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Han Hui,Xiao Hao,Wu Zhixin,Liu Liang,Chen Ming,Gu Hanwen,Wang Hui,Chen Liaobin 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
As a synthetic glucocorticoid, dexamethasone is widely used to treat potential premature delivery and related diseases. Our previous studies have shown that prenatal dexamethasone exposure (PDE) can cause bone dysplasia and susceptibility to osteoporosis in female rat offspring. However, whether the effect of PDE on bone development can be extended to the third generation (F3 generation) and its multigenerational mechanism of inheritance have not been reported. In this study, we found that PDE delayed fetal bone development and reduced adult bone mass in female rat offspring of the F1 generation, and this effect of low bone mass caused by PDE even continued to the F2 and F3 generations. Furthermore, we found that PDE increases the expression of miR-98-3p but decreases JAG1/Notch1 signaling in the bone tissue of female fetal rats. Moreover, the expression changes of miR-98-3p/JAG1/Notch1 caused by PDE continued from the F1 to F3 adult offspring. Furthermore, the expression levels of miR-98-3p in oocytes of the F1 and F2 generations were increased. We also confirmed that dexamethasone upregulates the expression of miR-98-3p in vitro and shows targeted inhibition of JAG1/Notch1 signaling, leading to poor osteogenic differentiation of bone marrow mesenchymal stem cells. In conclusion, maternal dexamethasone exposure caused low bone mass in female rat offspring with a multigenerational inheritance effect, the mechanism of which is related to the inhibition of JAG1/Notch1 signaling caused by the continuous upregulation of miR-98-3p expression in bone tissues transmitted by F2 and F3 oocytes.
Shang-Hui Yang,Jian-Shian Lin,Fuh-Shyang Juang,Ding-Chin Chou,Ming-Hua Chung,Chen-Ming Chen,Lung-Chang Liu 한국물리학회 2013 Current Applied Physics Vol.13 No.5
In this paper, white light emitting diodes (LEDs) with good color rendering indices (CRI) and high luminous efficiencies have been fabricated by the encapsulation of mixed and double-deck phosphors. Experimental results revealed that white LEDs with the encapsulation of double-deck phosphors exhibited better CRI and higher luminous efficiencies than those with the encapsulation of mixed phosphors because no secondary excitation took place. The hue, CRI, and luminous efficiencies of white LEDs with double-deck phosphors under 200 mA were CIEx,y =(0.357, 0.348), 90, and 62.3 lm/W,respectively while the hue, CRI, and luminous efficiencies of white LEDs with mixed phosphors under 200 mA were CIEx,y = (0.366, 0.354), 89, and 56.5 lm/W, respectively.
Ke-Ming Wang,Feng Chen,Hui Hu,Hui-Hao Xia,Xue-Lin Wang,Bo-Rong Shi,Qing-Ming Lu 한국진공학회(ASCT) 2003 Applied Science and Convergence Technology Vol.12 No.S1
Both LiNbO₃ and KTiOPO₄ samples were implanted with 350 keV H^+ and He^+ ions at different doses ranging from 1×10^(16) to of 5×10^(16) ions/㎠. Single and multi-energy implantations were performed at room temperature. Mono-mode or a few modes in both LiNbO₃ and KTiOPO₄ waveguides were observed. The effect of temperature on the refractive index profiles of LiNbO₃ and KTiOPO₄ waveguids was studied. The temperature covered from room temperature, 200℃, 194.5 K (dry ice) and 77K (liquid nitrogen). Different mechanisms are needed to interpret the observed behavior. A n_e increased mono-mode LiNbO₃ waveguide was formed by multi-energy keV He^+ ions.
Wang, Shao-Ming,Hu, Shang-Ying,Chen, Feng,Chen, Wen,Zhao, Fang-Hui,Zhang, Yu-Qing,Ma, Xin-Ming,Qiao, You-Lin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.17
Objective: To make the clinical evaluation of a solid-state human papillomavirus (HPV) sampling medium in combination with an economical HPV testing method ($careHPV^{TM}$) for cervical cancer screening. Methods: 396 women aged 25-65 years were enrolled for cervical cancer screening, and four samples were collected. Two samples were collected by woman themselves, among which one was stored in DCM preservative solution (called "liquid sample") and the other was applied on the Whatman Indicating FTA $Elute^{(R)}$ card (FTA card). Another two samples were collected by physician and stored in DCM preservative solution and FTA card, respectively. All the samples were detected by $careHPV^{TM}$ test. All the women were administered a colposcopy examination, and biopsies were taken for pathological confirmation if necessary. Results: FTA card demonstrated a comparable sensitivity of detecting high grade Cervical Intraepithelial Neoplasia (CIN) with the liquid sample carrier for self and physician-sampling, but showed a higher specificity than that of liquid sample carrier for self-sampling (FTA vs Liquid: 79.0% vs 71.6%, p=0.02). Generally, the FTA card had a comparable accuracy with that of Liquid-based medium by different sampling operators, with an area under the curve of 0.807 for physician &FTA, 0.781 for physician &Liquid, 0.728 for self & FTA, and 0.733 for self &Liquid (p>0.05). Conclusions: FTA card is a promising sample carrier for cervical cancer screening. With appropriate education programmes and further optimization of the experimental workflow, FTA card based self-collection in combination with centralized $careHPV^{TM}$ testing can help expand the coverage of cervical cancer screening in low-resource areas.
Tsai Yu-Chen,Cheng Tai-Shan,Liao Hsiu-Jung,Chuang Ming-Hsi,Chen Hui-Ting,Chen Chun-Hung,Zhang Kai-Ling,Chang Chih-Hung,Lin Po-Cheng,Huang Chi-Ying F. 한국조직공학과 재생의학회 2022 조직공학과 재생의학 Vol.19 No.6
BACKGROUND: Extracellular vesicles (EVs) are derived from internal cellular compartments, and have potential as a diagnostic and therapeutic tool in degenerative disease associated with aging. Mesenchymal stem cells (MSCs) have become a promising tool for functional EVs production. This study investigated the efficacy of EVs and its effect on differentiation capacity. METHODS: The characteristics of MSCs were evaluated by flow cytometry and stem cell differentiation analysis, and a production mode of functional EVs was scaled from MSCs. The concentration and size of EVs were quantitated by Nanoparticle Tracking Analysis (NTA). Western blot analysis was used to assess the protein expression of exosomespecific markers. The effects of MSC-derived EVs were assessed by chondrogenic and adipogenic differentiation analyses and histological observation. RESULTS: The range of the particle size of adipose-derived stem cells (ADSCs)- and Wharton’s jelly -MSCs-derived EVs were from 130 to 150 nm as measured by NTA, which showed positive expression of exosomal markers. The chondrogenic induction ability was weakened in the absence of EVs in vitro. Interestingly, after EV administration, type II collagen, a major component in the cartilage extracellular matrix, was upregulated compared to the EV-free condition. Moreover, EVs decreased the lipid accumulation rate during adipogenic induction. CONCLUSION: The results indicated that the production model could facilitate production of effective EVs and further demonstrated the role of MSC-derived EVs in cell differentiation. MSC-derived EVs could be successfully used in cell-free therapy to guide chondrogenic differentiation of ADSC for future clinical applications in cartilage regeneration.
Height Effect could be a Factor for the Musculoskeletal Disorder in Cleaning Occupation
( Ming Hsu Wang ),( Wen Ko Chiou ),( Bi Hui Chen ) 한국감성과학회 2014 춘계학술대회 Vol.2014 No.-
Clearly, cleaning is a demanding repetitive occupation, which incurs a high level of musculoskeletal disorders. The phrase work-related upper limb musculoskeletal disorders includes a variety of upper limb degenerative and inflammatory diseases and disorders, which result in pain and functional impairment. Inappropriate and poor working postures, lack of task variation, poor ergonomic design of work places, poor design of cleaning tools and work organization (e.g., long working hours, low salaries and awkward schedules) are all areas where relatively simple interventions can significantly reduce the rate of exposure to occupational disease. The poor working resources make the high rate of related musculoskeletal disorders for the cleaners. The aim of this study was to compare the musculoskeletal disorders with different height of the cleaners and to evaluate the effect of height on cleaners`working postures in a school environment. Thirty motivated professional female cleaners from one university in Taiwan took part in this survey. Their age ranged from 45 to 65 years and the average length of their work experience was 6.5 years. The survey was carried out according to the following steps: Step 1: Definition of the framework/theme of the survey. Step2: Establishment of the goal, Step3: Nordic Musculoskeletal Questionnaire (NMQ) survey, Step4: Development of a cleaning task analysis, Step5: Rapid Entire Body Assessment (REBA) survey, Step6: Evaluation for NMQ and REBA.
Hui-Ming Xiang,Zhen Chen,Xian-Wei Li,Yan-Qiong Guo,Xian-Chun li,Rui-Yan Ma 한국응용곤충학회 2019 Journal of Asia-Pacific Entomology Vol.22 No.4
Grapholita molesta (Busck) (Lepidoptera: Tortricidae) is a notorious pest of many Rosaceae crops worldwide. Enhancement of trap efficiency of its sex pheromone was devised by addition of E-β-ocimene and E-β-farnesene. The addition of E-β-ocimene or E-β-farnesene to sex pheromone increased electroantennogram response of male G. molesta compared to sex pheromone alone. Blend of pheromone and E-β-ocimene or E-β-farnesene in 1:0.1 increased the upwind flight and landing behaviors. Furthermore, field experiments showed that sex lures with Eβ-ocimene, or /and E-β-farnesene, enhanced trapping efficiency compared to sex pheromone alone. These results may provide the basis for the development of efficient pest management systems against G. molesta using plant volatiles and insect sex pheromones.
Inverse active wind load inputs estimation of the multilayer shearing stress structure
Chen, Tsung-Chien,Lee, Ming-Hui Techno-Press 2008 Wind and Structures, An International Journal (WAS Vol.11 No.1
This research investigates the adaptive input estimation method applied to the multilayer shearing stress structure. This method is to estimate the values of wind load inputs by analyzing the active reaction of the system. The Kalman filter without the input term and the adaptive weighted recursive least square estimator are two main portions of this method. The innovation vector can be produced by the Kalman filter, and be applied to the adaptive weighted recursive least square estimator to estimate the wind load input over time. This combined method can effectively estimate the wind loads to the structure system to enhance the reliability of the system active performance analysis. The forms of the simulated inputs (loads) in this paper include the periodic sinusoidal wave, the decaying exponent, the random combination of the sinusoidal wave and the decaying exponent, etc. The active reaction computed plus the simulation error is regard as the simulated measurement and is applied to the input estimation algorithm to implement the numerical simulation of the inverse input estimation process. The availability and the precision of the input estimation method proposed in this research can be verified by comparing the actual value and the one obtained by numerical simulation.