulates the expression of gluconeogenic and orexigenic genes, providing evidence that FA might exert its beneficial metabolic effects through inhibition of FoxO1 function in the periphery and the hypothalamus.
Characterization of Ag-Doped p-Type SnO Thin Films Prepared by DC Magnetron Sputtering
Pham, Hoai Phuong,Thuy, Thanh Giang Le,Tran, Quang Trung,Nguyen, Hoang Hung,My Hoa, Huynh Tran,Thi Thu, Hoang,Cuong, Tran Viet Hindawi Limited 2017 Journal of nanomaterials Vol.2017 No.-
<P>Crystalline structure and optoelectrical properties of silver-doped tin monoxide thin films with different dopant concentrations prepared by DC magnetron sputtering are investigated. The X-ray diffraction patterns reveal that the tetragonal SnO phase exhibits preferred orientations along (101) and (110) planes. Our results indicate that replacing Sn<SUP>2+</SUP> in the SnO lattice with Ag<SUP>+</SUP> ions produces smaller-sized crystallites, which may lead to enhanced carrier scattering at grain boundaries. This causes a deterioration in the carrier mobility, even though the carrier concentration improves by two orders of magnitude due to doping. In addition, the Ag-doped SnO thin films show a p-type semiconductor behavior, with a direct optical gap and decreasing transmittance with increasing Ag dopant concentration.</P>