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      • KCI등재

        만성폐쇄성폐질환 환자의 마취관리

        안현주 대한의사협회 2020 대한의사협회지 Vol.63 No.9

        Chronic obstructive pulmonary disease (COPD) is the third most common cause of death worldwide. It has a prevalence of 14% among Koreans aged above 40 years and a prevalence of 31% among those aged above 65 years. However, only 6% of the COPD patients receive treatment. Most of the patients do not seek medical attention, as they think that dyspnea, cough, and productive sputum, which are the common symptoms of COPD, are normal aging phenomena. Smoking is a major risk factor for COPD, but environmental hazards and genetic susceptibility are also involved. With aging, lung injuries due to these risk factors accumulate, leading to increased prevalence of COPD. The major concerns regarding perioperative management of COPD patients include preoperative evaluation of cardiopulmonary risks, optimization of lung function, and evaluation of COPD-related physiological functions that are easily aggravated during anesthesia. These include respiratory muscle dysfunction, dynamic hyperinflation and auto-positive end-expiratory pressure, hypoxia-hypercarbia, and pulmonary hypertension-associated heart failure. Therefore, anesthesia for COPD patients should focus on preoperative evaluation, risk reduction measures, and prevention of postoperative pulmonary complications.

      • KCI등재

        감마선 조사 숙면의 미생물 및 일반 품질특성 변화

        안현주,김동호,변명우,육홍선,조철훈 한국식품위생안전성학회 2000 한국식품위생안전성학회지 Vol.15 No.3

        Effect of gamma irradiation on quality properties of half-cooked noodle was studied. The noodle were treated with lactic acid(0.1%, w/w), heat(10 min in boiling water) or their combination after cooking for 3 min, and irradiated at 0, 5 and 10 kGy. The noodle were stored at 25℃ for 5 weeks and microbial population, Aw, pH, and texture profiles were examined. Fungi were completely eliminated by gamma-irradiation with 5 or 10 kGy does. Number of aerobic bacteria were also decreased by 2 and 4 log cycles with dose of 5 and 10 kGy, respectively. The D_(10) values of aerobic bacteria were 2.34-2.95 kGy. Growth of the aerobic bacteria that survived even at 10 kGy of irradiation were significantly inhibited during storage. Acidification of half-cooked noodle was suppressed by gamma irradiation but A_w were not affected. Stickiness was decreased at the beginning of storage by gamma irradiation but was restored after 3 weeks. The results indicated that the gamma irradiation would be useful to improve quality and storage stability of half-cooked noodle.

      • KCI등재

        사과 자엽의 기내 식물체 재분화와 배양 광조건 및 절편체 극성과의 관계

        안현주,예병우,임용표,신용억 한국식물생명공학회 2000 식물생명공학회지 Vol.27 No.1

        The experiment was carried out to investigate the influence of light condition and polarity of explant on adventitious shoot formation from cotyledon of apple in vitro The treatment of light culture after 10days dark treatment showed effective result than other treatments on the rate of adventitious shoot formation on light intensity treatments and also the treatment of blue light treatment after 4days dark treatment showed more effective result than other treatments in light quality treatments. The polarity of explant influence on adventitious shoot formation. Adventitious multiple shoot formation occured at the proximal end of an excised cotyledon. In other words. shoot organogenesis occured at the proximal cut surfaces of both proximal and distal explants rather than at the distal cut surface of proximal explants. 사과 자엽조직으로부터 기내에서 식물체를 재분화시키는 데에 있어서 배양 광조건 및 절편체 극성과의 관계를 살펴보고자 사과‘Fuji’품종의 자엽을 재료로하여 광조건 및 광질을 달리하여 배양하였고, 또한 여러 가지 형태의 절편체를 사용하여 시험을 수행하였다. 배양환경조건 중 광조성에 따른 신초 재분화율을 본 결과 배양 초기 10일간 암배양한 후 명 배양한 처리구에서 가장 높은 재분화율을 나타내었으며, 배양중기의 암처리는 효과가 없었다. 광질별로 비교할 때 전처리로 4일간 암배양한 후 청색광을 조사한 처리구에서 높은 신초 재분화율을 나타내었다. 신초 재분화 유기와 절편체 극성과의 관계를 보면 모든 신초의 형성은 절제된 자엽의 기부 끝쪽에서만 이루어졌다. 즉, 기부쪽 절편체의 말단부 절단면에서보다는 기부쪽 절편체와 말단 절편체의 기부쪽 절단면에서 식물체의 재분화가 이루어짐을 알 수 있었다. 신초 유기는 배축의 기부쪽 자엽 절편체 에서 매우 높게 나타난 반면 자엽의 말단부위에 가까운 곳에서는 현저히 감소하였다.

      • 仙方活命飮 및 구성약물의 세포독성에 관한 실험적 연구

        안현주,지선영,An Hyun-jue,Jee Seon-young 대한한의진단학회 2004 大韓韓醫診斷學會誌 Vol.17 No.1

        The purpose of this research was to investigate cytotoxity of Sunbanhwalmyungeum extract. Cytotoxity was determined by MTT assay method. After tumor cell lines(G361, BI6F10, MDA, A549) transplantation, the extracts of SunBangHwalMyungEum and its composition oriental medicines were administered, cytotoxity was measured by absorbance. The results were obtained as follows. 1. Sunbanhwalmyungeum extract and its composition oriental medicines extracts showed the concentration was higher, the more cytotoxity increased. 2. Both water and ethanol extracts of Sunbanhwalmyungeum showed excellent cytotoxity against G361, B16F10, MDA, A549 and high cytotoxity over 80$\%$ against G361, B16F10, MDA except A549 at the concentration of 1000ppm. 3. In water extract, Rhei Radix et Rhizoma, Gleditsiae Spina, Trichosanthis Radix, Glycyrrhizae Radix, Ledebouriellae Radix showed excellent cytotoxity. In ethanol extract, Gleditsiae Spina, Citri Pericarpium, Trichosanthis Radix, Paeoniae Radix Rubra, Myrrha showed excellent cytotoxity. 4. Rhei Radix et Rhizoma, Gleditsiae Spina, Trichosanthis Radix, Paeoniae Radix Rubra showed high cytotoxity in both water and ethanol extrats. 5. In water extract, Glycyrrhizae Radix, Ledebouriellae Radix, Myrrha showed high cytotoxity against A361, Lonicerae Flos, Olibanum, Fritillariae cirrhosae Bulbus, Paeoniae Radix Rubra, Manitis Squama against B16F10, Paeoniae Radix Rubra, Manitis Squama against MDA, Rhei Radix et Rhizoma, Angelicae gigantis Radix against A549. 6. In ethanol extract, Lonicerae Flos, Trichosanthis Radix showed high cytotoxity against G361, Rhei Radix et Rhizoma, Angelicae gigantis Radix, Gleditsiae Spina, Olibanum, Angelicae dahuricae Radix, Fritillariae cirrhosae Bulbus, Paeoniae Radix Rubra, Glycyrrhizae Radix, Ledebouriellae Radix, Myrrha against B16F10, Rhei Radix et Rhizoma, Manitis Squama against MDA, Citri Pericarpium, Manitis Squama against A549.

      • KCI등재

        하서(河西) 김인후(金麟厚)의 독서관에 관한 연구 - "하서전집"의 인용문헌 분석을 중심으로 -

        안현주,Ahn, Hyeon-Ju 한국도서관정보학회 2008 한국도서관정보학회지 Vol.39 No.3

        이 연구는 "하서전집"의 인용문헌 분석을 통해 김인후의 독서관을 고찰하였다. 그 결과 최소한 123종의 책을 독서했으며, "사서삼경", "사기", "한서", "장자", "고문진보", "초사", "문선"을 가장 많이 인용하였다. 김인후는 16세기 선비들이 보여주는 공통적인 독서범주를 뛰어넘은 다양한 독서, 시대상에 구애받지 않은 자유로운 독서를 했음을 알 수 있다. 그의 독서관은 성리학의 경서를 중요시 여겼으며 또한 다양한 독서를 통하여 실생활에 유익한 지식을 얻음과 동시에 방대한 저술의 바탕을 마련하였다. This study investigates Kim Inhue's view of reading through the analysis of reference books in Haseo-Chunjib(하서전집). As the result, he had read 123 different books ar least. He had quoted frequently $Sish{\bar{u}}$ $S{\bar{a}}nj{\bar{i}}ng$(사서삼경), $Sh{\check{i}}ji$(사기), $H{\grave{a}}nsh{\bar{u}}$(한서), $Zhu{\bar{a}}ngz{\check{i}}$(장자), $G{\check{u}}wenzh{\bar{e}}nb{\check{a}}o$(고문진보), $Ch{\check{u}}c{\acute{i}}$(초사), $W{\acute{e}}nxu{\check{a}}n$(문선). He had read books beyond the contemporary(sixteen centurtry) scholar's common list, and had enjoyed reading over the boundaries of stereotyped idea. While he had emphasized on the scripture of Confucian, had earned more knowledges for usefulness and the bases of scholarly writings by reading a wide spectrum of books.

      • SCOPUSKCI등재

        말기 암환자에 있어서 우울증의 정도 및 영향 요소들

        안현주,한태형 대한마취과학회 2000 Korean Journal of Anesthesiology Vol.39 No.4

        Background: This study was conducted to survey the incidences, severity, and variables influencing depression and the correlation between pain and depression in Korean cancer patients. Methods: The results of a survey were collected from 142 patients, 79 male and 63 female (mean age 51.9 years), who were hospitalized at a major metropolitan tertiary care hospital for cancer treatment from January to June of 1999. Factors of depression and the level of pain were examined by a selfreported survey employing the Korean version of the Beck Depression Inventory (BDI) and an abridged version of the Brief Pain Inventory respectively. Demographic and clinical characteristics of patients were compiled by reviewing their medical records. The difference in the level of depression among patient groups was analyzed with the t-test and ANOVA, and the correlation between variables with the Pearson correlation coefficient. Results: The mean scores of the worst pain for the last 24-hours was 6.1 ±2.2, the average pain for th last 24-hours 4.4 ±1.9, and the mean scores of pain at the time of the survey was 3.5 ±2.3, while the mean scores of the least pain for the last 24 hours was 2.3 ±1.8. The mean BDI scores were 23.7 ±1.0, and 55.6% of the patients were found to be in depression (cut off point 21). Scores of depression for cancer patients were higher than in the normal population. The correlations between the worst pain for the last 24 hours and depression, average pain for the last 24-hours and depression, pain at present and depression were significant. Significant differences were found among groups of cancer patients with pain with respect to gender,level of education, and ECOG. There was a significant positive correlation between depression and pain. Conclusions: More than 50% of cancer patients with pain were suffering from depression. The variables like the degree of pain, gender, level of education, ECOG, and age were significantly related to depression in cancer patients. The findings of this study could be ufor identifying high-risk patients in need of intervention and planning effective therapeutic strategies for cancer patients.

      • KCI등재

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